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Journal of Receptors and Signal Transduction Volume 38, 2018 - Issue 5-6
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Research Article

miR-21 promotes proliferation and inhibits apoptosis of hepatic stellate cells through targeting PTEN/PI3K/AKT pathway

Xin-Jie HaoHepatic Department, No. 6 Qingdao People’s Hospital, Qingdao, China;
,
Cheng-Zhen XuHepatic Department, No. 6 Qingdao People’s Hospital, Qingdao, China;
,
Jin-Tai WangOrthopedics Department, No. 8 Qingdao People’s Hospital, Qingdao, China;
,
Xiao-Jie LiHepatic Department, No. 6 Qingdao People’s Hospital, Qingdao, China;
,
Ming-Min WangHepatic Department, No. 6 Qingdao People’s Hospital, Qingdao, China;
,
Yi-Hai GuDepartment of Traditional Chinese Medicine, No. 6 Qingdao People’s Hospital, Qingdao, China; Correspondence[email protected]
&
Zhi-Gang LiangDepartment of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China
 show all
Pages 455-461 | Received 17 Sep 2018, Accepted 22 Jan 2019, Published online: 30 Apr 2019

References

  • Caballería L, Torán P, Caballería J. Markers of hepatic fibrosis. Med Clin (Barc). 2018;150:310–316.
  • Zoubek ME, Trautwein C, Strnad P. Reversal of liver fibrosis: from fiction to reality. Best Pract Res Clin Gastroenterol. 2017;31:129–141.
  • Kocabayoglu P, Friedman SL. Cellular basis of hepatic fibrosis and its role in inflammation and cancer. Front Biosci (Schol Ed). 2013;5:217–230.
  • Atta H, El-Rehany M, Hammam O, et al. Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibrosis in rats: role of ASH1 and EZH2 methyltransferases repression. PLoS One. 2014;9:e112384
  • Czaja AJ. Hepatic inflammation and progressive liver fibrosis in chronic liver disease. World J Gastroenterol. 2014;20:2515–2532.
  • Bermúdez Brito M, Goulielmaki E, Papakonstanti EA. Focus on PTEN regulation. Front Oncol. 2015;5:166
  • Miao Y, Zheng W, Li N, et al. MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway. Sci Rep. 2017;7:41942.
  • Zheng J, Wu C, Xu Z, et al. Hepatic stellate cell is activated by microRNA-181b via PTEN/Akt pathway. Mol Cell Biochem. 2015;398:1–9.
  • Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11:597–610.
  • Bhaskaran M, Mohan M. MicroRNAs: History, biogenesis, and their evolving role in animal development and disease. Vet Pathol. 2014;51:759–774.
  • Yu F, Yao H, Zhu P, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007;131:1109–1123.
  • Liu MX, Zhou KC, Cao Y. MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer. Mol Cancer. 2014;13:245
  • Iorio MV, Croce CM. microRNA involvement in human cancer. Carcinogenesis. 2012;33:1126–1133.
  • Leone E, Morelli E, Di Martino MT, et al. Targeting miR‑21 inhibits in vitro and in vivo multiple myeloma cell growth. Clin Cancer Res. 2013;19:2096–2106.
  • Zhang BG, Li JF, Yu BQ, et al. microRNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN. Oncol Rep. 2012;27:1019–1026.
  • Wang YG, Xu L, Wang T, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. WJG. 2015;21:8326–8339.
  • Yang J, Zou Y, Jiang D. Honokiol suppresses proliferation and induces apoptosis via regulation of the miR‑21/PTEN/PI3K/AKT signaling pathway in human osteosarcoma cells. Int J Mol Med. 2018;41:1845–1854.
  • Sun Q, Wang Y, Zhang J, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017;7:5498
  • Xu T, Pan Z, Dong M, et al. Ferulic acid suppresses activation of hepatic stellate cells through ERK1/2 and Smad signaling pathways in vitro. Biochem Pharmacol. 2015;93:49–58.
  • Feng J, Chen K, Xia Y, et al. Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways. Drug Des Devel Ther. 2018;12:1837–1853.
  • Li DM, Sun H. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Proc Natl Acad Sci USA. 1998;95:15406–15411.
  • Bellacosa A, Chan TO, Ahmed NN, et al. Akt activation by growth factors is a multiple-step process: The role of the PH domain. Oncogene. 1998;17:313–325.
  • Li JW, Wang XY, Zhang X, et al. Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway. Mol Med Rep. 2018;17:8300–8308.
  • Qin Y, Huo Z, Song X, et al. mir-106a regulates cell proliferation and apoptosis of colon cancer cells through targeting the PTEN/PI3K/AKT signaling pathway. Oncol Lett. 2018;15:3197–3201.

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