Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway

References

• Yau JW, Rogers SL, Kawasaki R, et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35(3):556–564. doi: 10.2337/dc11-1909
   PubMed Web of Science ®Google Scholar
• Inada M, Xu H, Takeuchi M, et al. Microglia increase tight-junction permeability in coordination with muller cells under hypoxic condition in an in vitro model of inner blood-retinal barrier. Exp Eye Res. 2021;205:108490. doi: 10.1016/j.exer.2021.108490
   PubMed Web of Science ®Google Scholar
• Wang L, Sun X, Zhu M, et al. Epigallocatechin-3-gallate stimulates autophagy and reduces apoptosis levels in retinal muller cells under high-glucose conditions. Exp Cell Res. 2019;380(2):149–158. doi: 10.1016/j.yexcr.2019.04.014
   PubMed Web of Science ®Google Scholar
• Tu Y, Li L, Zhu L, et al. Geniposide attenuates Hyperglycemia-Induced oxidative stress and inflammation by activating the Nrf2 signaling pathway in experimental diabetic retinopathy. Oxid Med Cell Longev. 2021;2021:9247947. doi: 10.1155/2021/9247947
   PubMed Web of Science ®Google Scholar
• Du H, Shao J, Gu P, et al. Improvement of glucose tolerance by rhein with restored early-phase insulin secretion in db/db mice. J Endocrinol Invest. 2012;35(6):607–612. doi: 10.1007/BF03345796
   PubMed Web of Science ®Google Scholar
• Zeng CC, Liu X, Chen GR, et al. The molecular mechanism of rhein in diabetic nephropathy. Evid Based Complement Alternat Med. 2014;2014:487097. doi: 10.1155/2014/487097
   PubMed Web of Science ®Google Scholar
• Wei J, Zhen YZ, Cui J, et al. Rhein lysinate decreases inflammation and adipose infiltration in KK/HlJ diabetic mice with non-alcoholic fatty liver disease. Arch Pharm Res. 2016;39(7):960–969. doi: 10.1007/s12272-016-0770-4
   PubMed Web of Science ®Google Scholar
• Wu MY, Yiang GT, Lai TT, et al. The oxidative stress and mitochondrial dysfunction during the pathogenesis of diabetic retinopathy. Oxid Med Cell Longev. 2018;2018:3420187.
   PubMed Web of Science ®Google Scholar
• Timon-Gomez A, Nyvltova E, Abriata LA, et al. Mitochondrial cytochrome c oxidase biogenesis: recent developments. Semin Cell Dev Biol. 2018;76:163–178. doi: 10.1016/j.semcdb.2017.08.055
   PubMed Web of Science ®Google Scholar
• Kang Q, Yang C. Oxidative stress and diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications. Redox Biol. 2020;37:101799. doi: 10.1016/j.redox.2020.101799
   PubMed Web of Science ®Google Scholar
• Forrester JV, Kuffova L, Delibegovic M. The role of inflammation in diabetic retinopathy. Front Immunol. 2020;11:583687. doi: 10.3389/fimmu.2020.583687
   PubMed Web of Science ®Google Scholar
• Coughlin BA, Feenstra DJ, Mohr S. Muller cells and diabetic retinopathy. Vision Res. 2017;139:93–100. doi: 10.1016/j.visres.2017.03.013
   PubMed Web of Science ®Google Scholar
• Wu S, Zhu X, Guo B, et al. Unfolded protein response pathways correlatively modulate endoplasmic reticulum stress responses in rat retinal muller cells. J Ophthalmol. 2019;2019:9028483. doi: 10.1155/2019/9028483
   PubMed Web of Science ®Google Scholar
• Qiu AW, Huang DR, Li B, et al. IL-17A injury to retinal ganglion cells is mediated by retinal muller cells in diabetic retinopathy. Cell Death Dis. 2021;12(11):1057. doi: 10.1038/s41419-021-04350-y
   PubMed Web of Science ®Google Scholar
• Hu F, Zhu D, Pei W, et al. Rhein inhibits ATP-triggered inflammatory responses in rheumatoid rat fibroblast-like synoviocytes. Int Immunopharmacol. 2019;75:105780. doi: 10.1016/j.intimp.2019.105780
   PubMed Web of Science ®Google Scholar
• Liu M, Wang L, Wu X, et al. Rhein protects 5/6 nephrectomized rat against renal injury by reducing inflammation via NF-kappaB signaling. Int Urol Nephrol. 2021;53(7):1473–1482. doi: 10.1007/s11255-020-02739-w
   PubMed Web of Science ®Google Scholar
• Ji L, Gu H. The anti-obesity effects of rhein on improving insulin resistance (IR) and blood lipid levels are involved in endoplasmic reticulum stress (ERs), inflammation, and oxidative stress in vivo and vitro. Bioengineered. 2021;12(1):5797–5813. doi: 10.1080/21655979.2021.1969196
   PubMed Web of Science ®Google Scholar
• Zhou Y, Gao C, Vong CT, et al. Rhein regulates redox-mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage-activated crosstalk. Br J Pharmacol. 2022 May;179(9):1978–1997. doi: 10.1111/bph.15773
   PubMed Web of Science ®Google Scholar
• Dong L, Du H, Zhang M, et al. Anti-inflammatory effect of rhein on ulcerative colitis via inhibiting PI3K/akt/mTOR signaling pathway and regulating gut microbiota. Phytother Res. 2022;36(5):2081–2094.
   PubMed Web of Science ®Google Scholar
• Xu Y, Zou H, Ding Q, et al. tiRNA-Val promotes angiogenesis via Sirt1-Hif-1alpha axis in mice with diabetic retinopathy. Biol Res. 2022;55(1):14. doi: 10.1186/s40659-022-00381-7
   PubMed Web of Science ®Google Scholar
• Ma C, Zhang D, Ma Q, et al. Arbutin inhibits inflammation and apoptosis by enhancing autophagy via SIRT1. Adv Clin Exp Med. 2021;30(5):535–544. doi: 10.17219/acem/133493
   PubMed Web of Science ®Google Scholar
• He M, Long P, Chen T, et al. ALDH2/SIRT1 contributes to type 1 and type 2 Diabetes-Induced retinopathy through depressing oxidative stress. Oxid Med Cell Longev. 2021;2021:1641717. doi: 10.1155/2021/1641717
   PubMedGoogle Scholar
• Karbasforooshan H, Karimi G. The role of SIRT1 in diabetic retinopathy. Biomed Pharmacother. 2018;97:190–194. doi: 10.1016/j.biopha.2017.10.075
   PubMed Web of Science ®Google Scholar
• Ji Q, Han J, Wang L, et al. MicroRNA-34a promotes apoptosis of retinal vascular endothelial cells by targeting SIRT1 in rats with diabetic retinopathy. Cell Cycle. 2020;19(21):2886–2896. doi: 10.1080/15384101.2020.1827509
   PubMed Web of Science ®Google Scholar
• Yin Z, Gao D, Du K, et al. Rhein ameliorates cognitive impairment in an APP/PS1 transgenic mouse model of alzheimer’s disease by relieving oxidative stress through activating the SIRT1/PGC-1alpha pathway. Oxid Med Cell Longev. 2022;2022:2524832. doi: 10.1155/2022/2524832
   PubMed Web of Science ®Google Scholar
• Song X, Du Z, Yao Z, et al. Rhein improves renal fibrosis by restoring Cpt1a-Mediated fatty acid oxidation through SirT1/STAT3/twist1 pathway. Molecules. 2022;27(7):2344. doi: 10.3390/molecules27072344
   PubMed Web of Science ®Google Scholar
• Kowluru RA. Diabetic retinopathy and NADPH oxidase-2: a sweet slippery road. Antioxidants. 2021;10(5):783. doi: 10.3390/antiox10050783
   Web of Science ®Google Scholar
• Gureev AP, Shaforostova EA, Popov VN. Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1alpha signaling pathways. Front Genet. 2019;10:435. doi: 10.3389/fgene.2019.00435
   PubMed Web of Science ®Google Scholar
• Yin Z, Geng X, Zhang Z, et al. Rhein relieves oxidative stress in an Abeta1-42 Oligomer-Burdened neuron model by activating the SIRT1/PGC-1alpha-Regulated mitochondrial biogenesis. Front Pharmacol. 2021;12:746711. doi: 10.3389/fphar.2021.746711
   PubMed Web of Science ®Google Scholar
• Tian L, Cao W, Yue R, et al. Pretreatment with tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha signaling pathway. J Pharmacol Sci. 2019;139(4):352–360. doi: 10.1016/j.jphs.2019.02.008
   PubMed Web of Science ®Google Scholar
• Guo Z, Fan D, Liu FY, et al. NEU1 regulates mitochondrial energy metabolism and oxidative stress post-myocardial infarction in mice via the SIRT1/PGC-1 alpha axis. Front Cardiovasc Med. 2022;9:821317. doi: 10.3389/fcvm.2022.821317
   PubMedGoogle Scholar