MicroRNA-320a-containing exosomes from human umbilical cord mesenchymal stem cells curtail proliferation and metastasis in lung cancer by binding to SOX4

References

• Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.
   PubMed Web of Science ®Google Scholar
• Lai XN, Li J, Tang LB, et al. MiRNAs and LncRNAs: dual roles in TGF-beta signaling-regulated metastasis in lung cancer. Int J Mol Sci. 2020;21:1193.
   Web of Science ®Google Scholar
• Riihimaki M, Hemminki A, Fallah M, et al. Metastatic sites and survival in lung cancer. Lung Cancer. 2014;86:78–84.
   PubMed Web of Science ®Google Scholar
• Lin H, Shangguan Z, Zhu M, et al. lncRNA FLVCR1-AS1 silencing inhibits lung cancer cell proliferation, migration, and invasion by inhibiting the activity of the Wnt/beta-catenin signaling pathway. J Cell Biochem. 2019;120:10625–10632.
   PubMed Web of Science ®Google Scholar
• Amiri A, Pourhanifeh MH, Mirzaei HR, et al. Exosomes and lung cancer: roles in pathophysiology, diagnosis and therapeutic applications. Curr Med Chem. 2021;28:308–328.
   PubMed Web of Science ®Google Scholar
• Xia Y, Wei K, Hu LQ, et al. Exosome-mediated transfer of miR-1260b promotes cell invasion through Wnt/beta-catenin signaling pathway in lung adenocarcinoma. J Cell Physiol. 2020;235:6843–6853.
   PubMed Web of Science ®Google Scholar
• Dong L, Pu Y, Zhang L, et al. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410. Cell Death Dis. 2018;9:218.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Zhou C, Chen X, et al. Suppression of tumor cell proliferation and migration by human umbilical cord mesenchymal stem cells: a possible role for apoptosis and Wnt signaling. Oncol Lett. 2018;15:8536–8544.
   PubMed Web of Science ®Google Scholar
• Yuan L, Liu Y, Qu Y, et al. Exosomes derived from microRNA-148b-3p-overexpressing human umbilical cord mesenchymal stem cells restrain breast cancer progression. Front Oncol. 2019;9:1076.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Li X, Sun W, et al. Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis. Cancer Lett. 2017; 397:33–42.
   PubMed Web of Science ®Google Scholar
• Cui Z, Sun Q, Yan W, et al. The role of miR-320a and its target gene GMEB1 in epithelial-mesenchymal transition and invasion of colorectal cancer. J Gene Med. 2021:e3327.
   PubMedGoogle Scholar
• Ma X, Wang Z, Ren H, et al. Long non-coding RNA GAS5 suppresses tumor progression and enhances the radiosensitivity of prostate cancer through the miR-320a/RAB21 Axis. CMAR. 2020;12:8833–8845.
   Google Scholar
• Xing B, Qiao XF, Qiu YH, et al. TMPO-AS1 regulates the aggressiveness-associated traits of nasopharyngeal carcinoma cells through sponging miR-320a. Cancer Manag Res. 2021;13:415–425.
   PubMed Web of Science ®Google Scholar
• Grimm D, Bauer J, Wise P, et al. The role of SOX family members in solid tumours and metastasis. Semin Cancer Biol. 2020;67:122–153.
   PubMed Web of Science ®Google Scholar
• Tiwari N, Tiwari VK, Waldmeier L, et al. Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming. Cancer Cell. 2013;23:768–783.
   PubMed Web of Science ®Google Scholar
• Quan X, Li X, Yin Z, et al. p53/miR-30a-5p/SOX4 feedback loop mediates cellular proliferation, apoptosis, and migration of non-small-cell lung cancer. J Cell Physiol. 2019;234:22884–22895.
   PubMed Web of Science ®Google Scholar
• Yang J, Lin X, Jiang W, et al. lncRNA LEF1-AS1 promotes malignancy in non-small-cell lung cancer by modulating the miR-489/SOX4 axis. DNA Cell Biol. 2019;38:1013–1021.
   PubMed Web of Science ®Google Scholar
• Zhong M, Wang WL, Yu DJ. Long non-coding RNA OR3A4 is associated with poor prognosis of human non-small cell lung cancer and regulates cell proliferation via up-regulating SOX4. Eur Rev Med Pharmacol Sci. 2019;23:6524–6530.
   PubMed Web of Science ®Google Scholar
• Kormish JD, Sinner D, Zorn AM. Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease. Dev Dyn. 2010;239:56–68.
   PubMed Web of Science ®Google Scholar
• Ying W, Riopel M, Bandyopadhyay G, et al. Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity. Cell. 2017;171:372–384.e12.
   PubMed Web of Science ®Google Scholar
• Lee H, Zhang D, Zhu Z, et al. Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs. Sci Rep. 2016;6:35250.
   PubMed Web of Science ®Google Scholar
• Li T, Zhang C, Ding Y, et al. Umbilical cord-derived mesenchymal stem cells promote proliferation and migration in MCF-7 and MDA-MB-231 breast cancer cells through activation of the ERK pathway. Oncol Rep. 2015;34:1469–1477.
   PubMed Web of Science ®Google Scholar
• Sun B, Yu KR, Bhandari DR, et al. Human umbilical cord blood mesenchymal stem cell-derived extracellular matrix prohibits metastatic cancer cell MDA-MB-231 proliferation. Cancer Lett. 2010;296:178–185.
   PubMed Web of Science ®Google Scholar
• Guiot J, Struman I, Louis E, et al. Exosomal miRNAs in lung diseases: from biologic function to therapeutic targets. J Clin Med. 2019;8:1345.
   Web of Science ®Google Scholar
• Fortunato O, Gasparini P, Boeri M, et al. Exo-miRNAs as a new tool for liquid biopsy in lung cancer. Cancers. 2019;11:888.
   Web of Science ®Google Scholar
• Kahlert C, Kalluri R. Exosomes in tumor microenvironment influence cancer progression and metastasis. J Mol Med. 2013;91:431–437.
   PubMed Web of Science ®Google Scholar
• Chen R, Xu X, Qian Z, et al. The biological functions and clinical applications of exosomes in lung cancer. Cell Mol Life Sci. 2019;76:4613–4633.
   PubMed Web of Science ®Google Scholar
• Yao Y, Chen R, Wang G, et al. Exosomes derived from mesenchymal stem cells reverse EMT via TGF-beta1/Smad pathway and promote repair of damaged endometrium. Stem Cell Res Ther. 2019;10:225.
   PubMed Web of Science ®Google Scholar
• Manterola L, Guruceaga E, Gallego Perez-LarCya J, et al. A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool. Neuro Oncol. 2014;16:520–527.
   PubMed Web of Science ®Google Scholar
• Xishan Z, Ziying L, Jing D, et al. MicroRNA-320a acts as a tumor suppressor by targeting BCR/ABL oncogene in chronic myeloid leukemia. Sci Rep. 2015;5:12460.
   PubMed Web of Science ®Google Scholar
• Qi X, Li J, Zhou C, et al. MicroRNA-320a inhibits cell proliferation, migration and invasion by targeting BMI-1 in nasopharyngeal carcinoma. FEBS Lett. 2014;588:3732–3738.
   PubMed Web of Science ®Google Scholar
• Zhang Y, He X, Liu Y, et al. microRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer. Oncol Rep. 2012;27:685–694.
   PubMed Web of Science ®Google Scholar
• Xie F, Yuan Y, Xie L, et al. miRNA-320a inhibits tumor proliferation and invasion by targeting c-Myc in human hepatocellular carcinoma. OTT. 2017;10:885–894.
   Google Scholar
• Wang J, Shi C, Wang J, et al. MicroRNA-320a is downregulated in non-small cell lung cancer and suppresses tumor cell growth and invasion by directly targeting insulin-like growth factor 1 receptor. Oncol Lett. 2017;13:3247–3252.
   PubMed Web of Science ®Google Scholar
• Xing A, Pan L, Gao J. p100 functions as a metastasis activator and is targeted by tumor suppressing microRNA-320a in lung cancer. Thorac Cancer. 2018;9:152–158.
   PubMed Web of Science ®Google Scholar
• Zhang P, Li J, Song Y, et al. MiR-129-5p inhibits proliferation and invasion of chondrosarcoma cells by regulating SOX4/Wnt/beta-catenin signaling pathway. Cell Physiol Biochem. 2017;42:242–253.
   PubMed Web of Science ®Google Scholar
• Lu C, Liao Z, Cai M, et al. MicroRNA-320a downregulation mediates human liver cancer cell proliferation through the Wnt/beta-catenin signaling pathway. Oncol Lett. 2017;13:573–578.
   PubMed Web of Science ®Google Scholar
• Xu H, Zhao G, Zhang Y, et al. Mesenchymal stem cell-derived exosomal microRNA-133b suppresses glioma progression via Wnt/beta-catenin signaling pathway by targeting EZH2. Stem Cell Res Ther. 2019;10:381.
   PubMed Web of Science ®Google Scholar
• Guo YZ, Xie XL, Fu J, et al. SOX9 regulated proliferation and apoptosis of human lung carcinoma cells by the Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 2018;22:4898–4907.
   PubMed Web of Science ®Google Scholar
• Besse B, Charrier M, Lapierre V, et al. Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC. Oncoimmunology. 2016;5:e1071008.
   PubMed Web of Science ®Google Scholar