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Original Articles

Expression of ADR-α1, 2 and ADR-β2 in cumulus cell culture of infertile women with polycystic ovary syndrome and poor responder who are a candidate for IVF: the novel strategic role of clonidine in this expression

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Pages 263-272 | Received 23 Jan 2020, Accepted 05 Jun 2020, Published online: 02 Sep 2020

References

  • Gerendai I, Kocsis K, Halasz B. Supraspinal connections of the ovary: structural and functional aspects. Microsc Res Tech. 2002;59(6):474–483.
  • Kaaja RJ, Poyhonen-Alho MK. Insulin resistance and sympathetic overactivity in women. J Hypertens. 2006;24(1):131–141.
  • Cruz G, Fernandois D, Paredes AH. Ovarian function and reproductive senescence in the rat: role of ovarian sympathetic innervation. Reproduction. 2017;153(2):R59–R68.
  • Aguado LI, Ojeda SR. Prepubertal ovarian function is finely regulated by direct adrenergic influences. Role of noradrenergic innervation. Endocrinology. 1984;1149:1845–1853.
  • Rosa ESA, Guimaraes MA, Padmanabhan V, et al. Prepubertal administration of estradiol valerate disrupts cyclicity and leads to cystic ovarian morphology during adult life in the rat: role of sympathetic innervation. Endocrinology. 2003;144(10):4289–4297.
  • Zhang X, Zhang L, Huo S, et al. Neonatal superior ovarian nerve transection inhibits follicle development by enhancing follicular atresia and suppressing granulosa cell proliferation in rats. Reprod Fertil Dev. 2010;22(7):1148–1158.
  • Doganay M, Simsek A, Tapisiz OL, et al. Superior ovarian nerve (SON) transection leads to stunted follicular maturation: a histomorphologic and morphometric analysis in the rat model. Fertil Steril. 2010;93(5):1711–1714.
  • Lara HE, Dorfman M, Venegas M, et al. Changes in sympathetic nerve activity of the mammalian ovary during a normal estrous cycle and in polycystic ovary syndrome: studies on norepinephrine release. Microsc Res Tech. 2002;59(6):495–502.
  • Romero C, Paredes A, Dissen GA, et al. Nerve growth factor induces the expression of functional FSH receptors in newly formed follicles of the rat ovary. Endocrinology. 2002;143(4):1485–1494.
  • Manni L, Holmäng A, Lundeberg T, et al. Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Auton Neurosci. 2005;118(1-2):79–87.
  • Itoh MT, Shizuka B. alpha1-Adrenergic receptor in rat ovary: presence and localization. Mol Cell Endocrinol. 2005;240(1-2):58–63.
  • Merz C, Saller S, Kunz L, et al. Expression of the beta-2 adrenergic receptor (ADRB-2) in human and monkey ovarian follicles: a marker of growing follicles?. J Ovarian Res. 2015;8:8.
  • Robker RL, Hennebold JD, Russell DL. Coordination of ovulation and oocyte maturation: a good egg at the right time. Endocrinology. 2018;159(9):3209–3218.
  • Richani D, Gilchrist RB. The epidermal growth factor network: role in oocyte growth, maturation and developmental competence. Hum Reprod Update. 2018;24(1):1–14.
  • Lara HE, Ferruz JL, Luza S, et al. Activation of ovarian sympathetic nerves in polycystic ovary syndrome. Endocrinology. 1993;133(6):2690–2695.
  • Aydos A, Gurel A, Oztemur Islakoglu Y, et al. Identification of polycystic ovary syndrome (PCOS) specific genes in cumulus and mural granulosa cells. PLoS One. 2016;11(12):e0168875.
  • Lansdown A, Rees DA. The sympathetic nervous system in polycystic ovary syndrome: a novel therapeutic target? Clin Endocrinol (Oxf). 2012;77(6):791–801.
  • Doi SAR, Towers PA, Scott CJ, et al. PCOS: an ovarian disorder that leads to dysregulation in the hypothalamic-pituitary-adrenal axis? Eur J Obstet Gynecol Reprod Biol. 2005;118(1):4–16.
  • Pasquali R, Zanotti L, Fanelli F, et al. Defining hyperandrogenism in women with polycystic ovary syndrome: a challenging perspective. J Clin Endocrinol Metab. 2016;101(5):2013–2022.
  • Rojas J, Chávez M, Olivar L, et al. Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth. Int J Reprod Med. 2014;2014:719050–719017.
  • Papadakis G, Kandaraki E, Papalou O, et al. Is cardiovascular risk in women with PCOS a real risk? Current insights. Minerva Endocrinol. 2017;42(4):340–355.
  • Helvaci N, Karabulut E, Demir AU, et al. Polycystic ovary syndrome and the risk of obstructive sleep apnea: a meta-analysis and review of the literature. Endocr Connect. 2017;6(7):437–445.
  • Acuña E, Fornes R, Fernandois D, et al. Increases in norepinephrine release and ovarian cyst formation during ageing in the rat. Reprod Biol Endocrinol. 2009; 7:64.
  • Cruz G, Barra R, Gonzalez D, et al. Temporal window in which exposure to estradiol permanently modifies ovarian function causing polycystic ovary morphology in rats. Fertil Steril. 2012;98(5):1283–1290.
  • Burden HW, Leonard MS, Smith CP, et al. The sensory innervation of the ovary: a horseradish peroxidase study in the rat. Anat Rec. 1983;207(4):623–627.
  • Stefenson A, Owman C, Sjöberg NO, et al. Comparative study of the autonomic innervation of the mammalian ovary, with particular regard to the follicular system. Cell Tissue Res. 1981;215(1):47–62.
  • Morán C, Morales L, Quiróz U, et al. Effects of unilateral or bilateral superior ovarian nerve section in infantile rats on follicular growth. J Endocrinol. 2000;166(1):205–211.
  • Hanada T, Uchida S, Hotta H, et al. Number, size, conduction, and vasoconstrictor ability of unmyelinated fibers of the ovarian nerve in adult and aged rats. Auton Neurosci. 2011;164(1-2):6–12.
  • Broekma FJ, Soules MR, Faus BC. Ovarian aging: mechanisms and clinical consequences. Endocr Rev. 2009;30(5):465–493.
  • Evers JL. Female subfertility. Lancet. 2002;360(9327):151–159.
  • Labarta E, Marin D, Remohí J, et al. Conventional versus minimal ovarian stimulation: an intra-patient comparison of ovarian response in poor-responder women according to Bologna Criteria. Reprod Biomed Online. 2018;37(4):434–441.
  • Benaglia L, Somigliana E, Vercellini P, et al. Endometriotic ovarian cysts negatively affect the rate of spontaneous ovulation. Hum Reprod. 2009;24(9):2183–2186.
  • Dierich A, Sairam MR, Monaco L, et al. Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci Usa. 1998;95(23):13612–13617.
  • Hillis SD, Joesoef R, Marchbanks PA, et al. Delayed care of pelvic inflammatory disease as a risk factor for impaired fertility. Am J Obstet Gynecol. 1993;168(5):1503–1509.
  • Tata LJ, Card TR, Logan RF, et al. Fertility and pregnancy-related events in women with celiac disease: a population-based cohort study. Gastroenterology. 2005;128(4):849–855.
  • McQueen D, McKillop JH, Gray HW, et al. Investigation of tubal infertility by radionuclide migration. Hum Reprod. 1991;6(4):529–532.
  • Ubaldi F, Vaiarelli A, D'Anna R, et al. Management of poor responders in IVF: is there anything new? Biomed Res Int. 2014; 2014:352098.
  • Te Velde ER, Pearson PL. The variability of female reproductive ageing. Hum Reprod Update. 2002;8(2):141–154.
  • Figueira RDCS, Braga DPAF, Nichi M, et al. Poor ovarian response in patients younger than 35 years: is it also a qualitative decline in ovarian function? Hum Fertil (Camb). 2009;12(3):160–165.
  • Haahr T, Esteves SC, Humaidan P. Individualized controlled ovarian stimulation in expected poor-responders: an update. Reprod Biol Endocrinol. 2018;16(1):20.
  • Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19–25.
  • Zangeneh FZ, Mohammadi A, Ejtemaeimehr S, et al. The role of opioid system and its interaction with sympathetic nervous system in the processing of polycystic ovary syndrome modeling in rat. Arch Gynecol Obstet. 2011;283(4):885–892.
  • Zangeneh FZ, Tehraninejad E, Naghizadeh MM. Effect of Alpha-2 adrenoceptor inhibitors on the growth of ovarian follicles in patients with polycystic ovary syndrome. Tehran Univ Med J. 2016;73:709–716. (Article in Persian)
  • Kagitani F, Uchida S, Hotta H. The role of alpha adrenoceptors in the vascular and estradiol secretory responses to stimulation of the superior ovarian nerve. J Physiol Sci. 2011;61(3):247–251.
  • Queiróz DB, Porto CS, Grossman G, et al. Immunolocalization of alpha(1A)-adrenoceptors in rat and human epididymis . Cell Tissue Res. 2008;332(3):509–522.
  • Jana B, Dzienis A, Wojtkiewicz J, et al. Surgical denervation of porcine ovaries during the middle luteal phase of the oestrous cycle changes their morphology and steroidogenic activity. Acta Vet Hung. 2007;55(1):107–122.
  • Kagitani F, Uchida S, Hotta H. Effects of electrical stimulation of the superior ovarian nerve and the ovarian plexus nerve on the ovarian estradiol secretion rate in rats. J Physiol Sci. 2008;58(2):133–138.
  • Neil MJ. Clonidine: clinical pharmacology and therapeutic use in pain management. Curr Clin Pharmacol. 2011;6(4):280–287.
  • Kumar A, Maitra S, Khanna P, et al. Clonidine for management of chronic pain: A brief review of the current evidences. Saudi J Anaesth. 2014;8(1):92–96.
  • Wrzosek A, Woron J, Dobrogowski J, et al. Topical clonidine for neuropathic pain. Cochrane Database Syst Rev. 2015; 8:CD010967.
  • Tofighi Rad A, Hassanzad A, Aryaie M. Clonidine premedication reduces postoperative pain in children. Eur J Exp Biol. 2014;4:102–105.
  • Veith RC, Best JD, Halte JB. Dose-dependent suppression of norepinephrine appearance rate in plasma by clonidine in man. J Clin Endocrinol Metab. 1984;59(1):151–155.
  • Mitchell A, Bührmann S, Opazo Saez A, et al. Clonidine lowers blood pressure by reducing vascular resistance and cardiac output in young, healthy males. Cardiovasc Drugs Ther. 2005;19(1):49–55.
  • Hall JE, Uhrich TU, Ebert TJ. Sedative, analgesic and cognitive effects of clonidine infusions in humans. Br J Anaesth. 2001;86(1):5–11.
  • Manni L, Lundeberg T, Holmang A, et al. Effect of electro-acupuncture on ovarian expression of alpha (1)- and beta (2)-adrenoceptors, and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Reprod Biol Endocrinol. 2005;3:21.
  • Venegas B, De León Gordillo LY, Rosas G, et al. In rats with estradiol valerate-induced polycystic ovary syndrome, the acute blockade of ovarian β-adrenoreceptors improve ovulation. Reprod Biol Endocrinol. 2019;17(1):95.
  • Zangeneh FZ, Abdollahi A, Tavassoli P, et al. The effect of cold stress on polycystic ovary syndrome in rat: before and during modeling. Arch Gynecol Obstet. 2011;284(3):651–657.
  • Herman JP, Flak J, Jankord R. Chronic stress plasticity in the hypothalamic paraventricular nucleus. Prog Brain Res. 2008;170:353–364.
  • Pardon M-C, Ma S, Morilak DA. Chronic cold stress sensitizes brain noradrenergic reactivity and noradrenergic facilitation of the HPA stress response in Wistar Kyoto rats. Brain Res. 2003;971(1):55–65.
  • Ma S, Morilak DA. Chronic intermittent cold stress sensitises the hypothalamic-pituitary-adrenal response to a novel acute stress by enhancing noradrenergic influence in the rat paraventricular nucleus. J Neuroendocrinol. 2005;17(11):761–769.
  • Flordellis CS, Berguerand M, Gouache P, et al. Alpha 2 adrenergic receptor subtypes expressed in Chinese hamster ovary cells activate differentially mitogen-activated protein kinase by a p21ras independent pathway. J Biol Chem. 1995;270(8):3491–3494.
  • Eason MG1, Jacinto MT, Liggett SB. Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs. Mol Pharmacol. 1994;45(4):696–702.
  • Andersen JD, Boylan KL, Jemmerson R, et al. Leucine-rich alpha-2-glycoprotein-1 is upregulated in sera and tumors of ovarian cancer patients. J Ovarian Res. 2010;3(1):21.
  • Lim W, Jeong W, Kim JH, et al. Differential expression of alpha 2 macroglobulin in response to dietylstilbestrol and in ovarian carcinomas in chickens. Reprod Biol Endocrinol. 2011;9:137.
  • Reckelhoff JF, Samson WK. Sex and gender differences in cardiovascular, renal and metabolic diseases. Am J Physiol Regul Integr Comp Physiol. 2015;309(9):R1057–R1059.
  • Boese AC, Kim SC, Yin KJ, et al. Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease. Am J Physiol Heart Circ Physiol. 2017;313(3):H524–H545.
  • Riedel K, Deussen AJ, Tolkmitt J, et al. Estrogen determines sex differences in adrenergic vessel tone by regulation of endothelial β-adrenoceptor expression. Am J Physiol Heart Circ Physiol. 2019;317(2):H243–H254.
  • Cikos S, Bukovská A, Koppel J. Relative quantification of mRNA: comparison of methods currently used for real-time PCR data analysis. BMC Mol Biol. 2007;8:113.
  • Heider U, Pedal I, Spanel-Borowski K. Increase in nerve fibers and loss of mast cells in polycystic and postmenopausal ovaries. Fertil Steril. 2001;75(6):1141–1147.
  • Campo MD, Piquer B, Witherington J, et al. Effect of superior ovarian nerve and plexus nerve sympathetic denervation on ovarian-derived infertility provoked by estradiol exposure to rats. Front Physiol. 2019;10:349.

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