Assessment of spatial heterogeneity in continuous twin screw wet granulation process using three-compartmental population balance model

References

• Barrasso D, Ramachandran R. 2015. Multi-scale modeling of granulation processes: bi-directional coupling of PBM with DEM via collision frequencies. Chem Eng Res Des. 93:304–317.
   Web of Science ®Google Scholar
• Barrasso D, Walia S, Ramachandran R. 2013. Multi-component population balance modeling of continuous granulation processes: a parametric study and comparison with experimental trends. Powder Technol. 241:85–97.
   Web of Science ®Google Scholar
• Chan Seem T, Rowson N, Gabbott A, de Matas IM, Reynolds GK, Ingram A. 2016. Asymmetric distribution in twin screw granulation. Eur J Pharm Biopharm. 106:50–58.
   PubMed Web of Science ®Google Scholar
• Dhenge RM, Cartwright JJ, Hounslow MJ, Salman AD. 2012. Twin screw granulation: steps in granule growth. Int J Pharm. 438:20–32.
   PubMed Web of Science ®Google Scholar
• Dhenge RM, Fyles RS, Cartwright JJ, Doughty DG, Hounslow MJ, Salman AD. 2010. Twin screw wet granulation: granule properties. Chem Eng J. 164:322–329.
   Web of Science ®Google Scholar
• Ding A, Hounslow MJ, Biggs CA. 2006. Population balance modelling of activated sludge flocculation: investigating the size dependence of aggregation, breakage and collision efficiency. Chem Eng Sci. 61:63–74.
   Web of Science ®Google Scholar
• Djuric D, Kleinebudde P. 2010. Continuous granulation with a twin-screw extruder: impact of material throughput. Pharm Dev Technol. 15:518–525.
   PubMed Web of Science ®Google Scholar
• Djuric D, Van Melkebeke B, Kleinebudde P, Remon JP, Vervaet C. 2009. Comparison of two twin-screw extruders for continuous granulation. Eur J Pharm Biopharm. 71:155–160.
   PubMed Web of Science ®Google Scholar
• El Hagrasy AS, Litster JD. 2013. Granulation rate processes in the kneading elements of a twin screw granulator. AIChE J. 59:4100–4115.
   Web of Science ®Google Scholar
• Hounslow MJ, Pearson JMK, Instone T. 2001. Tracer studies of high-shear granulation: II. Population balance modeling. AIChE J. 47:1984–1999.
   Web of Science ®Google Scholar
• Hounslow MJ, Ryall RL, Marshall VR. 1988. A discretized population balance for nucleation, growth, and aggregation. AIChE J. 34:1821–1832.
   Web of Science ®Google Scholar
• Iveson SM. 2002. Limitations of one-dimensional population balance models of wet granulation processes. Powder Technol. 124:219–229.
   Web of Science ®Google Scholar
• Iveson SM, Litster JD, Hapgood K, Ennis BJ. 2001. Nucleation, growth and breakage phenomena in agitated wet granulation processes: a review. Powder Technol. 117:3–39.
   Web of Science ®Google Scholar
• Keleb EI, Vermeire A, Vervaet C, Remon JP. 2002. Continuous twin screw extrusion for the wet granulation of lactose. Int J Pharm. 239:69–80.
   PubMed Web of Science ®Google Scholar
• Keleb EI, Vermeire A, Vervaet C, Remon JP. 2004. Twin screw granulation as a simple and efficient tool for continuous wet granulation. Int J Pharm. 273:183–194.
   PubMed Web of Science ®Google Scholar
• Kumar A, Dhondt J, De Leersnyder F, Vercruysse J, Vanhoorne V, Vervaet C, Remon JP, Gernaey KV, De Beer T, Nopens I. 2015. Evaluation of an in-line particle imaging tool for monitoring twin-screw granulation performance. Powder Technol. 285:80–87.
   Web of Science ®Google Scholar
• Kumar A, Dhondt J, Vercruysse J, De Leersnyder F, Vanhoorne V, Vervaet C, Remon JP, Gernaey KV, De Beer T, Nopens I. 2016. Development of a process map: a step towards a regime map for steady-state high shear wet twin screw granulation. Powder Technol. 300:73–82.
   Web of Science ®Google Scholar
• Kumar A, Vercruysse J, Toiviainen M, Panouillot P-E, Juuti M, Vanhoorne V, Vervaet C, Remon JP, Gernaey KV, De Beer T, et al. 2014. Mixing and transport during pharmaceutical twin-screw wet granulation: experimental analysis via chemical imaging. Eur J Pharm Biopharm. 87:279–289.
   PubMed Web of Science ®Google Scholar
• Li H, Thompson MR, O’Donnell KP. 2014. Understanding wet granulation in the kneading block of twin screw extruders. Chem Eng Sci. 113:11–21.
   Web of Science ®Google Scholar
• Liu H. 2014. Modeling and control of batch pulsed top-spray fluidized bed granulation [PhD thesis]. UK: De Montfort University.
   Google Scholar
• Liu H, Galbraith SC, Ricart B, Stanton C, Smith-Goettler B, Verdi L, O’Connor T, Lee S, Yoon S. 2017a. Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data. Int J Pharm. 525:249–263.
   PubMedGoogle Scholar
• Liu H, Li M. 2014a. Population balance modelling and multi-stage optimal control of a pulsed spray fluidized bed granulation. Int J Pharm. 468:223–233.
   PubMed Web of Science ®Google Scholar
• Liu H, Li M. 2014b. Two-compartmental population balance modeling of a pulsed spray fluidized bed granulation based on computational fluid dynamics (CFD) analysis. Int J Pharm. 475:256–269.
   PubMed Web of Science ®Google Scholar
• Liu H, Wang K, Schlindwein W, Li M. 2013. Using the Box–Behnken experimental design to optimise operating parameters in pulsed spray fluidised bed granulation. Int J Pharm. 448:329–338.
   PubMed Web of Science ®Google Scholar
• Liu H, Yoon S, Li M. 2017b. Three-dimensional computational fluid dynamics (CFD) study of the gas-particle circulation pattern within a fluidized bed granulator: by full-factorial design of fluidization velocity and particle size. Dry Technol. 35:1043–1058.
   Web of Science ®Google Scholar
• Liu H, O’Connor T, Lee S, Yoon S. 2018. A process optimization strategy of a pulsed-spray fluidized bed granulation process based on predictive three-stage population balance model. Powder Technol. 327:188–200.
   Web of Science ®Google Scholar
• Lute SV, Dhenge RM, Hounslow MJ, Salman AD. 2016. Twin screw granulation: understanding the mechanism of granule formation along the barrel length. Chem Eng Res Des. 110:43–53.
   Web of Science ®Google Scholar
• Portillo PM, Muzzio FJ, Ierapetritou MG. 2007. Hybrid DEM-compartment modeling approach for granular mixing. AIChE J. 53:119–128.
   Web of Science ®Google Scholar
• Reynolds GK, Fu JS, Cheong YS, Hounslow MJ, Salman AD. 2005. Breakage in granulation: a review. Chem Eng Sci. 60:3969–3992.
   Web of Science ®Google Scholar
• Tan HS, Salman AD, Hounslow MJ. 2004. Kinetics of fluidised bed melt granulation: IV. Selecting the breakage model. Powder Technol. 143–144:65–83.
   Web of Science ®Google Scholar
• Thompson MR, Sun J. 2010. Wet granulation in a twin screw extruder: implications of screw design. J Pharm Sci. 99:2090–2103.
   PubMed Web of Science ®Google Scholar
• Verstraeten M, Van Hauwermeiren D, Lee K, Turnbull N, Wilsdon D, am Ende M, Doshi P, Vervaet C, Brouckaert D, Mortier STFC, et al. 2017. In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding. Int J Pharm. 529:678–693.
   PubMedGoogle Scholar