A Conceptual Framework for Evaluating the Interaction of a Chemical and Nonchemical Stressor in Human Health Risk Assessments: A Case Study for Lead and Psychosocial Stress

REFERENCES

• Adler NE, Boyce T, Chesney MA, et al. 1994. Socioeconomic status and health: The challenge of the gradient. Am Psychol 49:15–24
   PubMed Web of Science ®Google Scholar
• Altmann L, Weinsberg F, Sveinsson K, et al. 1993. Impairment of long-term potentiation and learning following chronic lead exposure. Toxicol Lett 66:105–12
   PubMed Web of Science ®Google Scholar
• Anderson DW, Pothakos K, and Schneider JS. 2012. Sex and rearing condition modify the effects of perinatal lead exposure on learning and memory. Neurotoxicology 33:985–96
   PubMed Web of Science ®Google Scholar
• Ankarcrona M, Dypbukt JM, Bonfoco E, et al. 1995. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961–73
   PubMed Web of Science ®Google Scholar
• Baghurst PA, McMichael AJ, Wigg NR, et al. 1992. Environmental exposure to lead and children's intelligence at the age of seven years. The Port Pirie Cohort Study. N Engl J Med 327:1279–84
   PubMed Web of Science ®Google Scholar
• Bellinger D, Leviton A, Waternaux C, et al. 1987. Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. N Engl J Med 316:1037–43
   PubMed Web of Science ®Google Scholar
• Bellinger DC, Leviton A, Waternaux C, et al. 1989. Low-level lead exposure, social class, and infant development. Neurotoxic Teratol 10:497–503
   Web of Science ®Google Scholar
• Bellinger DC, Leviton A, and Sloman A. 1990. Antecedents and correlates of improved cognitive performance in children exposed in utero to low levels of lead. Environ. Health Perspect 89:5–11
   Google Scholar
• Bellinger D, Sloman J, Leviton A, et al. 1991. Low-level lead exposure and children's cognitive function in the preschool years. Pediatrics 87:219–27
   PubMed Web of Science ®Google Scholar
• Bellinger DC, Stiles KM, and Needleman HL. 1992. Low-level lead exposure, intelligence and academic achievement: A long-term follow-up study. Pediatrics 90:855–61
   PubMed Web of Science ®Google Scholar
• Bellinger DC. 2008. Very low lead exposures and children's neurodevelopment. Curr Opin Pediatr 20:172–7
   PubMed Web of Science ®Google Scholar
• Brenner AB, Zimmerman MA, Bauermeister JA, et al. 2013. Neighborhood context and perceptions of stress over time: an ecological model of neighborhood stressors and intrapersonal and interpersonal resources. Am J Community Psychol. 51:544–56
   PubMed Web of Science ®Google Scholar
• Braun JM, Wright RJ, Just AC, et al. 2014. Relationships between lead biomarkers and diurnal salivary cortisol indices in pregnant women from Mexico City: A cross-sectional study. Environ Health. 13:50
   PubMed Web of Science ®Google Scholar
• Budtz-Jorgensen E, Bellinger D, Lamphear B, et al. 2013. An international pooled analysis for obtaining a benchmark dose for environmental lead exposure in children. Risk Anal 33:450–61
   PubMed Web of Science ®Google Scholar
• Bullard R. 1990. Dumping in Dixie: Race, Class, and Environmental Quality. Westview Press, Boulder, CO, USA
   Google Scholar
• Buss C, Davis EP, Muftuler LT, et al. 2010. High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6–9-year-old children. Psychoneuroendocrinology 35:141–53
   PubMed Web of Science ®Google Scholar
• Canfield RL, Kreher DA, Cornwell C, et al. 2003. Low-level lead exposure, executive functioning, and learning in early childhood. Child Neuropsychol 9:35–53
   PubMed Web of Science ®Google Scholar
• Cao X, Huang S, and Ruan D. 2008. Enriched environment restores impaired hippocampal long-term potentiation and water maze performance induced by developmental lead exposure in rats. Dev Psychobiol 50:307–13
   PubMed Web of Science ®Google Scholar
• Carbone DL, and Handa RJ. 2013. Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor. Neurosci 239:295–303
   PubMed Web of Science ®Google Scholar
• CDC (Centers for Disease Control). 2012. What you need to know to protect your children. Available at http://www.cdc.gov/nceh/lead/ACCLPP/blood_lead_levels.htm (accessed July 2014)
   Google Scholar
• Chen E, and Paterson LQ. 2006. Neighborhood, family, and subjective socioeconomic status: How do they relate to adolescent health? Health Psychol 25:704–14
   PubMed Web of Science ®Google Scholar
• Chen E, Schreier HMC, Strunk RC, et al. 2008. Chronic traffic-related air pollution and stress interact to predict biologic and clinical outcomes in asthma. Environ Health Perspect 116:970–5
   PubMed Web of Science ®Google Scholar
• Chisolm JJ Jr. 1984. The continuing hazard of lead exposure and its effects in children. Neurotoxicology 5:23–42
   PubMed Web of Science ®Google Scholar
• Clougherty JE, Levy JL, Kubzansky LD, et al. 2007. Synergistic effects of traffic-related air pollution and exposure to violence on urban asthma etiology. Environ Health Perspect 115:1140–6
   PubMed Web of Science ®Google Scholar
• Clougherty JE, Rossi, CA, Lawrence J., et al. 2010. Chronic social stress and susceptibility to concentrated ambient fine particles in rats. Environ Health Perspect 118:769–75
   PubMed Web of Science ®Google Scholar
• Cohen S, Doyle WJ, and Baum A. 2006. Socioeconomic status is associated with stress hormones. Psychosom Med. 68:414–20
   PubMed Web of Science ®Google Scholar
• Cooney GH, Bell A, McBride W, et al. 1989. Low-level exposures to lead: The Sydney lead study. Dev Med Child Neurol 31:640–9
   PubMed Web of Science ®Google Scholar
• Cory-Slechta DA, Virgolini MB, Thiruchelvam M, et al. 2004. Maternal stress modulates the effects of developmental lead exposure. Environ Health Perspect 112:717–30
   PubMed Web of Science ®Google Scholar
• Cory-Slechta DA, Stern S, Weston D, et al. 2010. Enhanced learning deficits in female rats following lifetime Pb exposure combined with prenatal stress. Toxicol Sci 117:427–38
   PubMed Web of Science ®Google Scholar
• Cory-Slechta DA, Virgolini MB, Liu S, et al. 2012. Enhanced stimulus sequence-dependent repeated learning in male offspring after prenatal stress alone or in conjunction with lead exposure. Neurotoxicology 33:1188–1202
   PubMed Web of Science ®Google Scholar
• Cory-Slechta DA, Merchant-Borna K, Allen JL, et al. 2013. Variations in the nature of behavioral experience can differentially alter the consequences of developmental exposures to lead, prenatal stress, and the combination. Toxicol Sci 131:194–205
   PubMed Web of Science ®Google Scholar
• Debono M, Ghobadi C, Rostami-Hodjegan A, et al. 2009. Modified-release hydrocortisone to provide circadian cortisol profiles. J Clin Endocrinol Metab 94:1548–54
   PubMed Web of Science ®Google Scholar
• Dietrich KN, Berger OG, Succop PA, et al. 1993. The developmental consequences of low to moderate prenatal and postnatal lead exposure: intellectual attainment in the Cincinnati Lead Study Cohort following school entry. Neurotoxicol Teratol 15:37–44
   PubMed Web of Science ®Google Scholar
• Dipietro JA, Novak MF, Costigan KA, et al. 2006. Maternal psychological distress during pregnancy in relation to child development at age two. Child Dev 77:573–87
   PubMed Web of Science ®Google Scholar
• Du J, McEwen B, and Manji HK. 2009. Glucocorticoid receptors modulate mitochondrial function: A novel mechanism for neuroprotection. Commun Integr Biol 2:350–2
   PubMedGoogle Scholar
• Ernhart CB, Morrow-Tlucak M, and Wolf AW. 1988. Low level lead exposure and intelligence in the preschool years. Sci Total Environ 71:453–59
   PubMed Web of Science ®Google Scholar
• Evans GW, and English K. 2002. The environment of poverty: Multiple stressor exposure, psychophysiological stress, and socioemotional adjustment. Child Dev 73:1238–48
   PubMed Web of Science ®Google Scholar
• Evans GW, and Kim P. 2007. Childhood poverty and health: Cumulative risk exposure and stress dysregulation. Psychol Sci 18:953–7
   PubMed Web of Science ®Google Scholar
• Factor-Litvak P, Wasserman G, Kline JK, et al. 1999. The Yugoslavia Prospective Study of environmental lead exposure. Environ Health Perspect 107:9–15
   PubMed Web of Science ®Google Scholar
• Fortin MC, Cory-Slechta DA, Ohman-Strickland P, et al. 2012. Increased lead biomarker levels are associated with changes in hormonal response to stress in occupationally exposed male participants. Environ Health Perspect 120:278–83
   PubMed Web of Science ®Google Scholar
• Fox C, Merali Z, and Harrison C. 2006. Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress. Behav Brain Res 175:1–8
   PubMed Web of Science ®Google Scholar
• Fujioka A, Fujioka T, Ishida Y, et al. 2006. Differential effects of prenatal stress on the morphological maturation of hippocampal neurons. Neurosci 141:907–15
   PubMed Web of Science ®Google Scholar
• Gilbert SG, and Rice DC. 1987. Low-level lifetime lead exposure produces behavioral toxicity (spatial discrimination reversal) in adult monkeys. Toxicol Appl Pharmacol 91:484–90
   PubMed Web of Science ®Google Scholar
• Glover V, O’Connor TG, and O’Donnell K. 2010. Prenatal stress and the programming of the HPA axis. Neurosci Biobehav R 35:17–22
   PubMed Web of Science ®Google Scholar
• Goodman E, McEwen BS, Huang B, et al. 2005. Social inequalities in biomarkers of cardiovascular risk in adolescence. Psychosom Med 67:9–15
   PubMed Web of Science ®Google Scholar
• Gould E, and Tanapat P. 1999. Stress and hippocampal neurogenesis. Biol Psychiatry 46:1472–9
   PubMed Web of Science ®Google Scholar
• Graham, DL, Grace CE, Braun AA, et al. 2011. Effects of developmental stress and lead (Pb) on corticosterone after chronic and acute stress, brain monoamines, and blood Pb levels in rats. Intl J Dev Neurosci 29:45–55
   PubMed Web of Science ®Google Scholar
• Greene, T, Ernhart, CB, and Boyd TA. 1992. Contributions of risk factors to elevated blood and dentine lead levels in preschool children. Sci Total Environ 115:239–260
   PubMed Web of Science ®Google Scholar
• Guilarte TR, Toscano, CD, McGlothan JL, et al. 2003. Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure. Ann Neurol 53:50–6
   PubMed Web of Science ®Google Scholar
• Gump BB, Stewart P, Reihman J, et al. 2008a. Low-level prenatal and postnatal blood lead exposure and adrenocortical responses to acute stress in children. Environ Health Perspect 116:249–255
   PubMed Web of Science ®Google Scholar
• Gump BB, Reihman J, Stewart P, et al. 2008b. Blood lead levels: Further evidence for an environmental mechanism explaining the association between socioeconomic status and psychophysiological dysregulation in children. Health Psychol 28:614–20
   Web of Science ®Google Scholar
• Haider S, Saleem S, Tabassum S, et al. 2013. Alteration in plasma corticosterone levels following long term oral administration of lead produces depression like symptoms in rats. Metab Brain Dis 28:85–92
   PubMed Web of Science ®Google Scholar
• Herman, JP, and Seroogy, K. 2006. Hypothalamic-Pituitary-Adrenal axis, glucocorticoids, and neurologic disease. Neurol Clin 24:461–81
   PubMed Web of Science ®Google Scholar
• Hicken MT, Gee GC, Connell C, et al. 2013. Black-White blood pressure disparities: Depressive symptoms and differential vulnerability to blood lead. Environ Health Perspect 121:205–9
   PubMed Web of Science ®Google Scholar
• Huizink, AC, Robles De Medina, PG, Mulder, EJ, et al. 2003. Stress during pregnancy is associated with developmental outcome in infancy. J. Child Psychol Psychiatry 44:810–8
   PubMed Web of Science ®Google Scholar
• Islam T, Uman R, Gauderman JW, et al. 2011. Parental stress increases the detrimental effect of traffic exposure on children's lung function. Am J Respir Crit Care Med 184:822–7
   PubMed Web of Science ®Google Scholar
• Juster RP, McEwen BS, and Lupien S. 2009. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobeh Rev 35:2–16
   PubMed Web of Science ®Google Scholar
• Kapuku GL, Treiber FA, and Davis HC. 2002. Relationships among socioeconomic status, stress induced changes in cortisol, and blood pressure in African American males. Ann Behav Med 24:320–5
   PubMed Web of Science ®Google Scholar
• Lanphear BP, Hornung R, Khoury J, et al. 2005. Low-level environmental lead exposure and children's intellectual function: an international pooled analysis. Environ Health Perspect 113:894–9
   PubMed Web of Science ®Google Scholar
• Laplante DP, Barr RG, Brunet A, et al. 2004. Stress during pregnancy affects general intellectual and language functioning in human toddlers. Pediatr Res 56:400–10
   PubMed Web of Science ®Google Scholar
• Laplante DP, Brunet A, Schmitz N, et al. 2008. Project Ice Storm: Prenatal maternal stress affects cognitive and linguistic functioning in 5 1/2-year-old children. J Am Acad Child Adolesc Psychiatry 47:1063–72
   PubMed Web of Science ®Google Scholar
• Lemaire V, Koehl M, Le Moal M, et al. 2000. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. PNAS 97:11032–7
   PubMed Web of Science ®Google Scholar
• Lemaire V, Lamarque S, Le Moal M, et al. 2006. Postnatal stimulation of the pups counteracts prenatal stress-induced deficits in hippocampal neurogenesis. Biol Psychiatry 59:786–92
   PubMed Web of Science ®Google Scholar
• Linder SH, and Sexton K. 2011. Conceptual models for cumulative risk assessment. Am J Public Health 101 Suppl 1:S74–S81
   PubMed Web of Science ®Google Scholar
• Lipfert FW. 2004. Air pollution and poverty: Does the sword cut both ways? Air Pollution. J Epidemiol Commun H 58:2–3
   PubMed Web of Science ®Google Scholar
• Lupien SJ, and McEwen BS. 1997. The acute effects of corticosteroids on integration of animal and human model studies. Brain Res Rev 24:1–27
   PubMed Web of Science ®Google Scholar
• Lupien SJ, King S, Meaney MJ, et al. 2000. Child's stress hormone levels correlate with mother's socioeconomic status and depressive state. Biol Psychiatry 48:976–80
   PubMed Web of Science ®Google Scholar
• Lupien SJ, King S, Meaney MJ, et al. 2001. Can poverty get under your skin? Basal cortisol levels and cognitive functions in children from low and high economic status. Dev Psychopathol 13:653–73
   PubMed Web of Science ®Google Scholar
• Mahaffey KR, Annest JL, Roberts J, et al. 1982. National estimates of blood lead levels: United States, 1976–1980: Association with selected demographic and socioeconomic factors. N Engl J Med 307:573–9
   PubMed Web of Science ®Google Scholar
• Martins, MCH, Fatigati, FL, Vespoli, TC, et al. 2004. Influence of socioeconomic conditions on air pollution adverse health effects in elderly people: an analysis of six regions in Sao Paulo, Brazil. J Epidemiol Commun H 58:41–6
   PubMed Web of Science ®Google Scholar
• McEwen BS. 2000. The neurobiology of stress: From serendipity to clinical relevance. Brain Res 886:172–89
   PubMed Web of Science ®Google Scholar
• McMichael AJ, Baghurst PA, Wigg NR, et al. 1988. Port Pirie Cohort Study: Environmental exposure to lead and children's abilities at the age of four years. N Engl J Med 319(8):468–75
   PubMed Web of Science ®Google Scholar
• McMichael AJ, Baghurst, PA, Vimpani GV, et al. 1992. Sociodemographic factors modifying the effect of environmental lead on neuropsychological development in early childhood. Neurotoxicol Teratol 14:321–327
   PubMed Web of Science ®Google Scholar
• Moisiadis VG, and Matthews SG. 2014. Glucocorticoids and fetal programming part 1: Outcomes. Nat Rev Endocrinol 10.
   Web of Science ®Google Scholar
• Morello-Frosch R, and Shenassa ED. 2006. The environmental riskscape and social inequality: Implications for explaining maternal and child health disparities. Environ Health Perspect 114:1150–3
   PubMed Web of Science ®Google Scholar
• National Research Council. 2009. Science and Decisions: Advancing Risk Assessment, 213–239. National Academy Press, Washington, DC, USA
   Google Scholar
• Nieto-Fernandez FE, Ruiz A, Ntukogu N, et al. 2006. Short term lead exposure induces a stress-like response in adult mice. Med Sci Monit 12:BR325–9
   PubMed Web of Science ®Google Scholar
• Niu R, Sun Z, Cheng Z, et al. 2009. Decreased learning ability and low hippocampus glutamate in offspring rats exposed to fluoride and lead. Environ Toxicol Pharmacol 28:254–8
   PubMed Web of Science ®Google Scholar
• Noorlander CW, Tijsseling D, Hessel EV, et al. 2014. Antenatal glucocorticoid treatment affects hippocampal development in mice. PLoS ONE 9:e85671
   PubMed Web of Science ®Google Scholar
• Ou C-Q, Hedley AJ, Chung RY. 2008. Socioeconomic disparities in air pollution-associated mortality. Environ Res 107:237–244
   PubMed Web of Science ®Google Scholar
• Peters JL, Lubzansky L, and McNeeley E. 2007. Stress as a potential modifier on the impact of lead levels on blood pressure: The normative aging study. Environ Health Perspect 115:1154–59
   PubMed Web of Science ®Google Scholar
• Pirkle JL, Kaufmann RB, Brody DJ, et al. 1998. Exposure of the US population to lead, 1991–1994. Environ Health Perspect 106:745–50
   PubMed Web of Science ®Google Scholar
• Rice DC, and Karpinski KF. 1988. Lifetime low-level lead exposure produces deficits in delayed alternation in adult monkeys. Neurotoxicol Teratol 10:207–14
   PubMed Web of Science ®Google Scholar
• Ris MD, Dietrich KN, Succop PA, et al. 2004. Early exposure to lead and neuropsychological outcome in adolescence. J Int Neuropsychol Soc 10:261–70
   PubMed Web of Science ®Google Scholar
• Rodriguez A, and Bohlin G. 2005. Are maternal smoking and stress during pregnancy related to ADHD symptoms in children? J Child Psychol Psychiatry 46:246–54
   PubMed Web of Science ®Google Scholar
• Rossi-George A, Virgolini MB, Weston D, et al. 2009. Alterations in glucocorticoid negative feedback following maternal Pb, prenatal stress and the combination. A potential biological unifying mechanism for their corresponding disease profiles. Toxicol Appl Pharm 234:117–127
   PubMed Web of Science ®Google Scholar
• Rossi-George A, Virgolini MB, Weston D, et al. 2011. Interactions of lifetime lead exposure and stress: Behavioral, neurochemical and HPA axis effects. Neurotoxicology 32:83–99
   PubMed Web of Science ®Google Scholar
• Schnaas L, Rothenberg SJ, Perroni E, et al. 2000. Temporal pattern in the effect of postnatal blood lead level on intellectual development of young children. Neurotoxicol Teratol 22:805–810
   PubMed Web of Science ®Google Scholar
• Schnaas L, Rothenberg SJ, Flores MF, et al. 2004. Blood lead secular trend in a cohort of children in Mexico City (1987–2002). Environ Health Perspect 112:1110–15
   PubMed Web of Science ®Google Scholar
• Schnaas L, Rothenberg SJ, Flores MF, et al. 2006. Reduced intellectual development in children with prenatal lead exposure. Environ Health Perspect 114:791–7
   PubMed Web of Science ®Google Scholar
• Schneider JS, Lee MH, Anderson DW, et al. 2001. Enriched environment during development is protective against lead-induced neurotoxicity. Brain Res 896:48–55
   PubMed Web of Science ®Google Scholar
• Seeman TE, McEwen BS, Singer BH, et al. 1997. Increase in urinary cortisol excretion and memory declines: MacArthur studies of successful aging. J Clin Endocrinol Metab 82:2458–65
   PubMed Web of Science ®Google Scholar
• Skwara AJ, Karwoski TE, Czambel RK, et al. 2012. Influence of environmental enrichment on hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine by osmotic mini-pumps, and nicotine withdrawal by mecamylamine in male and female rats. Behav Brain Res 234:1–10
   PubMed Web of Science ®Google Scholar
• Smith MA, Makino S, Kvetnanský R, et al. 1995. Effects of stress on neurotrophic factor expression in the rat brain. Ann NY Acad Sci 771:234–9
   PubMed Web of Science ®Google Scholar
• Stangle DE, Smith DR, Beaudin SA, et al. 2007. Succimer chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure. Environ Health Perspect 115:201–9
   PubMed Web of Science ®Google Scholar
• Sterling P, and Eyer J. 1988. Allostasis: A new paradigm to explain arousal pathology. In: Fisher S and Reason J (eds), Handbook of Life Stress, Cognition and Health, pp 629–49. John Wiley & Sons, New York, NY, USA
   Google Scholar
• Tong S, Baghurst P, McMichael A, et al. 1996. Lifetime exposure to environmental lead and children's intelligence at 11–13 years: The Port Pirie cohort study. BMJ 312(7046):1569–75
   PubMed Web of Science ®Google Scholar
• Tong S, McMichael AJ, and Baghurst PA. 2000. Interactions between environmental lead exposure and sociodemographic factors on cognitive development. Arch Environ Health 55:330–5
   PubMed Web of Science ®Google Scholar
• Uno H, Eisele S, Sakal A, et al. 1994. Neurotoxicology of glucocorticoids in the primate brain. Horm Behav 28:336–48
   PubMed Web of Science ®Google Scholar
• USEPA (US Environmental Protection Agency). 2003. Framework for Cumulative Risk Assessment. EPA/630/P-02/001F. Risk Assessment Forum, Washington, DC, USA
   Google Scholar
• USEPA. 2013. Integrated Science Assessment for Lead (Final Report). EPA/600/R-10/075F. Office of Research and Development, Washington, DC, USA
   Google Scholar
• Van den Bergh BR, and Marcoen A. 2004. High antenatal maternal anxiety is related to ADHD symptoms, externalizing problems, and anxiety in 8- and 9-year-olds. Child Dev 75:1085–97
   PubMed Web of Science ®Google Scholar
• Van den Bergh BR, Mennes M, Stevens V, et al. 2006. ADHD deficit as measured in adolescent boys with a continuous performance task is related to antenatal maternal anxiety. Pediatr Res 59:78–82
   PubMed Web of Science ®Google Scholar
• Virgolini MB, Chen K, Weston DD, et al. 2005. Interactions of chronic lead exposures and intermittent stress: Consequences for brain catecholamine systems and associated behaviors and HPA axis function. Toxicol Sci 87:469–82
   PubMed Web of Science ®Google Scholar
• Virgolini MB, Bauter MR, Weston DD, et al. 2006. Permanent alterations in stress responsivity in female offspring subjected to combined maternal lead exposure and/or stress. Neurotoxicology 27:11–21
   PubMed Web of Science ®Google Scholar
• Virgolini MB, Rossi-George A, Weston DD, et al. 2008a. Influence of low level Pb exposure and prenatal stress on offspring stress challenge responsivity. Neurotoxicology 29:928–39
   PubMed Web of Science ®Google Scholar
• Virgolini MB, Rossi-George A, Lisek R, et al. 2008b. CNS effects of developmental Pb exposure are enhanced by combined maternal and offspring stress. Neurotoxicology 29:812–27
   PubMed Web of Science ®Google Scholar
• Vyskocil A, Fiala Z, Ettlerová E, and Tenjnorová I. 1990. Influence of chronic lead exposure on hormone levels in developing rats. J Appl Toxicol 10:301–2
   PubMed Web of Science ®Google Scholar
• Wasserman G, Graziano JH, Factor-Litvak R, et al. 1992. Independent effects of lead exposure and iron deficiency anemia on developmental outcome at age 2 years. J Pediatr 121:695–703
   PubMed Web of Science ®Google Scholar
• Wasserman GA, Graziano JH, Factor-Litvak P, et al. 1994. Consequences of lead exposure and iron supplementation on childhood development at age 4 years. Neurotoxicol Teratol 16:233–40
   PubMed Web of Science ®Google Scholar
• Weinstock M. 2005. The potential influence of maternal stress hormones on development and mental health of the offspring. Brain Behav Immun 19:296–308
   PubMed Web of Science ®Google Scholar
• Weinstock M. 2008. The long-term behavioural consequences of prenatal stress. Neurosci Biobehav Rev 32:1073–86
   PubMed Web of Science ®Google Scholar
• White LD, Cory-Slechta DA, Gilbert ME, et al. 2007. New and evolving concepts in the neurotoxicology of lead. Toxicol Appl Pharmacol 225:1–27
   PubMed Web of Science ®Google Scholar
• Winneke G, and Kraemer U. 1984. Neuropsychological effects of lead in children: Interactions with social background variables. Neuropsychobiology 11:195–202
   PubMed Web of Science ®Google Scholar
• Wong C-M, Ou C-Q, and Chan K-P. 2008. The effects of air pollution on mortality in socially deprived urban areas in Hong Kong, China. Environ Health Perspect 116:1189–94
   PubMed Web of Science ®Google Scholar
• Woolley SE, Gould E, and McEwen BS. 1990. Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons. Brain Res 531:225–31
   PubMed Web of Science ®Google Scholar
• Zalewski M, Lengua LJ, Kiff CJ, and Fisher PA. 2012. Understanding the relation of low income to HPA-axis functioning in preschool children: Cumulative family risk and parenting as pathways to disruptions in cortisol. Child Psychiatry Hum Dev 43:924–42
   PubMed Web of Science ®Google Scholar
• Zuloaga DG, Carbone DL, Quihuis A, et al. 2012. Perinatal dexamethasone-induced alterations in apoptosis within the hippocampus and paraventricular nucleus of the hypothalamus are influenced by age and sex. J Neurosci Res 90:1403–12
   PubMed Web of Science ®Google Scholar