Development of a Liquid Chromatography-Negative ESI-Tandem Mass Spectrometry Method for Ibuprofen with Minimization of Matrix Effects Associated with Phospholipids

REFERENCES

• Little , J.L. ; Wempe , M.F. ; Buchanan , C.M. Liquid chromatography–mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma . J. Chromatogr. B. 2006 , 833 , 219 – 230 .
   PubMed Web of Science ®Google Scholar
• Van Horne , K.C. ; Bennett , P.K. Preventing matrix effects by using new sorbents to remove phospholipids from biological samples. Proceedings of the American Association of Pharmaceutical Scientists (AAPS) conference, Salt Lake City, Utah, 2003. Available at http://www.tandemlabs.com/capabilities_publications.html
   Google Scholar
• Bennett , P.K. ; Van Horne , K.C. Identification of the major endogenous and persistent compounds in plasma, serum, and tissue that cause matrix effects with electrospray LC/MS techniques Proceedings of the American Association of Pharmaceutical Scientists (AAPS) conference, Salt Lake City, Utah, 2003. p.2, available at http://www.tandemlabs.com/capabilities_publications.html
   Google Scholar
• Chambers , E. ; Wagrowski-Diehl , D.M. ; Lu , Z. ; Mazzeo , J.R. Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS Analyses . J. Chromatogr. B. 2007 , 852 , 22 – 34 .
   PubMed Web of Science ®Google Scholar
• Shen , J.X. ; Motyka , R.J. ; Roach , J.P. ; Hayes , R.N. Minimization of ion suppression in LC-MS/MS analysis through the application of strong cation exchange solid phase extraction (SCX-SPE) . J. Pharm. Biomed. Anal. 2005 , 37 , 359 – 367 .
   PubMed Web of Science ®Google Scholar
• Zhang , T. ; Meng , M. ; Horne , K.C. ; Bennett , P.K. Implication of phospholipids in significant matrix effects in negative ion ES-MS/MS. Proceedings of the American Association of Pharmaceutical Scientists (AAPS) conference, Nashville, TN, 2005. p.9, available at http://www.tandemlabs.com/capabilities_ publications.html.
   Google Scholar
• Lytle , C.A. ; Gan , Y.D. ; White , D.C. Electrospray ionization/mass spectrometry compatible reversed-phase separation of phospholipids: Piperidine as a post column modifier for negative ion detection . J. Microbiol. Meth. 2000 , 41 , 227 – 234 .
   PubMed Web of Science ®Google Scholar
• The U.S.P 24 revision, NF 19; United States Pharmacopeial Convention : Rockville , MD , 2000 ; pp. 821 and 439 .
   Google Scholar
• Goth , A. Medical Pharmacology Principals and Concepts ; Mosby Press : St Louis , Missouri , 1981 ; 348 and 512 .
   Google Scholar
• Hilton , M.J. ; Thomas , K.V. Determination of selected human pharmaceutical compounds in effluent and surface water samples by high-performance liquid chromatography–electrospray tandem mass spectrometry . J. Chromatogr. A. 2003 , 1015 , 129 – 141 .
   PubMed Web of Science ®Google Scholar
• Gómez , M.J. ; Petrović , M. ; F-Alba , A.R. ; Barceló , D. Determination of pharmaceuticals of various therapeutic classes by solid-phase extraction and liquid chromatography–tandem mass spectrometry analysis in hospital effluent wastewaters . J. Chromatogr. A. 2006 , 1114 ( 2 ), 224 – 233 .
   PubMed Web of Science ®Google Scholar
• Gros , M. ; Petrović , M. ; Barceló , D. Development of a multi-residue analytical methodology based on liquid chromatography–tandem mass spectrometry (LC–MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters . Talanta. 2006 , 70 , 678 – 690 .
   PubMed Web of Science ®Google Scholar
• Gómez , M.J. ; Agüera , A. ; Mezcua , M. ; Hurtado , J. ; Mocholí , F. ; Fernández-Alba , A.R. Simultaneous analysis of neutral and acidic pharmaceuticals as well as related compounds by gas chromatography–tandem mass spectrometry in wastewater . Talanta 2007 , 73 , 314 – 320 .
   PubMed Web of Science ®Google Scholar
• Gibson , R. ; Becerril-Bravo , E. ; Silva-Castro , V. ; Jiménez , B. Determination of acidic pharmaceuticals and potential endocrine disrupting compounds in wastewaters and spring waters by selective elution and analysis by gas chromatography–mass spectrometry . J. Chromatogr. A. 2007 , 1169 , 31 – 39 .
   PubMed Web of Science ®Google Scholar
• Kasprzyk-Hordern , B. ; Dinsdale , R.M. ; Guwy , A.J. The effect of signal suppression and mobile phase composition on the simultaneous analysis of multiple classes of acidic/neutral pharmaceuticals and personal care products in surface water by solid-phase extraction and ultra performance liquid chromatography–negative electrospray tandem mass spectrometry . Talanta. 2008 , 74 , 1299 – 1312 .
   PubMed Web of Science ®Google Scholar
• Bonato , P.S. ; Del Lama , M.P.F.M. ; de Carvalho , R. Enantioselective determination of ibuprofen in plasma by high-performance liquid chromatography–electrospray mass spectrometry . J. Chromatogr. B. 2003 , 796 ( 2 ), 413 – 420 .
   PubMed Web of Science ®Google Scholar
• Forrester , J.S. ; Milne , S.B. ; Ivanova , P.T. ; Brown , H.A. Computational lipidomics: A multiplexed analysis of dynamic changes in membrane lipid composition during Signal transduction . Molec. Pharmacol. 2004 , 65 ( 4 ), 813 – 821 .
   PubMed Web of Science ®Google Scholar
• Xu , R.N. ; Fan , L. ; Rieser , M.J. ; El-Shourbagy , T.A. Recent advances in high-throughput quantitative bioanalysis by LC–MS/MS . J. Pharm. Biomed. Anal. 2007 , 44 ( 2 ), 342 – 355 .
   PubMed Web of Science ®Google Scholar