JAK2/STAT3 inhibitor reduced 5-FU resistance and autophagy through ATF6-mediated ER stress

References

• Lazăr DC, Avram MF, Romoșan I, et al. Prognostic significance of tumor immune microenvironment and immunotherapy: novel insights and future perspectives in gastric cancer. World J Gastroenterol. 2018;24(32):3583–3616.
   PubMed Web of Science ®Google Scholar
• Wang FH, Shen L, Li J, et al. The Chinese Society of Clinical Oncology (CSCO): clinical guidelines for the diagnosis and treatment of gastric cancer. Cancer Commun. 2019;39(1):10.
   PubMed Web of Science ®Google Scholar
• Leelakanok N, Geary S, Salem A. Fabrication and use of poly(d,l-lactide-co-glycolide)-based formulations designed for modified release of 5-fluorouracil. J Pharm Sci. 2018;107(2):513–528.
   PubMed Web of Science ®Google Scholar
• Chen X, Zeng L. Ginkgo biloba extract 761 enhances 5-fluorouracil chemosensitivity in colorectal cancer cells through regulation of high mobility group-box 3 expression. Am J Transl Res. 2018;10(6):1773–1783.
   PubMed Web of Science ®Google Scholar
• Zhao GL, Yu LM, Gao WL, et al. Berberine protects rat heart from ischemia/reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress. Acta Pharmacol Sin. 2016;37(3):354–367.
   PubMed Web of Science ®Google Scholar
• Meng J, Liu K, Shao Y, et al. ID1 confers cancer cell chemoresistance through STAT3/ATF6-mediated induction of autophagy. Cell Death Dis. 2020;11(2):137.
   PubMed Web of Science ®Google Scholar
• Zhang B, Han H, Fu S, et al. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. Biochem Pharmacol. 2016;104:8–18.
   PubMed Web of Science ®Google Scholar
• Lee WS, Yoo WH, Chae HJ. ER stress and autophagy. Curr Mol Med. 2015;15(8):735–745.
   PubMed Web of Science ®Google Scholar
• Sun X, Zhang X, Zhai H, et al. Chicoric acid (CA) induces autophagy in gastric cancer through promoting endoplasmic reticulum (ER) stress regulated by AMPK. Biomed Pharmacother. 2019;118:109144.
   PubMed Web of Science ®Google Scholar
• Song S, Tan J, Miao Y, et al. Crosstalk of ER stress-mediated autophagy and ER-phagy: involvement of UPR and the core autophagy machinery. J Cell Physiol. 2018;233(5):3867–3874.
   PubMed Web of Science ®Google Scholar
• Zhang X, Cheng J, He P, et al. Active monomer RTR-1 derived from the root of Rhodomyrtus tomentosa induces apoptosis in gastric carcinoma cells by inducing ER stress and inhibiting the STAT3 signaling pathway. Cancer Manag Res. 2020;12:3117–3129.
   PubMed Web of Science ®Google Scholar
• Feng R, Zhai WL, Yang HY, et al. Induction of ER stress protects gastric cancer cells against apoptosis induced by cisplatin and doxorubicin through activation of p38 MAPK. Biochem Biophys Res Commun. 2011;406(2):299–304.
   PubMed Web of Science ®Google Scholar
• Na YJ, Lee DH, Kim JL, et al. Cyclopamine sensitizes TRAIL-resistant gastric cancer cells to TRAIL-induced apoptosis via endoplasmic reticulum stress-mediated increase of death receptor 5 and survivin degradation. Int J Biochem Cell Biol. 2017;89:147–156.
   PubMed Web of Science ®Google Scholar
• Zhao J, Nie Y, Wang H, et al. MiR-181a suppresses autophagy and sensitizes gastric cancer cells to cisplatin. Gene. 2016;576(2 Pt 2):828–833.
   PubMed Web of Science ®Google Scholar
• Kim TW, Lee SY, Kim M, et al. DSGOST regulates resistance via activation of autophagy in gastric cancer. Cell Death Dis. 2018;9(6):649.
   PubMedGoogle Scholar
• Kim MJ, Nam HJ, Kim HP, et al. OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett. 2013;335(1):145–152.
   PubMed Web of Science ®Google Scholar
• Kong FB, Deng QM, Deng HQ, et al. Siva-1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NF-κB pathway. Mol Med Rep. 2020;22(2):1558–1566.
   PubMed Web of Science ®Google Scholar
• Geng M, Wang L, Chen X, et al. The association between chemosensitivity and Pgp, GST-π and Topo II expression in gastric cancer. Diagn Pathol. 2013;8(1):198.
   PubMedGoogle Scholar
• Tang H, Zhang X, Cui S, et al. Role and mechanism research on reversal of 5-fluorouracil resistance by epigallocatechin gallate in gastric cancer drug-resistance cells lines SGC-7901/5-FU. Zhonghua Wei Chang Wai Ke Za Zhi. 2016;19:1170–1175.
   PubMedGoogle Scholar
• Cao Y, Luo Y, Zou J, et al. Autophagy and its role in gastric cancer. Clin Chim Acta. 2019;489:10–20.
   PubMed Web of Science ®Google Scholar
• Masuda GO, Yashiro M, Kitayama K, et al. Clinicopathological correlations of autophagy-related proteins LC3, Beclin 1 and p62 in gastric cancer. Anticancer Res. 2016;36(1):129–136.
   PubMed Web of Science ®Google Scholar
• Guo W, Li W, Yuan L, et al. MicroRNA-106a-3p induces apatinib resistance and activates Janus-activated kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) by targeting the SOCS system in gastric cancer. Med Sci Monit. 2019;25:10122–10128.
   PubMed Web of Science ®Google Scholar
• Heo YJ, Choi SE, Jeon JY, et al. Visfatin induces inflammation and insulin resistance via the NF-κB and STAT3 signaling pathways in hepatocytes. J Diabetes Res. 2019;2019:4021623.
   PubMed Web of Science ®Google Scholar
• Wörmann SM, Song L, Ai J, et al. Loss of P53 function activates JAK2-STAT3 signaling to promote pancreatic tumor growth, stroma modification, and gemcitabine resistance in mice and is associated with patient survival. Gastroenterology. 2016;151(1):180–193.e112.
   PubMed Web of Science ®Google Scholar
• Zhang W, Qiao B, Fan J. Overexpression of miR-4443 promotes the resistance of non-small cell lung cancer cells to epirubicin by targeting INPP4A and regulating the activation of JAK2/STAT3 pathway. Pharmazie. 2018;73(7):386–392.
   PubMed Web of Science ®Google Scholar
• Cao Y, Wang J, Tian H, et al. Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer. J Exp Clin Cancer Res. 2020;39(1):119.
   PubMed Web of Science ®Google Scholar
• Liang L, Hui K, Hu C, et al. Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells. J Exp Clin Cancer Res. 2019;38(1):71.
   PubMedGoogle Scholar
• Wang H, Wang L, Cao L, et al. Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate through JAK2/STAT3 pathway in lung cancer cells. Mol Carcinog. 2018;57(4):522–535.
   PubMed Web of Science ®Google Scholar
• Xia Y, Xia H, Chen D, et al. Mechanisms of autophagy and apoptosis mediated by JAK2 signaling pathway after spinal cord injury of rats. Exp Ther Med. 2017;14(2):1589–1593.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhu W, Tao J, et al. Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways. PLoS One. 2012;7(10):e48115.
   PubMed Web of Science ®Google Scholar
• Wu S, Ye S, Lin X, et al. Small hepatitis B virus surface antigen promotes malignant progression of hepatocellular carcinoma via endoplasmic reticulum stress-induced FGF19/JAK2/STAT3 signaling. Cancer Lett. 2020;499:175–187.
   PubMed Web of Science ®Google Scholar
• Shang L, Dong P, Du L, et al. SERP1 prevents hypoxia-reoxygenation-induced H9c2 apoptosis through activating JAK2/STAT3 pathway-dependent attenuation of endoplasmic reticulum stress. Biochem Biophys Res Commun. 2019;508(1):256–262.
   PubMed Web of Science ®Google Scholar
• Hou L, Dong J, Zhu S, et al. Seneca valley virus activates autophagy through the PERK and ATF6 UPR pathways. Virology. 2019;537:254–263.
   PubMed Web of Science ®Google Scholar
• Sharma M, Bhattacharyya S, Sharma KB, et al. Japanese encephalitis virus activates autophagy through XBP1 and ATF6 ER stress sensors in neuronal cells. J Gen Virol. 2017;98(5):1027–1039.
   PubMed Web of Science ®Google Scholar
• Kania E, Pająk B, Orzechowski A. Calcium homeostasis and ER stress in control of autophagy in cancer cells. Biomed Res Int. 2015;2015:352794.
   PubMed Web of Science ®Google Scholar