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Journal of Receptors and Signal Transduction Volume 38, 2018 - Issue 4
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Research Article

In silico screening for identification of fatty acid synthase inhibitors and evaluation of their antiproliferative activity using human cancer cell lines

Amrutha Nisthul A.Department of Biotechnology and Microbiology, Kannur University, Kannur, India; View further author information
,
Archana P. RetnakumariDivision of Cancer Research, Rajiv Gandhi Center for Biotechnology, Thiruvananthapuram, IndiaView further author information
,
Shabna A.Division of Cancer Research, Rajiv Gandhi Center for Biotechnology, Thiruvananthapuram, IndiaView further author information
,
Ruby John AntoDivision of Cancer Research, Rajiv Gandhi Center for Biotechnology, Thiruvananthapuram, IndiaView further author information
&
C. SadasivanDepartment of Biotechnology and Microbiology, Kannur University, Kannur, India; Correspondence[email protected]
View further author information
Pages 335-341 | Received 24 May 2018, Accepted 05 Aug 2018, Published online: 26 Sep 2018

References

  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–674.
  • Hirschey MD, DeBerardinis RJ, Diehl AME, et al. Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol. 2015;35:S129–S150.
  • Baenke F, Peck B, Miess H, et al. Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development. Dis Model Mech. 2013;6:1353–1363.
  • Zhang F, Du G. Dysregulated lipid metabolism in cancer. World J Biol Chem. 2012;3:167–174.
  • Wakil SJ. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry 1989;28:4523–4530.
  • Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000;1:31–39.
  • Sebti SM. Protein farnesylation: implications for normal physiology, malignant transformation, and cancer therapy. Cancer Cell. 2005;7:297–300.
  • Currie E, Schulze A, Zechner R, et al. Cellular fatty acid metabolism and cancer. Cell Metab. 2013;18:153–161.
  • Jensen-Urstad APL, Semenkovich CF. Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger? BBA Mol Cell Biol Lipids. 2012;1821:747–753.
  • Migita T, Ruiz S, Fornari A, et al. Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst. 2009;101:519–532.
  • Kuhajda FP. Fatty acid synthase and cancer: new application of an old pathway. Cancer Res. 2006;66:5977–5980.
  • Rysman E, Brusselmans K, Scheys K, et al. De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res. 2010;70:8117–8126.
  • Liu H, Liu Y, Zhang JT. A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction. Mol Cancer Ther. 2008;7:263–270.
  • Menendez JA, Colomer R, Lupu R. Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids? Med Hypotheses. 2005;64:342–349.
  • O’Farrell M, Heuer T, Grimmer K, et al. Abstract LB-214: FASN inhibitor TVB-2640 shows pharmacodynamic effect and evidence of clinical activity in KRAS-mutant NSCLC patients in a phase I study. Cancer Res. 2016;76:LB-214–LB-214.
  • Lionta E, Spyrou G, Vassilatis DK, et al. Structure-based virtual screening for drug discovery: principles, applications and recent advances. Curr Top Med Chem. 2014;14:1923–1938.
  • Anderson AC. The process of structure-based drug design. Chem Biol. 2003;10:787–797.
  • Talele TT, Khedkar SA, Rigby AC. Successful applications of computer aided drug discovery: moving drugs from concept to the clinic. Ctmc. 2010;10:127–141.
  • Soulère L, Alix PM, Croze ML, et al. Identification of novel antilipogenic agents targeting fatty acid biosynthesis through structure‐based virtual screening. Chem Biol Drug Des 2018;92:1366–1372.
  • Smith S, Witkowski A, Joshi AK. Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res. 2003;42:289–317.
  • Smith S. The animal fatty acid synthase: one gene, one polypeptide, seven enzymes. Faseb J. 1994;8:1248–1259.
  • Qikprop, version 3.5. New York (NY): Schrodinger, LLC; 2012.
  • Lipinski CA, Lombardo F, Dominy BW, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 2001;46:3–26.
  • Mahto MK, Yellapu NK, Kilaru RB, et al. Molecular designing and in silico evaluation of darunavir derivatives as anticancer agents. Bioinformation 2014;10:221–226.
  • Glide, version 5.5. New York (NY): Schrödinger, LLC; 2009
  • Prime, version 2.1. New York (NY): Schrödinger, LLC; 2009
  • Repasky MP, Shelley M, Friesner RA. Flexible ligand docking with glide. Curr Protoc Bioinformatics. 2007;18:8–12.
  • Zaytseva YY, Harris JW, Mitov MI, et al. Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration. Oncotarget. 2015;6:18891.
  • Zaytseva YY, Rychahou PG, Le AT, et al. Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. Oncotarget. 2018;9:24787.
  • Wang H, Xi Q, Wu G. Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway. Cancer Med. 2016;5:1599–1606.

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