167
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Role of key enzymes in the production of docosahexaenoic acid (DHA) by Thraustochytrium sp. T01

, , &

References

  • Leray, C. Lipids Nutrition and Health; Boca Raton: CRC Press, 2015, pp. 183–227. DOI: 10.1201/b17656.
  • Nodari, S.; Metra, M.; Milesi, G.; Manerba, A.; Cesana, B. M.; Gheorghiade, M.; Dei Cas, L. The Role of n-3 PUFAs in Preventing the Arrhythmic Risk in Patients with Idiopathic Dilated Cardiomyopathy. Cardiovasc. Drugs Ther. 2009, 23, 5–15. DOI: 10.1007/s10557-008-6142-7.
  • Calder, P. C. Omega-3 Fatty Acids and Inflammatory Processes. Nutrients 2010, 2, 355–374. DOI: 10.3390/nu2030355.
  • Hathaway, D.; Pandav, K.; Patel, M.; Riva-Moscoso, A.; Singh, B. M.; Patel, A.; Min, Z. C.; Singh-Makkar, S.; Sana, M. K.; Sanchez-Dopazo, R.; et al. Omega 3 Fatty Acids and COVID-19: A Comprehensive Review. Infect. Chemother. 2020, 52, 478–495. DOI: 10.3947/ic.2020.52.4.478.
  • Storelli, M. M. Potential Human Health Risks from Metals (Hg, Cd, and Pb) and Polychlorinated Biphenyls (PCBs) via Seafood Consumption: Estimation of Target Hazard Quotients (THQs) and Toxic Equivalents (TEQs). Food Chem. Toxicol. 2008, 46, 2782–2788. DOI: 10.1016/j.fct.2008.05.011.
  • Yano, Y.; Nakayama, A.; Saito, H.; Ishihara, K. Production of Docosahexaenoic Acid by Marine Bacteria Isolated from Deep Sea Fish. Lipids 1994, 29, 527–528. DOI: 10.1007/BF02578252.
  • Vadivelan, G.; Venkateswaran, G. Production and Enhancement of Omega-3 Fatty Acid from Mortierella Alpina CFR-GV15: Its Food and Therapeutic Application. Biomed Res. Int. 2014, 2014, 657414. DOI: 10.1155/2014/657414.
  • Petrie, J. R.; Shrestha, P.; Belide, S.; Kennedy, Y.; Lester, G.; Liu, Q.; Divi, U. K.; Mulder, R. J.; Mansour, M. P.; Nichols, P. D.; Singh, S. P. Metabolic Engineering Camelina Sativa with Fish Oil-Like Levels of DHA. PLOS One 2014, 9, e85061. DOI: 10.1371/journal.pone.0085061.
  • Raghukumar, S. Ecology of the Marine Protists, the Labyrinthulomycetes (Thraustochytrids and Labyrinthulids). Eur. J. Protistol. 2002, 38, 127–145. DOI: 10.1078/0932-4739-00832.
  • Raghukumar, S. Thraustochytrid Marine Protists: production of PUFAs and Other Emerging Technologies. Mar. Biotechnol. 2008, 10, 631–640. DOI: 10.1007/s10126-008-9135-4.
  • Yokochi, T.; Honda, D.; Higashihara, T.; Nakahara, T. Optimization of Docosahexaenoic Acid Production by Schizochytrium limacinum SR21. Appl. Microbiol. Biotechnol. 1998, 49, 72–76. DOI: 10.1007/s002530051139.
  • Jain, R.; Raghukumar, S.; Sambaiah, K.; Kumon, Y.; Nakahara, T. Docosahexaenoic Acid Accumulation in Thraustochytrids: Search for the Rationale. Mar. Biol. 2007, 151, 1657–1664. DOI: 10.1007/s00227-007-0608-1.
  • Jakobsen, A. N.; Aasen, I. M.; Josefsen, K. D.; Strom, A. R. Accumulation of Docosahexaenoic Acid-Rich Lipid in Thraustochytrid Aurantiochytrium sp. strain T66: Effects of N and P Starvation and O2 Limitation. Appl. Microbiol. Biotechnol. 2008, 80, 297–306. DOI: 10.1007/s00253-008-1537-8.
  • Li, J.; Liu, R.; Chang, G.; Li, X.; Chang, M.; Liu, Y.; Jin, Q.; Wang, X. A Strategy for the Highly Efficient Production of Docosahexaenoic Acid by Aurantiochytrium limacinum SR21 Using Glucose and Glycerol as the Mixed Carbon Sources. Bioresour. Technol. 2015, 177, 51–57. DOI: 10.1016/j.biortech.2014.11.046.
  • Behrouzian, B.; Buist, P. H. Mechanism of Fatty Acid Desaturation: A Bioorganic Perspective. Prostaglandins Leukot. Essent. Fatty Acids 2003, 68, 107–112. DOI: 10.1016/S0952-3278(02)00260-0.
  • Ren, L. J.; Huang, H.; Xiao, A. H.; Lian, M.; Jin, L. J.; Ji, X. J. Enhanced Docosahexaenoic Acid Production by Reinforcing acetyl-CoA and NADPH Supply in Schizochytrium sp. HX-308. Bioprocess Biosyst. Eng. 2009, 32, 837–843. DOI: 10.1007/s00449-009-0310-4.
  • Zhang, Y.; Min, Q.; Xu, J.; Zhang, K.; Chen, S.; Wang, H.; Li, D. Effect of Malate on Docosahexaenoic Acid Production from Schizochytrium Sp. B4D1. Electron. J. Biotechnol. 2016, 19, 56–60. DOI: 10.1016/j.ejbt.2015.11.006.
  • Patil, K. P.; Gogate, P. R. Improved Synthesis of Docosahexaenoic Acid (DHA) Using Schizochytrium limacinum SR21 and Sustainable Media. Chem. Eng. J. 2015, 268, 187–196. DOI: 10.1016/j.cej.2015.01.050.
  • James, G.; Metz, C.; W, A.; Kuner, J. Schizochytrium fatty acid synthase (FAS) and products and methods related thereto. US patent-US7700320B2, 2010.
  • Tamano, K.; Bruno, K. S.; Karagiosis, S. A.; Culley, D. E.; Deng, S.; Collett, J. R.; Umemura, M.; Koike, H.; Baker, S. E.; Machida, M. Increased Production of Fatty Acids and Triglycerides in Aspergillus oryzae by Enhancing Expressions of Fatty Acid Synthesis-Related Genes. Appl. Microbiol. Biotechnol. 2013, 97, 269–281. DOI: 10.1007/s00253-012-4193-y.
  • Zhang, Y.; Adams, I. P.; Ratledge, C. Malic Enzyme: The Controlling Activity for Lipid Production? Overexpression of Malic Enzyme in Mucor circinelloides Leads to a 2.5-Fold Increase in Lipid Accumulation. Microbiology 2007, 153, 2013–2025. DOI: 10.1099/mic.0.2006/002683-0.
  • Chandrasekaran, K.; Roy, R. K.; Chadha, A. Docosahexaenoic Acid Production by a Novel High Yielding Strain of Thraustochytrium sp. of Indian Origin: Isolation and Bioprocess Optimization Studies. Algal Res. 2018, 32, 93–100. DOI: 10.1016/j.algal.2018.03.011.
  • Chandrasekaran, K.; Muthu, D.; Chadha, A. Addition of Organic Acid and Inorganic Salts Affect Docosahexaenoic Acid (DHA) Production by a Locally Isolated Strain of Thraustochytrium sp. T01. Prep. Biochem. Biotechnol. 2018, 48, 599–604. DOI: 10.1080/10826068.2018.1476882.
  • Folch, J.; Lees, M.; Sloane Stanley, G. H. A Simple Method for the Isolation and Purification of Total Lipids from Animal Tissues. J. Biol. Chem. 1957, 226, 497–509. DOI: 10.1016/S0021-9258(18)64849-5.
  • Lian, M.; Huang, H.; Ren, L.; Ji, X.; Zhu, J.; Jin, L. Increase of Docosahexaenoic Acid Production by Schizochytrium sp. Through Mutagenesis and Enzyme Assay. Appl. Biochem. Biotechnol. 2010, 162, 935–941. DOI: 10.1007/s12010-009-8865-8.
  • Hsu, R. Y.; Lardy, H. A. Malic Enzyme. Methods Enzymol. 1969, 13, 230–235.
  • Betke, K. Standardized Method for G-6-PD Assay of Haemolysates. WHO Tech. Rep. Ser. 1967, 366, 30–32.
  • Srere, P. A. The Citrate Cleavage Enzyme. I. Distribution and Purification. J. Biol. Chem. 1959, 234, 2544–2547. DOI: 10.1016/S0021-9258(18)69735-2.
  • Kim, J.; Yoo, G.; Lee, H.; Lim, J.; Kim, K.; Kim, C. W.; Park, M. S.; Yang, J.-W. Methods of Downstream Processing for the Production of Biodiesel from Microalgae. Biotechnol. Adv. 2013, 31, 862–876. DOI: 10.1016/j.biotechadv.2013.04.006.
  • Bligh, E. G.; Dyer, W. J. A Rapid Method of Total Lipid Extraction and Purification. Can. J. Biochem. Physiol. 1959, 37, 911–917. DOI: 10.1139/o59-099.
  • Ye, H.; He, Y.; Xie, Y.; Sen, B.; Wang, G. Fed-Batch Fermentation of Mixed Carbon Source Significantly Enhances the Production of Docosahexaenoic Acid in Thraustochytriidae sp. PKU#Mn16 by Differentially Regulating Fatty Acids Biosynthetic Pathways. Bioresour. Technol. 2020, 297, 122402. DOI: 10.1016/j.biortech.2019.122402.
  • Cui, G.-Z.; Ma, Z.; Liu, Y.-J.; Feng, Y.; Sun, Z.; Cheng, Y.; Song, X.; Cui, Q. Overexpression of Glucose-6-Phosphate Dehydrogenase Enhanced the Polyunsaturated Fatty Acid Composition of Aurantiochytrium sp. SD116. Algal Res. 2016, 19, 138–145. DOI: 10.1016/j.algal.2016.08.005.
  • Nazir, Y.; Shuib, S.; Kalil, M. S.; Song, Y.; Hamid, A. A. Optimization of Culture Conditions for Enhanced Growth, Lipid and Docosahexaenoic Acid (DHA) Production of Aurantiochytrium SW1 by Response Surface Methodology. Sci. Rep. 2018, 8, 8909. 10.1038/s41598-018-27309-0.
  • Ratledge, C.; Wynn, J. P. The Biochemistry and Molecular Biology of Lipid Accumulation in Oleaginous Microorganisms. Adv. Appl. Microbiol. 2002, 51, 1–51.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.