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Original Articles

CHIRAL HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF ENANTIOMERS OF THREO-LOSIGAMONE

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Pages 1238-1244 | Published online: 09 May 2012

REFERENCES

  • Borowicz , K. K. ; Malek , R. ; Kimber-Trojnar , Z. ; Sobieszek , G. Isobolographic Analysis of the Interactions of Losigamone, Remacemide, Zonisamide with Conventional Antiepileptic Drugs in the Maximal Electroshock Test in Mice-Preliminary Report . Neurol. Neurochir. Pol. 2003 , 3 , 35 – 36 .
  • Zhang , C. L. ; Chatterjee , S. S. ; Stein , U. ; Heinemann , U. Comparison of the Effects of Losigamone and Its Isomers on Maximal Electroshock Induced Convulsions in Mice and on Three Different Patterns of Low Magnesium Induced Epilepticform Activity in Slices of the Rat Temporal Cortex . Naunyn-Schmiedeberg's Arch. Pharmacol. 1992 , 345 , 85 – 92 .
  • Kohr , G. ; Heinemann , U. Effects of the Tetronic Acid Derivatives AO33 (losigamone) and AO78 on Epileptiform Activity and on Stimulus-Induced Calcium Concentration Changes in Rat Hippocampal Slices. Epilepsy Res. 1990, 7, 49–58.
  • Schmitz , D. ; Gloveli , T. ; Heinemann , U. Effects of Losigamone on Synaptic Potentials and Spike Frequency Habituation in Rat Entorhinal Cortex and Hippocarnpal CA1 Neurones . Neurosci. Lett. 1995 , 200 , 141 – 143 .
  • Bialer , M. ; Johannessen , S. I. ; Kupferberg , H. J. ; Levy , R. H. ; Loiseau , P. ; Perucca , E. Progress Report on New Antiepileptic Drugs: A Summary of the Fourth EILAT Conference (EILAT IV) . Epilepsy Res. 1999 , 34 , 1 – 41 .
  • Draguhn , A. ; Jungclaus , M. ; Sokolowa , S. ; Heimemann , U. Losigamone Decreases Spontaneous Synaptic Activity in Cultured Hippocampal Neurons . Eur. J. Pharmacol. 1997 , 325 , 245 – 251 .
  • Baulac , M. ; Klement , S. Efficacy and Safety of Losigamone in Partial Seizures: A Randomized Double-Blind Study . Epilepsy Res. 2003 , 55 , 177 – 189 .
  • Gebhardt , C. ; Breustedt , J. M. ; Nöldner , M. ; Chatterjee , S. S. ; Heinemann , U. The Antiepileptic Drug Losigamone Decreases the Persistent Na+ Current in Rat Hippocampal Neurons . Brain Res. 2001 , 920 , 27 – 31 .
  • Srinivasan , J. ; Richens , A. ; Davies , J. A. The Effect of Losigamone (AO-33) on Electrical Activity and Excitatory Amino Acid Release in Mouse Cortical Slices . Br. J. Pharmacol. 1997 , 122 , 1490 – 1494 .
  • Torchin , C. D. ; Yonekawa , W. D. ; Kapetanovic , I. M. ; Kupferberg , H. J. Chiral High-Performance Liquid Chromatographic Analysis of Enantiomers of Losigamone: A New Candidate Antiepileptic Drug . J. Chromatogr. B 1999 , 724 , 101 – 108 .
  • Peeters , P. A. M. ; Van Lier , J. J. ; Van De Merbel , N. ; Oosterhuis , B. ; Wieling , J. ; Jonkman , J. H. G. ; Klessing , K. ; Biber , A. Pharmacokinetics of [14C]-Labeled Losigamone and Enantiomers After Oral Administration to Healthy Subjects . Eur. J. Drug Metab. Pharmacokinet 1998 , 23 , 45 – 53 .
  • Zhang , T. ; Nguyen , D. ; Franco , P. Reversed-Phase Screening Strategies for Liquid Chromatography on Poly Saccharide-Derived Chiral Stationary Phases . J. Chromatogr. A 2010 , 1217 , 1048 – 1055 .
  • Zhang , T. ; Nguyen , D. ; Franco , P. ; Murakami , T. ; Ohnishi , A. ; Kurosawa , H. Cellulose 3,5-dimethylphenylcarbamate Immobilized on Silica: A New Chiral Stationary Phase for the Analysis of Enantiomers . Anal. Chim. Acta 2006 , 557 , 221 – 228 .
  • Peng , L. ; Jayapalan , S. ; Chankvetadze , B. ; Chankvetadze , B. ; Farkas , T. Reversed-Phase Chiral HPLC and LC/MS Analysis with Tris(chloromethylphenycarbamate) Derivatives of Cellulose and Amylase as Chiral Stationary Phase . J. Chromatogr. A 2010 , 1217 , 6942 – 6955 .
  • Liu , G. Z. Design, Synthesis and Bioactivities of New Polysubstituted Butneolides Derivatives . National Natural Science Foundation of China , China No.20772112 , 2010 .
  • Zhou , J. ; Ren , Q. L. ; Wu , P. D. Chromatographic Separation of Fluoxetine Hydrochloride Enantiomers by Cellulose Chiral Stationary Phase . J. Liq. Chromatogr. R. T. 2005 , 28 , 3229 – 3242 .

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