Isoflurane activates AMP-activated protein kinase to inhibit proliferation, and promote apoptosis and autophagy in cervical carcinoma both in vitro and in vivo

References

• Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Li T, Assani G, et al. Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo. Biomed Pharmacother. 2019;112:108602.
   PubMed Web of Science ®Google Scholar
• Roden RB, Stern PL. Opportunities and challenges for human papillomavirus vaccination in cancer. Nat Rev Cancer. 2018;18(4):240–254.
   PubMed Web of Science ®Google Scholar
• Baik S, Mehta FF, Chung S-H. Medroxyprogesterone acetate prevention of cervical cancer through progesterone receptor in a human papillomavirus transgenic mouse model. Am J Pathol. 2019;189(12):2459–2468.
   PubMed Web of Science ®Google Scholar
• Li C, Hou L, Chen D, et al. Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels. Am J Transl Res. 2017;9(3):1162–1172.
   PubMed Web of Science ®Google Scholar
• Loeven AM, Receno CN, DeRuisseau LR. Breathing and blood pressure in conscious and 1% isoflurane anesthetized mice. FASEB J. 2018;32(1_supplement):914.1–914.1.
   Web of Science ®Google Scholar
• Liu H-J, Liu B. Inhibition of MicroRNA-23 contributes to the isoflurane-mediated cardioprotection against oxidative stress. Cardiovasc Toxicol. 2018;18(5):450–458.
   PubMed Web of Science ®Google Scholar
• Zhou CH, Zhang YH, Xue F, et al. Isoflurane exposure regulates the cell viability and BDNF expression of astrocytes via upregulation of TREK-1. Mol Med Rep. 2017;16(5):7305–7314.
   PubMed Web of Science ®Google Scholar
• Hu J, Hu J, Jiao H, et al. Anesthetic effects of isoflurane and the molecular mechanism underlying isoflurane-inhibited aggressiveness of hepatic carcinoma. Mol Med Rep. 2018;18(1):184–192.
   PubMed Web of Science ®Google Scholar
• Zhang W, Shao X. Isoflurane promotes non-small cell lung cancer malignancy by activating the Akt-mammalian target of rapamycin (mTOR) signaling pathway. Med Sci Monit. 2016;22:4644–4650.
   PubMed Web of Science ®Google Scholar
• Iwasaki M, Zhao H, Jaffer T, et al. Volatile anaesthetics enhance the metastasis related cellular signalling including CXCR2 of ovarian cancer cells. Oncotarget. 2016;7(18):26042–26056.
   PubMedGoogle Scholar
• Itoh T, Hirota K, Hisano T, et al. The volatile anesthetics halothane and isoflurane differentially modulate proinflammatory cytokine-induced p38 mitogen-activated protein kinase activation. J Anesth. 2004;18(3):203–209.
   PubMedGoogle Scholar
• Zhu M, Li M, Zhou Y, et al. Isoflurane enhances the malignant potential of glioblastoma stem cells by promoting their viability, mobility in vitro and migratory capacity in vivo. Br J Anaesth. 2016;116(6):870–877.
   PubMed Web of Science ®Google Scholar
• Yanhua LRL, Jiang L, Xudong D, et al. Isoflurane promotes proliferation and invasion of cervical carcinoma cells via downregulation of miR-375 expression. Eur J Gynaecol Oncol. 2019;40(3):368–372.
   Web of Science ®Google Scholar
• Kang HM, Noh KH, Chang TK, et al. Ubiquitination of MAP1LC3B by pVHL is associated with autophagy and cell death in renal cell carcinoma. Cell Death Dis. 2019;10(4):279.
   PubMedGoogle Scholar
• Martinet W, De Meyer GR. Autophagy in atherosclerosis. Curr Atheroscler Rep. 2008;10(3):216–223.
   PubMed Web of Science ®Google Scholar
• Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999;402(6762):672–676.
   PubMed Web of Science ®Google Scholar
• Auberger P, Puissant A. Autophagy, a key mechanism of oncogenesis and resistance in leukemia. Blood. 2017;129(5):547–552.
   PubMed Web of Science ®Google Scholar
• Rao Z, Pan X, Zhang H, et al. Isoflurane preconditioning alleviated murine liver ischemia and reperfusion injury by restoring AMPK/mTOR-mediated autophagy. Anesth Analg. 2017;125(4):1355–1363.
   PubMed Web of Science ®Google Scholar
• Dastjerdi MN, Babazadeh Z, Rabbani M, et al. Effects of disulfiram on apoptosis in PANC-1 human pancreatic cancer cell line. Res Pharma Sci. 2014;9(4):287–294.
   PubMedGoogle Scholar
• Benzonana LL, Perry NJ, Watts HR, et al. Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro. Anesthesiology. 2013;119(3):593–605.
   PubMed Web of Science ®Google Scholar
• Nagata S. Apoptosis by death factor. Cell. 1997;88(3):355–365.
   PubMed Web of Science ®Google Scholar
• Shao D, Wu Z, Bai S, et al. The function of miRNA-153 against isoflurane-induced neurotoxicity via Nrf2/ARE cytoprotection. Mol Med Rep. 2019;19(5):4001–4010.
   PubMed Web of Science ®Google Scholar
• Zhang B, Tian M, Zhen Y, et al. The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg. 2012;114(2):410–415.
   PubMed Web of Science ®Google Scholar
• Cheng B, Zhang Y, Wang A, et al. Vitamin C attenuates isoflurane-induced caspase-3 activation and cognitive impairment. Mol Neurobiol. 2015;52(3):1580–1589.
   PubMed Web of Science ®Google Scholar
• Szewczyk A, Czyz A, Wojcik G, et al. ATP-regulated K + channel in mitochondria: pharmacology and function. J Bioenerg Biomembr. 1996;28(2):147–152.
   PubMed Web of Science ®Google Scholar
• Yang Y, Chen X, Min H, et al. Persistent mitoKATP activation is involved in the isoflurane-induced cytotoxicity. Mol Neurobiol. 2017;54(2):1101–1110.
   PubMed Web of Science ®Google Scholar
• Wang Q, Zou M-H. Measurement of reactive oxygen species (ROS) and mitochondrial ROS in AMPK knockout mice blood vessels. Methods Mol Biol. 2018;1732:507–517.
   Google Scholar
• Hinchy EC, Gruszczyk AV, Willows R, et al. Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly. J Biol Chem. 2018;293(44):17208–17217.
   PubMed Web of Science ®Google Scholar
• Wu H, Song A, Hu W, et al. The anti-atherosclerotic effect of paeonol against vascular smooth muscle cell proliferation by up-regulation of autophagy via the AMPK/mTOR signaling pathway. Front Pharmacol. 2017;8:948.
   PubMed Web of Science ®Google Scholar
• Du X, Jiang C, Lv Y, et al. Isoflurane promotes phagocytosis of apoptotic neutrophils through AMPK-mediated ADAM17/Mer signaling. PLoS One. 2017;12(7):e0180213.
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1–222.
   PubMed Web of Science ®Google Scholar
• Mortensen M, Soilleux EJ, Djordjevic G, et al. The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med. 2011;208(3):455–467.
   PubMed Web of Science ®Google Scholar
• Qian X, Li X, Cai Q, et al. Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy. Mol Cell. 2017;65(5):917–931.e6.
   PubMed Web of Science ®Google Scholar
• Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000;19(21):5720–5728.
   PubMed Web of Science ®Google Scholar
• Meijles DN, Zoumpoulidou G, Markou T, et al. The cardiomyocyte "redox rheostat": redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death. J Mol Cell Cardiol. 2019;129:118–129.
   PubMed Web of Science ®Google Scholar
• Paquette M, El-Houjeiri L, Pause A. mTOR pathways in cancer and autophagy. Cancers. 2018;10(1):18.
   PubMed Web of Science ®Google Scholar
• Garcia D, Shaw RJ. AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance. Mol Cell. 2017;66(6):789–800.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Hu W, Chen P, et al. Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: a systematic review and meta-analysis. Medicine. 2017;96(34):e7911.
   PubMed Web of Science ®Google Scholar
• Shi L, Sun G. DMC is not better than TMZ on intracranial anti-glioma effects. J Cell Biochem. 2018;119(7):6057–6064.
   PubMed Web of Science ®Google Scholar
• Flecknell P, Lofgren JLS, Dyson MC, et al. Chapter 24 - Preanesthesia, anesthesia, analgesia, and euthanasia. In: Fox JG, Anderson LC, Otto GM, et al. editors. Laboratory animal medicine. 3rd ed. Boston: Academic Press; 2015. p. 1135–1200.
   Google Scholar
• Frink EJ Jr, Malan TP, Atlas M, et al. Clinical comparison of sevoflurane and isoflurane in healthy patients. Anesth Analg. 1992;74(2):241–245.
   PubMed Web of Science ®Google Scholar