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Research Article

Gemcitabine hydrochloride-loaded liposomes and nanoparticles: comparison of encapsulation efficiency, drug release, particle size, and cytotoxicity

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Pages 76-86 | Received 24 Mar 2017, Accepted 13 Jul 2017, Published online: 31 Jul 2017

References

  • Abbruzzese JL, Grunewald R, Weeks EA, Gravel D, Adams T, Nowak B, Mineishi S, Tarassoff P, Satterlee W, Raber MN. 1991. A phase I clinical, plasma, and cellular pharmacology study of gemcitabine. J Clin Oncol. 9:491–498.
  • Achim M, Tomuta I, Muntean D, Porfire A, Tefas LR, Patras L, Licarete E, Alupei MC, Vlase L, Banciu M. 2017. Optimization and in vitro evaluation of 5-fluorouracil – loaded long – circulating liposomes. Farmacia. 65:82–91.
  • Barichello JM, Morishita M, Takayama K, Nagai T. 1999. Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method. Drug Dev Ind Pharm. 25:471–476.
  • Bian Y, Gao D, Liu Y, Li N, Zhang X, Zheng RY, Wang Q, Luo L, Dai K. 2015. Preparation and study on anti-tumor effect of chitosan-coated oleanolic acid liposomes. RSC. 5:18725–18732.
  • Bilati U, Allémann E, Doelker E. 2005. Poly(D,L-lactide-co-glycolide) protein-loaded nanoparticles prepared by the double emulsion method-processing and formulation issues for enhanced entrapment efficiency. J Microencapsul. 22:205–214.
  • Briuglia ML, Rotella C, McFarlane A, Lamprou DA. 2015. Influence of cholesterol on liposome stability and on in vitro drug release. Drug Deliv Transl Res. 5:231–242.
  • Cohen-Sela E, Teitlboim S, Chorny M, Koroukhov N, Danenberg HD, Gao J, Golomb G. 2009. Single and double emulsion manufacturing techniques of an amphiphilic drug in PLGA nanoparticles: formulations of mithramycin and bioactivity. J Pharm Sci. 98:1452–1462.
  • Cosco D, Paolino D, Cilurzo F, Casale F, Fresta M. 2012. Gemcitabine and tamoxifen-loaded liposomes as multidrug carriers for the treatment of breast cancer diseases. Int J Pharm. 422:229–237.
  • Derakhshandeh K, Fathi S. 2012. Role of chitosan nanoparticles in the oral absorption of gemcitabine. Int J Pharm. 437:172–177.
  • El-Nesr OH, Yahiya SA, El-Gazayerly ON. 2010. Effect of formulation design and freeze-drying on properties of fluconazole multilamellar liposomes. Saudi Pharm J. 18:217–224.
  • Eloy JO, Claro de Souza M, Petrilli R, Barcellos JP, Lee RJ, Marchetti JM. 2014. Liposomes as carriers of hydrophilic small molecule drugs: strategies to enhance encapsulation and delivery. Colloids Surf B Biointerfaces. 123:345–363.
  • Gandhi M, Pandya T, Gandhi R, Patel S, Mashru R, Misra A, Tandel H. 2015. Inhalable liposomal dry powder of gemcitabine-HCl: formulation, in vitro characterization and in vivo studies. Int J Pharm. 496:886–895.
  • Harris JM, Chess RB. 2004. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov. 2:214–221.
  • Hinrichs WL, Manceñido FA, Sanders NN, Braeckmans K, De Smedt SC, Demeester J, Frijlink HW. 2006. The choice of a suitable oligosaccharide to prevent aggregation of PEGylated nanoparticles during freeze thawing and freeze drying. Int J Pharm. 311:237–244.
  • Holgado MA, Arias JL, Cózar MJ, Alvarez-Fuentes J, Gañán-Calvo AM, Fernández-Arévalo M. 2008. Synthesis of lidocaine-loaded PLGA microparticles by flow focusing. Effects on Drug Loading and Release Properties. Int J Pharm. 358:27–35.
  • Hosta-Rigau L, Schattling P, Teo BM, Lynge ME, Stadler B. 2014. Recent progress of liposomes in nanomedicine. J Mater Chem B. 2:6686–6691.
  • Hou Y, Yao C, Ling L, Du Y, He R, Ismail M, Zhang Y, Fu Z, Li X. 2017. Novel dual VES phospholipid self-assembled liposomes with an extremely high drug loading efficiency. Colloids Surf B Biointerfaces. 156:29–37.
  • Immordino ML, Dosio F, Cattel L. 2006. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int J Nanomedicine. 1:297–315.
  • Jain RA. 2000. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials. 21:2475–2490.
  • Kadari A, Gudem S, Kulhari H, Bhandi MM, Borkar RM, Kolapalli VR, Sistla R. 2017. Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles. Drug Deliv. 24:224–232.
  • Li Y, Pei Y, Zhang X, Gu Z, Zhou Z, Yuan W, Zhou J, Zhu J, Gao X. 2001. PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. J Control Release. 71:203–211.
  • Liu J, Qiu Z, Wang S, Zhou L, Zhang S. 2010. A modified double-emulsion method for the preparation of daunorubicin-loaded polymeric nanoparticle with enhanced in vitro anti-tumor activity. Biomed Mater. 5:1–10.
  • Liu N, Park HJ. 2009. Chitosan-coated nanoliposome as vitamin E carrier. J Microencapsul. 26:235–242.
  • Maherani B, Arab-tehrany E, Kheirolomoom A, Reshetov V, Stebe MJ, Linder M. 2012. Optimization and characterization of liposome formulation by mixture design. Analyst. 137:773–786.
  • Maitani Y, Nakamura A, Tanaka T, Aso Y. 2012. Hydration of surfactant-modified and PEGylated cationic cholesterol based liposomes and corresponding lipoplexes by monitoring a fluorescent probe and the dielectric relaxation time. Int J Pharm. 427:372–378.
  • Makadia HK, Siegel SJ. 2011. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers (Basel). 3:1377–1397.
  • Martín-Banderas L, Sáez-Fernández E, Holgado MÁ, Durán-Lobato MM, Prados JC, Melguizo C, Arias JL. 2013. Biocompatible gemcitabine-based nanomedicine engineered by flow focusing for efficient antitumor activity. Int J Pharm. 443:103–109.
  • Mehrabi M, Esmaeilpour P, Akbarzadeh A, Saffari Z, Farahnak M, Farhangi A, Chiani M. 2016. Efficacy of pegylated liposomal etoposide nanoparticles on breast cancer cell lines. Turk J Med Sci. 46:567–571.
  • Mittal G, Sahana DK, Bhardwaj V, Ravi Kumar MN. 2007. Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. J Control Release. 119:77–85.
  • Mondalek FG, Lawrence BJ, Kropp BP, Grady BP, Fung KM, Madihally SV, Lin HK. 2008. The incorporation of poly(lactic-co-glycolic) acid nanoparticles into porcine small intestinal submucosa biomaterials. The incorporation of poly(lactic-co-glycolic) acid nanoparticles into porcine small intestinal submucosa biomaterials. Biomaterials. 29:1159–1166.
  • Paolino D, Cosco D, Racanicchi L, Trapasso E, Celia C, Iannone M, Puxeddu E, Costante G, Filetti S, Russo D, et al. 2010. Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity. J Control Release. 144:144–150.
  • Seju U, Kumar A, Sawant KK. 2011. Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: in vitro and in vivo studies. Acta Biomater. 7:4169–4176.
  • Shi L, Wang X, Zhao F, Luan H, Tu Q, Huang Z, Wang H, Wang H. 2013. In vitro evaluation of 5-aminolevulinic acid (ALA) loaded PLGA nanoparticles. Int J Nanomedicine. 8:2669–2676.
  • Stevanovic M, Uskokovic D. 2009. Poly (lactide-co-glycolide)-based micro and nanoparticles for the controlled drug delivery of vitamins. Curr Nanosci. 5:1–14.
  • Tabandeh H, Mortazavi SA. 2013. An investigation into some effective factors on encapsulation efficiency of alpha-tocopherol in MLVs and the release profile from the corresponding liposomal gel. Iranian J Pharm Res. 12:21–30.
  • Tewes F, Munnier E, Antoon B, Ngaboni Okassa L, Cohen-Jonathan S, Marchais H, Douziech-Eyrolles L, Soucé M, Dubois P, Chourpa I. 2007. Comparative study of doxorubicin-loaded poly(lactide-co-glycolide) nanoparticles prepared by single and double emulsion methods. Eur J Pharm Biopharm. 66:488–492.
  • Trickler WJ, Khurana J, Nagvekar AA, Dash AK. 2010. Chitosan and glyceryl monooleate nanostructures containing gemcitabine: potential delivery system for pancreatic cancer treatment. AAPS PharmSciTech. 11:392–401.
  • Tsotas VA, Mourtas S, Antimisiaris SG. 2007. Dexamethasone incorporating liposomes: effect of lipid composition on drug trapping efficiency and vesicle stability. Drug Deliv. 14:441–445.
  • Vali AM, Toliyat T, Shafaghi B, Dadashzadeh S. 2008. Preparation, optimization, and characterization of topotecan loaded PEGylated liposomes using factorial design. Drug Dev Ind Pharm. 34:10–23.
  • Vandana M, Sahoo SK. 2010. Long circulation and cytotoxicity of PEGylated gemcitabine and its potential for the treatment of pancreatic cancer. Biomaterials. 31:9340–9356.
  • Vaze OS. 2016. Pharmaceutical nanocarriers (liposomes and micelles) in cancer therapy. J Nanomed Nanotechnol. 7:1–2.
  • Vijayakumar MR, Kosuru R, Vuddanda PR, Singh SK, Singh S. 2016. Trans resveratrol loaded DSPE PEG 2000 coated liposomes: an evidence for prolonged systemic circulation and passive brain targeting. J Drug Deliv Sci Technol. 33:125–135.
  • Vrignaud S, Benoit JP, Saulnier P. 2011. Strategies for the nanoencapsulation of hydrophilic molecules in polymer-based nanoparticles. Biomaterials. 32:8593–8604.
  • Wolfram J, Suri K, Yang Y, Shen J, Celia C, Fresta M, Zhao Y, Shen H, Ferrari M. 2014. Shrinkage of pegylated and non-pegylated liposomes in serum. Colloids Surf B Biointerfaces. 114:294–300.
  • Xu X, Khan MA, Burgess DJ. 2012. Predicting hydrophilic drug encapsulation inside unilamellar liposomes. Int J Pharm. 423:410–418.
  • Yerlikaya F, Ozgen A, Vural I, Guven O, Karaagaoglu E, Khan MA, Capan Y. 2013. Development and evaluation of paclitaxel nanoparticles using a quality-by-design approach. J Pharm Sci. 102:3748–3761.

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