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Journal of Liquid Chromatography & Related Technologies Volume 30, 2007 - Issue 19
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Original Articles

Validation of a Liquid Chromatographic Method for the Determination of Acyclovir in Human Plasma: Application to Bioequivalence Study

Liberato Brum Junior BIOCINESE, Centro de Estudos Biofarmacêuticos, Toledo‐PR, BrasilCorrespondence[email protected]
,
Ana Maria Pugens BIOCINESE, Centro de Estudos Biofarmacêuticos, Toledo‐PR, Brasil
,
Alexandre Dal'Maso BIOCINESE, Centro de Estudos Biofarmacêuticos, Toledo‐PR, Brasil
,
Eduardo Gomes BIOCINESE, Centro de Estudos Biofarmacêuticos, Toledo‐PR, Brasil
,
Maurício Bedim dos Santos BIOCINESE, Centro de Estudos Biofarmacêuticos, Toledo‐PR, Brasil
&
Josélia Larger Manfio BIOCINESE, Centro de Estudos Biofarmacêuticos, Toledo‐PR, Brasil
Pages 2903-2915 | Received 30 Apr 2007, Accepted 19 May 2007, Published online: 09 Nov 2007

References

  • Bahrami , G. , Mirzaeei , S. and Kiani , A. 2005 . Determination of acyclovir in human serum by high‐performance liquid chromatography using liquid‐liquid extraction and its application in pharmacokinetic studies . J. Chromatogr. B , 816 : 327 – 331 .
  • Fernandez , M. , Sepúlveda , J. , Aránguiz , T. and Plessing , C. 2003 . Technique validation by liquid chromatography for the determination of acyclovir in plasma . J. Chromatogr. B , 791 : 357 – 363 .
  • Boulieu , R. , Gallant , C. and Silberstein , N. 1997 . Determination of acyclovir in human plasma by high‐performance liquid chromatography . J. Chromatogr. B , 693 : 233 – 236 .
  • Mascher , H. , Kikuta , C. , Metz , R. and Vergin , H. New . 1992 . high sensitivity high‐performance liquid chromatographic method for the determination of acyclovir in human plasma, using fluorometric detection . J. Chromatogr. , 583 : 122 – 127 .
  • Brown , S. D. , White , C. A. , Chu , C. K. and Bartlett , M. G. 2002 . Determination of acyclovir in maternal plasma, amniotic fluid, fetal and placental tissues by high‐performance liquid chromatography . J. Chromatogr. B , 772 : 327 – 334 .
  • Bangaru , R. A. , Bansal , Y. K. , Rao , A. R.M. and Gandhi , T. P. Rapid . 2000 . simple and sensitive high‐performance liquid chromatographic method for detection and determination of acyclovir in human plasma and its use in bioavailability studies . J. Chromatogr. B , 739 : 231 – 237 .
  • Pham‐Huy , C. , Stathoulopoulou , F. , Sandouk , P. , Scherrmann , J. M. , Palombo , S. and Girre , C. 1999 . Rapid determination of valaciclovir and acyclovir in human biological fluids by high‐performance liquid chromatography using isocratic elution . J. Chromatogr. B , 732 : 47 – 53 .
  • Peh , K. K. and Yuen , K. H. 1997 . Simple high‐performance liquid chromatographic method for the determination of acyclovir in human plasma using fluorescence detection . J. Chromatogr. B , 693 : 241 – 244 .
  • Kishino , S. , Takekuma , M. , Sugawara , M. , Shimamura , T. , Furukawa , H. , Todo , S. and Miyazaki , K. 2002 . Liquid chromatographic method for the determination of ganciclovir and/or acyclovir in human plasma using pulse amperometric detection . J. Chromatogr. B , 780 : 289 – 294 .
  • 2001 . “ US Department of Health and Human Services, Food and Drug administration, Center for Drug Evaluation and Research ” . In Guidance for Industry: Bioanalytical Method Validation Rockville, MD

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