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Journal of Liquid Chromatography & Related Technologies Volume 35, 2012 - Issue 16
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Original Articles

LC, LC-MS/MS STUDIES FOR IDENTIFICATION AND CHARACTERIZATION OF DEGRADATION PRODUCTS OF LAMOTRIGINE AND ESTABLISHMENT OF MECHANISTIC APPROACH TOWARDS DEGRADATION

Anand Avinash Mahajan School of Pharmacy and Technology Management, SVKMs NMIMS, Mumbai, India
,
Anil Keshavlal Thaker School of Pharmacy and Technology Management, SVKMs NMIMS, Mumbai, India
,
Sandeep Kale DBT-ICT Center for Energy Biosciences, Institute of Chemical Technology, Mumbai, India
&
Krishnapriya Mohanraj Bombay College of Pharmacy, Kalina, Mumbai, IndiaCorrespondence[email protected]
Pages 2255-2271 | Published online: 05 Oct 2012

REFERENCES

  • Bakshi , M. ; Singh , S. Development of Validated Stability Indicating Assay Method – Critical Review . J. Pharm. Biomed. Anal. 2002 , 28 , 1011 – 1040 .
  • ICH Topic Q1A (R2) . 2003 . Guideline on stability testing of new drug substances and products , Geneva .
  • ICH Topic Q3B (R2). 2006. Guideline on Impurities in new Drug products, Geneva .
  • ICH Topic Q6A. 1999. Guideline on Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances, Geneva .
  • US Food and Drug Administration (USFDA 21CFR211). 2008. Current Good Manufacturing Practice for Finished Pharmaceuticals , Rockville , MD , USA .
  • Bakshi , M. ; Singh , S. Guidance on Conduct of Stress Tests to Determine Inherent Stability of Drugs. Pharmaceutical Technology On-Line. 2000.
  • Sweetman , S. C. Martindale, the Complete Drug Reference, , 35 ed. , 2007 , Pharmaceutical Press , London , pp. 439 – 441 .
  • Emami , J. ; Ghassami , N. ; Ahmadi , F. Development and Validation of a New HPLC Method for Determination of Lamotrigine and Related Compounds in Tablet Formulations . J. Pharm. Biomed. Anal. 2006 , 40 ( 4 ), 999 – 1005 .
  • Elizabeth , G. S.; Darla R. L. ; Mohamed , A. V. ; Matthew , D. K. Simultaneous Determination of Lamotrigine, Zonisamide, and Carbamazepine in Human Plasma by High-Performance Liquid Chromatography. Biomed. Chromatogr. 2007, 21 (3), 225–228.
  • Dumortier , D. ; Pons , D. ; Zerrouk , A. ; Januel , D. ; Saba , G. ; Degrassat , K. Concomitant HPLC Method for Determination of Lamotrigine, Carbamazepine, and 10, 11- Carbamazepine Epoxide in Plasma Using Dual UV 240–220 nm Wavelength Detection . J. Liq. Chromatogr. R. T. 2001 , 24 ( 20 ), 3171 – 3180 .
  • Shah , H. J. ; Subbaiah , G. ; Patel , D. M. ; Suhagia , B. N. ; Patel , C. N. Rapid Quantification of Lamotrigine in Human Plasma by Two LC Systems Connected with Tandem MS . J. Chromatogr. Sci. 2010 , 48 ( 5 ), 375 – 381 .
  • Beck , O. ; Ohman , I. ; Nordgren , H. K. Determination of Lamotrigine and Its Metabolites in Human Plasma by Liquid Chromatography-Mass Spectrometry . Therapeut. Drug Monitor. 2006 , 28 ( 5 ), 603 – 607 .
  • Polisetty , S. ; Khagga , M. ; Buchi , R. R. ; Koduri , S. ; Srinivas , V. Development of a Validated Stability Indicating LC Method for Lamotrigine . Chromatographia 2009 , 70 , 271 – 276 .
  • ICH Topic Q1B . 1996 . Guideline on Photostability Testing of New Drug Substances and Products , Geneva .
  • ICH Topic Q2 (R1) . 2005 . Validation of Analytical Procedures: Text and Methodology , Geneva .

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