Advanced search
Publication Cover
Journal of Receptors and Signal Transduction Volume 42, 2022 - Issue 6
Submit an article Journal homepage
1,091
Views
1
CrossRef citations to date
0
Altmetric
Research Articles

Pharmacological characterization of the α2A-adrenergic receptor inhibiting rat hippocampal CA3 epileptiform activity: comparison of ligand efficacy and potency

Joseph P. Bigganea Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USAView further author information
,
Ke Xua Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USAView further author information
,
Brianna L. Goldensteina Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USAView further author information
,
Kylie L. Davisa Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USAView further author information
,
Elizabeth J. Lugera Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USAView further author information
,
Bethany A. Davisa Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USAView further author information
,
Chris W.D. Jurgensa Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USAView further author information
,
Dianne M. Perezb Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, USAORCID Iconhttps://orcid.org/0000-0002-1790-5776View further author information
ORCID Icon,
James E. Portera Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USAView further author information
&
Van A. Dozea Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5288-9564View further author information
ORCID Icon show all
Pages 580-587 | Received 03 Jun 2022, Accepted 02 Aug 2022, Published online: 19 Aug 2022

References

  • Giorgi FS, Pizzanelli C, Biagioni F, et al. The role of norepinephrine in epilepsy: from the bench to the bedside. Neurosci Biobehav Rev. 2004;28(5):507–524.
  • Happe HK, Coulter CL, Gerety ME, et al. α2-adrenergic receptor development in rat CNS: an autoradiographic study. Neuroscience. 2004;123(1):167–178.
  • Zilles K, Gross G, Schleicher A, et al. Regional and laminar distributions of alpha1-adrenoceptors and their subtypes in human and rat hippocampus. Neuroscience. 1991;40(2):307–320.
  • Weinshenker D, Szot P. The role of catecholamines in seizure susceptibility: new results using genetically engineered mice. Pharmacol Ther. 2002;94(3):213–233.
  • Clinckers R, Zgavc T, Vermoesen K, et al. Pharmacological and neurochemical characterization of the involvement of hippocampal adrenoreceptor subtypes in the modulation of acute limbic seizures. J Neurochem. 2010;115(6):1595–1607.
  • Ghasemi M, Mehranfard N. Mechanisms underlying anticonvulsant and proconvulsant actions of norepinephrine. Neuropharmacology. 2018;137:297–308.
  • Iváñez V, Ojeda J. Exacerbation of seizures in medial temporal lobe epilepsy due to an alpha1-adrenergic antagonist. Epilepsia. 2006;47(10):1741–1742.
  • Löscher W, Czuczwar SJ. Comparison of drugs with different selectivity for Central alpha1- and alpha2-adrenoceptors in animal models of epilepsy. Epilepsy Res. 1987;1(3):165–172.
  • Weinshenker D, Szot P, Miller NS, et al. Alpha(1) and beta(2)-adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine. J Pharmacol Exp Ther. 2001;298(3):1042–1048.
  • Jurgens CWD, Hammad HM, Lichter JA, et al. α2A adrenergic receptor activation inhibits epiletiform activity in the rat hippocampal CA3 region. Mol Pharmacol. 2007;71(6):1572–1581.
  • Gill CH, Soffin EM, Hagan JJ, et al. 5-HT7 receptors modulate synchronized network activity in rat hippocampus. Neuropharmacology. 2002;42(1):82–92.
  • Tesson F, Limon-Boulez I, Urban P, et al. Localization of I2-imidazoline binding sites on monoamine oxidases. J Biol Chem. 1995;270(17):9856–9861.
  • Hauser WA. Seizure disorders: the changes with age. Epilepsia. 1992;33 Suppl 4(Suppl 4):S6–S14.
  • Savic I. Sex differences in human epilepsy. Exp Neurol. 2014;259:38–43.
  • Arunlakshana O, Schild HO. Some quantitative uses of drug antagonists. Br J Pharmacol Chemother. 1959;14(1):48–58.
  • Uhlén S, Dambrova M, Näsman J, et al. 3H]RS79948-197 binding to human, rat, guinea pig and pig α2A-, α2B- and α2C-adrenoceptor. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur J Pharmacol. 1998;343(1):93–101.
  • Beck SG, Choi KC, List TJ. Comparison of 5-hydroxytryptamine1A-mediated hyperpolarization in CA1 and CA3 hippocampal pyramidal cells. J Pharmacol Exp Ther. 1992;263(1):350–359.
  • Ruffolo RR, Jr, Rice PJ, Patil PN, et al. Differences in the applicability of the easson-stedman hypothesis to the alpha1- and alpha2-adrenergic effects of phenethylamines and imidazolines. Eur J Pharmacol. 1983;86(3-4):471–475.
  • Jasper JR, Lesnick JD, Chang LK, et al. Ligand efficacy and potency at recombinant α2-adrenergic receptors: agonist-mediated [35S]GTPγS binding. Biochem Pharmacol. 1998;55(7):1035–1043.
  • Chen X, Xu Y, Qu L, et al. Molecular mechanism for ligand recognition and subtype selectivity of α2C-Adrenergic receptor. Cell Rep. 2019;29(10):2936–2943.e4.
  • Yuan D, Liu Z, Kaindl J, et al. Activation of the α2B-adrenoceptor by the sedative sympatholytic dexmedetomidine. Nat Chem Biol. 2020;16(5):507–512.
  • Qu L, Zhou Q, Xu Y, et al. Structural basis of the diversity of adrenergic receptors. Cell Rep. 2019;29(10):2929–2935.e4.
  • Xu J, Cao S, Hübner H, et al. Structural insights into ligand recognition, activation, and signaling of the α2Aadrenergic receptor. Sci Adv. 2022;8(9)eabj:5347.
  • Strange PG. Agonist binding, agonist affinity and agonist efficacy at G protein-coupled receptors. Br J Pharmacol. 2008;153(7):1353–1363.
  • Soldin OP, Mattison DR. Sex differences in pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2009;48(3):143–157.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.