258
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

Enantiomeric Separation of Tenofovir on an Achiral C18 Column by HPLC Using L‐Phenylalanine as a Chiral Mobile Phase Additive

, , &
Pages 410-420 | Received 03 Dec 2006, Accepted 27 Aug 2007, Published online: 20 Dec 2007

References

  • Deeks , S. G. , Bardicht‐Crovo , P. , Lietman , P. S. , Hwang , F. , Cundy , K. C. , Rooney , J. F. , Hellmann , N. S. , Safrin , S. and Kahn , J. O. 1998 . Safety, pharmacokinetics and antiretroviral activity of intravenous 9‐[2‐(R)‐(phosphonomethoxy)propyl]‐adenine, a novel anti‐human immunodeficiency virus (HIV) therapy, in HIV‐infected adults . Antimicrob. Agents Chemother. , 42 : 2380 – 2384 .
  • Shaw , J. P. , Sueoka , C. M. , Oliyai , R. , Lee , W. A. , Arimilli , K. M. , Kim , C. U. and Cundy , K. C. 1997 . Metabolism and pharmacokinetics of novel oral prodrugs of 9‐[(R)‐2‐phosphonomethoxypropyl]adenine (PMPA) in dogs . Pharm. Res. , 14 : 1824 – 1829 .
  • Arimilli , M. N. , Kim , C. U. , Dougherty , J. , Mulato , A. , Oliyai , R. , Shaw , J.‐P. , Cundy , K. C. and Bischofberger , N. Synthesis. 1997 . In vivo biological evaluation and oral bioavailability of 9‐(2‐(phosphonomethoxy)propyl)adenine (PMPA) prodrugs . Antivir. Chem. Chemother. , 8 : 557 – 564 .
  • Sentenac , S. , Fernandez , C. , Thuillier , A. , Lechat , P. and Aymard , G. 2003 . Sensitive determination of tenofovir in human plasma samples using reversed‐phase liquid chromatography . J. Chromatogr. B , 793 : 317 – 324 .
  • Rezk , N. L. , Crutchley , R. D. and Kashuba , A. D. 2005 . Simultaneous quantification of emtricitabine and tenofovir in human plasma using high‐performance liquid chromatography after solid phase extraction . J. Chromatogr. B , 822 : 201 – 208 .
  • Vincent , J. , Jean‐Marc , T. , Gérard , P. and Elisabeth , R. 2003 . Determination of tenofovir in human plasma by high‐performance liquid chromatography with spectrofluorimetric detection . J. Chromatogr. B , 785 : 377 – 381 .
  • Vincent , B. , Philippe , M. , Philippe , C. , Ghislaine , L. and Luigi , A. 2005 . Simultaneous analysis of several antiretroviral nucleosides in rat‐plasma by high‐performance liquid chromatography with UV using acetic acid/hydroxylamine buffer . J. Chromatogr. B , 821 : 132 – 143 .
  • Delahunty , T. , Bushman , L. and Fletcher , C. V. 2006 . Sensitive assay for determining plasma tenofovir concentrations by LC/MS/MS . J. Chromatogr. B , 830 : 6 – 12 .
  • Wang , R. , Jia , Z. P. , Hu , X. L. , Xu , L. T. , Li , Y. M. and Chen , L. R. 2003 . Determination of serum thyroxine enantiomers in patients by liquid chromatography with a chiral mobile phase . J. Chromatogr. B , 785 : 353 – 359 .
  • Galaverna , G. , Corradini , R. , Dallavalle , F. , Folesani , G. , Dossena , A. and Marchelli , R. 2001 . Comparison of Chirasil‐DEX CB as gas chromatographic and ULMO as liquid chromatographic chiral stationary phase for enantioseparation of aryl‐ and heteroarylcarbinols . J. Chromatogr. A , 992 : 151 – 157 .
  • Galaverna , G. , Corradini , R. , Dossena , A. , Marchelli , R. and Dallavalle , F. 1996 . Copper(II) complexes of N 2‐alkyl‐(S)‐amino acid amides as chiral selectors for dynamically coated chiral stationary phases in RP‐HPLC . Chirality , 8 : 189 – 196 .
  • Duchateau , A. , Crombach , M. , Aussems , M. and Bongers , J. 1989 . Determination of the enantiomers of α‐amino acids and α‐amino acid amides by high‐performance liquid chromatography with a chiral mobile phase . J. Chromatogr. A , 461 : 419 – 428 .
  • Davankov , V. A. 2003 . Enantioselective ligand exchange in modern separation techniques . J. Chromatogr. A , 1000 : 891 – 915 .
  • Kurganov , A. 2001 . Chiral chromatographic separations based on ligand exchange . J. Chromatogr. A , 906 : 51 – 71 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.