HPLC and LC/MS Analysis of Pharmaceutical Container Closure System Leachables and Extractables

REFERENCES

• Q3A(R) Impurities in New Drug Substances; ICH Harmonized Tripartite Guideline; International Conference On Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use; February 7, 2002, 1–11 .
   Google Scholar
• Q3B(R) Impurities in New Drug Products; Guidance for Industry; U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CEDER); Rockville, MD, November 2003; 1–7 .
   Google Scholar
• U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CEDER) and Center for Biologics Evaluation and Research (CBER); Rockville, MD, Container Closure Systems for Packaging Human Drugs and Biologics; Guidance for Industry; May 1999; 1–41 .
   Google Scholar
• <661> Containers - Plastics. in The United States Pharmacopeia, USP 31 ; USP Convention, Inc. : Rockville , MD , 2008; 251–255.
   Google Scholar
• <381> Elastomeric Closures for Injections . in The United States Pharmacopeia, USP 31 ; USP Convention, Inc. : Rockville , MD , 2008 ; 144 – 145 .
   Google Scholar
• Norwood , D.L. ; Nagao , L. ; Lyapustina , S. ; Munos , M. Application of modern analytical technologies to the identification of extractables and leachables . Amer. Pharm. Rev. 2005 , 8 ( 1 ), 78 – 87 .
   Google Scholar
• Metered Dose Inhaler (MDI) and Dry Powder Inhaler (DPI) Drug Products ; Draft Guidance for Industry; U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CEDER) : Rockville , MD , October 1998 ; 1 – 62 .
   Google Scholar
• Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products – Chemistry, Manufacturing, and Controls Documentation ; Guidance for Industry; U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CEDER) : Rockville , MD , July 2002 ; 1 – 45 .
   Google Scholar
• Norwood , D.L. ; Granger , A.T. ; Paskiet , D.M. Extractables and Leachables in Drugs and Packaging . in Encyclopedia of Pharmaceutical Technology, , 3rd Edition ; Marcel Dekker Encyclopedias : New York , 2006 ; 1693 – 1711 .
   Google Scholar
• Norwood , Daniel L. (Chair), Product Quality Research Institute. September 2006. Safety Thresholds and Best Practices For Extractables and Leachables in Orally Inhaled and Nasal Drug Products. Submitted to the PQRI Drug Product Technical Committee, PQRI Steering Committee, and U.S. Food and Drug Administration by the PQRI Leachables and Extractables Working Group. http://pqri.org/pdfs/LE_Recommendations_to_FDA_09-29-06.pdf (accessed 11/15/2006) .
   Google Scholar
• Ball , D. ; Blanchard , J. ; Jacobson-Kram , D. ; McClellan , R. ; McGovern , T. ; Norwood , D.L. ; Vogel , M. ; Wolff , R. ; Nagao , L. Development of safety qualification thresholds and their use in orally inhaled and nasal drug product evaluation . Tox. Sci. 2007 , 97 ( 2 ), 226 – 236 .
   PubMed Web of Science ®Google Scholar
• Norwood , D.L. ; Paskiet , D. ; Ruberto , M. ; Feinberg , T. ; Schroeder , A. ; Poochikian , G. ; Wang , Q. ; Deng , T.J. ; DeGrazio , F. ; Munos , M.K. ; Nagao , L.M. Best practices for extractables and leachables in orally inhaled and nasal drug products: An overview of the pqri recommendations . Pharm. Res. 2008 , 25 ( 4 ), 727 – 739 .
   PubMed Web of Science ®Google Scholar
• Rabek , J.F. Photostabilization of Polymers: Principles and Applications ; Elsevier Applied Science : London , 1990 .
   Google Scholar
• Norwood , D.L. ; Prime , D. ; Downey , B.P. ; Creasey , J. ; Satinder , S.K. ; Haywood , P. Analysis of polycyclic aromatic hydrocarbons in metered dose inhaler drug formulations by isotope dilution gas chromatography/mass spectrometry . J. Pharm. Biomed. Anal. 1995 , 13 ( 3 ), 293 – 304 .
   PubMed Web of Science ®Google Scholar
• Valcárcel , M. Principles of Analytical Chemistry – A Textbook ; Springer-Verlag : Berlin , 2000 .
   Google Scholar
• Purewal , T.S. ; Grant , J.W.G. , Eds.; Metered Dose Inhaler Technology ; Interpharm Press : Buffalo Grove , Illinois , 1998 .
   Google Scholar
• Jenke , D.R. Guidelines for the design, implementation, and interpretation of validations for chromatographic methods used to quantitate leachables/extractables in pharmaceutical solutions. J. Liq. Chromatogr. & Rel. Technol. 2005, 27, 3141–3176.
   Web of Science ®Google Scholar
• Jenke , D.R. ; Garber , M.J. ; Zietlow , D. Validation of a liquid chromatographic method for quantitation of organic compounds leached from a plastic container into a pharmaceutical formulation . J. Liq. Chromatogr. & Rel. Technol. 2005 , 28 , 199 – 222 .
   Web of Science ®Google Scholar
• Jenke , D.R. Extractable/leachable substances from plastic materials used as pharmaceutical product containers/devices . J. Pharm. Sci. Technol. 2002 , 56 ( 6 ), 332 – 364 .
   Google Scholar
• Jenke , D.R. Extractable substances from plastic materials used in solution contact applications: an updated review . J. Pharm. Sci. Technol. 2006 , 60 ( 3 ), 191 – 207 .
   Google Scholar
• Jenke , D.R. Chromatographic Methods Used to Identify and Quantify Organic Polymer Additives, J. Liq. Chromatogr. & Rel. Technol. 2003 , 26 , 2417 – 2447 .
   Web of Science ®Google Scholar
• Jenke , D.R. Organic extractables from packaging materials: Chromatographic methods used for identification and quantification . J. Liq. Chromatogr. & Rel. Technol. 2003 , 26 , 2449 – 2464 .
   Web of Science ®Google Scholar
• Lau , O.W. ; Wong , S.K. Contamination in food from packaging material . J. Chromatogr. A. 2000 , 882 , 255 – 270 .
   PubMed Web of Science ®Google Scholar
• Garcia , R.S. ; Silva , A.S. ; Copper , I. ; Franz , R. ; Losada , P.P. Revision of analytical strategies to evaluate different migrants from food packaging materials . Trends Food Sci. Technol. 2006 , 17 , 354 – 366 .
   Web of Science ®Google Scholar
• Silva , A.S. ; Garcia , R.S. ; Copper , I. ; Franz , R. ; Losada , P.P. Compilation of analytical methods and guidelines for the determination of selected model migrants from plastic packaging . Trends Food Sci. Technol. 2006 , 17 , 535 – 546 .
   Web of Science ®Google Scholar
• Zhang , F. ; Chang , A. ; Karaisz , K. ; Feng , R. ; Cai , J. Structural identification of extractables from rubber closures used for pre-filled semisolid drug applicator by chromatography, mass spectrometry, and organic synthesis . J. Pharm. Biomed. Anal. 2004 , 34 , 841 – 849 .
   PubMed Web of Science ®Google Scholar
• DePaolis , A. ; Zhu , L. ; Gunturi , S. ; Deng , F. ; Begum , S. ; Tolman , G. ; Templeman , T. ; Ghobrial , I. Rapid screening of UV absorbing leachables in biologic product placebos . Am. Pharm. Rev. 2006 , 9 ( 5 ), 54 – 59 .
   Google Scholar
• Pan , C. ; Harmon , F. ; Toscano , K. ; Liu , F. ; Vivilecchia , R. Strategy for identification of leachables in packaged pharmaceutical liquid formulations . J. Pharm. Biomed. Anal. 2008 , 46 , 520 – 527 .
   Google Scholar
• Castner , J. ; Williams , N. ; Bresnick , M. Leachables found in parenteral drug products . Am. Pharm. Rev. 2004 , 7 ( 2 ), 70 – 75 .
   Google Scholar
• Castner , J. ; Anderson , J. ; Benites , P. Strategy for development and characterization of HPLC methods to investigate extractables and leachables (Part II) . Am. Pharm. Rev. 2007 , 10 ( 3 ), 10 – 18 .
   Google Scholar
• Xiao , B. ; Gozob , S.K. ; Herz , L. Development and validation of HPLC methods for the determination of potential extractables from elastomeric stoppers in the presence of a complex surfactant vehicle used in the preparation of parenteral drug products . J. Pharm. Biomed. Anal. 2007 , 43 , 558 – 565 .
   Google Scholar
• Nasser , A.L.M. ; Lopes , L.M.X. ; Eberlin , M.N. ; Monteiro , M. Identification of oligomers in polyethyleneterephthalate bottles for mineral oil and fruit juice. Development and validation of a high-performance liquid chromatographic method for the determination of first series cyclic trimer. J. Chromtogr. A. 2005, 1097, 130–137.
   Google Scholar
• Sanches-Silva , A. ; Cruz , J.M. ; Sendon Garcia , R. ; Franz , R. ; Paseiro Losada , P. Kinetic migration studies from packaging films into meat products . Meat Sci. 2007 , 77 , 238 – 245 .
   PubMed Web of Science ®Google Scholar
• Sanches-Silva , A. ; Cruz Freire , J.M. ; Sendon Garcia , R. ; Franz , R. ; Paseiro Losada , P. Time-temperature study of the kinetics of migration of DPBP from plastics into chocolate, chocolate spread and margarine . Food Res. Intl. 2007 , 40 , 679 – 686 .
   Google Scholar
• Sanches-Silva , A. ; Pastorelli , S. ; Cruz , J.M. ; Simoneau , C. ; Castanheira , I. ; Paseiro Losada , P. Development of an analytical method for the determination of photoinitiators used for food packaging materials with potential to migrate into milk . J. Dairy Sci. 2008 , 91 , 906 – 909 .
   Google Scholar
• Fang , X. ; Cherico , N. ; Barbacci , D. ; Harmon , A.M. ; Piserchio , M. ; Perpall , H. Leachable study on solid dosage form . Am. Pharm. Rev. 2006 , 9 , 58 , 60 – 63 .
   Google Scholar
• Jenke , D. ; Swanson , S. ; Edgcomb , E. ; Couch , T. ; Chacko , M. ; Garber , M.J. ; Fang , L. Strategy for assessing the leachables impact of a material change made in a container/closure system . PDA J. Pharm. Sci. Technol. 2005 , 59 , 360 – 380 .
   Google Scholar
• Mudumba , R. ; Padsalgikar , A.D. ; Littler , S.W. Evaluation of aqueous extracts from Elast-Eon polymers for methylene dianiline (MDA) by high-performance liquid chromatography (HPLC) . Austral. J. Chem. 2005 , 58 , 845 – 850 .
   Web of Science ®Google Scholar
• Dopico-Garcia , M.S. ; Lopez-Vilarino , J.M. ; Gonzalez-Rodriguez , M.V. Antioxidant content of and migration from commercial polyethylene, polypropylene, and polyvinyl chloride packages . J. Agric. Food Chem. 2007 , 55 , 3225 – 3231 .
   PubMed Web of Science ®Google Scholar
• Sanchez-Silva , A. ; Cruz , J.M. ; Sendon-Garcia , R. ; Paseior-Losada , P. Determination of butylated hydroxytoluene in food samples by high-performance liquid chromatography with ultraviolet detection and gas chromatography/mass spectrometry . JAOAC 2007 , 90 , 277 – 283 .
   Google Scholar
• Burman , L. ; Albertsson , A.C. ; Hoglund , A. Solid-phase microextraction for qualitative and quantitative determination of migrated degradation products of antioxidants in an organic aqueous solution . J. Chromatogr. A. 2005 , 1080 , 107 – 116 .
   PubMed Web of Science ®Google Scholar
• Lennon, III , J.D. ; Hendricker , A.D. ; Feinberg , T.N. Identifying packaging-related drug product impurities . LC/GC N. Amer. 2007 , 25 , 710 – 717 .
   Google Scholar
• Strong , R. ; Hurst , C. Continuing challenges for leachables characterization of materials used in biopharmaceutical manufacturing . Am. Pharm. Rev. 2008 , 11 , 28 , 30 , 32 , 34 , 35 .
   Google Scholar
• Wang , Q. Selection of analytical techniques for pharmaceutical leachables studies . Am. Pharm. Rev. 2005 , 8 , 38 , 40 , 42 – 44 .
   Google Scholar
• Kim , B.H. ; Yang , D.-K. ; Hoa Ok , J. Analysis of Polymer Additives in High-Temperature Liquid Chromatography. J. Chromatogr. Sci. 2007, 45, 16–21.
   PubMedGoogle Scholar
• Mitani , K. ; Narimatsu , S. ; Izushi , F. ; Kataoka , H. Simple and rapid analysis of endocrine disruptors in liquid medicines and intravenous injection solutions by automated in-tube solid-phase microextraction/high performance liquid chromatography . J. Pharm. Biomed. Anal. 2003 , 32 , 469 – 478 .
   PubMed Web of Science ®Google Scholar
• Jen , J.F. ; Liu , T.C. Determination of phthalate esters from food-contacted materials by on-line microdialysis and liquid chromatography . J. Chromatogr. A. 2006 , 1130 , 28 – 33 .
   PubMed Web of Science ®Google Scholar
• Noguerol-Cal , R. ; Lopez-Vilarino , J.M. ; Gonzalez-Rodriguez , M.V. ; Barral-Losada , L.F. Development of an ultraperformance liquid chromatography method for improved determination of additives in polymeric materials . J. Sep. Sci. 2007 , 30 , 2452 – 2459 .
   Google Scholar
• Hansson , C. ; Bergendorff , O. ; Ezzelarab , M. ; Sterner , O. Extraction of mercaptobenzothiazole compounds from rubber products . Contact Dermatitis. 1997 , 36 , 195 – 200 .
   Google Scholar
• Bergendorff , O. ; Persson , C.M.L. ; Hansson , C. High-performance liquid chromatography analysis of rubber allergens in protective gloves used in health care . Contact Dermatitis 2006 , 55 , 210 – 215 .
   Google Scholar
• Bergendorff , O. ; Hansson , C. Contact dermatitis to a rubber allergen with both dithiocarbamate and benzothiazole structure . Contact Dermatitis. 2007 , 56 ( 5 ), 278 – 280 .
   PubMed Web of Science ®Google Scholar
• Bergendorff , O. ; Persson , C. ; Luedtke , A. ; Hansson , C. Chemical changes in rubber allergens during vulcanization . Contact Dermatitis. 2007 , 57 ( 5 ), 152 – 157 .
   PubMedGoogle Scholar
• Wang , L.H. Simultaneous determination of seven sunscreen benzophenones in cosmetic products by High-performance liquid chromatography . Chromatographia. 1999 , 50 , 565 – 570 .
   Google Scholar
• Bergendorff , O. ; Persson , C.M.L. ; Hansson , C. HPLC analysis of alkyl thioureas in an orthopedic brace and patch testing with pure ethylbutylthiourea . Contact Dermatitis. 2004 , 51 , 273 – 277 .
   Google Scholar
• Lian , H.Z. ; Wei , Y.N. ; Liu , W.W. ; Li , D.D. HPLC-UV Detection for analysis of p-benzoquinone dioxime and p-nitrosophenol, and chromatographic fingerprint applied in quality control of industrial p-benzoquinone dioxime . J. Liq. Chromatogr. & Rel. Technol. 2006 , 29 , 509 – 520 .
   Web of Science ®Google Scholar
• Yao , J. ; Xua , H. ; Lv , L. ; Song , D. ; Cui , Y. ; Zhang , T. ; Feng , Y.Q. A novel liquid-phase microextraction method combined with high performance liquid chromatography for analysis of phthalate esters in landfill leachates . Anal. Chim. Acta 2008 , 616 , 42 – 48 .
   PubMed Web of Science ®Google Scholar
• Ekroth , S.B. ; Ohlin , B. ; Österdahl , B.G. Rapid and simple method for determination of thiram in fruits and vegetables with high-performance liquid chromatography with ultraviolet detection . J. Agric. Food Chem. 1998 , 46 , 5302 – 5304 .
   Web of Science ®Google Scholar
• Willoughby , R. ; Sheehan , E. ; Mitrovich , S. A Global View of LC/MS ; Global View Publishing : Pittsburg , PA , 1998 .
   Google Scholar
• Norwood , D.L. ; Mullis , J.O. ; Feinberg , T.N. Hyphenated Techniques, in HPLC Method Development of Pharmaceuticals , Chapter 7; Vol. 8 of Separation Science and Technology ; Ahuja , S. Rasmussen , H. Eds.; Elsevier Academic Press : London , 2007.
   Google Scholar
• de Hoffmann , E. ; Stroobant , V. Mass Spectrometry Principles and Applications ; John Wiley and Sons, Ltd. : Chichester , 2007 .
   Google Scholar
• Blakley , C.R. ; Vestal , M.L. Thermospray interface for liquid chromatography/mass spectrometry . Anal. Chem. 1983 , 55 ( 4 ), 750 – 754 .
   Web of Science ®Google Scholar
• Caprioli , R.M. ; Fan , T. ; Cottrell , J.S. A continuous-flow sample probe for fast atom bombardment mass spectrometry . Anal. Chem. 1986 , 58 ( 14 ), 2949 – 2954 .
   PubMed Web of Science ®Google Scholar
• Fenn , J.B. ; Mann , M. ; Meng , C.K. ; Wong , S.F. ; Whitehouse , C.M. Electrospray ionization for mass spectrometry of large biomolecules . Science. 1989 , 246 , 64 – 71 .
   PubMed Web of Science ®Google Scholar
• Bruins , A.P. ; Covey , T.R. ; Henion , J.D. Ion spray interface for combined liquid chromatography/atmospheric pressure ionization mass spectrometry . Anal. Chem. 1987 , 59 , 2642 – 2646 .
   Web of Science ®Google Scholar
• Boyd , R.K. ; Basic , C. ; Bethem , R.A. Trace Quantitative Analysis by Mass Spectrometry ; John Wiley and Sons, Ltd. : Chichester , 2008 .
   Google Scholar
• Gross , J.H. Mass Spectrometry–A Textbook ; Springer-Verlag : Berlin , Heidelberg , 2004 .
   Google Scholar
• Harrison , A.G. Chemical Ionization Mass Spectrometry ; CRC Press : Boca Raton , Florida , 1983 .
   Google Scholar
• Cohen , L.R.H. ; Rossi , D.T. The LC/MS experiment , in Mass Spectrometry in Drug Discovery , Rossi , D.T. , Sinz , M.W. , Eds.; Marcel Dekker : New York , 2002 ; 125 – 169 .
   Google Scholar
• Duchateau , A.L.L. ; Munsters , B.H.M. ; Kwakkenbos , G.T.C. ; Van Leuken , R.G.J. Selection of buffers and of an ion-pairing agent for thermospray liquid chromatographic-mass spectrometric analysis of ionic compounds . J. Chromatogr. A. 1991 , 552 , 605 – 612 .
   Google Scholar
• Vervoort , R.J.M. ; Debets , A.J.J. ; Lamers , R.J. ; Claessens , H.A. ; Jansen , J.G.M. ; Cramers , C.A. Preliminary study on the effect of miniaturization and use of volatile mobile phases in LC for the on-line LC-MS analysis of basic pharmaceuticals . J. Pharm. Biomed. Anal. 1999 , 21 , 273 – 289 .
   Google Scholar
• de Miguel , I. ; Puech-Costes , E. ; Samain , D. Use of mixed perfluorinated ion-pairing agents as solvents in ion-pair high-performance liquid chromatography for the preparative purification of aminoglycoside antibiotics . J. Chromatogr. 1987 , 407 , 109 – 119 .
   Google Scholar
• Franey , T. A volatile ion-pairing chromatography reagent for an LC-MS mobile phase . LC/GC N. Amer. 2003 , 21 , 54 – 58 .
   Google Scholar
• Zacharis , E. ; Hallinh , P.J. ; Rees , D.G. Volatile buffers can override the “pH memory” of subtilisin catalysis on organic media . Proc. Natl. Acad. Sci. USA 1999 , 96 ( 4 ), 1201 – 1205 .
   PubMed Web of Science ®Google Scholar
• Fischer , W.H. ; Hoeger , C.A. ; Meisenhelder , J. ; Hunter , T. ; Craig , A.G. Determination of phosphorylation sites in peptides and proteins employing a volatile Edman reagent . J. Prot. Chem. 1997 , 16 , 329 – 334 .
   Google Scholar
• Bajic , S. ; Doerge , D.R. ; Lu , L. ; Hansen , Jr. , E.B. Analysis of erythromycin by liquid chromatography/mass spectrometry using involatile mobile phases with a novel atmospheric pressure ionization source. Rapid Comm. Mass Spectrom. 2000, 14, 156–160.
   Google Scholar
• Gardner , M.S. ; Voyksner , R.D. ; Haney , C.A. Analysis of pesticides by LC-electrospray-MS with postcolumn removal of nonvolatile buffers . Anal. Chem. 2000 , 72 ( 19 ), 4659 – 4666 .
   PubMed Web of Science ®Google Scholar
• McLafferty , F.W. ; Turecek , F. Interpretation of Mass Spectra, , 4th Edition ; University Science Books : Sausalito , California , 1993 .
   Google Scholar
• Budzikiewicz , H. ; Djerassi , C. ; Williams , D.H. Mass Spectrometry of Organic Compounds ; Holden-Day : San Francisco , 1967 .
   Google Scholar
• Marand , A. ; Karlsson , D. ; Dalene , M. ; Skarping , G. Extractable organic compounds in polyurethane foam with special reference to aromatic amines and derivatives thereof . Anal. Chim. Acta 2004 , 510 , 109 – 119 .
   Web of Science ®Google Scholar
• Ito , R. ; Seshimo , F. ; Miura , N. ; Kawaguchi , M. ; Saito , K. ; Nakazawa , H. High-throughput determination of mono- and di(2-ethylhexyl)phthalate migration from PVC tubing to drugs using liquid chromatography-tandem mass spectrometry . J. Pharm. Biomed. Anal. 2005 , 39 , 1036 – 1041 .
   PubMedGoogle Scholar
• Fichtner , S. ; Giese , U. ; Pahl , I. ; Reif , O.W. Determination of “extractables” on polymer materials by means of HPLC-MS . PDA. J. Pharm. Sci. Technol. 2006 , 60 , 291 – 301 .
   Google Scholar
• Scott , K.W. Exploring potential extractables and leachables from medical polymers using analytical techniques ; Medical Polymer 2004, International Conference Focusing on Polymers used in the Medical Industry, 4th, Dublin, Ireland, Nov. 15–16, 2004. Rapa Technology Ltd. Publishers : Shrewsbury, UK , 2004 ; 89 – 110 .
   Google Scholar
• Mortensen , S.K. ; Trier , X.T. ; Foverskov , A. ; Petersen , J.H. Specific determination of 20 primary aromatic amines in aqueous food simulants by liquid chromatography-electrospray ionization-tandem mass spectrometry . J. Chromatogr. A. 2005 , 1091 , 40 – 50 .
   PubMed Web of Science ®Google Scholar
• Rogalewicz , R. ; Batko , K. ; Voelkel , A. Identification of organic extractables from commercial resin-modified glass-ionomers using HPLC-MS . J. Environ. Monit. 2006 , 8 , 750 – 758 .
   PubMedGoogle Scholar
• Jenke , D.R. ; Jene , J.M. ; Poss , M. ; Story , J. ; Tsilipetros , T. ; Odufu , A. ; Terbush , W. Accumulation of extractables in buffer solutions from a polyolefin plastic container . Intl. J. Pharm. 2005 , 297 , 120 – 133 .
   Google Scholar
• Jenke , D.R. ; Zietlow , D. ; Garber , M.J. ; Sadain , S. ; Reiber , D. ; Terbush , W. Accumulation of organic compounds leached from plastic materials used in biopharmaceutical process containers . PDA. J. Pharm. Sci. Technol. 2007 , 61 , 286 – 302 .
   Google Scholar
• Jenke , D.R. ; Story , J. ; Lalani , R. Extractables/Leachables from plastic tubing used in product manufacturing . Intl. J. Pharm. 2006 , 315 , 75 – 92 .
   Google Scholar
• Soeborg , T. ; Hansen , S.H. ; Halling-Sorensen , B. Determination of bisphenol diglycidyl ethers in topical dosage forms . J. Pharm. Biomed. Anal. 2006 , 40 ( 2 ), 322 – 330 .
   PubMed Web of Science ®Google Scholar
• Spahl , W. ; Budzikiewicz , H. ; Geurtsen , W. Determination of leachable components from four commercial dental composites by gas and liquid chromatography/mass spectrometry. J. Dentistry. 1998, 26 (2), 137–145.
   PubMed Web of Science ®Google Scholar
• Pico , Y. ; Farre , M. ; Soler , C. ; Barcelo , D. Identification of unknown pesticides in fruits using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry . J. Chromatogr. A. 2007 , 1176 ( 1–2 ), 123 – 134 .
   Google Scholar
• Guo , X. ; Bruins , A.P. ; Covey , T.R. Characterization of typical chemical background interferences in atmospheric pressure ionization Liquid Chromatography-Mass Spectrometry . Rapid Comm. Mass Spectrom. 2006 , 20 ( 20 ), 3145 – 3150 .
   PubMed Web of Science ®Google Scholar
• Kaerrman , A. ; Van Avel , B. ; Jaernberg , U. ; Hardell , L. ; Lindstroem , G. Development of an solid-phase extraction-HPLC/Single quadrupole MS method for quantification of perfluorochemicals in whole blood . Anal. Chem. 2005 , 77 ( 3 ), 864 – 870 .
   PubMed Web of Science ®Google Scholar
• Heinz , L.C. ; Siewing , A. ; Pasch , H. Two-dimensional chromatography of complex polymers, 5. Separation of blends of styrene-butadiene rubber and butyl rubber . e-Polymers 2003 , No. 065.
   Google Scholar
• Heinz , L.C. ; Graef , S. ; Macko , T. ; Brüll , R. ; Balk , S. ; Keul , H. ; Pasch , H. Development of high-temperature separation techniques for the chemical composition analysis of ethylene – methyl methacrylate block copolymers . e-Polymers 2005 , No. 054.
   Google Scholar
• Moreno , E. ; Reza , J. ; Trejo , A. Extraction of polycyclic aromatic hydrocarbons from soil using water under subcritical conditions . Polycyclic Arom. Cpd. 2007 , 27 ( 4 ), 239 – 260 .
   Web of Science ®Google Scholar
• Bourdat-Deschamps , M. ; Daudin , J.-J. ; Barriuso , E. An experimental design approach to optimize the determination of polycyclic aromatic hydrocarbons from rainfall water using stir bar sorptive extraction and high performance liquid chromatography-fluorescence detection . J. Chromatogr. A. 2007 , 1167 ( 2 ), 143 – 153 .
   PubMed Web of Science ®Google Scholar
• Wang , W.-D. ; Huang , Y.-M. ; Shu , W.-Q. ; Cao , J. Multiwalled carbon nanotubes as adsorbants of solid-phase extraction for determination of polycyclic aromatic hydrocarbons in environmental waters coupled with high-performance liquid chromatography . J. Chromatogr. A. 2007 , 1173 ( 1–2 ), 27 – 36 .
   Google Scholar
• Zhang , C. ; Zhang , X. ; Yang , J. ; Liu , Z. Analysis of polynuclear aromatic hydrocarbons in heavy products derived from coal and petroleum by high performance liquid chromatography . J. Chromatogr. A. 2007 , 1167 ( 2 ), 171 – 177 .
   PubMed Web of Science ®Google Scholar
• Hashi , Y. ; Wang , T.-R. ; Li , Y.-Q. ; Lin , J.-M. On-line enrichment and determination of polycyclic aromatic hydrocarbons in atmospheric particulates using high performance liquid chromatography with fluorescence as detector . J. Environ. Sci. (Beijing, China). 2007 , 19 ( 10 ), 1261 – 1265 .
   PubMed Web of Science ®Google Scholar
• Santosh , H.S. ; Nandini , N. ; Pandit , G.G. ; Sharma , S. Quantification of polycyclic aromatic hydrocarbons in size fractionated ambient aerosol and their source identification using wind profile data . Asian J. Microbiol. Biotech. Environ. Sci. 2007 , 9 ( 4 ), 855 – 860 .
   Google Scholar
• Santos , J.L. ; Aparicio , I. ; Alonso , E. A new method for the routine analysis of LAS and PAH in sewage sludge by simultaneous sonication-assisted extraction prior to liquid chromatographic determination. Anal. Chim. Acta. 2007, 605 (1), 102–109.
   PubMed Web of Science ®Google Scholar
• Vinas , P. ; Campillo , N. ; Aguinaga , N. ; Perez-Canovas , E. ; Hernandez-Cordoba , M. Use of headspace solid-phase microextraction coupled to liquid chromatography for the analysis of polycyclic aromatic hydrocarbons in tea infusions . J. Chromatogr. A. 2007 , 1164 ( 1–2 ), 10 – 17 .
   PubMed Web of Science ®Google Scholar
• Brasseur , C. ; Brose , F. ; Pirlot , A. ; Douny , C. ; Eppe , G. ; Maghuin-Rogister , G. ; Scippo , M.-L. Validation of the analytical procedure for the determination of polyaromatic hydrocarbons in smoke flavorings using high performance liquid chromatography coupled to an ultraviolet, diode array or fluorescence detector . Accred. Qual. Assur. 2007 , 12 ( 10 ), 535 – 542 .
   Web of Science ®Google Scholar
• Glod , K. ; Wegrzyn , E. ; Grzeskiewicz , S. ; Poplawska , W. Validation and estimation of uncertainty for the determination of PAHs using RP-HPLC with fluorescence detection and SEC for sample preparation . Tluszcze Jadalne. 2007 , 42 ( 1/2 ), 61 – 71 .
   Google Scholar
• Halim , N. ; Kuntom , A. ; Ai , T.Y. Determination of benzo(a)pyrene in vegetable oils . J. Oil Palm Res. 2007 , 19 , 428 – 434 .
   Web of Science ®Google Scholar
• Piszcz , P. ; Suszek , M. ; Grzeskiewicz , S. ; Glod , B.K. Analysis of PAHs in food using improved GC/MS and RP-HPLC assays: Influence of temperature on selectivity . Tluszcze Jadalne. 2007 , 42 ( 3/4 ), 193 – 200 .
   Google Scholar
• Krauss , M. ; Hollender , J. Analysis of nitrosamines in wastewater: exploring the trace level quantification capabilities of a hybrid linear ion trap/orbitrap mass spectrometer . Anal. Chem. 2008 , 80 ( 3 ), 834 – 842 .
   PubMed Web of Science ®Google Scholar
• Liu , X. ; Zhao , Y.-Y. ; Chan , K. ; Hrudey , S.E. ; Li , X.F. ; Li , J. Analysis of nitrosamines by capillary electrospray-high field asymmetric waveform ion mobility spectrometry-MS with programmed compensation voltage . Electrophoresis. 2007 , 28 ( 9 ), 1327 – 1334 .
   PubMed Web of Science ®Google Scholar
• Zhao , Y.-Y. ; Boyd , J. ; Hrudey , S.E. ; Li , X.F. Characterization of new nitrosamines in drinking water using liquid chromatography tandem mass spectrometry . Environ. Sci. Technol. 2006 , 40 ( 24 ), 7636 – 7641 .
   PubMed Web of Science ®Google Scholar
• Eerola , S. ; Otegui , I. ; Saari , L. ; Rizzo , A. Applications of liquid chromatography-atmospheric pressure chemical ionization mass spectrometry and tandem mass spectrometry to the determination of volatile nitrosamines in dry sausages . Food Addit. Contam. 1998 , 15 ( 3 ), 270 – 279 .
   PubMedGoogle Scholar
• Cardenes , L. ; Ayala , J.H. ; Gonzalez , V. ; Afonso , A.M. Fast microwave-assisted dansylation of N-nitrosamines . Analysis by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. A. 2002 , 946 ( 1–2 ), 133 – 140 .
   Google Scholar
• Kargaki , S. ; Mylona , K. ; Kouvarakis , A. ; Pergantis , S.A. ; Stephanou , E.G. Emerging contaminants: Analysis of biocides and corrosion inhibitors in wastewater treatment plants using liquid chromatography tandem mass spectrometry . Preprints of Extended Abstracts presented at the ACS National Meeting, American Chemical Society, Division of Environmental Chemistry 2006 , 46 ( 2 ), 1049 .
   Google Scholar
• Kloepfer , A. ; Quintana , J. B. ; Reemtsma , T. Operational options to reduce matrix effects in liquid chromatography-electrospray ionization-mass spectrometry analysis of aqueous environmental samples. J. Chromatogr. A 2005, 1067 (1–2), 153–160.
   Google Scholar
• Kloepfer , A. ; Jekel , M. ; Reemtsma , T. Determination of benzothiazoles from complex aqueous samples by liquid chromatography-mass spectrometry following solid-phase extraction . J. Chromatogr. A 2004 , 1058 ( 1–2 ), 81 – 88 .
   Google Scholar
• Reemtsma , T. Determination of 2-substituted benzothiazoles of industrial use from water by liquid chromatography/electrospray ionization tandem mass spectrometry . Rapid Comm. Mass Spectrom. 2000 , 14 ( 17 ), 1612 – 1618 .
   PubMed Web of Science ®Google Scholar