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Original Articles

Quantitation of lovastatin and its hydroxy acid in human plasma by high-performance liquid chromatography-tandem mass spectrometry

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Pages 668-675 | Received 30 Jun 2018, Accepted 02 Aug 2018, Published online: 08 Oct 2018

References

  • Armstrong, E. J.; Safo, P. K. Pharmacology of cholesterol and lipoprotein metabolism. In Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy; Lippincott Williams &Wilkins: Baltimore, MD, 2005; pp 369–389.
  • Bradford, R. H.; Shear, C. L.; Chremos, A. N.; Dujovne, C.; Downton, M.; Franklin, F. A.; Gould, A. L.; Hesney, M.; Higgins, J.; Hurley, D. P. Expanded Clinical Evaluation of Lovastatin (EXCEL) Study Results. I. Efficacy in Modifying Plasma Lipoproteins and Adverse Event Profile in 8245 Patients with Moderate Hypercholesterolemia. Arch. Intern. Med. 1991, 151, 43–49. DOI: 10.1001/archinte.1991.00400010067008.
  • Alberts, A. W.; Chen, J.; Kuron, G.; Hunt, V.; Huff, J.; Hoffman, C.; Rothrock, J.; Lopez, M.; Joshua, H.; Harris, E. Mevinolin: A Highly Potent Competitive Inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc. Natl. Acad. Sci. USA. 1980, 77, 3957–3961. DOI: 10.1073/pnas.77.7.3957.
  • Curran, M. P.; Goa, K. L. Lovastatin Extended Release: A Review of Its Use in the Management of Hypercholesterolaemia. Drugs 2003, 63, 685–699. DOI: 10.2165/00003495-200363070-00007.
  • Martin-Castillo, F.; Martinez, A. A.; Escobar, N. P.; Escribano, N. B. Therapeutic Compliance in the Prevention of Primary Cardiovascular Diseases with Lovastatine. PRELOVAS Study. Med. Clin. 2004, 123, 692–696. DOI: 10.1016/S0025-7753(04)75332-4.
  • Góralczyk, K.; Soszyńska, K.; Haus, O.; Bielis, R.; Rość, D. The Influence of Lovastatin on Thrombomodulin Gene Expression in Vascular Endothelial Cells-in Vitro Study. Folia Histochem. Cytobiol. 2009, 47, 43–45. DOI:10.2478/v10042-009-0012-4.
  • Zhao, Q.; Li, M.; Chen, M.; Zhou, L.; Zhao, L.; Hu, R.; Yan, R.; Dai, K. Lovastatin Induces Platelet Apoptosis. Environ. Toxicol. Phar. 2016, 42, 69–75. DOI: 10.1016/j.etap.2016.01.002.
  • Nölting, S.; Maurer, J.; Spöttl, G.; Aristizabal Prada, E. T.; Reuther, C.; Young, K.; Korbonits, M.; Göke, B.; Grossman, A.; Auernhammer, C. J. Additive Anti-Tumor Effects of Lovastatin and Everolimus In Vitro through Simultaneous Inhibition of Signaling Pathways. PLoS One 2015, 10, e0143830. DOI: 10.1371/journal.pone.0143830.
  • Lennernäs, H.; Fager, G. Pharmacodynamics and Pharmacokinetics of the HMG-CoA Reductase Inhibitors. Similarities and differences. Clin. Pharmacokinet. 1997, 32, 403–425. DOI: 10.2165/00003088-199732050-00005.
  • Zhang, Z. F.; Yang Zh, Y. HPLC Determination of Lovastatin in Rat Tissue. Chroma. 2007, 66, 487–491. DOI: 10.1365/s10337-007-0395-3.
  • Morris, M. J.; Gilbert, J. D.; Hsieh, J. Y.; Matuszewski, B. K.; Ramjit, H. G.; Bayne, W. F. Determination of the HMG-CoA Reductase Inhibitors Simvastatin, Lovastatin, and Pravastatin in Plasma by Gas Chromatography/Chemical Ionization Mass Spectrometry. Biol. Mass Spectrom. 1993, 22, 1–8. DOI: 10.1002/bms.1200220102.
  • Zeng, W. H.; Cai, J. H.; Wu, Y. L. Determination of Lovastatin in Human Plasma by GC-MS. Fenxi Ceshi Xuebao 2000, 19, 69–73. DOI: 10.3969/j.issn.1004-4957.2000.04.022
  • Li, M.; Fan, L.-Y.; Zhang, W.; Cao, C.-X. Stacking and quantitative analysis of lovastatin in urine samples by the transient moving chemical reaction boundary method in capillary electrophoresis. Anal. Bioanal. Chem. 2007, 387, 2719–2725. DOI: 10.1007/s00216-007-1169-3.
  • Ye, L. Y.; Firby, P. S.; Moore, M. J. Determination of Lovastatin in Human Plasma Using Reverse-Phase High-Performance Liquid Chromatography with UV Detection. Ther Drug Monit. 2000, 22, 737–741. DOI: 10.1097/00007691-200012000-00014.
  • Li, L.; Sun, J.; Sun, Y. X.; He, Z. G. LC-ESI-MS Determination of Lovastatin in Human Plasma. Chroma. 2008, 67, 621–625. DOI: 10.1365/s10337-008-0554-1.
  • Yuan, H. Y.; Wang, F.; Tu, J. Y.; Peng, W. X.; Li, H. D. Determination of Lovastatin in Human Plasma by Ultra-Performance Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry and Its Application in a Pharmacokinetic Study. J. Pharm. Biomed. Anal. 2008, 46, 808–813. DOI: 10.1016/j.jpba.2007.12.005.
  • Wang, D.; Wang, D. M.; Qin, F.; Chen, L. Y.; Li, F. M. Determination of Lovastatin in Human Plasma by Ultra-Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry. Biomed. Chromatogr. 2008, 22, 511–518. DOI: 10.1002/bmc.962.
  • Liao, D. X.; Qin, Y. P.; Gong, X. L.; Liang, M. Z.; Yu, Q.; Nan, F.; Xiang, J. Determination of Lovastatin and Its Active Metabolites in Human Plasma with High Performance Liquid Chromatography-Tandem Mass Spectrometry. J. Sichuan Univ. (Med. Sci. Edu.). 2009, 40, 730–733. DOI: 10.3969/j.issn.1672-173X.2009.04.040
  • Wu, Y.; Zhao, J.; Henion, J.; Korfmacher, W. A.; Lapiguera, A. P.; Lin, C. C. Microsample Determination of Lovastatin and Its Hydroxy Acid Metabolite in Mouse and Rat Plasma by Liquid Chromatography/Ionspray Tandem Mass Spectrometry. J. Mass Spectrom. 1997, 32, 379–387. DOI: 10.1002/(SICI)1096-9888(199704)32:4<379::AID-JMS461>3.0.CO;2-9.
  • Mignini, F.; Tomassoni, D.; Streccioni, V.; Traini, E.; Amenta, F. Pharmacokinetics and Bioequivalence Study of Two Tablet Formulations of Lovastatin in Healthy Volunteers. Clin. Exp. Hypertens. 2008, 30, 95–108. DOI: 10.1080/10641960801944249.
  • Ju, W. J.; Peng, K. W.; Yang, S. Y.; Sun, H. J.; Mario, S.; Zhuo, W. M. A Simple Protein Precipitation-Based Simultaneous Quantification of Lovastatin and Its Active Metabolite Lovastatin Acid in Human Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Using Polarity Switching. J. Chromatogr. Sep. Tech. 2015, 6, 268–276. DOI: 10.4172/2157-7064.1000268
  • Guo, M.; Zhao, L.; Li, M.; Fu, Q.; Pu, X.; Liu, B.; He, Z.; Yang, L. Simultaneous Determination of Lovastatin and Its Metabolite Lovastatin Acid in Rat Plasma Using UPLC-MS/MS with Positive/Negative Ion-Switching Electrospray Ionization: Application to a Pharmacokinetic Study of Lovastatin Nanosuspension. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2016, 1023–1024, 55–61. DOI: 10.1016/j.jchromb.2016.04.044.
  • Food and Drug Administration. Guidance for Industry: Bioanalytical Method Validation; US Department of Health and Human Services, FDA, Center for Drug Evaluation and Research: Rockville, MD, 2013.
  • Zhang, M.; Gao, F.; Cui, X.; Zhang, Y.; Sun, Y.; Gu, J. Development and Validation of an Improved Method for the Quantitation of Sertraline in Human Plasma Using LC-MS-MS and Its Application to Bioequivalence Studies. J. Chromatogr. Sci. 2011, 49, 89–93. DOI: 10.1093/chrsci/49.2.89.
  • Apostolou, C.; Kousoulos, C.; Dotsikas, Y.; Soumelas, G. S.; Kolocouri, F.; Ziaka, A.; Loukas, Y. L. An Improved and Fully Validated LC-MS/MS Method for the simultaneous Quantification of Simvastatin and Simvastatin Acid in Human Plasma. J. Pharm. Biomed. Anal. 2008, 46, 771–779. DOI: 10.1016/j.jpba.2007.12.001.
  • Yang, A. Y.; Sun, L.; Musson, D. G.; Zhao, J. J. Application of a Novel Ultra-Low Elution Volume 96-Well Solid-Phase Extraction Method to the LC/MS/MS Determination of Simvastatin and Simvastatin Acid in Human Plasma. J. Pharm. Biomed. Anal. 2005, 38, 521–527. DOI: 10.1016/j.jpba.2005.01.016.
  • Shah, V. P.; Midha, K. K.; Findlay, J. W.; Hill, H. M.; Hulse, J. D.; McGilveray, I. J.; McKay, G.; Miller, K. J.; Patnaik, R. N.; Powell, M. L.; et al. Bioanalytical Method Validation-A Revisit with a Decade of Progress. Pharm. Res. 2000, 17, 1551–1557. DOI: 10.1023/A:1007669411738.

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