LC, LC–MS/TOF, AND MS^N STUDIES FOR THE SEPARATION, IDENTIFICATION, AND CHARACTERIZATION OF DEGRADATION PRODUCTS OF LINEZOLID

REFERENCES

• Anderegg , T. ; Sader , H. ; Fritsche , T. Trends in Linezolid Susceptibility Patterns: Report from the 2002–2003 Worldwide ZYVOX Annual Appraisal of Potency and Spectrum (ZAAPS) Program . Int. J. Antimicrob. Agents. 2005 , 26 , 13 – 21 .
   PubMed Web of Science ®Google Scholar
• Fortun , J. ; Martin-Davila , P. ; Navas , E. ; Jesus Perez-Elias , M. ; Cobo , J. ; Tato , M. ; De la Pedrosa , E. G. ; Gomez-Mampaso , E. ; Moreno , S. Linezolid for the Treatment of Multidrug-Resistant Tuberculosis . J. Antimicrob. Chemother. 2005 , 56 , 180 – 185 .
   PubMed Web of Science ®Google Scholar
• Shinabarger , D. ; Marotti , K. ; Murray , R. ; Lin , A. ; Melchior , E. ; Swaney , S. ; Dunyak , D. ; Demyan , W. ; Buysse , J. Mechanism of Action of Oxazolidinones: Effects of Linezolid and Eperezolid on Translation Reactions . Antimicrob. Agents. Chemother. 1997 , 41 , 2132 – 2161 .
   PubMed Web of Science ®Google Scholar
• Zhang , H. ; Hu , F. ; Wang , Q. Determination of Linezolid in Human Plasma by HPLC . Chin. Pharm. J. 2010 , 18 , 1417 – 1420 .
   Google Scholar
• Phillips , O. A. ; Abdel-Hamid , M. E. Determination of Novel Antibacterial Triazolylmethyl Oxazolidinones Concentration in Human Plasma by APCI-LC-MS: Application to Stability Study . J. Pharm. Pharmaceut. Sci. 2008 , 11 , 22 – 31 .
   Web of Science ®Google Scholar
• Traunmuller , F. ; Mauric , O. ; Popovic , M. ; Joukhadar , C. Rapid and Sensitive Determination of the Antibiotic Linezolid in Low Plasma Volumes by High-Performance Liquid Chromatography . J. Chromatogr. Sci. 2010 , 48 , 325 – 327 .
   PubMed Web of Science ®Google Scholar
• Peng , G. W. ; Stryd , R. P. ; Murata , S. ; Igarashi , M. ; Shiba , K. ; Aoyama , H. ; Aoyama , M. T. Zenki , T. ; Ozawa , N. Determination of Linezolid in Plasma by Reverse-Phase High-Performance Liquid Chromatography . J. Pharm. Biomed. Anal. 1999 , 20 , 65 – 73 .
   PubMed Web of Science ®Google Scholar
• Lopes , C. ; Salgado , H. Development of a Validated Stability Indicating LC Assay and Stress Degradation Studies of Linezolid in Tablets . Chromatographia. 2009 , 69 , 129 – 135 .
   Web of Science ®Google Scholar
• Agrawal , H. ; Mahadik , K. R. ; Paradkar , R. ; Kaul , N. Stability Indicating HPTLC Determination of Linezolid as Bulk Drug and in Pharmaceutical Dosage Form . Drug Dev. Ind. Pharm. 2003 , 29 , 1119 – 1126 .
   PubMed Web of Science ®Google Scholar
• Bebawy , L. I. Stability Indicating Method for the Determination of Linezolid in the Presence of Its Alkaline-Induced Degradation Products . Talanta. 2003 , 60 , 945 – 953 .
   PubMed Web of Science ®Google Scholar
• Gordi , T. ; Tan , L. H. ; Hong , C. ; Hopkins , N. J. ; Francom , S. F. ; Slatter , J. G. ; Antal , E. J. The Pharmacokinetics of Linezolid are not Affected by Concomitant Intake of the Antioxidant Vitamins C and E . J. Clin. Pharmacol. 2003 , 43 , 1161 – 1167 .
   PubMed Web of Science ®Google Scholar
• Slatter , J. G. ; Adams , L. A. ; Bush , E. C. ; Chiba , K. ; Daley-Yates , P. T. ; Feenstra , K. L. ; Koike , S. ; Ozawa , N. ; Peng , G. W. ; Sams , J. P. ; Schuette , M. R. ; Yamazaki , S. Pharmacokinetics, Toxicokinetics, Distribution, Metabolism and Excretion of Linezolid in Mouse, Rat and Dog. Xenobiotica. 2002, 32, 907–924.
   PubMed Web of Science ®Google Scholar
• Krishna Reddy , K. ; Rao , S. M. ; Reddy , G. O. ; Suresh , T. ; Babu , J. M. ; Dubey , P. K. ; Vyas , K. Isolation and Characterization of Process-Related Impurities in Linezolid . J. Pharm. Biomed. Anal. 2002 , 30 , 635 – 642 .
   PubMed Web of Science ®Google Scholar
• ICH, Stability Testing of New Drug Substances and Products Q1A(R2). In International Conference on Harmonization; IFMPA: Geneva, 2003 .
   Google Scholar
• WHO, Draft Stability Testing of Active Pharmaceutical Ingredients and Pharmaceutical Products, World Health Organization: Geneva, 2007 .
   Google Scholar
• ICH, Stability Testing: Photostability Testing of New Drug Substances and Products Q1B. In International Conference on Harmonization; IFPMA: Geneva, 1996 .
   Google Scholar
• Singh , S. ; Bakshi , M. Guidance on Conduct of Stress Tests to Determine Inherent Stability of Drugs . Pharm. Technol. On-line 2000 , 24 , 1 – 14 .
   Google Scholar
• ICH, Validation of Analytical Procedures: Text and Methodology, Q2(R1). In International Conference on Harmonization; IFPMA: Geneva, 2005 .
   Google Scholar