159
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

QUANTITATIVE DETERMINATION OF LEVETIRACETAM IN HUMAN URINE USING HPLC-UV AND ITS IDENTIFICATION BY LC-ESI-MS

, &
Pages 2568-2579 | Published online: 01 Aug 2013

REFERENCES

  • Sweetman , S. C. Martindale – The Complete Drug Reference, , 33rd ed. , Pharmaceutical Press : London , 2002 .
  • Lakshmana Rao , A. ; Naga Jahnavi , V. E. A Validated RP-HPLC Method for the Estimation of Levetiracetam in Bulk and Pharmaceutical Formulations . E. J. Chem. 2010 , 7 ( 2 ), 600 – 604 .
  • Joetta , J. ; Brown , P. I. ; Urry , F. M. ; McMillin , G. A. Drug Monitoring and Toxicology: A Procedure for the Monitoring of Levetiracetam and Zonisamide by HPLC–UV . J. Anal. Toxicol. 2006 , 30 ( 1 ), 27 – 30 .
  • Martens-Lobenhoffer , J. ; Bode-Böger , S. M. Determination of Levetiracetam in Human Plasma with Minimal Sample Pretreatment . J. Chromatogr. B 2005 , 819 ( 1 ), 197 – 200 .
  • Al Masud , A. ; Shamsul Arefeen , M. D. ; Kaisarul Islam , M. ; Hasan , M. Development and Validation of a RP-HPLC Method for the Estimation of Levetiracetam in Bulk and Pharmaceutical Formulation . J. Chem. Pharm. Res. 2011 , 3 ( 1 ), 324 – 329 .
  • Saravanan , G. ; Jyothi , G. ; Suresh , Y. ; Annerao , A. ; Ramakrishna , M. ; Yogeshwar , R. M. ; Ravibabu , B. LC Method for the Determination of the Stability of Levetiracetam Drug Substance under Stressing Conditions . Chromatographia 2008 , 67 ( 1–2 ), 173 – 177 .
  • Guoa , T. ; Oswalda , L. M. ; Rao Mendua , D. ; Soldin , S. J. Determination of Levetiracetam in Human Plasma/Serum/Saliva by Liquid Chromatography-Electrospray Tandem Mass Spectrometry . Clinica Chimica Acta 2007 , 375 ( 1–2 ), 115 – 118 .
  • Contin , M. ; Mohamed , S. ; Albani , F. ; Riva , R. ; Baruzzi , A. Simple and Validated HPLC–UV Analysis of Levetiracetam in Deproteinized Plasma of Patients with Epilepsy . J. Chromatogr. B 2008 , 873 ( 1 ), 129 – 132 .
  • Rao Mendua , D. ; Soldin , S. J. Simultaneous Determination of Levetiracetam and its Acid Metabolite (ucb L057) in Serum/Plasma by Liquid Chromatography Tandem Mass Spectrometry . J. Clin. Biochem. 2010 , 43 ( 4–5 ), 485 – 489 .
  • Matar , K. M. Quantification of Levetiracetam in Human Plasma by Liquid Chromatography–Tandem Mass Spectrometry: Application Totherapeutic Drug Monitoring . J. Pharm. Biomed. Anal. 2008 , 48 ( 3 ), 822 – 828 .
  • Pucci , V. ; Raggi , M. A. Analysis of Antiepileptic Drugs in Biological Fluids by Means of Electrokinetic Chromatography . Electrophoresis 2005 , 26 ( 4–5 ), 767 – 782 .
  • Shihabi , Z. K. ; Oles , K. ; Hinsdale , M. Analysis of the Antiepileptic Drug Keppra by Capillary Electrophoresis . J. Chromatogr. A 2003 , A1004 ( 1–2 ), 9 – 12 .
  • Greiner-Sosanko , E. ; Giannoutsos , S. ; Lower , D. R. ; Virji , M. A. ; Krasowski , M. D. Drug Monitoring: Simultaneous Analysis of Lamotrigine, Oxcarbazepine, 10-hydroxycarbazepine, and Zonisamide by HPLC-UV and a rapid GC method using a Nitrogen-Phosphorus Detector for Levetiracetam . J. Chromatogr. Sci. 2007 , 45 ( 9 ), 612 – 622 .
  • Isoherranen , N. ; Roeder , M. ; Soback , S. ; Yagen , B. ; Schurig , V. ; Bialer , M. Enantioselective Analysis of Levetiracetam and its enantiomer R-alpha-ethyl-2-oxo-pyrrolidine Acetamide using Gas Chromatography and Ion Trap Mass Spectrometric Detection. J. Chromatogr. B Biomed. Sci. 2000, 745 (2), 325–332.
  • Asunción Alonso-Lomillo , M. ; Domínguez-Renedo , O. ; Matos , P. J. ; Arcos-Martínez , M. Electrochemical Determination of Levetiracetam by Screen-Printed based Biosensors . Bioelectrochemistry 2009 , 74 ( 2 ), 306 – 309 .
  • Juan , J. B. N. ; Carmen , G. C. ; Maria , J. V. L. ; Virginia , R. R. Enantiomeric Determination, Validation and Robustness Studies of Racemic Citalopram in Pharmaceutical Formulations by Capillary Electrophoresis . J. Chromatogr. A 2005 , 1072 ( 2 ), 249 – 257 .
  • Draper , N. R. ; Smith , H. Fitting a Straight Line by Least Squares . In Applied Regression Analysis ; Wiley : New York , 1981 , pp 22 – 40 .
  • The European Agency for the Evaluation of Medical Products ICH Topic Q2B Note for Guidance on Validation of Analytical Procedures: Methodology; GPMP/ICH/281/95, IFPMA, Geneva, 1996, 1–8 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.