The hidden role of the Sigma1 receptor in muscle cells

References

• Hanner M, Moebius FF, Flandorfer A, et al. Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci USA. 1996;93(15):8072–8077.
   PubMed Web of Science ®Google Scholar
• Kekuda R, Prasad PD, Fei YJ, et al. Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1). Biochem Biophys Res Commun. 1996;229(2):553–558.
   PubMed Web of Science ®Google Scholar
• Seth P, Fei YJ, Li HW, et al. Cloning and functional characterization of a sigma receptor from rat brain. J Neurochem. 2002;70(3):922–931.
   Google Scholar
• Pan YX, Mei J, Xu J, et al. Cloning and characterization of a mouse sigma1 receptor. J Neurochem. 2002;70(6):2279–2285.
   Google Scholar
• Moebius FF, Reiter RJ, Hanner M, et al. High affinity of sigma 1-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8–C7 isomerase. Br J Pharmacol. 1997;121(1):1–6.
   PubMed Web of Science ®Google Scholar
• Mei J, Pasternak GW. Molecular cloning and pharmacological characterization of the rat sigma1 receptor. Biochem Pharmacol. 2001;62(3):349–355.
   PubMed Web of Science ®Google Scholar
• Prasad PD, Li HW, Fei Y-J, et al. Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene. J Neurochem. 2002;70(2):443–451.
   Google Scholar
• Schutze MP, Peterson PA, Jackson MR. An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum. Embo J. 1994;13(7):1696–1705.
   PubMed Web of Science ®Google Scholar
• Guitart X, Codony X, Monroy X. Sigma receptors: biology and therapeutic potential. Psychopharmacology (Berl). 2004;174(3):301–319.
   PubMed Web of Science ®Google Scholar
• Itzhak Y, Alerhand S. Differential regulation of sigma and PCP receptors after chronic administration of haloperidol and phencyclidine in mice. Faseb J. 1989;3(7):1868–1872.
   PubMed Web of Science ®Google Scholar
• Al-Saif A, Al-Mohanna F, Bohlega S. A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis. Ann Neurol. 2011;70(6):913–919.
   PubMed Web of Science ®Google Scholar
• Kim HJ, Kwon MJ, Choi WJ, et al. Mutations in UBQLN2 and SIGMAR1 genes are rare in Korean patients with amyotrophic lateral sclerosis. Neurobiol Aging. 2014;35(8):e1957–e1958.
   PubMed Web of Science ®Google Scholar
• Uchida N, Ujike H, Tanaka Y, et al. A variant of the sigma receptor type-1 gene is a protective factor for Alzheimer disease. Am J Geriatr Psychiatry. 2005;13(12):1062–1066.
   PubMed Web of Science ®Google Scholar
• Huang Y, Zheng L, Halliday G, et al. Genetic polymorphisms in sigma- 1 receptor and apolipoprotein E interact to influence the severity of Alzheimer’s disease. CAR. 2011;8(7):765–770.
   Google Scholar
• Feher A, Juhasz A, Laszlo A, et al. Association between a variant of the sigma-1 receptor gene and Alzheimer’s disease. Neurosci Lett. 2012;517(2):136–139.
   PubMed Web of Science ®Google Scholar
• Maruszak A, Safranow K, Gacia M, et al. Sigma receptor type 1 gene variation in a group of Polish patients with Alzheimer’s disease and mild cognitive impairment. Dement Geriatr Cogn Disord. 2007;23(6):432–438.
   PubMed Web of Science ®Google Scholar
• Ohmori O, Shinkai T, Suzuki T, et al. Polymorphisms of the sigma(1) receptor gene in schizophrenia: an association study. Am J Med Genet. 2000;96(1):118–122.
   PubMed Web of Science ®Google Scholar
• Uchida N, Ujike H, Nakata K, et al. No association between the sigma receptor type 1 gene and schizophrenia: results of analysis and meta-analysis of case-control studies. BMC Psychiatry. 2003;3(1):13.
   PubMedGoogle Scholar
• Satoh F, Miyatake R, Furukawa A, et al. Lack of association between sigma receptor gene variants and schizophrenia. Psychiatry Clin Neurosci. 2004;58(4):359–363.
   PubMed Web of Science ®Google Scholar
• Takizawa R, Hashimoto K, Tochigi M, et al. Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(3):491–498.
   PubMed Web of Science ®Google Scholar
• Ohi K, Hashimoto R, Yasuda Y, et al. The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(5):1309–1315.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Alvear GM, Werling LL. Sigma1 Receptors in rat striatum regulate NMDA stimulated [3H]dopamine release via a presynaptic mechanism. Eur J Pharmacol. 1995;294(2–3):713–719.
   PubMed Web of Science ®Google Scholar
• Schetz JA, Perez E, Liu R, et al. A prototypical Sigma-1 receptor antagonist protects against brain ischemia. Brain Res. 2007;1181:1–9.
   PubMed Web of Science ®Google Scholar
• Szatkowski M, Attwell D. Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms. Trends Neurosci. 1994;17(9):359–365.
   PubMed Web of Science ®Google Scholar
• Shen YC, Wang YH, Chou YC, et al. Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation. J Neurochem. 2008;104(2):558–572.
   PubMed Web of Science ®Google Scholar
• Katnik C, Guerrero WR, Pennypacker KR, et al. Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia. J Pharmacol Exp Ther. 2006;319(3):1355–1365.
   PubMed Web of Science ®Google Scholar
• Spruce BA, Campbell LA, McTavish N, et al. Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res. 2004;64(14):4875–4886.
   PubMed Web of Science ®Google Scholar
• Brent PJ, Saunders H, Dunkley PR. Intrasynaptosomal free calcium levels in rat forebrain synaptosomes: modulation by sigma receptor ligands. Neurosci Lett. 1996;211(2):138–142.
   PubMed Web of Science ®Google Scholar
• Hayashi T, Maurice T, Su TP. Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration. J Pharmacol Exp Ther. 2000;293(3):788–798.
   PubMed Web of Science ®Google Scholar
• Aydar E, Palmer CP, Klyachko VA, et al. The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron. 2002;34(3):399–410.
   PubMed Web of Science ®Google Scholar
• Cheng ZX, Lan DM, Wu PY, et al. Neurosteroid dehydroepiandrosterone sulfate inhibits persistent sodium current in rat medial prefrontal cortex via activation of sigma-1 receptors. Exp Neurol. 2008;210(1):128–136.
   PubMed Web of Science ®Google Scholar
• Renaudo A, L'Hoste S, Guizouarn H, et al. Cancer cell cycle modulated by a functional coupling between sigma-1 receptors and Cl-channels. J Biol Chem. 2007;282(4):2259–2267.
   PubMed Web of Science ®Google Scholar
• Lupardus PJ, Wilke RA, Aydar E, et al. Membrane-delimited coupling between sigma receptors and K + channels in rat neurohypophysial terminals requires neither G-protein nor ATP. J Physiol. 2000;526(3):527–539.
   PubMed Web of Science ®Google Scholar
• Pal A, Fontanilla D, Gopalakrishnan A, et al. The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements. Eur J Pharmacol. 2012;682(1–3):12–20.
   PubMed Web of Science ®Google Scholar
• Duchen MR. Mitochondria and calcium: from cell signaling to cell death. J Physiol. 2000;529(1):57–68.
   PubMed Web of Science ®Google Scholar
• Hayashi T, Rizzuto R, Hajnoczky G, et al. MAM: more than just a housekeeper. Trends Cell Biol. 2009;19(2):81–88.
   PubMed Web of Science ®Google Scholar
• Szabadkai Grgy, Bianchi Katiuscia, Várnai Péter, et al. Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels. J Cell Biol. 2006;175(6):901–911.
   PubMed Web of Science ®Google Scholar
• Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 2004;427(6972):360–364.
   PubMed Web of Science ®Google Scholar
• Rostovtseva TK, Bezrukov SM. VDAC regulation: role of cytosolic proteins and mitochondrial lipids. J Bioenerg Biomembr. 2008;40(3):163–170.
   PubMed Web of Science ®Google Scholar
• Hopper RK, Carroll S, Aponte AM, et al. Mitochondrial matrix phosphoproteome: effect of extra mitochondrial calcium. Biochemistry. 2006;45(8):2524–2536.
   PubMed Web of Science ®Google Scholar
• Alzayady KJ, Wojcikiewicz RJ. The role of Ca2+ in triggering inositol 1,4,5-trisphosphate receptor ubiquitination. Biochem J. 2005;392(3):601–606.
   PubMedGoogle Scholar
• Bhanumathy CD, Nakao SK, Joseph SK. Mechanism of proteasomal degradation of inositol trisphosphate receptors in CHOK1 cells. J Biol Chem. 2006;281(6):3722–3730.
   PubMed Web of Science ®Google Scholar
• Mori T, Hayashi T, Hayashi E, et al. Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival. PLoS One. 2013;8(10):e76941.
   PubMed Web of Science ®Google Scholar
• Eisner V, Csordas G, Hajnóczky G. Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle – pivotal roles in Ca2+ and reactive oxygen species signaling. J. Cell Sci. 2013;126(14):2965–2978.
   PubMed Web of Science ®Google Scholar
• Hong TT, Shaw RM. Cardiac T-tubule microanatomyand function. Physiol Rev. 2017;97(1):227–252.
   PubMed Web of Science ®Google Scholar
• Best JM, Kamp TJ. Different subcellular populations of L-type Ca2_ channels exhibitunique regulation and functional roles in cardiomyocytes. J Mol Cell Cardiol. 2012;52(2):376–387.
   PubMed Web of Science ®Google Scholar
• Pasek M, Simurda J, Orchard CH. Role of t-tubules in the control of trans-sarcolemmal ion flux and intracellular Ca2+ in a model of the rat cardiac ventricular myocyte. Eur Biophys J. 2012;41:491–503.
   PubMed Web of Science ®Google Scholar
• Brookes PS, Yoon Y, Robotham JL, et al. Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol. 2004;287(4):C817–C833.
   PubMed Web of Science ®Google Scholar
• Pacher P, Thomas AP, Hajnoczky G. Ca2+ marks: miniature calciumsignals in single mitochondria driven by ryanodine receptors. Proc Natl Acad Sci USA. 2002;99(4):2380–2385.
   PubMed Web of Science ®Google Scholar
• Davidson SM, Yellon DM, Murphy MP, et al. Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation. Cardiovasc. Res. 2012;93(3):445–453.
   PubMed Web of Science ®Google Scholar
• Bhuiyan S, Fukunaga K, Tagashira H. Crucial interactions between selective serotonin uptake inhibitors and Sigma-1 receptor in heart failure. J Pharmacol Sci. 2013;121(3):177–184.
   PubMed Web of Science ®Google Scholar
• Abdullah CS, Alam S, Aishwarya R, et al. Cardiac dysfunction in the Sigma 1 receptor knockout mouse associated with impaired mitochondrial dynamics and bioenergetics. J Am Heart Assoc. 2018;7(20):e009775.
   PubMed Web of Science ®Google Scholar
• Alam S, Abdullah CS, Aishwarya R, et al. Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes. Biosc Rep. 2017;37(4):BSR20170898.
   PubMed Web of Science ®Google Scholar
• Yamamoto K, Sato T, Matsui T, et al. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6_ and XBP1. Develop Cell. 2007;13(3):365–376.
   PubMed Web of Science ®Google Scholar
• Tagashira H, Matsumoto T, Taguchi K, et al. Vascular endothelial σ1-receptor stimulation with SA4503rescues aortic relaxation via Akt/eNOS signaling in ovariectomized rats with aortic banding. Circ J. 2013;77:2831–2840.
   PubMed Web of Science ®Google Scholar
• Klee CB, Ren H, Wang X. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem. 1998;273(22):13367–13370.
   PubMed Web of Science ®Google Scholar
• Cameron AM, Steiner JP, Roskams AJ, et al. Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. Cell. 1995;83(3):463–472.
   PubMed Web of Science ®Google Scholar
• Blaeser F, Ho N, Prywes R, et al. Ca(2+)-dependent gene expression mediated by MEF2 transcription factors. J Biol Chem. 2000;275(1):197–209.
   PubMed Web of Science ®Google Scholar
• Trushin SA, Pennington KN, Algeciras-Schimnich A, et al. Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes. J Biol Chem. 1999;274(33):22923–22931.
   PubMed Web of Science ®Google Scholar
• Hegyi B, Bers DM, Bossuyt J. CaMKII signaling in heart diseases: emerging role in diabetic cardiomyopathy. J Mol Cell Card. 2019;127:246–259.
   PubMed Web of Science ®Google Scholar
• Zhang T, Kohlhaas M, Backs J, et al. CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem. 2007;282(48):35078–35087.
   PubMed Web of Science ®Google Scholar
• Hama N, Paliogianni F, Fessler BJ, et al. Calcium/calmodulin dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells. J Exp Med. 1995;181(3):1217–1222.
   PubMed Web of Science ®Google Scholar
• MacDonnell S, Weisser-Thomas J, Kubo H, et al. CaMKII negatively regulates calcineurin–NFAT signaling in cardiac myocytes. Circ Res. 2009;14:316–325.
   Google Scholar
• Park CH, Kim YS, Kim YH, et al. Calcineurin mediates AKT dephosphorylation in the ischemic rat retina. Brain Res. 2008;1234:148–157.
   PubMed Web of Science ®Google Scholar
• Wang L, Wormstone IM, Reddan JR, et al. Growth factor receptor signaling in human lens cells: role of the calcium store. Exp Eye Res. 2005;80(6):885–895.
   PubMed Web of Science ®Google Scholar
• Mari Y, Katnik C, Cuevas J. SigmaR-1 receptor inhibition of ASIC1a channels is dependent on a pertussis toxin-sensitive G-Protein and an AKAP150/calcineurin complex. Neurochem Res. 2015;40(10):2055–2067.
   PubMed Web of Science ®Google Scholar
• Pabba M. The essential roles of protein-protein interaction in sigma-1 receptor functions. Front Cell Neurosci. 2013;7:50
   PubMed Web of Science ®Google Scholar
• Hayashi T, Su TP. Regulating ankyrin dynamics: roles of sigma-1 receptors. PNAS. 2001;98(2):491–496.
   PubMed Web of Science ®Google Scholar
• Camors E, Mohler PJ, Bers DM, et al. Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity. J Mol Cell Card. 2012;52(6):1240–1248.
   PubMed Web of Science ®Google Scholar
• Tuvia S, Buhusi M, Davis L, et al. Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. J Cell Biol. 1999;147(5):995–1007.
   PubMed Web of Science ®Google Scholar
• Popescu Iuliana, Galice Samuel, Mohler PeterJ, et al. Elevated local [Ca2+] and CaMKII promote spontaneous Ca2+ release in ankyrin-B deficient hearts. Cardiovasc Res. 2016;111(3):287–294.,
   PubMed Web of Science ®Google Scholar
• Tagashira H, Bhuiyan S, Fukunaga K. Diverse regulation of IP3 and ryanodine receptors by pentazocine through sigma1-receptor in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2013;305(8):H1201–H1212.
   PubMed Web of Science ®Google Scholar
• Su TP, Su TC, Nakamura Y, et al. Sigma-1 receptor as a pluripotent modulator in the living system. Trends Pharmacol Sci. 2016;37(4):262–278.
   PubMed Web of Science ®Google Scholar
• Fernandez-Sanz C, Ruiz-Meana M, Miro-Casas E, et al. Defective sarcoplasmic reticulum mitochondria calcium exchange in aged mouse myocardium. Cell Death Dis. 2014;5(12):e1573–e1573.
   PubMed Web of Science ®Google Scholar
• Herrera-Cruz MS, Simmen T. Of yeast, mice and men: MAMs come in two flavors. Biol Direct. 2017;12(1):3
   PubMedGoogle Scholar
• Paillard M, Tubbs E, Thiebaut PA, et al. Depressing mitochondria-reticulum interactions protects cardiomyocytes from lethal hypoxia-reoxygenation injury. Circ. 2013;128(14):1555–1565.
   PubMed Web of Science ®Google Scholar
• Chaudhari N, Talwar P, Parimisetty A, et al. A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress. Front Cell Neurosci. 2014;8:213
   PubMed Web of Science ®Google Scholar
• Ha Y, Dun Y, Thangaraju M, et al. Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons. Invest Ophthalmol Vis Sci. 2011;52(1):527–540.
   PubMed Web of Science ®Google Scholar
• Mitsuda T, Omi T, Tanimukai H, et al. Sigma-1Rs are upregulated via PERK/eIF2a/ATF4 pathway and execute protective function in ER stress. Bioch Biophys Res Comm. 2011;415(3):519–525.
   PubMed Web of Science ®Google Scholar
• Raturi A, Simme T. Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM). Bioch Biophys Acta. 2013;1833(1):213–224.
   PubMed Web of Science ®Google Scholar
• Lee AS. The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods. 2005;35(4):373–381.
   PubMed Web of Science ®Google Scholar
• Taylor CW. Regulation of IP3 receptors by cyclic AMP. Cell Calc. 2017;63:48–52.
   PubMed Web of Science ®Google Scholar
• Yaniv Y, Spurgeon HA, Ziman BD, et al. Ca2+/calmodulin-dependent protein kinase II (CaMKII)activity and sinoatrial nodal pacemaker cell energetics. PLOS One. 2013;8(2):e57079.
   PubMed Web of Science ®Google Scholar
• Zhang P. CaMKII: the molecular villain that aggravates cardiovascular disease. Exp Ther Med. 2017;13(3):815–820.
   PubMed Web of Science ®Google Scholar
• Tscheschner H, Meinhardt E, Schlegel P, et al. CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression. Plos One. 2019;29:1–20.
   Google Scholar