The Effect of Krocina™ on Decreasing Substance User Withdrawal Syndrome, Craving, Depression and Stress: A Double-Blind Randomized Parallel Clinical Trial

References

• Abbaszadeh-Mashkani, S., Hoque, S. S., Banafshe, H. R., & Ghaderi, A. (2021). The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment. Phytotherapy Research: PTR, 35(3), 1486–1494. https://doi.org/https://doi.org/10.1002/ptr.6913
   PubMed Web of Science ®Google Scholar
• Adamson, S. J., Deering, D. E., Sellman, J. D., Sheridan, J., Henderson, C., Robertson, R., Pooley, S., Campbell, S. D., & Frampton, C. M. (2012). An estimation of the prevalence of opioid dependence in New Zealand. The International Journal on Drug Policy, 23(1), 87–89.
   PubMed Web of Science ®Google Scholar
• Akhondzadeh, S., Tahmacebi‐Pour, N., Noorbala, A. A., Amini, H., Fallah‐Pour, H., Jamshidi, A. H., & Khani, M. (2005). Crocus sativus L. in the treatment of mild to moderate depression: a double‐blind, randomized and placebo‐controlled trial. Phytotherapy Research, 19(2), 148–151. https://doi.org/https://doi.org/10.1002/ptr.1647
   PubMed Web of Science ®Google Scholar
• Amin-Esmaeili, M., Rahimi-Movaghar, A., Sharifi, V., Hajebi, A., Radgoodarzi, R., Mojtabai, R., Hefazi, M., & Motevalian, A. (2016). Epidemiology of illicit drug use disorders in Iran: prevalence, correlates, comorbidity and service utilization results from the Iranian Mental Health Survey. Addiction, 111(10), 1836–1847. https://doi.org/https://doi.org/10.1111/add.13453
   PubMed Web of Science ®Google Scholar
• Angarita, G. A., Emadi, N., Hodges, S., & Morgan, P. T. (2016). Sleep abnormalities associated with alcohol, cannabis, cocaine, and opiate use: a comprehensive review. Addiction Science & Clinical Practice, 11(1), 9. https://doi.org/https://doi.org/10.1186/s13722-016-0056-7
   PubMedGoogle Scholar
• Asghari, A., Saed, F., & Dibajnia, P. (2008). Psychometric properties of the Depression Anxiety Stress Scales-21 (DASS-21) in a non-clinical Iranian sample. International Journal of Psychology, 2(2), 82–102.
   Google Scholar
• Ayatollahi, H., Javan, A. O., Khajedaluee, M., Shahroodian, M., & Hosseinzadeh, H. (2014). Effect of Crocus sativus L.(saffron) on coagulation and anticoagulation systems in healthy volunteers. Phytotherapy Research: PTR, 28(4), 539–543.
   PubMed Web of Science ®Google Scholar
• Azadfard, M. H. M., & Leaming, J. M. (2021). Opioid Addiction. [Updated 2021 Apr 19]. In: StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK448203/.
   Google Scholar
• Bennett, G., (1992). Miller, W. R., & Rollnick, S. (1991). Motivational interviewing: Preparing people to change addictive behavior. New York: Guilford Press, 1991. Pp. xvii + 348. £24.95 hardback, £11.50 paper. ISBN 0–89862–566–1. Journal of Community & Applied Social Psychology, 2(4), 299–300. https://doi.org/https://doi.org/10.1002/casp.2450020410
   Web of Science ®Google Scholar
• Callaly, T., Trauer, T., Munro, L., & Whelan, G. (2001). Prevalence of psychiatric disorder in a methadone maintenance population. Australian & New Zealand Journal of Psychiatry, 35(5), 601–605. https://doi.org/https://doi.org/10.1080/0004867010060507
   PubMed Web of Science ®Google Scholar
• Coloma-Carmona, A., Carballo, J. L., Rodríguez-Marín, J., & Pérez-Carbonell, A. (2019). Withdrawal symptoms predict prescription opioid dependence in chronic pain patients. Drug and Alcohol Dependence, 195, 27–32.
   PubMed Web of Science ®Google Scholar
• Curran, H. V., Kleckham, J., Bearn, J., Strang, J., & Wanigaratne, S. (2001). Effects of methadone on cognition, mood and craving in detoxifying opiate addicts: a dose-response study. Psychopharmacology, 154(2), 153–160. https://doi.org/https://doi.org/10.1007/s002130000628
   PubMed Web of Science ®Google Scholar
• Dorri, S. A., Hosseinzadeh, H., Abnous, K., Hasani, F. V., Robati, R. Y., & Razavi, B. M. (2015). Involvement of brain-derived neurotrophic factor (BDNF) on Malathion induced depressive-like behavior in subacute exposure and protective effects of crocin. Iranian Journal of Basic Medical Sciences, 18(10), 958–966.
   PubMed Web of Science ®Google Scholar
• Dunlap, B., & Cifu, A. S. (2016). Clinical management of opioid use disorder. JAMA, 316(3), 338–339. https://doi.org/https://doi.org/10.1001/jama.2016.9795
   PubMed Web of Science ®Google Scholar
• Eghtesadi, R., Safavi, S., Rasouli-Azad, M., & Ghaderi, A. (2020). The effects of saffron on psychiatric disorders: A review. International Journal of Pharmaceutical Research, 12(2), 292–302.
   Google Scholar
• Ghaderi, A., Asbaghi, O., Reiner, Ž., Kolahdooz, F., Amirani, E., Mirzaei, H., Banafshe, H. R., Dana, P. M., & Asemi, Z. (2020). The effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trials. Complementary Therapies in Medicine, 48, 102250.
   PubMed Web of Science ®Google Scholar
• Ghaderi, A., Banafshe, H. R., Mirhosseini, N., Motmaen, M., Mehrzad, F., Bahmani, F., Aghadavod, E., Mansournia, M. A., Reiter, R. J., Karimi, M. ‐A., & Asemi, Z. (2019). The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment. Addiction Biology, 24(4), 754–764. https://doi.org/https://doi.org/10.1111/adb.12650
   PubMed Web of Science ®Google Scholar
• Ghaderi, A., Rasouli-Azad, M., Vahed, N., Banafshe, H. R., Soleimani, A., Omidi, A., Ghoreishi, F. S., & Asemi, Z. (2019). Clinical and metabolic responses to crocin in patients under methadone maintenance treatment: A randomized clinical trial. Phytotherapy Research, 33(10), 2714–2725. https://doi.org/https://doi.org/10.1002/ptr.6445
   PubMed Web of Science ®Google Scholar
• Hassani-Abharian, P., Mokri, A., Ganjgahi, H., Oghabian, M.-A., & Ekhtiari, H. (2016). Validation for Persian versions of “desire for drug questionnaire” and “obsessive compulsive drug use scale” in heroin dependents. Archives of Iranian Medicine, 19(9), 0–0.
   Web of Science ®Google Scholar
• Hosseini, A., Razavi, B. M., & Hosseinzadeh, H. (2018). Saffron (Crocus sativus) petal as a new pharmacological target: a review. Iranian Journal of Basic Medical Sciences, 21(11), 1091–1099.
   PubMed Web of Science ®Google Scholar
• Hosseinzadeh, H., & Jahanian, Z. (2010). Effect of Crocus sativus L.(saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Phytotherapy Research: PTR, 24(5), 726–730. https://doi.org/https://doi.org/10.1002/ptr.3011
   PubMed Web of Science ®Google Scholar
• Jam, I. N., Sahebkar, A. H., Eslami, S., Mokhber, N., Nosrati, M., Khademi, M., Foroutan-Tanha, M., Ghayour-Mobarhan, M., Hadizadeh, F., Ferns, G., & Abbasi, M. (2017). The effects of crocin on the symptoms of depression in subjects with metabolic syndrome. Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University, 26(6), 925–930.
   PubMed Web of Science ®Google Scholar
• Javandoost, A., Afshari, A., Nikbakht-Jam, I., Khademi, M., Eslami, S., Nosrati, M., Foroutan-Tanha, M., Sahebkar, A., Tavalaie, S., Ghayour-Mobarhan, M., Ferns, G., Hadizadeh, F., Tabassi, A., & Mohajeri, A. (2017). Effect of crocin, a carotenoid from saffron, on plasma cholesteryl ester transfer protein and lipid profile in subjects with metabolic syndrome: A double blind randomized clinical trial. ARYA Atherosclerosis, 13(5), 245–252.
   PubMed Web of Science ®Google Scholar
• Kell, G., Rao, A., Beccaria, G., Clayton, P., Inarejos-García, A. M., & Prodanov, M. (2017). affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complementary Therapies in Medicine, 33, 58–64. https://doi.org/https://doi.org/10.1016/j.ctim.2017.06.001
   PubMed Web of Science ®Google Scholar
• Khalatbari-Mohseni, A., Banafshe, H. R., Mirhosseini, N., Asemi, Z., Ghaderi, A., & Omidi, A. (2019). The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial. Substance Abuse Treatment, Prevention, and Policy, 14(1), 9.
   PubMedGoogle Scholar
• Malek, A., Amiri, S., & Habibi Asl, B. (2013). The therapeutic effect of adding dextromethorphan to clonidine for reducing symptoms of opioid withdrawal: A Randomized Clinical Trial. ISRN Psychiatry, 2013, 1–5. https://doi.org/https://doi.org/10.1155/2013/546030
   Google Scholar
• Miller, W., & Rollnick, S. (1991). Principles of motivational interviewing. In Motivational interviewing: Preparing people to change addictive behavior. Guilford Press.
   Google Scholar
• Moravej Aleali, A., Amani, R., Shahbazian, H., Namjooyan, F., Latifi, S. M., & Cheraghian, B. (2019). The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabetes mellitus: A randomized double‐blind clinical trial. Phytotherapy Research, 33(6), 1648–1657. https://doi.org/https://doi.org/10.1002/ptr.6351
   PubMed Web of Science ®Google Scholar
• Nemat Shahi, M., Asadi, A., Behnam Talab, E., & Nemat Shahi, M. (2017). The impact of saffron on symptoms of withdrawal syndrome in patients undergoing maintenance treatment for opioid addiction in Sabzevar parish in 2017. Advances in Medicine, 2017, 5. doi: https://doi.org/10.1155/2017/1079132.1079132.
   Google Scholar
• Nguyen, C. D., Kim, J. W., Grunstein, R. R., Thamrin, C., & Wang, D. (2016). Respiratory variability during sleep in methadone maintenance treatment patients. Journal of Clinical Sleep Medicine, 12(4), 607–616. https://doi.org/https://doi.org/10.5664/jcsm.5702
   PubMed Web of Science ®Google Scholar
• Proctor, S. L., Copeland, A. L., Kopak, A. M., Hoffmann, N. G., Herschman, P. L., & Polukhina, N. (2015). Predictors of patient retention in methadone maintenance treatment. Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors, 29(4), 906–917.
   PubMed Web of Science ®Google Scholar
• Rajabizadeh, G., Yazdanpanah, F., & Ramezani, M. A. (2017). The evaluation of relationship between sexual self-concept and sexual dysfunction in individuals undergoing methadone maintenance treatment. Addiction & Health, 9(2), 88–95.
   PubMedGoogle Scholar
• Sahraian, A., Jelodar, S., Javid, Z., Mowla, A., & Ahmadzadeh, L. (2016). Study the effects of saffron on depression and lipid profiles: A double blind comparative study. Asian Journal of Psychiatry, 22, 174–176. https://doi.org/https://doi.org/10.1016/j.ajp.2015.10.012
   PubMed Web of Science ®Google Scholar
• Satre, D. D., Leibowitz, A., Sterling, S. A., Lu, Y., Travis, A., & Weisner, C. (2016). A randomized clinical trial of Motivational Interviewing to reduce alcohol and drug use among patients with depression. Journal of Consulting and Clinical Psychology, 84(7), 571–579. https://doi.org/https://doi.org/10.1037/ccp0000096
   PubMed Web of Science ®Google Scholar
• Schuckit, M. A. (2016). Treatment of opioid-use disorders. The New England Journal of Medicine, 375(4), 357–368. https://doi.org/https://doi.org/10.1056/NEJMra1604339
   PubMed Web of Science ®Google Scholar
• Shafiee, M., Arekhi, S., Omranzadeh, A., & Sahebkar, A. (2018). Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action. Journal of Affective Disorders, 227, 330–337.
   PubMed Web of Science ®Google Scholar
• Shoja, M., Mehri, S., Amin, B., Askari, V. R., & Hosseinzadeh, H. (2018). The prophylactic and therapeutic effects of saffron extract and crocin on ethanol withdrawal syndrome in mice. Journal of Pharmacopuncture, 21(4), 277–283.
   PubMed Web of Science ®Google Scholar
• Smedslund, G., Berg, R. C., Hammerstrøm, K. T., Steiro, A., Leiknes, K. A., Dahl, H. M., & Karlsen, K. (2011). Motivational interviewing for substance abuse. Cochrane Database of Systematic Reviews, (5), CD008063. https://doi.org/https://doi.org/10.1002/14651858.CD008063
   Google Scholar
• Sotodeh Asl, N., Behnam, B., & Ghorbani, R. (2013). Effectiveness of narcotics anonymous training programs in personality characters in substance abuse patients. Koomesh, 14(3), 316–320.
   Google Scholar
• Tabeshpour, J., Sobhani, F., Sadjadi, S. A., Hosseinzadeh, H., Mohajeri, S. A., Rajabi, O., Taherzadeh, Z., & Eslami, S. (2017). A double-blind, randomized, placebo-controlled trial of saffron stigma (Crocus sativus L.) in mothers suffering from mild-to-moderate postpartum depression. Phytomedicine, 36, 145–152. https://doi.org/https://doi.org/10.1016/j.phymed.2017.10.005
   PubMed Web of Science ®Google Scholar
• Talaei, A., Moghadam, M. H., Tabassi, S. A. S., & Mohajeri, S. A. (2015). Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial. Journal of Affective Disorders, 174, 51–56. https://doi.org/https://doi.org/10.1016/j.jad.2014.11.035
   PubMed Web of Science ®Google Scholar
• Thushara, R. M., Hemshekhar, M., Paul, M., Sundaram, M. S., Shankar, R. L., Kemparaju, K., & Girish, K. S. (2014). Crocin prevents sesamol-induced oxidative stress and apoptosis in human platelets. Journal of Thrombosis and Thrombolysis, 38(3), 321–330.
   PubMed Web of Science ®Google Scholar
• Vasilev, G., Milcheva, S., & Vassileva, J. (2016). Opioid use in the twenty first century: Similarities and differences across national borders. Current Treatment Options in Psychiatry, 3(3), 293–305. https://doi.org/https://doi.org/10.1007/s40501-016-0089-2
   PubMedGoogle Scholar
• Wagner, C. C., & Ingersoll, K. S. (2012). Motivational interviewing in groups. Guilford Press.
   Google Scholar
• World Drug Report 2021. (2021). United Nations Office on Drugs and Crime. https://www.unodc.org/unodc/en/data-and-analysis/wdr2021.html
   Google Scholar
• Yarijani, Z. M., Pourmotabbed, A., Pourmotabbed, T., & Najafi, H. (2017). Crocin has anti-inflammatory and protective effects in ischemia-reperfusion induced renal injuries. Iranian Journal of Basic Medical Sciences, 20(7), 753.
   PubMed Web of Science ®Google Scholar
• Yin, W., Pang, L., Cao, X., McGoogan, J. M., Liu, M., Zhang, C., Li, Z., Li, J., & Rou, K. (2015). Factors associated with depression and anxiety among patients attending community‐based methadone maintenance treatment in C hina. Addiction, 110, 51–60. https://doi.org/https://doi.org/10.1111/add.12780
   PubMed Web of Science ®Google Scholar