Trimetazidine alleviates hypoxia/reoxygenation-induced apoptosis in neonatal mice cardiomyocytes via up-regulating HMGB1 expression to promote autophagy

References

• Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest. 2011;121(11):4210–4221.
   PubMed Web of Science ®Google Scholar
• Munshi R, Hsu C, Himmelfarb J. Advances in understanding ischemic acute kidney injury. BMC Med. 2011;9:11.
   PubMed Web of Science ®Google Scholar
• Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007;357(11):1121–1135.
   PubMed Web of Science ®Google Scholar
• Kantor PF, Lucien A, Kozak R, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000;86(5):580–588.
   PubMed Web of Science ®Google Scholar
• Saikumar P, Dong Z, Weinberg JM, et al. Mechanisms of cell death in hypoxia/reoxygenation injury. Oncogene. 1998;17(25):3341–3349.
   PubMed Web of Science ®Google Scholar
• Ruixing Y, Wenwu L, Al-Ghazali R. Trimetazidine inhibits cardiomyocyte apoptosis in a rabbit model of ischemia-reperfusion. Trans Res: J Lab Clin Med. 2007;149(3):152–160.
   Google Scholar
• Wei J, Xu H, Shi L, et al. Trimetazidine protects cardiomyocytes against hypoxia-induced injury through ameliorates calcium homeostasis. Chem Biol Interact. 2015;236:47–56.
   PubMed Web of Science ®Google Scholar
• Li YJ, Wang PH, Chen C, et al. Improvement of mechanical heart function by trimetazidine in db/db mice. Acta Pharmacol Sin. 2010;31(5):560–569.
   PubMed Web of Science ®Google Scholar
• Mouquet F, Rousseau D, Domergue-Dupont V, et al. Effects of trimetazidine, a partial inhibitor of fatty acid oxidation, on ventricular function and survival after myocardial infarction and reperfusion in the rat. Fundam Clin Pharmacol. 2010;24(4):469–476.
   PubMed Web of Science ®Google Scholar
• Zhong Y, Zhong P, He S, et al. Trimetazidine protects cardiomyocytes against hypoxia/reoxygenation injury by promoting AMP-activated protein kinase-dependent autophagic flux. J Cardiovasc Pharmacol. 2017;69(6):389–397.
   PubMed Web of Science ®Google Scholar
• Yang J, Wu LJ, Tashino S, et al. Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells. Free Radic Res. 2008;42(5):492–504.
   PubMed Web of Science ®Google Scholar
• Ma S, Wang Y, Chen Y, et al. The role of the autophagy in myocardial ischemia/reperfusion injury. Biochim Biophys Acta. 2015;1852(2):271–276.
   PubMed Web of Science ®Google Scholar
• Dosenko VE, Nagibin VS, Tumanovska LV, et al. Protective effect of autophagy in anoxia-reoxygenation of isolated cardiomyocyte? Autophagy. 2006;2(4):305–306.
   PubMed Web of Science ®Google Scholar
• Przyklenk K, Dong Y, Undyala VV, et al. Autophagy as a therapeutic target for ischaemia /reperfusion injury? Concepts, controversies, and challenges. Cardiovasc Res. 2012;94(2):197–205.
   PubMed Web of Science ®Google Scholar
• Vilahur G, Juan-Babot O, Pena E, et al. Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction. J Mol Cell Cardiol. 2011;50(3):522–533.
   PubMed Web of Science ®Google Scholar
• Tang D, Kang R, Livesey KM, et al. Endogenous HMGB1 regulates autophagy. J Cell Biol. 2010;190(5):881–892.
   PubMed Web of Science ®Google Scholar
• Scherz-Shouval R, Elazar Z. ROS, mitochondria and the regulation of autophagy. Trends Cell Biol. 2007;17(9):422–427.
   PubMed Web of Science ®Google Scholar
• Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol. 2005;5(4):331–342.
   PubMed Web of Science ®Google Scholar
• Ding HS, Yang J, Chen P, et al. The HMGB1-TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis. Gene. 2013;527(1):389–393.
   PubMed Web of Science ®Google Scholar
• Wang Y, Ouyang M, Wang Q, et al. MicroRNA-142-3p inhibits hypoxia/reoxygenation-induced apoptosis and fibrosis of cardiomyocytes by targeting high mobility group box 1. Int J Mol Med. 2016;38(5):1377–1386.
   PubMed Web of Science ®Google Scholar
• Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem. 2006;281(40):29776–29787.
   PubMed Web of Science ®Google Scholar
• Jaffrezou JP, Bettaieb A, Levade T, et al. Antitumor agent-induced apoptosis in myeloid leukemia cells: a controlled suicide. Leuk Lymphoma. 1998;29(5–6):453–463.
   PubMed Web of Science ®Google Scholar
• Zhang L, Wang K, Lei Y, et al. Redox signaling: potential arbitrator of autophagy and apoptosis in therapeutic response. Free Radic Biol Med. 2015;89:452–465.
   PubMed Web of Science ®Google Scholar
• Ravikumar B, Berger Z, Vacher C, et al. Rapamycin pre-treatment protects against apoptosis. Hum Mol Genet. 2006;15(7):1209–1216.
   PubMed Web of Science ®Google Scholar
• Rio DC, Ares M, Jr., Hannon GJ, et al. Purification of RNA using TRIzol (TRI reagent). Cold Spring Harb Protoc. 2010;2010(6):.
   Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Xie J, Zhou X, Hu X, et al. H2O2 evokes injury of cardiomyocytes through upregulating HMGB1. Hellenic J Cardiol. 2014;55(2):101–106.
   PubMed Web of Science ®Google Scholar
• Yang Q, Yang K, Li AY. Trimetazidine protects against hypoxia-reperfusion-induced cardiomyocyte apoptosis by increasing microRNA-21 expression. Int J Clin Exp Pathol. 2015;8(4):3735–3741.
   PubMed Web of Science ®Google Scholar
• Zhang L, Ding WY, Wang ZH, et al. Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy. J Transl Med. 2016;14(1):109.
   PubMed Web of Science ®Google Scholar
• Zheng W, Liu C. The cystathionine γ-lyase/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress. Anatol J Cardiol. 2019;22(3):102–111.
   PubMed Web of Science ®Google Scholar
• Detry JM, Sellier P, Pennaforte S, et al. Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group. Br J Clin Pharmacol. 1994;37(3):279–288.
   PubMed Web of Science ®Google Scholar
• Dalla-Volta S, Maraglino G, Della-Valentina P, et al. Comparison of trimetazidine with nifedipine in effort angina: a double-blind, crossover study. Cardiovasc Drugs Ther. 1990;4(4):853–859.
   PubMedGoogle Scholar
• Ferraro E, Giammarioli AM, Caldarola S, et al. The metabolic modulator trimetazidine triggers autophagy and counteracts stress-induced atrophy in skeletal muscle myotubes. FEBS J. 2013;280(20):5094–5108.
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science. 2000;290(5497):1717–1721.
   PubMed Web of Science ®Google Scholar
• Ferraro E, Cecconi F. Autophagic and apoptotic response to stress signals in mammalian cells. Arch Biochem Biophys. 2007;462(2):210–219.
   PubMed Web of Science ®Google Scholar
• Tang D, Kang R, Cheh CW, et al. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene. 2010;29(38):5299–5310.
   PubMed Web of Science ®Google Scholar
• Sciarretta S, Maejima Y, Zablocki D, et al. The role of autophagy in the heart. Annu Rev Physiol. 2018;80:1–26.
   PubMed Web of Science ®Google Scholar
• Huang Z, Wu S, Kong F, et al. MicroRNA-21 protects against cardiac hypoxia/reoxygenation injury by inhibiting excessive autophagy in H9c2 cells via the Akt/mTOR pathway. J Cell Mol Med. 2017;21(3):467–474.
   PubMed Web of Science ®Google Scholar
• Fan G, Yu J, Asare PF, et al. Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling. J Cell Mol Med. 2016;20(10):1908–1919.
   PubMed Web of Science ®Google Scholar
• Wu S, Chang G, Gao L, et al. Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy. J Mol Med. 2018;96(8):791–806.
   PubMed Web of Science ®Google Scholar
• Eisenberg-Lerner A, Bialik S, Simon HU, et al. Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ. 2009;16(7):966–975.
   PubMed Web of Science ®Google Scholar