RP-HPLC of New Antidepressant 2-Amino-2-Oxazolines: A Comparative Study of Their Lipophilicity

References

• Bourin , M. , Creuzet , M. H. , Jarry , C. and Collombel , M. C. 1988 . A 2-amino-2-oxazoline derivative as an antidepressant in mice . Arzneim.-Forsch./Drug Res. , 38 : 666 – 688 .
   PubMedGoogle Scholar
• Bosc , J. J. , Jarry , C. , Carpy , A. , Panconi , E. and Descas , P. 1992 . Synthesi antidepressant activity of 5-(1-aryl-4-piperazino)methy-2-am., oxazoiines . Eur. J. Med. Chem. , in press
   Google Scholar
• Vaugien , B. , Descas , P. , Jarry , C. , Panconi , E. and Mosser , J. 1991 . Drugs of the Future , 16 : 893 – 894 . J. Roux 3224
   Google Scholar
• Leo , A. , Hansch , C. and EIkins , D. 1971 . Chem. Rev. , 71 : 525 – 616 . Partitions coefficients and their
   Web of Science ®Google Scholar
• McCall , J. 1975 . Liquid-liquid partition coefficients by high pressure chromatography . J. Med. Chem. , 18 : 549 – 552 .
   PubMed Web of Science ®Google Scholar
• Carney , C. F. 1985 . Estimation of molecular parameters by HPLC . Chromatogr. , 8 : 2781 – 2789 .
   Google Scholar
• Braumann , T. 1986 . Determination of hydrophobic parameters by RP-HPLC Theory, experimental techniques and application in studies on quantitative structure-activity relationships . J. Chromatogr. , 373 : 225
   Google Scholar
• Demotes-Mainard , F. , Jarry , C. , Thomas , J. and Dallet , P. 1991 . RP - HPLC retention data of new 2-amino-2-oxazolines. An approach of their lipophilic properties . J. Liq. Chromatogr. , 14 : 795 – 805 .
   Web of Science ®Google Scholar
• Bourgeois , G. , Jarry , C. C. , Bosc , J. J. , Deleris , G. and Pays , E. 1991 . Electron impact of new 5-substituted 2-amino-2-oxazolines . Org. Mass Spectrom , 26 : 109 – 112 .
   Google Scholar
• Albert , A. and Serjeant , E. P. 1962 . Ionization constants of acids and bases Methuen London
   Google Scholar
• Jarry , C. , Bosc , J. J. , Ouhabi , J. and Carpy , A. 1990 . 2-amino-2-oxazoline I. Crystal and molecular structure of 5-(1-aryl-4-piperazino)methyl substituted derivatives with antidepressant activity . Arch. Pharm. , 323 : 157 – 161 .
   PubMed Web of Science ®Google Scholar
• Broto , P. , Moreau , G. and Vandyke , C. 1984 . Molecular structures : perception autocorrelation descriptor and SAR studies . Eur. J. Med. Chem. , 19 : 71 – 78 .
   Web of Science ®Google Scholar
• Topliss , J. G. 1972 . Utilization of operational schemes for analog synnalog drug design . J. Med. Chem. , 15 : 1006 – 1011 .
   PubMed Web of Science ®Google Scholar
• Minick , D. J. , Frenz , J. H. , Patrick , M. A. and Brent , D. A. 1988 . A cornprend method for determining hydrophobicity constants by RP- . J. Med. Chem. , 31 : 1923 – 1933 .
   PubMed Web of Science ®Google Scholar
• Bosc , J. J. , Jarry , C. , Carpy , A. , Panconi , E. and Descas , P. 1992 . Synthesis and antidepressant activity of 5-(1-aryl-4-piperazino)methy-2-amino-2-oxazolines . Eur. J. Med. Chem. , in press
   Google Scholar
• Vaugien , B. , Descas , P. , Jarry , C. , Panconi , E. and Mosser , J. 1991 . Drugs of the Future , 16 : 893 – 894 . J. Roux, COR 3224
   Google Scholar
• Leo , A. , Hansch , C. and EIkins , D. 1971 . Partitions coefficients and their uses . Chem. Rev. , 71 : 525 – 616 .
   Web of Science ®Google Scholar
• Mc Call , J. 1975 . Liquid-liquid partition coefficients by high pressure liquid chromatography . J. Med. Chem. , 18 : 549 – 552 .
   PubMed Web of Science ®Google Scholar
• Carney , C. F. 1985 . Estimation of molecular parameters by HPLC . J. Liq. Chromatogr. , 8 : 2781 – 2789 .
   Web of Science ®Google Scholar
• Braumann , T. 1986 . Determination of hydrophobic parameters by RP-HPLC. Theory, experimental techniques and application in studies on quantitative structure-activity relationships . J. Chromatogr. , 373 : 191 – 225 .
   PubMed Web of Science ®Google Scholar
• Demotes-Mainard , F. , Jarry , C. , Thomas , J. and Dallet , P. 1991 . RP - HPLC retention data of new 2-amino-2-oxazolines. An approach of their lipophilic properties . J. Liq. Chromatogr. , 14 : 795 – 805 .
   Web of Science ®Google Scholar
• Bourgeois , G. , Jarry , C. C. , Bosc , J. J. , Deleris , G. and Pays , E. 1991 . Electron impact of new 5-substituted 2-amino-2-oxazolines . Org. Mass Spectrom. , 26 : 109 – 112 .
   Google Scholar
• Albert , A. and Serjeant , E. P. 1962 . Ionization constants of acids and bases , London : Methuen .
   Google Scholar
• Jarry , C. , Bosc , J. J. , Ouhabi , J. and Carpy , A. 1990 . 2-amino-2-oxazoline I. Crystal and molecular structure of 5-(1-aryl-4-piperazino)methyl substituted derivatives with antidepressant activity . Arch. Pharm. , 323 : 157 – 161 .
   PubMed Web of Science ®Google Scholar
• Broto , P. , Moreau , G. and Vandyke , C. 1984 . Molecular structures : perception, autocorrelation descriptor and SAR studies . Eur. J. Med. Chem. , 19 : 71 – 78 .
   Web of Science ®Google Scholar
• Topliss , J. G. 1972 . Utilization of operational schemes for analog synthesis in drug design . J. Med. Chem. , 15 : 1006 – 1011 .
   PubMed Web of Science ®Google Scholar
• MIniek , D. J. , Frenz , J. H. , Patrick , M. A. and Brent , D. A. 1988 . A comprehensive method for determining hydrophobicity constants by RP-HPLC . J. Med. Chem. , 31 : 1923 – 1933 .
   PubMedGoogle Scholar
• Forfar , I. , Jarry , C. , Fayet , J. P. and Carpy , A. 1992 . 2-amino-2-oxazolines VI., Study of the tautomerism by experimental and theoretical methods . Arch. Pharm. , in press
   Google Scholar
• Hansch , C. and Leo , A. 1979 . Substituent constants for correlations analysis in chemistry and biology , New York : John Wiley and Sons .
   Google Scholar