135
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

MiR-190b impedes pancreatic β cell proliferation and insulin secretion by targeting NKX6-1 and may associate to gestational diabetes mellitus

ORCID Icon, , , , &
Pages 349-356 | Received 14 Jul 2020, Accepted 11 Aug 2020, Published online: 30 Aug 2020

References

  • Mack LR, Tomich PG. Gestational diabetes: diagnosis, classification, and clinical care. Obstet Gynecol Clin North Am. 2017;44(2):207–217.
  • Bagci H, Melekoglu R, Gursu M, et al. Associations between serum levels of adiponectin and resistin and metabolic parameters in pregnant women with gestational diabetes mellitus. Clin Exp Obstet Gynecol. 2018;45:539–543.
  • Johns EC, Denison FC, Norman JE, et al. Gestational diabetes mellitus: mechanisms, treatment, and complications. Trends Endocrinol Metab. 2018;29(11):743–754.
  • Ben-Haroush A, Yogev Y, Hod M. Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes. Diabet Med. 2004;21(2):103–113.
  • Law KP, Zhang H. The pathogenesis and pathophysiology of gestational diabetes mellitus: Deductions from a three-part longitudinal metabolomics study in China. Clin Chim Acta. 2017;468:60–70.
  • Plows JF, Stanley JL, Baker PN, et al. The pathophysiology of gestational diabetes mellitus. IJMS. 2018;19(11):3342.
  • Moyce BL, Dolinsky VW. Maternal beta-cell adaptations in pregnancy and placental signalling: implications for gestational diabetes. IJMS. 2018;19(11):3467.
  • Karnik SK, Chen H, McLean GW, et al. Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science. 2007;318(5851):806–809.
  • Pan Y, Yuan F, Li Y, et al. Bromodomain PHD-finger transcription factor promotes glioma progression and indicates poor prognosis. Oncol Rep. 2019;41(1):246–256.
  • Qi S, Wang X. Decreased expression of miR-185 in serum and placenta of patients with gestational diabetes mellitus. Clin Lab. 2019;65(12/2019):19–22.
  • Peng HY, Li MQ, Li HP. MiR-137 restricts the viability and migration of HTR-8/SVneo cells by downregulating FNDC5 in gestational diabetes mellitus. Curr Mol Med. 2019;19(7):494–505.
  • He Y, Bai J, Liu P, et al. miR-494 protects pancreatic β-cell function by targeting PTEN in gestational diabetes mellitus . Excli J. 2017;16:1297–1307.
  • Zhao Q, Liu C, Cui Q, et al. miR-190b promotes colorectal cancer progression through targeting forkhead box protein P2. Exp Ther Med. 2020;19(1):79–84.
  • Hung TM, Ho CM, Liu YC, et al. Up-regulation of microRNA-190b plays a role for decreased IGF-1 that induces insulin resistance in human hepatocellular carcinoma. PloS One. 2014;9(2):e89446.
  • Tseng IC, Yeh MM, Yang CY, et al. NKX6-1 is a novel immunohistochemical marker for pancreatic and duodenal neuroendocrine tumors. Am J Surg Pathol. 2015;39(6):850–857.
  • Ray JD, Kener KB, Bitner BF, et al. Nkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos . FEBS Lett. 2016;590(12):1791–1803.
  • Tessem JS, Moss LG, Chao LC, et al. Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors . Proc Natl Acad Sci USA. 2014;111(14):5242–5247.
  • Schisler JC, Fueger PT, Babu DA, et al. Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Mol Cell Biol. 2008;28(10):3465–3476.
  • Wijesekara N, Zhang LH, Kang MH, et al. miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets. Diabetes. 2012;61(3):653–658.
  • Xu H, Abuhatzira L, Carmona GN, et al. The Ia-2β intronic miRNA, miR-153, is a negative regulator of insulin and dopamine secretion through its effect on the Cacna1c gene in mice. Diabetologia. 2015;58(10):2298–2306.
  • Spaight C, Gross J, Horsch A, et al. Gestational diabetes mellitus. Endocr Dev. 2016;31:163–178.
  • Chen Y, Lv P, Du M, et al. Increased retinol-free RBP4 contributes to insulin resistance in gestational diabetes mellitus. Arch Gynecol Obstet. 2017;296(1):53–61.
  • Chakraborty C, Doss CG, Bandyopadhyay S, et al. Influence of miRNA in insulin signaling pathway and insulin resistance: micro-molecules with a major role in type-2 diabetes. Wiley Interdiscip Rev Rna. 2014;5(5):697–712.
  • Tang XW, Qin QX. miR-335-5p induces insulin resistance and pancreatic islet β-cell secretion in gestational diabetes mellitus mice through VASH1-mediated TGF-β signaling pathway . J Cell Physiol. 2019;234(5):6654–6666.
  • Chen SH, Liu XN, Peng Y. MicroRNA-351 eases insulin resistance and liver gluconeogenesis via the PI3K/AKT pathway by inhibiting FLOT2 in mice of gestational diabetes mellitus. J Cell Mol Med. 2019;23(9):5895–5906.
  • Wang C, Qiao C. MicroRNA-190b confers radio-sensitivity through negative regulation of Bcl-2 in gastric cancer cells. Biotechnol Lett. 2017;39(4):485–490.
  • Chen Z, Yang L, Chen L, et al. miR-190b promotes tumor growth and metastasis via suppressing NLRC3 in bladder carcinoma. Faseb J. 2020;34(3):4072–4084.
  • Minchenko DO. Insulin resistance in obese adolescents affects the expression of genes associated with immune response. Endocr Regul. 2019;53(2):71–82.
  • Xu M, Zheng XM, Jiang F, et al. MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease. J Cell Biochem. 2018;119(7):5864–5874.
  • Taylor BL, Liu FF, Sander M. Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep. 2013;4(6):1262–1275.
  • Schisler JC, Jensen PB, Taylor DG, et al. The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci Usa. 2005;102(20):7297–7302.
  • Rezania A, Bruin JE, Xu J, et al. Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Stem Cells. 2013;31(11):2432–2442.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.