A LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY METHOD FOR THE SIMULTANEOUS DETERMINATION OF CAPECITABINE, 5′-DEOXY-5-FLUOROCYTIDINE, 5′-DEOXY-5-FLUOROURIDINE, 5-FLUOROURACIL, AND 5-FLUORODIHYDROURACIL IN HUMAN PLASMA

REFERENCES

• Lamont , E. B. ; Schilsky , R. L. The Oral Fluoropyrimidines in Cancer Chemotherapy . Clin. Cancer Res. 1999 , 5 , 2289 – 2296 .
   PubMed Web of Science ®Google Scholar
• Malet-Martino , M. ; Martino , R. Clinical Studies of Three Oral Prodrugs of 5-Fluorouracil (Capecitabine, UFT, S-1): A Review . Oncologist 2002 , 7 , 288 – 323 .
   PubMed Web of Science ®Google Scholar
• Johnston , P. G. ; Kaye , S. Capecitabine: A Novel Agent for the Treatment of Solid Tumors . Anticancer Drugs 2001 , 12 , 639 – 646 .
   PubMed Web of Science ®Google Scholar
• Grem , J. L. 5-Fluorouracil: Forty-Plus and Still Ticking. A Review of Its Preclinical and Clinical Development . Invest. New Drugs 2000 , 18 , 299 – 313 .
   PubMed Web of Science ®Google Scholar
• Wagstaff , A. J. ; Ibbotson , T. ; Goa , K. L. Capecitabine: A Review of Its Pharmacology and Therapeutic Efficacy in the Management of Advanced Breast Cancer . Drugs 2003 , 63 , 217 – 236 .
   PubMed Web of Science ®Google Scholar
• Lassere , Y. ; Hoff , P. Management of Hand-Foot Syndrome in Patients Treated with Capecitabine (Xeloda®) . Eur. J. Oncol. Nurs. 2004 , 8 , S31 – S40 .
   PubMedGoogle Scholar
• Webster-Gandy , J. D. ; How , C. ; Harrold , K. Palmar-plantar Erythrodysesthesia (PPE): A literature Review with Commentary on Experience in a Cancer Centre . Eur. J. Oncol. Nurs. 2007 , 11 , 238 – 246 .
   PubMed Web of Science ®Google Scholar
• Zufía , L. ; Aldaz , A. ; Giráldez , J. Simple Determination of Capecitabine and Its Metabolites by Liquid Chromatography with Ultraviolet Detection in a Single Injection . J. Chromatogr. B 2004 , 809 , 51 – 58 .
   PubMed Web of Science ®Google Scholar
• Xu , Y. ; Grem , J. L. Liquid chromatography-Mass Spectrometry Method for the Analysis of the Anti-Cancer Agent Capecitabine and Its Nucleoside Metabolites in Human Plasma . J. Chromatogr. B 2003 , 783 , 273 – 285 .
   PubMed Web of Science ®Google Scholar
• Guichard , S. M. ; Mayer , I.; I. Jodrell , D. Simultaneous Determination of Capecitabine and Its Metabolites by HPLC and Mass Spectrometry for Preclinical and Clinical Studies . J. Chromatogr. B 2005 , 826 , 232 – 237 .
   PubMed Web of Science ®Google Scholar
• Siethoff , C. ; Orth , M. ; Ortling , A. ; Brendel , E. ; Wagner-Redeker , W. Simultaneous Determination of Capecitabine and Its Metabolite 5-fluorouracil by Column Switching and Liquid Chromatographic/Tandem Mass Spectrometry . J. Mass. Spectrom. 2004 , 39 , 884 – 889 .
   PubMed Web of Science ®Google Scholar
• Licea-Perez , H. ; Wang , S. ; Bowen , C. Development of a Sensitive and Selective LC-MS/MS Method for the Determination of Alpha-fluoro-beta-alanine, 5-fluorouracil and Capecitabine in Human Plasma. J. Chromatogr. B. 2009, 877, 1040–1046.
   Google Scholar
• Vainchtein , L. D. ; Rosing , H. ; Schellens , J. H. ; Beijnen , J. H. A New, Validated HPLC-MS/MS Method for the Simultaneous Determination of the Anti-Cancer Agent Capecitabine and its Metabolites: 5′-deoxy-5-fluorocytidine, 5′-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in Human Plasma . Biomed. Chromatogr. 2009 , 24 , 374 – 378 .
   Google Scholar
• Dhananjeyan , M. R. ; Liu , J. ; Bykowski , C. ; Trendel , J. A. ; Sarver , J. G. ; Ando , H. ; Erhardt , P. W. Rapid and Simultaneous Determination of Capecitabine and its Metabolites in Mouse Plasma, Mouse Serum, and in Rabbit Bile by High-performance Liquid Chromatography . J. Chromatogr. A 2007 , 1138 , 101 – 108 .
   PubMed Web of Science ®Google Scholar
• U.S. Food and Drug Administration. Guidance for industry. Bioanalytical Method Validation, http://www.fda.gov/cder/guidance/index.html (accessed May 2004) .
   Google Scholar
• Viswanathan , C. T. ; Bansal , S. ; Booth , B. ; DeStefano , A. J. ; Rose , M. J. ; Sailstad , J. ; Shah , V. P. ; Skelly , J. P. ; Swann , P. G. ; Weiner , R. Quantitative Bioanalytical Methods Validation and Implementation: Best Practices for Chromatographic and Ligand Binding Assays . Pharm. Res. 2007 , 24 , 1962 – 1973 .
   PubMed Web of Science ®Google Scholar
• Farenc , C. ; Fabreguette , J. R. ; Bressolle , F. Pk-fit: A Pharmacokinetic/Pharmacodynamic and Statistical Data Analysis Software . Comput. Biomed. Res. 2000 , 33 , 315 – 329 .
   Google Scholar
• Research and Development for Population Pharmacokinetics (RDPP) . Pk-Fit Computer Program, Ver. 2.1. , RDPP : Montpellier , France , 1999 .
   Google Scholar
• Bressolle , F. ; Bromet-Petit , M. ; Audran , M. Validation of Liquid Chromatographic and Gas Chromatographic Methods. Applications to Pharmacokinetics . J. Chromatogr. B. 1996 , 686 , 3 – 10 .
   PubMed Web of Science ®Google Scholar
• Poole , C. ; Gardiner , J. ; Twelves , C. ; Johnston , P. ; Harper , P. ; Cassidy , J. ; Monkhouse , J. ; Banken , L. ; Weidekamm , E. ; Reigner , B. Effect of Renal Impairment on the Pharmacokinetics and Tolerability of Capecitabine (Xeloda) in Cancer Patients . Cancer Chemother. Pharmacol. 2002 , 49 , 225 – 234 .
   PubMed Web of Science ®Google Scholar
• Reigner , B. ; Blesch , K. ; Weidekamm , E. Clinical Pharmacokinetics of Capecitabine . Clin. Pharmacokinet. 2001 , 40 , 85 – 104 .
   PubMed Web of Science ®Google Scholar
• Reigner , B. ; Watanabe , T. ; Schuller , J. ; Lucraft , H. ; Sasaki , Y. ; Bridgewater , J. ; Saeki , T. ; McAleer , J. ; Kuranami , M. ; Poole , C. ; Kimura , M. ; Monkhouse , J. ; Yorulmaz , C. ; Weidekamm , E. ; Grange , S. Pharmacokinetics of Capecitabine (Xeloda) in Japanese and Caucasian Patients with Breast Cancer . Cancer Chemother. Pharmacol. 2003 , 52 , 193 – 201 .
   PubMed Web of Science ®Google Scholar
• Urien , S. ; Rezai , K. ; Lokiec , F. Pharmacokinetic Modelling of 5-FU Production from Capecitabine - A Population Study in 40 Adult Patients with Metastatic Cancer . J. Pharmacokinet. Pharmacodyn. 2005 , 32 , 817 – 833 .
   Google Scholar