Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-κB signaling

References

• Rhodes A, Evans LE, Alhazzani W, et al. Surviving sepsis campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017;43(3):304–377.
   PubMed Web of Science ®Google Scholar
• Fleischmann C, Scherag A, Adhikari NK, et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259–272.
   PubMed Web of Science ®Google Scholar
• Thompson K, Venkatesh B, Finfer S. Sepsis and septic shock: current approaches to management. Intern Med J. 2019;49(2):160–170.
   PubMed Web of Science ®Google Scholar
• Denstaedt SJ, Singer BH, Standiford TJ. Sepsis and nosocomial infection: patient characteristics, mechanisms, and modulation. Front Immunol. 2018;9:2446.
   PubMed Web of Science ®Google Scholar
• Kim MJ, Bae SH, Ryu JC, et al. SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages. Autophagy. 2016;12(8):1272–1291.
   PubMed Web of Science ®Google Scholar
• Bordon Y. Mucosal immunology: inflammasomes induce sepsis following community breakdown. Nat Rev Immunol. 2012;12(6):400–401.
   PubMed Web of Science ®Google Scholar
• Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature. 2007;449(7164):819–826.
   PubMed Web of Science ®Google Scholar
• Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21(7):677–687.
   PubMed Web of Science ®Google Scholar
• Wang L, Ko ER, Gilchrist JJ, et al. Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis. Sci Adv. 2017;3(3):e1602096.
   PubMed Web of Science ®Google Scholar
• Pu Q, Gan C, Li R, et al. Atg7 deficiency intensifies inflammasome activation and pyroptosis in pseudomonas sepsis. J Immunol. 2017;198(8):3205–3213.
   PubMed Web of Science ®Google Scholar
• Rathinam VA, Fitzgerald KA. Inflammasome complexes: emerging mechanisms and effector functions. Cell. 2016;165(4):792–800.
   PubMed Web of Science ®Google Scholar
• Marshall JC. Why have clinical trials in sepsis failed? Trends Mol Med. 2014;20(4):195–203.
   PubMed Web of Science ®Google Scholar
• Franchi L, Warner N, Viani K, et al. Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev. 2009;227(1):106–128.
   PubMedGoogle Scholar
• Franchi L, Muñoz-Planillo R, Núñez G. Sensing and reacting to microbes through the inflammasomes. Nat Immunol. 2012;13(4):325–332.
   PubMed Web of Science ®Google Scholar
• Park J, Min J-S, Kim B, et al. Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways. Neurosci Lett. 2015;584:191–196.
   PubMed Web of Science ®Google Scholar
• Schoonbroodt S, Ferreira V, Best-Belpomme M, et al. Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of I kappa B alpha in NF-kappa B activation by an oxidative stress. J Immunol. 2000;164(8):4292–4300.
   PubMed Web of Science ®Google Scholar
• Li Q, Engelhardt JF. Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase. J Biol Chem. 2006;281(3):1495–1505.
   PubMed Web of Science ®Google Scholar
• Zhang J, Wang X, Vikash V, et al. ROS and ROS-mediated cellular signaling. Oxid Med Cell Longev. 2016;2016:4350965.
   PubMed Web of Science ®Google Scholar
• Fatouros IG. Is irisin the new player in exercise-induced adaptations or not? A 2017 update. Clin Chem Lab Med. 2018;56(4):525–548.
   PubMed Web of Science ®Google Scholar
• Mazur-Bialy AI, Pocheć E, Zarawski M. Anti-inflammatory properties of irisin, mediator of physical activity, are connected with TLR4/MyD88 signaling pathway activation. IJMS. 2017;18(4):701.
   Google Scholar
• So WY, Leung PS. Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling. Int J Biochem Cell Biol. 2016;78:237–247.
   PubMed Web of Science ®Google Scholar
• Polyzos SA, Anastasilakis AD, Efstathiadou ZA, et al. Irisin in metabolic diseases. Endocrine. 2018;59(2):260–274.
   PubMed Web of Science ®Google Scholar
• Leung PS. The potential of irisin as a therapeutic for diabetes. Future Med Chem. 2017;9(6):529–532.
   PubMed Web of Science ®Google Scholar
• Narayanan SA, Metzger CE, Bloomfield SA, et al. Inflammation-induced lymphatic architecture and bone turnover changes are ameliorated by irisin treatment in chronic inflammatory bowel disease. Faseb J. 2018;32(9):4848–4861.
   PubMed Web of Science ®Google Scholar
• Zhu D, Wang H, Zhang J, et al. Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses. J Mol Cell Cardiol. 2015;87:138–147.
   PubMed Web of Science ®Google Scholar
• Shao L, Meng D, Yang F, et al. Irisin-mediated protective effect on LPS-induced acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells. Biochem Biophys Res Commun. 2017;487(2):194–200.
   PubMed Web of Science ®Google Scholar
• Tan Y, Ouyang H, Xiao X, et al. Irisin ameliorates septic cardiomyopathy via inhibiting DRP1-related mitochondrial fission and normalizing the JNK-LATS2 signaling pathway. Cell Stress Chaperones. 2019;24(3):595–608.
   PubMed Web of Science ®Google Scholar
• Dong M, Hu N, Hua Y, et al. Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress. Biochim Biophys Acta. 2013;1832(6):848–863.
   PubMed Web of Science ®Google Scholar
• Li R, Xin T, Li D, et al. Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: the role of the ERK-CREB pathway and Bnip3-mediated mitophagy. Redox Biol. 2018;18:229–243.
   PubMed Web of Science ®Google Scholar
• Zhou H, Shi C, Hu S, et al. BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk-Nox2-Drp1-mitochondrial fission pathways. Angiogenesis. 2018;21(3):599–615.
   PubMed Web of Science ®Google Scholar
• Jin Q, Li R, Hu N, et al. DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways. Redox Biol. 2018;14:576–587.
   PubMed Web of Science ®Google Scholar
• Zhou H, Wang S, Zhu P, et al. Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission. Redox Biol. 2018;15:335–346.
   PubMed Web of Science ®Google Scholar
• Imber M, Pietrzyk-Brzezinska AJ, Antelmann H. Redox regulation by reversible protein S-thiolation in Gram-positive bacteria. Redox Biol. 2019;20:130–145.
   PubMed Web of Science ®Google Scholar
• Bellot GL, Dong X, Lahiri A, et al. MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): a case in point for MnSOD mimetics as adjuvants for wound management. Redox Biol. 2019;20:307–320.
   PubMed Web of Science ®Google Scholar
• Kadel D, Zhang Y, Sun HR, et al. Current perspectives of cancer-associated fibroblast in therapeutic resistance: potential mechanism and future strategy. Cell Biol Toxicol. 2019;35(5):407–421.
   PubMed Web of Science ®Google Scholar
• Kowaltowski AJ. Strategies to detect mitochondrial oxidants. Redox Biol. 2019;21:101065.
   PubMed Web of Science ®Google Scholar
• Lee BWL, Ghode P, Ong DST. Redox regulation of cell state and fate. Redox Biol. 2019;25:101056.
   PubMed Web of Science ®Google Scholar
• Li RB, Toan S, Zhou H. Role of mitochondrial quality control in the pathogenesis of nonalcoholic fatty liver disease. Aging. 2020;12(7):6467–6485.
   PubMedGoogle Scholar
• Wang J, Toan S, Zhou H. Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: New insights into the mechanisms and therapeutic potentials. Pharmacol Res. 2020;156:104771.
   PubMed Web of Science ®Google Scholar
• Chousterman BG, Swirski FK, Weber GF. Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol. 2017;39(5):517–528.
   PubMed Web of Science ®Google Scholar
• Qiu Z, He Y, Ming H, et al. Lipopolysaccharide (LPS) aggravates high glucose- and hypoxia/reoxygenation-induced injury through activating ROS-dependent NLRP3 inflammasome-mediated pyroptosis in H9C2 cardiomyocytes. J Diabetes Res. 2019;2019:8151836.
   PubMed Web of Science ®Google Scholar
• Yu X, Lan P, Hou X, et al. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production. J Hepatol. 2017;66(4):693–702.
   PubMed Web of Science ®Google Scholar
• Liu Z, Gan L, Xu Y, et al. Melatonin alleviates inflammasome-induced pyroptosis  through inhibiting NF-κB/GSDMD signal in mice adipose tissue. J Pineal Res. 2017;63(1):e12414.
   Google Scholar
• Chen X, Liu G, Yuan Y, et al. NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling. Cell Death Dis. 2019;10(12):906.
   PubMedGoogle Scholar
• Luo M, Hu L, Li D, et al. MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell line. Mol Immunol. 2017;90:1–10.
   PubMed Web of Science ®Google Scholar
• Li RL, Wu SS, Wu Y, et al. Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway. J Mol Cell Cardiol. 2018;121:242–255.
   PubMed Web of Science ®Google Scholar
• Polyzos SA, Kountouras J, Anastasilakis AD, et al. Irisin in patients with nonalcoholic fatty liver disease. Metabolism. 2014;63(2):207–217.
   PubMed Web of Science ®Google Scholar
• Mahgoub MO, D'Souza C, Al Darmaki R, et al. An update on the role of irisin in the regulation of endocrine and metabolic functions. Peptides. 2018;104:15–23.
   PubMed Web of Science ®Google Scholar
• Liu Q, Yang H, Xu S, et al. Downregulation of p300 alleviates LPS-induced inflammatory injuries through regulation of RhoA/ROCK/NF-κB pathways in A549 cells. Biomed Pharmacother. 2018;97:369–374.
   PubMed Web of Science ®Google Scholar
• Yuan Q, Zhang D, Liu C, et al. Chikusetsusaponin V inhibits LPS-activated inflammatory responses via SIRT1/NF-κB signaling pathway in RAW264.7 cells. Inflammation. 2018;41(6):2149–2159.
   PubMed Web of Science ®Google Scholar
• Yuan H, Ma J, Li T, et al. MiR-29b aggravates lipopolysaccharide-induced endothelial cells inflammatory damage by regulation of NF-κB and JNK signaling pathways. Biomed Pharmacother. 2018;99:451–461.
   PubMed Web of Science ®Google Scholar
• Abais JM, Xia M, Zhang Y, et al. Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector? Antioxid Redox Signal. 2015;22(13):1111–1129.
   PubMed Web of Science ®Google Scholar
• Crane DD, Bauler TJ, Wehrly TD, et al. Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome. Front Microbiol. 2014;5:438.
   PubMed Web of Science ®Google Scholar
• Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42(4):245–254.
   PubMed Web of Science ®Google Scholar
• Kesavardhana S, Kanneganti TD. Mechanisms governing inflammasome activation, assembly and pyroptosis induction. Int Immunol. 2017;29(5):201–210.
   PubMed Web of Science ®Google Scholar
• Pfalzgraff A, Heinbockel L, Su Q, et al. Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses. Biochem Pharmacol. 2017;140:64–72.
   PubMed Web of Science ®Google Scholar
• Aglietti RA, Dueber EC. Recent insights into the molecular mechanisms underlying pyroptosis and gasdermin family functions. Trends Immunol. 2017;38(4):261–271.
   PubMed Web of Science ®Google Scholar
• Esquerdo KF, Sharma NK, Brunialti MKC, et al. Inflammasome gene profile is modulated in septic patients, with a greater magnitude in non-survivors. Clin Exp Immunol. 2017;189(2):232–240.
   PubMed Web of Science ®Google Scholar
• Liu Y, Jing YY, Zeng CY, et al. Scutellarin suppresses NLRP3 inflammasome activation in macrophages and protects mice against bacterial sepsis. Front Pharmacol. 2017;8:975.
   PubMed Web of Science ®Google Scholar
• Lee S, Nakahira K, Dalli J, et al. NLRP3 inflammasome deficiency protects against microbial sepsis via increased lipoxin B4 synthesis. Am J Respir Crit Care Med. 2017;196(6):713–726.
   PubMed Web of Science ®Google Scholar