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Original Articles

A Rapid Hydrophilic Interaction Liquid Chromatographic Method for Simultaneous Determination of Three Ephedrine Alkaloids in Ephedra Herb and Its Preparations

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References

  • Hailer, C. A.; Duan, M.; Benowitz, N. L.; Jacob, P. Concentrations of Ephedra Alkaloids and Caffeine in Commercial Dietary Supplements. J. Anal. Toxicol. 2004, 28, 145–151.
  • Hong, H.; Chen, H. B.; Yang, D. H.; Shang, M. Y.; Wang, X.; Cai, S. Q.; Mikage, M. Comparison of Contents of Five Ephedrine Alkaloids in Three Official Origins of Ephedra Herb in China by High-Performance Liquid Chromatography. J. Nat. Med. 2011, 65, 623–628.
  • Bensky, D.; Clavey, S.; Stöger, E. (eds.) Materia Medica. In Chinese Herbal Medicine (third ed.); Seattle: Eastland Press, 2004; 3–6 pp.
  • Pellati, F.; Benvenuti, S. Determination of Ephedrine Alkaloids in Ephedra Natural Products using HPLC on a Pentafluorophenylpropyl Stationary Phase. J. Pharm. Biomed. Anal. 2008, 48, 254–263.
  • Chinese Pharmacopoeia Commission, Pharmacopoeia of the People’s Republic of China, Chinese, Beijing, 2010.
  • Jiang, T. F.; Lv, Z. H.; Wang, Y. H. Chiral Separation of Ephedrine Alkaloids from Ephedra Sinica Extract and its Medicinal Preparation using Cyclodextrin-modified Capillary Zone Electrophoresis. J. Anal. Chem. 2007, 62, 85–89.
  • Ma, Y. J.; Li, Q. L.; Wang, W. F.; Zhou, M.; He, C. X.; Liu, J. Separation and Determination of Ephedrine, Pseudoephedrine and Methylephedrine by Capillary Electrophoresis with Electrochemiluminescence Detection. J. Instrum. Anal. 2012, 31, 127–132.
  • Hou, J. G.; Zheng, J.; Shamsi, S. A. Simultaneous Chiral Separation of Ephedrine Alkaloids by MEKC-ESI-MS using Polymeric Surfactant II: Application in Dietary Supplements. Electrophoresis 2007, 28, 1426–1434.
  • Wang, M.; Marriott, P. J.; Chan, W. H. Enantiomeric Separation and Quantification of Ephedrine-type Alkaloids in Herbal Materials by Comprehensive Two-dimensional Gas Chromatography. J. Chromatogr. A. 2006, 1112, 361–368.
  • Lin, K.; Fan, Q.; Yang, C. G.; Deng, K. Y. Determination of Ephedrine, Pseudoephedrine and Methylephedrine by RP-LC in Mahuang. Chin. Trad. Herb Drugs. 2006, 37, 282–284.
  • An, Q.; Lu, N. W.; Dong, Y. M. Chromatographic Fingerprint Coupled with Hierarchical Clustering Analysis and Principal Component Analysis for Quality Evaluation and Original Discrimination of Rhizomes of Helleborus Thibetanus Franch by HPLC-DAD. Anal. Methods 2013, 5, 5775–5784.
  • Zou, P.; Wang, S. Y.; Zhang, Z. Q. Determination of Ephedrine Alkaloids in Xiaoerqingrezhike Oral Liquid by Off-line 2D-HPLC System. Lishizhen Med. Mater. Med. Mater. 2006, 17, 1643–1644.
  • Heaton, J.; Gray, N.; Cowan, D. A.; Plumb, R. S.; Legido-Quigley, C.; Smith, N. W. Practical Observations on the Performance of Bare Silica in Hydrophilicinteraction Compared with C18 Reversed-phase Liquid Chromatography. J. Chromatogr. A. 2012, 1228, 329–337.
  • Buszewski, B.; Welerowicz, T.; Kowalkowski, T. Effect of Chemically Bonded Stationary Phases and Mobile Phase Composition on B-blockers Retention in RP-HPLC. Biomed. Chromatogr. 2009, 23, 324–333.
  • Rütters, H.; Möhring, Th.; Rullkötter, J.; Griep-Raming, J.; Metzger, J. O. The Persistent Memory Effect of Triethylamine in the Analysis of Phospholipids by Liquid Chromatography/Mass Spectrometry. Rapid. Commun. Mass. Sp. 2000, 14, 122–123.
  • Bard, B.; Carrupt, P. A.; Martel, S. Lipophilicity of Basic Drugs Measured by Hydrophilic Interaction Chromatography. J. Med. Chem. 2009, 52, 3416–3419.
  • Al-Tannak, N. F.; Bawazeer, S.; Siddiqui, T. H.; Watson, D. G. The Hydrophilic Interaction Like Properties of Some Reversed Phase High Performance Liquid Chromatography Columns in the Analysis of Basic Compounds. J. Chromatogr. A. 2011, 1218, 1486–1491.
  • Petruczynik, A.; Waksmundzka-Hajnos, M. Application of Hydrophilic Interaction Chromatography in Phytochemical Analysis. Acta Chromatogr. 2013, 25, 1–25.
  • Hemström, P.; Irgum, K. Hydrophilic Interaction Chromatography. J. Sep. Sci. 2006, 29, 1784–1821.
  • van Nuijs, A. L. N.; Tarcomnicu, I.; Covaci, A. Application of Hydrophilic Interaction Chromatography for the Analysis of Polar Contaminants in Food and Environmental Samples. J. Chromatogr. A. 2011, 1218, 5964–5874.
  • Naidong, W. Bioanalytical Liquid Chromatography Tandem Mass Spectrometry Methods on Underivatized Silica Columns with Aqueous/Organic Mobile Phases. J. Chromatogr. B. 2003, 796, 209–224.
  • Buszewski, B.; Noga, S. Hydrophilic Interaction Liquid Chromatography (HILIC)—A Powerful Separation Technique. Anal. Bioanal. Chem. 2012, 402, 231–247.
  • Kahsay, G.; Song, H.; Van Schepdael, A.; Cabooter, D.; Adams, E. Hydrophilic Interaction Chromatography (HILIC) in the Analysis of Antibiotics. J. Pharmaceut. Biomed. 2014, 87, 142–154.
  • Heaton, J. C.; Wang, X.; Barber, W. E.; Buckenmaierc, S. M. C.; McCalley, D. V. Practical Observations on the Performance of Bare Silica in Hydrophilic Interaction Compared with C18 Reversed-phase Liquidchromatography. J. Chromatogr. A. 2014, 1328, 7–15.
  • Hasemann, P.; ter Balk, M.; Preu, L.; Wätzig, H. Separation of Cold Medicine Ingredients using a Precise MEKC Method at Elevated pH. Electrophoresis 2007, 28, 1779–1787.
  • DrugBank. http://www.drugbank.ca/drugs/DB00852 (accessed May 10, 2014).
  • Bianchini, R. M.; Castellano, P. M.; Kaufman, T. S. Development and Validation of an HPLC Method for the Determination of Process-related Impurities in Pridinol Mesylate, Employing Experimental Designs. Anal. Chim. Acta 2009, 654, 141–147.
  • Wiberg, K.; Andersson, M.; Hagman, A.; Jacobsson, S. P. Peak Purity Determination with Principal Component Analysis of High-performance Liquid Chromatography–Diode Array Detection Data. J. Chromat. A. 2004, 1029, 13–20.

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