Investigation of Chromatographic Behavior of Leflunomide and its Identification in Pharmaceutical Dosage form by Reversed Phase Liquid Chromatography

References

• Bartlett , R. R. ; Brendel , S. ; Zielinski , T. ; Schorlemmer , H. U. Lefunomide, an Immunorestoring Drug for the Therapy of Autoimmune Disorders, Especially Rheumatoid Arthritis . Transplantation Proceedings 1996 , 28 , 3074 – 3078 .
   PubMed Web of Science ®Google Scholar
• Bergés , R. ; Sanz-Nebot , V. ; Barbosa , J. 2000 . Modelling Retention in Liquid Chromatography as a Function of Solvent Composition and pH of the Mobile Phase . J. Chromatogr. A 2000 , 869 , 27 – 39 .
   PubMed Web of Science ®Google Scholar
• Demiralay , E. C. ; Koc , D. ; Daldal , Y. D. ; Cakır , C. Determination of Chromatographic and Spectrophotometric Dissociation Constants of Some Beta Lactam Antibiotics . J Pharm. and Biomed. Anal. 2012 , 71 , 139 – 143 .
   PubMed Web of Science ®Google Scholar
• Sanz-Nebot , V. ; Toro , I. ; Barbosa , J. Prediction of Retention Behavior and Evaluation of pK a Values of Peptides and Quinolones in Liquid Chromatography . J. Chromatogr. A 2001 , 933 , 45 – 56 .
   PubMed Web of Science ®Google Scholar
• Caliaro , G. A. ; Herbots , C. A. Determination of pKa Values of Basic New Drug Substances by CE . J. Pharm. Biomed. Anal. 2001 , 26 , 427 – 434 .
   PubMed Web of Science ®Google Scholar
• Davies , N. H. ; Euerby , M. R. ; McCalley , D. V. Study of Overload for Basic Compounds in Reversed-Phase High Performance Liquid Chromatography as a Function of Mobile Phase pH . J. Chromatogr. A 2006 , 1119 , 11 – 19 .
   PubMed Web of Science ®Google Scholar
• Buckenmaier , S. ; McCalley , D. V. ; Euerby , M. R. Determination of pKa Values of Organic Bases in Aqueous Acetonitrile Solutions Using Capillary Electrophoresis . J. Chromatogr. A 2003 , 1004 , 71 – 79 .
   PubMed Web of Science ®Google Scholar
• Demiralay , E. C. ; Cubuk , B. ; Alsancak , G. ; Ozkan , S. A. Combined Effect of Polarity and pH on The Chromatographic Behaviour of Some Angiotensin II Receptor Antagonists and Optimization of Their Determination in Pharmaceutical Dosage Forms . J. Pharm. Biomed. Anal. 2010 , 53 , 475 – 482 .
   PubMed Web of Science ®Google Scholar
• Ruiz , R. ; Ràfols , C. ; Rosés , M. ; Bosch , E. A Potentially Simpler Approach to Measure Aqueous pKa of Insoluble Basic Drugs Containing Amino Groups . J. Pharm. Sci. 2003 , 92 , 1473 – 1481 .
   PubMed Web of Science ®Google Scholar
• Yasuda , M. Dissociation Constants of Some Carboxylic Acids in Mixed Aqueous Solvents . Bull. Chem. Soc. Japan 1959 , 32 , 429 – 432 .
   Web of Science ®Google Scholar
• Shedlovsky , T. Electrolytes . New York : Pergamon Press , 1962 .
   Google Scholar
• Chan , V. ; Charles , B. G. ; Tett , S. E. Rapid Determination of the Active Leflunomide Metabolite A77 1726 in Human Plasma by High-Performance Liquid Chromatography . J. Chromatogr. B 2004 , 803 , 331 – 335 .
   PubMed Web of Science ®Google Scholar
• Pawiñski , T. ; Gralak , B. HPLC Determination of Active Metabolite of Leflunomide in Plasma . Chem. Anal. (Warsaw) 2005 , 50 , 785 – 790 .
   Web of Science ®Google Scholar
• Roon , E. N. V. ; Yska , J. P. ; Raemaekers , J. ; Jansen , T. L. Th. A. ; Wanrooy , M. V. ; Brouwers , J. R. B. J. A Rapid and Simple Determination of A77 1726 in Human Serum by High-Performance Liquid Chromatography and Its Application for Optimization of Leflunomide Therapy . J. Pharm. Biomed. Anal. 2004 , 36 , 17 – 22 .
   PubMed Web of Science ®Google Scholar
• Scmidt , A. ; Schwind , B. ; Gillich , M. ; Brune , K. ; Hinz , B. Simultaneous Determination of Leflunomide and Its Active Metabolite, A771726, in Human Plasma by High-Performance Liquid Chromatography . Biomed. Chromatogr. 2003 , 17 , 276 – 281 .
   PubMed Web of Science ®Google Scholar
• Sobhani , K. ; Garrett , D. A. ; Liu , D. P. ; Rainey , P. M. A Rapid and Simple High-Performance Liquid Chromatography Assay for the Leflunomide Metabolite, Teriflunomide (A77 1726), in Renal Transplant Recipients . Am. J. Clin. Pathol. 2010 , 133 ( 3 ), 454 – 457 .
   PubMed Web of Science ®Google Scholar
• Miron , D. S. ; Soldattelli , C. ; Schapoval , E. E. S. HPLC with Diode-Array Detection for Determination of Leflunomide in Tablets. Chromatographia 2006, 63, 283–287.
   Web of Science ®Google Scholar
• Srinivas , R. V. ; Sunanda , K. K. ; Narasimha , R. M. ; Allam , A. R. ; Maheswari , I. L. ; Srinubabu , G. Development and Validation of LC Method for the Determination of Leflunomide in Pharmaceutical Formulations Using an Experimental Design . African J. Pure Appl. Chem. 2008 , 2 ( 2 ), 10 – 17 .
   Google Scholar
• Yeniceli , D. ; Doğrukol-Ak , D. ; Tuncel , M. Determination of Leflunomide in Tablets by High Performance Liquid Chromatography . J. Pharm. Biomed. Anal. 2006 , 40 , 197 – 201 .
   PubMed Web of Science ®Google Scholar
• Rondinini , S. ; Mussini , P. R. ; Mussini , T. Reference Value Standard and Primary Standard for pH Measurements in Organic Solvents and Water-Organic Solvent Mixtures of Moderate to High Permittivities . Pure Appl. Chem. 1987 , 59 , 1549 – 1560 .
   Web of Science ®Google Scholar
• Sýkora , D. ; Tesařová , E. ; Popl , M. Interactions of Basic Compounds in Reversed-Phase High-Performance Liquid Chromatography Influence of Sorbent Character, Mobile Phase Composition, and pH on Retention of Basic Compounds . J. Chromatogr. A 1997 , 758 , 37 – 51 .
   Web of Science ®Google Scholar
• NLREG Version 4.0. P.H. Sherrod. http:/www.sandh.com/Sherrod, 1991 .
   Google Scholar
• Marvin Sketch program, Chemaxon, http://www.chemaxon.com, 2011 .
   Google Scholar
• McNally , R. The United States Pharmacopoeia . Taunton , M.A : United States Pharmacopoeial Convention, Inc., 2000 .
   Google Scholar
• Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/ljlc.
   Google Scholar