32
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

Simultaneous Determination of the N‐Dealkylated Metabolites of Four Butyrophenone‐Type Agents in Rat Plasma by HPLC with Fluorescence Detection after Precolumn Derivatization with 4‐Fluoro‐7‐Nitro‐2,1,3‐Benzoxadiazole

, &
Pages 2747-2754 | Received 21 Feb 2007, Accepted 22 May 2007, Published online: 17 Aug 2007

References

  • Fang , J. , McKay , G. , Song , J. , Remillrd , A. , Li , X. and Midha , K. 2001 . In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes . Drug Metab. Dispos. , 29 : 1638 – 1643 .
  • Kalgutkar , A. S. , Taylor , T. J. , Venkatakrishnan , K. and Isin , E. M. 2003 . Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway . Drug Metab. Dispos. , 31 : 243 – 249 .
  • Ablordeppey , S. Y. , Borne , R. F. and Davis , W. M. 1992 . Freezing action of a metabolite of haloperidol in frogs . Biochem. Pharmacol. , 43 : 2181 – 2187 .
  • Bowen , W. D. , Moses , E. L. , Tolentino , P. J. and Walker , J. M. 1990 . Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D‐2 receptors . Eur. J. Pharmacol. , 177 : 111 – 118 .
  • Fukuoka , T. , Nakano , M. , Kohda , A. , Okuno , Y. and Matsuo , M. 1997 . The common marmoset (Callithrix jacchus) as a model for neuroleptic‐induced acute dystonia . Pharmacol. Biochem. Behavior , 58 : 947 – 953 .
  • Yasui‐Furukori , N. , Kondo , T. , Ishida , M. , Tanaka , O. , Mihara , K. , Kaneko , S. and Otani , K. 2002 . The characteristics of side‐effects of bromperidol in schizophrenic patients . Psychiatry Clin. Neurosci. , 56 : 103 – 106 .
  • Fornai , F. , Schluter , O. M. , Lenzi , P. , Gesi , M. , Ruffoli , R. , Ferrucci , M. , Lazzeri , G. , Busceti , C. L. , Pontarelli , F. , Battaglia , G. , Pellegrini , A. , Nicoletti , F. , Ruggieri , S. , Paparelli , A. and Sudhof , T. C. 2005 . Parkinson‐like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin‐proteasome system and alpha‐synuclein . Proc. Natl. Acad. Sci. USA. , 102 : 3413 – 3418 .
  • Fang , J. , Baker , G. B. and Coutts , R. T. 1996 . Determination of 4‐(4‐chlorophenyl)‐4‐hydroxypiperidine, a metabolite of haloperidol, by gas chromatography with electron‐capture detection . J. Chromatogr. B , 682 : 283 – 288 .
  • Arinobu , T. , Hattori , H. , Iwai , M. , Ishii , A. , Kumazawa , T. , Suzuki , O. and Seno , H. 2002a . Liquid chromatographic‐mass spectrometric determination of haloperidol and its metabolites in human plasma and urine . J. Chromatogr. B , 776 : 107 – 113 .
  • Arinobu , T. , Hattori , H. , Seno , H. , Ishii , A. and Suzuki , O. 2002b . Comparison of SSI with APCI as an interface of HPLC‐mass spectrometry for analysis of a drug and its metabolites . J. Am. Soc. Mass Spectrom. , 13 : 204 – 208 .
  • Gorrod , J. W. and Fang , J. 1993 . On the metabolism of haloperidol . Xenobiotica , 23 : 495 – 508 .
  • Fang , J. and Gorrod , J. W. 1993 . High performance liquid chromatographic method for the detection and quantitation of haloperidol and seven of its metabolites in microsomal preparations . J. Chromatogr. , 614 : 267 – 273 .
  • Higashi , Y. , Kitahara , M. and Fujii , Y. 2006a . Simultaneous analysis of haloperidol, its three metabolites and two other butyrophenone‐type neuroleptics by high performance liquid chromatography with dual ultraviolet detection . Biomed. Chromatogr. , 20 : 166 – 172 .
  • Higashi , Y. , Nakamura , S. and Fujii , Y. 2006b . Sensitive determination of 4‐(4‐chlorophenyl)‐4‐hydroxypiperidine, a metabolite of haloperidol, in a rat biological sample by HPLC with fluorescence detection after precolumn derivatization using 4‐fluoro‐7‐nitro‐2,1,3‐benzoxadiazole . Biomed. Chromatogr. , 20 : 964 – 970 .
  • Higashi , Y. , Sakata , M. and Fujii , Y. 2006c . Simultaneous determination of four basic metabolites formed from butyrophenone‐type agents by high performance liquid chromatography with dual ultraviolet detection . J. Liq. Chromatogr. & Relat. Technol. , 29 : 2853 – 2862 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.