New RP‐HPLC Method for the Estimation of 6‐Mercaptopurine in Rat Plasma and Various Tissue Homogenates

References

• Janine , E. and Friedman , J. M. 2002 . Teratogen update: azathioprine and 6‐mercaptopurine . Teratology , 65 : 240 – 261 .
   PubMedGoogle Scholar
• Federico , I. , Antonello , D. P. and Barbara , L. 1996 . Clinical and experimental pharmacokinetic interaction between 6‐mercaptopurine and methotrexate . Cancer Chemother. Pharmacol. , 37 : 409 – 414 .
   PubMed Web of Science ®Google Scholar
• Hayder , S. , Lafolie , P. , Bjork , O. and Peterson , C. 1989 . 6‐Mercaptopurine plasma levels in children with acute lymphoblastic leukemia: relation to relapse risk and myelotoxicity . Ther. Drug Monit. , 11 : 617
   PubMed Web of Science ®Google Scholar
• Lafolie , P. , Hayder , S. , Bjork , O. , Ahstrom , L. , Liliemark , J. and Peterson , C. 1986 . Large interindividual variations in the pharmacokinetics of oral 6‐mercaptopurine in maintenance therapy of children with acute leukemia and non‐Hodgkin's lymphoma . Acta Paediatr. Scand. , 75 : 797
   PubMed Web of Science ®Google Scholar
• Riccardi , R. , Balis , F. , Ferrara , P. , Lasorella , A. , Poplack , D. and Mastrangelo , R. 1986 . Influence of food intake on bioavailability of oral 6‐mercaptopurine in children with acute lymphoblastic leukemia . Pediatr. Hematol. Oncol. , 3 : 319
   PubMed Web of Science ®Google Scholar
• Sulh , H. , Koren , G. , Whalen , C. , Soldin , S. , Zipursky , A. and Greenberg , M. 1986 . Pharmacokinetic determinations of 6‐mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia . Clin. Pharmacol. Ther. , 40 : 604
   PubMed Web of Science ®Google Scholar
• Zimm , S. , Collins , J. M. , Riccardi , R. , O'Neill , D. , Narang , P. K. , Chabner , B. and Poplack , D. G. 1983 . Variable bioavailability of oral mercaptopurine: is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered? . N. Engl. J. Med. , 308 : 1005
   PubMed Web of Science ®Google Scholar
• Lockhart , S. , Plunkett , W. , Jeha , S. , Ramirez , I. , Zipf , T. , Cork , A. and Pinkel , D. 1994 . High‐dose mercaptopurine followed by intermediate‐dose cytarabine in relapsed acute leukemia . J. Clin. Oncol. , 12 : 587
   PubMed Web of Science ®Google Scholar
• Chalmers , A. H. 1975 . A spectrophotometric method for the estimation of urinary azathioprine, 6‐mercaptopurine, and 6‐thiouric acid . Biochem. Med. , 12 ( 3 ) : 234 – 241 .
   PubMedGoogle Scholar
• Erb , N. , Haverland , U. , Harms , D. O. , Escherich , G. and Janka‐Schaub , G. 2003 . High performance liquid chromatographic assay of metabolites of thioguanine and mercaptopurine in capillary blood . J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , 796 ( 1 ) : 87 – 94 .
   PubMed Web of Science ®Google Scholar
• Oliveira , B. M. , Romanha , A. J. , Alves , T. M. , Viana , M. B. and Zani , C. L. 2004 . An improved HPLC method for the quantitation of 6‐mercaptopurine and its metabolites in red blood cells . Braz. J. Med. Biol. Res. , 37 ( 5 ) : 649 – 658 .
   PubMed Web of Science ®Google Scholar
• Su , Y. , Hon , Y. Y. , Chu , Y. , Van de Poll , M. E. and Relling , M. V. 1999 . Assay of 6‐MP and its metabolites in patient plasma by high performance liquid chromatography with diode‐array detection . Chromatogr B Biomed. Sci. Appl. , 732 ( 2 ) : 459 – 468 .
   PubMed Web of Science ®Google Scholar
• Welch , J. , Lennard , L. , Morton , G. C. and Lilleyman , J. S. 1997 . Pharmacokinetics of mercaptopurine: plasma drug and red cell metabolite concentrations after an oral dose . Ther. Drug Monit. , 19 ( 4 ) : 382 – 385 .
   PubMed Web of Science ®Google Scholar
• Tang , J. , Zhou , S. , Huang , L. , Huang , Y. and Zhang , H. 1998 . Determination of azathiopurine and 6‐mercaptopurine in serum by reversed‐phase high performance liquid chromatography . Se Pu. , 16 ( 6 ) : 513 – 515 .
   PubMedGoogle Scholar
• Camparero , M. A. , Sacaba , B. and Garcia‐Quelglas , E. 1998 . J. Chromatogr. B , 706 : 311 – 317 .
   PubMedGoogle Scholar
• Innocenti , F. , Danesi , R. , Bocci , G. , Fogli , S. , Di Paolo , A. and Del‐Tacca , M. 1999 . Metabolism of 6‐mercaptopurine in the erythrocytes, liver, and kidney of rats during multiple‐dose regimens . Cancer Chemother. Pharmacol. , 43 ( 2 ) : 133 – 140 .
   PubMed Web of Science ®Google Scholar
• Merodia , M. , Mirshahi , T. and Mirshahi , M. 2000 . J. Chromatogr. , 870 : 159 – 167 .
   Web of Science ®Google Scholar
• Gibaldi , M. and Perrier , D. 1982 . Pharmacokinetics 409 – 416 . New York : Marcel Dekker, Inc .
   Google Scholar
• Zimm , S. , Collins , J. M. , O'Neill , D. , Chabner , B. A. and Poplack , D. G. 1983 . Inhibition of first‐pass metabolism in cancer chemotherapy: interaction of 6‐mercaptopurine and allopurinol . Clin. Pharmacol. Ther. , 34 : 810
   PubMed Web of Science ®Google Scholar
• Lennard , L. , Keen , D. and Lilleyman , J. S. 1986 . Oral 6‐mercaptopurine in childhood leukemia: parent drug pharmacokinetics and active metabolite concentrations . Clin. Pharmacol. Ther. , 40 : 287
   PubMed Web of Science ®Google Scholar
• Lennard , L. , Lilleyman , J. S. , Van Loon , J. and Weinshilboum , R. M. 1990 . Genetic variation in response to 6‐mercaptopurine for childhood acute lymphoblastic leukemia . Lancet. , 336 : 225
   PubMed Web of Science ®Google Scholar
• Lennard , L. and Lilleyman , J. S. 1989 . Variable 6‐mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia . J. Clin. Oncol. , 7 : 1816
   PubMed Web of Science ®Google Scholar