Development and Validation of a Stability-Indicating HPLC Method for the Determination of Tobramycin and Its Related Substances in an Ophthalmic Suspension

REFERENCES

• 1994 . “ The United States Pharmacopeia 23 ” . In Tobramycin Monograph , 1558 Rockville, MD : US Pharmacopeial Convention .
   Google Scholar
• Barends , D. M. , Blauw , J. H. , Mijnsbergen , C. W. , Govers , C. J. L. R. and Hulshoff , A. 1985 . Pre-column derivatization of aminoglycosides with 1-Fluoro-2,4-Dinitrofluorobenzene . J. Chromatogr. , 322 : 321 – 331 .
   Web of Science ®Google Scholar
• Barends , D. M. , Zwann , C. L. and Hulsoff , A. 1981 . Micro-determination of Tobramycin in serum by high-performance liquid chromatography with ultraviolet detection . J. Chromatogr. , 225 : 417 – 426 .
   PubMed Web of Science ®Google Scholar
• Rubasheva , L. M. , Lavrova , M. F. and Brazhnikova , M. G. 1983 . Quantitative determination of the antibiotic tobramycin using high-performance liquid chromatography . Antibiotiki , 28 : 254 – 258 .
   PubMedGoogle Scholar
• Gambardella , P. , Punziano , R. , Gionti , M. , Guadalupi , C. , Mancini , G. and Mangia , A. 1985 . Quantitative determination and separation of analogues of aminoglycosides antibiotics by high-performance liquid chromatography . J. Chromatog. , 348 : 229 – 240 .
   PubMed Web of Science ®Google Scholar
• Lai , F. and Sheehan , T. 1992 . Enhancement of detection sensitivity and cleanup selectivity for tobramycin through pre-column derivatization . J. Chromatogr. , 609 : 173 – 179 .
   PubMed Web of Science ®Google Scholar
• 1994 . The United States Pharmacopeia 23 621, Chromatography Monograph , 1768 – 1779 . Rockville, MD : U. S. Pharmacopeal Convention .
   Google Scholar