Sauchinone inhibits hypoxia-induced invasion and epithelial–mesenchymal transition in osteosarcoma cells via inactivation of the sonic hedgehog pathway

References

• Eaton BR, Schwarz R, Vatner R, et al. Osteosarcoma. Pediatr Blood Cancer. 2020;11:e28352.
   Google Scholar
• Buckley JD, Pendergrass TW, Buckley CM, et al. Epidemiology of osteosarcoma and Ewing's sarcoma in childhood: a study of 305 cases by the Children's Cancer Group. Cancer. 1998;83(7):1440–1448.
   PubMed Web of Science ®Google Scholar
• Cortini M, Baldini N, Avnet S. New advances in the study of bone tumors: a lesson from the 3D environment. Front Physiol. 2019;10:814.
   PubMed Web of Science ®Google Scholar
• Harrison DJ, Geller DS, Gill JD, et al. Current and future therapeutic approaches for osteosarcoma. Expert Rev Anticancer Ther. 2018;18(1):39–50.
   PubMed Web of Science ®Google Scholar
• Bellini G, Pinto D, Tortora C, et al. The role of mifamurtide in chemotherapy-induced osteoporosis of children with osteosarcoma. Curr Cancer Drug Targets. 2017;17(7):650–656.
   PubMed Web of Science ®Google Scholar
• Geng L, Chen JY, Meng XU, et al. Progress on treatment of osteosarcoma: a review of the literature. Orthopedic J. 2015;24:1469–1475.
   Google Scholar
• Kager L, Tamamyan G, Bielack S. Novel insights and therapeutic interventions for pediatric osteosarcoma. Future Oncol. 2017;13(4):357–368.
   Google Scholar
• Ferguson JL, Turner SP. Bone cancer: diagnosis and treatment principles. Am Fam Physician. 2018;98(4):205–213.
   PubMed Web of Science ®Google Scholar
• Dong S, Huo H, Mao Y, et al. A risk score model for the prediction of osteosarcoma metastasis. FEBS Open Bio. 2019;9(3):519–526.
   PubMed Web of Science ®Google Scholar
• Johnson D. Hypoxia, hyperventilation, and supplemental oxygen systems. Soaring. 2018;82:19–27.
   Google Scholar
• Stone L. Hypoxia-related gene panel is prognostic. Nat Rev Urol. 2018;15(7):398
   Web of Science ®Google Scholar
• Saxena K, Jolly MK, Balamurugan K. Hypoxia, partial EMT and collective migration: emerging culprits in metastasis. Transl Oncol. 2020;13(11):100845.
   PubMed Web of Science ®Google Scholar
• Carballo GB, Honorato JR, de Lopes GPF, et al. A highlight on Sonic hedgehog pathway. Cell Commun Signal. 2018;16(1):11.
   PubMed Web of Science ®Google Scholar
• Tanushree P, Stacey O. Contributions of noncanonical smoothened signaling during embryonic development. J Dev Biol. 2017;5:11.
   PubMed Web of Science ®Google Scholar
• Qu W, Wang Y, Wu Q, et al. Emodin impairs radioresistance of human osteosarcoma cells by suppressing sonic Hedgehog signaling. Med Sci Monit. 2017;23:5767–5773.
   PubMed Web of Science ®Google Scholar
• Jeng KS, Jeng CJ, Jeng WJ, et al. Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review). Oncol Lett. 2019;18(5):4377–4384.
   PubMed Web of Science ®Google Scholar
• Hu Y, Wang J. Interactions between clopidogrel and traditional Chinese medicine. J Thromb Thrombolysis. 2019;48(3):491–499.
   PubMed Web of Science ®Google Scholar
• Jin L, Yang J, Liu C, et al. Characterization of the complete plastome of medicinal plant Saururus chinensis (Saururaceae). Mitochondrial DNA B Resour. 2019;4(2):3206–3207.
   PubMed Web of Science ®Google Scholar
• You B, Gong E, Young C. Inhibitory effect of sauchinone on UDP-glucuronosyltransferase (UGT) 2B7 activity. Molecules. 2018;23(2):366.
   PubMed Web of Science ®Google Scholar
• Gao Y, Zhao H, Li Y. Sauchinone prevents IL-1β-induced inflammatory response in human chondrocytes. J Biochem Mol Toxicol. 2018;32(3):e22033.
   PubMed Web of Science ®Google Scholar
• Shi Y, Zhang Y, Li Y, et al. Sauchinone inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells. RSC Adv. 2019;9(30):17065–17071.
   PubMed Web of Science ®Google Scholar
• Xiao J, Wang JX, Chen YX, et al. Sauchinone ameliorates intestinal inflammation and promotes Th17 cell production of IL-10 via Blimp-1. Biochem Biophys Res Commun. 2020;522(2):435–441.
   PubMed Web of Science ®Google Scholar
• Kim YW, Jang EJ, Kim CH, et al. Sauchinone exerts anticancer effects by targeting AMPK signaling in hepatocellular carcinoma cells. Chem Biol Interact. 2017;261:108–117.
   PubMed Web of Science ®Google Scholar
• He ZK, Dong WX, Li QY, et al. Sauchinone prevents TGF-β-induced EMT and metastasis in gastric cancer cells. Biomed Pharmacother. 2018;101:355–361.
   PubMed Web of Science ®Google Scholar
• Qiao Y, Yan LJ, Yan C. Sauchinone inhibits hypoxia-induced epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma cells through the Wnt/β-catenin pathway. Anticancer Drugs. 2020;31(9):918–924.
   PubMed Web of Science ®Google Scholar
• Curtis ID, Chiaretti S. Role of liprins in the regulation of tumor cell motility and invasion. Curr Cancer Drug Targets. 2016;16(3):238–248.
   PubMed Web of Science ®Google Scholar
• Stuelten CH, Parent CA, Montell DJ. Cell motility in cancer invasion and metastasis: insights from simple model organisms. Nat Rev Cancer. 2018;18(5):296–312.
   PubMed Web of Science ®Google Scholar
• Pal M, Bhattacharya S, Kalyan G, et al. Cadherin profiling for therapeutic interventions in Epithelial Mesenchymal Transition (EMT) and tumorigenesis. Exp Cell Res. 2018;368(2):137–146.
   PubMed Web of Science ®Google Scholar
• Kang X, Wang J, Li C. Exposing the underlying relationship of cancer metastasis to metabolism and epithelial-mesenchymal transitions. iScience. 2019;21:754–772.
   PubMed Web of Science ®Google Scholar
• Cao L, Xiao X, Lei J, et al. Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway. Oncol Rep. 2016;35(6):3728–3734.
   PubMed Web of Science ®Google Scholar
• Liu Z, Tu K, Wang Y, et al. Hypoxia accelerates aggressiveness of hepatocellular carcinoma cells involving oxidative stress, epithelial-mesenchymal transition and non-canonical Hedgehog signaling. Cell Physiol Biochem. 2017;44(5):1856–1868.
   PubMedGoogle Scholar
• Arraf AA, Yelin R, Reshef I, et al. Hedgehog signaling regulates epithelial morphogenesis to position the ventral embryonic midline. Dev Cell. 2020;53(5):589–602.
   PubMed Web of Science ®Google Scholar