157
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

RELATIONSHIP BETWEEN HYDROPHOBICITY AND RPLC RETENTION BEHAVIOR OF AMPHOTERIC COMPOUNDS

, , , &

REFERENCES

  • Snyder , L. R. ; Dolan , J. W. ; Gant , J. R. Gradient Elution in High-Performance Liquid-Chromatography . J. Chromatogr. 1979 , 165 ( 1 ), 3 – 30 .
  • Lu , P. C. ; Lu , X. M. Development of a High-Performance Liquid Chromatograph with Artificial-Intelligence . J. Chromatogr. 1984 , 292 ( 1 ), 169 – 188 .
  • Poole , C. F. ; Poole , S. K. Column Selectivity from the Perspective of the Solvation Parameter Model . J. Chromatogr. A 2002 , 965 ( 1–2 ), 263 – 299 .
  • Black , J. P. L. HPLC Separation of Analyte in Sample Mixture of Dihydromorphine, Morphine, Morphinone and Hydromorphone, Where the Isocratic HPLC Method Employ Ion-Pair Solute-Solute Ion-Exchange Mobile Phase Techniques in Reversed Phase Chromatography. U.S. Patent 2008206883-A1, August 28, 2008.
  • Schoenmakers , P. J. ; Vanmolle , S. ; Hayes , C. M. G. ; Uunk , L. G. M. Effects of pH in Reversed-Phase Liquid-Chromatography . Anal. Chim. Acta 1991 , 250 ( 1 ), 1 – 19 .
  • Marko-Varga , G. ; Barcelo , D. Liquid Chromatographic Retention and Separation of Phenols and Related Aromatic Compounds on Reversed Phase Columns . Chromatographia 1992 , 34 ( 3–4 ), 146 – 154 .
  • Gritti , F. ; Guiochon , G. Comparison Between the Adsorption Behaviors of an Organic Cation and an Organic Anion on Several Reversed-Phase Liquid Chromatography Adsorbents . J. Chromatogr. A 2004 , 1048 ( 1 ), 1 – 15 .
  • Ming , X. ; Han , S. Y. ; Qi , Z. C. ; Sheng , D. ; Lian , H. Z. Chromatographic Retention Prediction and Octanol-Water Partition Coefficient Determination of Monobasic Weak Acidic Compounds in Ion-Suppression Reversed-Phase Liquid Chromatography Using Acids as Ion-Suppressors . Talanta 2009 , 79 ( 3 ), 752 – 761 .
  • Cao , X. W. ; Ming , X. ; Wei , Y. N. ; Liu , C. C. ; Han , S. Y. ; Chen , F. Y. ; Lian , H. Z. ; Ge , X. Retention Behavior of Weakly Ionizable Acidic Compounds in Ion-Suppression Reverse-Phase Liquid Chromatography with Ternary Mobile Phase . Asian J. Chem. 2012 , 24 ( 5 ), 1979 – 1982 .
  • Han , S. Y. ; Ming , X. ; Qi , Z. C. ; Sheng , D. ; Lian , H. Z. Retention Prediction and Hydrophobicity Estimation of Weak Acidic Compounds by Reversed-Phase Liquid Chromatography Using Acetic and Perchloric Acids as Ion Suppressors . Anal. Bioanal. Chem. 2010 , 398 ( 6 ), 2731 – 2743 .
  • Qi , Z. C. ; Han , S. Y. ; Wu , Z. Y. ; Chen , F. Y. ; Cao , X. W. ; Lian , H. Z. ; Mao , L. Retention Prediction and Hydrophobicity Measurement of Weakly Basic Compounds in Reversed-Phase Liquid Chromatography Using Ammonia and Triethylamine as Ion-Suppressors . Curr. Anal. Chem. 2014 , 10 ( 1 ), 172 – 181 .
  • Du , C. M. ; Valko , K. ; Bevan , C. ; Reynolds , D. ; Abraham , M. H. Rapid Gradient RP HPLC Method for Lipophilicity Determination: A Solvation Equation Based Comparison with Isocratic Methods . Anal. Chem. 1998 , 70 ( 20 ), 4228 – 4234 .
  • Griffin , S. ; Wyllie , S. G. ; Markham , J. Determination of Octanol-Water Partition Coefficient for Terpenoids Using Reversed-Phase High-Performance Liquid Chromatography . J. Chromatogr. A 1999 , 864 ( 2 ), 221 – 228 .
  • Berthod , A. ; Carda-Broch , S. ; Garcia-Alvarez-Coque , M. C. Hydrophobicity of Ionizable Compounds. A Theoretical Study and Measurements of Diuretic Octanol-Water Partition Coefficients by Countercurrent Chromatography . Anal. Chem. 1999 , 71 ( 4 ), 879 – 888 .
  • Mant , C. T. ; Hodges , R. S. Reversed-Phase Liquid Chromatography as a Tool in the Determination of the Hydrophilicity/Hydrophobicity of Amino Acid Side-Chains at a Ligand-Receptor Interface in the Presence of Different Aqueous Environments-II. Effect of Varying Peptide Ligand Hydrophobicity . J. Chromatogr. A 2002 , 972 ( 1 ), 61 – 75 .
  • Mant , C. T. ; Kovacs , J. M. ; Kim , H. M. ; Pollock , D. D. ; Hodges , R. S. Intrinsic Amino Acid Side-Chain Hydrophilicity/Hydrophobicity Coefficients Determined by Reversed-Phase High-Performance Liquid Chromatography of Model Peptides: Comparison with Other Hydrophilicity/Hydrophobicity Scales . Biopolymers 2009 , 92 ( 6 ), 573 – 595 .
  • Takacsnovak , K. ; Szasz , G. ; Budvaribarany , Z. ; Jozan , M. ; Lore , A. Relationship Study Between Reversed-Phase HPLC Retention and Octanol Water Partition Among Amphoteric Compounds . J. Liq. Chromatogr. 1995 , 18 ( 4 ), 807 – 825 .
  • Bronaugh , R. L. ; Congdon , E. R. Percutaneous Absorption of Hair-Dyes: Correlation with Partition Coefficients . J. Invest. Dermatol. 1984 , 83 ( 2 ), 124 – 127 .
  • Hansch , C. ; Bjorkroth , J. P. ; Leo , A. Hydrophobicity and Central Nervous System Agents on the Principle of Minimal Hydrophobicity in Drug Design . J. Pharm. Sci. 1987 , 76 ( 9 ), 663 – 687 .
  • Rekker , R. F. The Hydrophobic Fragmental Constant-A Citation-Classic Commentary on the Hydrophobic Fragmental Constant-Its Derivation and Application with a Means of Characterizing MembraneSystems by Rekker, R. F. CC/Eng. Tech. Appl. Sci. 1993 , ( 20 ), 8 – 8 .
  • Braumann , T. Determination of Hydrophobic Paramenters by Reversed-Phased Liquid Chromatography: Theory, Experimental Techiniques, and Application in Studies on Quantitative Structure-Activity Relationships . J. Chromatogr. 1986 , 373 ( 2 ), 191 – 225 .
  • Helweg , C. ; Nielsen , T. ; Hansen , P. E. Determination of Octanol-Water Partition Coefficients of Polar Polycyclic Aromatic Compounds (N-PAC) by High Performance Liquid Chromatography. Chemosphere 1997, 34 (8), 1673–1684.
  • Lian , H. Z. ; Wang , W. H. ; Li , D. N. Retention Behavior of o-Phthalic, 3-Nitrophthalic, and 4-Nitrophthalic Acids in Ion-Suppression Reversed-Phase High Performance Liquid Chromatography Using Acids Instead of Buffers as Ion-Suppressors . J. Sep. Sci. 2005 , 28 ( 11 ), 1179 – 1187 .
  • Han , S. Y. ; Liang , C. ; Zou , K. ; Qiao , J. Q. ; Lian , H. Z. ; Ge , X. Influence of Variation in Mobile Phase pH and Solute pKa with the Change of Organic Modifier Fraction on QSRRs of Hydrophobicity and RP-HPLC Retention of Weakly Acidic Compounds . Talanta 2012 , 101 , 64 – 70 .
  • Han , S. Y. ; Qiao , J. Q. ; Zhang , Y. Y. ; Lian , H. Z. ; Ge , X. Determination of n-Octanol/Water Partition Coefficients of Weak Ionizable Solutes by RP-HPLC with Neutral Model Compounds . Talanta 2012 , 97 , 355 – 361 .
  • Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/ljlc.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.