176
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

Formononetin inhibits inflammation and promotes gastric mucosal angiogenesis in gastric ulcer rats through regulating NF-κB signaling pathway

, , , &
Pages 16-22 | Received 15 Sep 2020, Accepted 12 Oct 2020, Published online: 26 Oct 2020

References

  • Hui S, Fangyu W. Protective effects of bilobalide against ethanol-induced gastric ulcer in vivo/vitro. Biomed Pharmacother. 2017;85:592–600.
  • Khoder G, Al-Menhali AA, Al-Yassir F, et al. Potential role of probiotics in the management of gastric ulcer. Exp Ther Med. 2016;12(1):3–17.
  • Viana AF, Fernandes HB, Silva FV, Oliveira IS, et al. Gastroprotective activity of Cenostigma macrophyllum Tul. var. acuminata Teles Freire leaves on experimental ulcer models. J Ethnopharmacol. 2013;150(1):316–323.
  • de Souza Almeida ES, Filho VC, Niero R, et al. Pharmacological mechanisms underlying the anti-ulcer activity of methanol extract and canthin-6-one of Simaba ferruginea A. St-Hil. in animal models. J Ethnopharmacol. 2011;134(3):630–636.
  • Behrman SW. Management of complicated peptic ulcer disease. Arch Surg. 2005;140(2):201–208.
  • Hwang JJ, Lee DH, Lee AR, et al. Characteristics of gastric cancer in peptic ulcer patients with Helicobacter pylori infection. WJG. 2015;21(16):4954–4960.
  • Wu JZ, Liu YH, Liang JL, et al. Protective role of β-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. Phytomedicine. 2018;39:111–118.
  • Mahmoud YI, Abd El-Ghffar EA. Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. Biomed Pharmacother. 2019;109:314–321.
  • Ha X, Peng J, Zhao H, et al. Enhancement of gastric ulcer healing and angiogenesis by hepatocyte growth factor gene mediated by attenuated salmonella in rats. J Korean Med Sci. 2017;32(2):186–194.
  • Pascual M, Baliño P, Aragón CM, et al. Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: role of TLR4 and TLR2. Neuropharmacology. 2015;89:352–359.
  • Luo JC, Peng YL, Chen TS, et al. Clopidogrel inhibits angiogenesis of gastric ulcer healing via downregulation of vascular endothelial growth factor receptor 2. J Formos Med Assoc. 2016;115(9):764–772.
  • Jiang D, Rasul A, Batool R, et al. Potential anticancer properties and mechanisms of action of formononetin. Biomed Res Int. 2019;2019:5854315.
  • Wu XY, Xu H, Wu ZF, et al. Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models. Oncotarget. 2015;6(42):44563–44578.
  • Zavoshti FR, Andrews FM. Therapeutics for equine gastric ulcer syndrome. Vet Clin North Am Equine Pract. 2017;33(1):141–162.
  • Eisner F, Hermann D, Bajaeifer K, et al. Gastric ulcer complications after the introduction of proton pump inhibitors into clinical routine: 20-year experience. Visc Med. 2017;33(3):221–226.
  • Svestka T, Krechler T, Brůha R, et al. Ochranné mechanizmy zaludecní sliznice [Protective mechanism of the gastric mucosa]. Cas Lek Cesk. 2005;144:40–43.
  • Herrington JL, Jr, Sawyers JL. Gastric ulcer. Curr Probl Surg. 1987;24(12):759–865.
  • Ding X, Gu R, Zhang M, et al. Microglia enhanced the angiogenesis, migration and proliferation of co-cultured RMECs. BMC Ophthalmol. 2018;18(1):249.
  • Zhang L, Liu H, Peng YM, et al. Vascular endothelial growth factor increases GEnC permeability by affecting the distributions of occludin, ZO-1 and tight juction assembly. Eur Rev Med Pharmacol Sci. 2015;19:2621–2627.
  • Abbruscato TJ, Lopez SP, Mark KS, et al. Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells. J Pharm Sci. 2002;91(12):2525–2538.
  • Houde M, Desbiens L, D'Orléans-Juste P. Endothelin-1: biosynthesis, signaling and vasoreactivity. Adv Pharmacol. 2016;77:143–175.
  • Melincovici CS, Boşca AB, Şuşman S, et al. Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. Rom J Morphol Embryol. 2018;59(2):455–467.
  • Kanazawa S, Tsunoda T, Onuma E, et al. VEGF, basic-FGF, and TGF-beta in Crohn's disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation. Am J Gastroenterology. 2001;96(3):822–828.
  • Akanda MR, Park BY. Involvement of MAPK/NF-κB signal transduction pathways: Camellia japonica mitigates inflammation and gastric ulcer. Biomed Pharmacother. 2017;95:1139–1146.
  • Aratani Y. Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function. Arch Biochem Biophys. 2018;640:47–52.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.