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Original Articles

Determination of Phenytoin and Its Major Metabolite, 5-(p-Hydroxyphenyl)-5-phenylhydantoin in Urine by High-Performance Liquid Chromatography

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Pages 1135-1142 | Received 17 Jun 1992, Accepted 06 Jul 1992, Published online: 23 Sep 2006

References

  • Sawchuk , R. J. and Cartier , L. L. 1980 . Liquid-chromatographic Method for Simultaneous Determination of Phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in Plasma and Urine . Clin Chem. , 26/27 : 835 – 839 .
  • Dickinson , R. G. , Hooper , W. D. , Patterson , M. , Eddie , M. J. and Maguire , B. 1985 . Extent of Urinary Excretion of p-hydroxyphenytoin in Healthy Subjects Given Phenytoin . Ther. Drug Monitor. , 7 : 283 – 289 .
  • Boucher , B. A. , Rodman , J. H. , Jaresko , G. S. , Rasmussen , S. N. , Watridge , C. B. and Fabian , T. C. 1988 . Phenytoin Pharmacokinetics in Critically I11 Trauma Patients . Clin. Pharmacol. Ther. , 44 : 675 – 683 .
  • Nolan , P. E. , Marcus , F. I. , Hoyer , G. L. , Bliss , M. and Gear , K. 1989 . Pharmacokinetic Interaction Between Phenytoin and Amiodarone in Healthy Volunteers . Clin. Pharmacol. Ther. , 46 : 43 – 50 .

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