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Research Article

Evaluation of topical econazole nitrate formulations with potential for treating Raynaud’s phenomenon

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Pages 689-699 | Received 21 Sep 2018, Accepted 30 Jan 2019, Published online: 26 Apr 2019

References

  • Allen LV Jr. 2017. Progesterone 50 mg/g in VersaBase Cream. US Pharm. 42:47–48.
  • Baumhäkel M, Böhm M. 2010. Recent achievements in the management of Raynaud's phenomenon. Vasc Health Risk Manag. 6:207.
  • Böhling A, Bielfeldt S, Himmelmann A, Keskin M, Wilhelm KP. 2014. Comparison of the stratum corneum thickness measured in vivo with confocal Raman spectroscopy and confocal reflectance microscopy. Skin Res Technol. 20:50–57.
  • Bousmina M. 1999. Rheology of polymer blends: linear model for viscoelastic emulsions. Rheologica Acta. 38:73–83.
  • Brodin B, Steffansen B, Nielsen CU. 2010. Passive diffusion of drug substances: the concepts of flux and permeability. In: Steffansen B, Brodin B, Nielsen CU, editors. Molecular biopharmaceutics: aspects of drug characterisation, drug delivery and dosage form evaluation. London: Pharmaceutical Press; p. 135–151.
  • Brown KM, Middaugh SJ, Haythornthwaite JA, Bielory L. 2001. The effects of stress, anxiety, and outdoor temperature on the frequency and severity of Raynaud's attacks: the Raynaud's Treatment Study. J Behav Med. 24:137–153.
  • Carvalho FC, Barbi MS, Sarmento VHV, Chiavacci LA, Netto FM, Gremiao MP. 2010. Surfactant systems for nasal zidovudine delivery: structural, rheological and mucoadhesive properties. J Pharm Pharmacol. 62:430–439.
  • Chung L, Shapiro L, Fiorentino D, Baron M, Shanahan J, Sule S, Hsu V, Rothfield N, Steen V, Martin RW. 2009. MQX‐503, a novel formulation of nitroglycerin, improves the severity of Raynaud's phenomenon: a randomized, controlled trial. Arthritis Rheum. 60:870–877.
  • Coppock JS, Hardman J, Bacon P, Woods K, Kendall M. 1986. Objective relief of vasospasm by glyceryl trinitrate in secondary Raynaud’s phenomenon. Postgrad Med J. 62:15–18.
  • Dantas MGB, Reis SAGB, Damasceno CMD, Rolim LA, Rolim-Neto PJ, Carvalho FO, Quintans-Junior LJ, Almeida JRGdS. 2016. Development and evaluation of stability of a gel formulation containing the monoterpene borneol. ScientificWorldJournal. 2016:1.
  • Dick IP, Scott RC. 1992. Pig ear skin as an in-vitro model for human skin permeability. J Pharm Pharmacol. 44:640–645.
  • Djalil A, Ambarwati T, Genatrika E. 2018. Characterization of sunscreen cream containing benzophenone-3,3’,4,4’-tetracarboxylate dianhydride. Iop Conf Ser Mater Sci Eng. 434:012090.
  • Firooz A, Nafisi S, Maibach HI. 2015. Novel drug delivery strategies for improving econazole antifungal action. Int J Pharm. 495:599–607.
  • Fraenkel L, Zhang Y, Chaisson CE, Evans SR, Wilson PW, Felson DT. 1998. The association of estrogen replacement therapy and the Raynaud phenomenon in postmenopausal women. Ann Intern Med. 129:208–211.
  • Fraenkel L. 2002. Raynaud's phenomenon: epidemiology and risk factors. Curr Rheumatol Rep. 4:123–128.
  • Franks A. 1982. Topical glyceryl trinitrate as adjunctive treatment in Raynaud's disease. The Lancet. 319:76–77.
  • Gajra B, Pandya SS, Singh S, Rabari HA. 2014. Mucoadhesive hydrogel films of econazole nitrate: formulation and optimization using factorial design. J Drug Deliv. 2014:1.
  • Ge S, Lin Y, Lu H, Li Q, He J, Chen B, Wu C, Xu Y. 2014. Percutaneous delivery of econazole using microemulsion as vehicle: formulation, evaluation and vesicle-skin interaction. Int J Pharm. 465:120–131.
  • Goto N, Morita Y, Terada K. 2016. Deposits from creams containing 20%(w/w) urea and suppression of crystallization (part 1): rate of crystallization from cream containing 20% (w/w) urea and evaluation of the properties of the deposit. Chem Pharm Bull. 64:1084–1091.
  • Hadgraft J, Lane ME. 2005. Skin permeation: the years of enlightenment. Int J Pharm. 305:2–12.
  • Heel R, Brogden R, Speight T, Avery G. 1978. Econazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 16:177–201.
  • Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH. 2007. Ibuprofen transport into and through skin from topical formulations: in vitro–in vivo comparison. J Investig Dermatol. 127:135–142.
  • Herrick AL. 2012. The pathogenesis, diagnosis and treatment of Raynaud phenomenon. Nat Rev Rheumatol. 8:469–479.
  • Jones DS. 2016. Pharmaceutical disperse systems 3: ointments, pastes, lotions, gels and related formulations. In: Jones DS, editor. FASTtrack pharmaceutics dosage form and design. London: Pharmaceutical Press; p. 75–99.
  • Jorge LL, Feres CC, Teles VE. 2011. Topical preparations for pain relief: efficacy and patient adherence. J Pain Res. 4:11.
  • Jug M, Mennini N, Kövér KE, Mura P. 2014. Comparative analysis of binary and ternary cyclodextrin complexes with econazole nitrate in solution and in solid state. J Pharm Biomed Anal. 91:81–91.
  • Kahaleh B, Altorok N, Boddu SHS, Nagaraja V, inventors. 2017 Mar 16. Treatment of Raynaud's phenomenon by inhibition of transient receptor potential melastatin-8 (trpm-8). United States patent US WO2017044458A1.
  • Kesarpu S. 2015. Evaluation of drug release & anti-fungal activity of econazole nitrate from dermatological bases using reduced level of the drug. The Brooklyn Center: Long Island University.
  • Kranz G, Schaefer H, Zesch A. 1977. Hydrocortisone (cortisol) concentration and penetration gradient. Acta Dermato-Venereologica. 57:269–273.
  • Lambers H, Piessens S, Bloem A, Pronk H, Finkel P. 2006. Natural skin surface pH is on average below 5, which is beneficial for its resident flora. Int J Cosmet Sci. 28:359–370.
  • LeRoy EC. 1996. Systemic sclerosis: a vascular perspective. Rheum Dis Clin North Am. 22:675–694.
  • Levien TL. 2010. Advances in the treatment of Raynaud's phenomenon. Vasc Health Risk Manag. 6:167.
  • Lewis T. 1929. Experiments relating to the peripheral mechanism involved in spasmodic arrest of the circulation in the fingers: a variety of Raynaud's disease. Heart. 15:7–101.
  • Mohamed AI, Abd-Motagaly AME, Ahmed OA, Amin S, Mohamed Ali AI. 2017. Investigation of drug–polymer compatibility using chemometric-assisted UV-spectrophotometry. Pharmaceutics. 9:7.
  • Nishimoto Y, Kaneki Y. 2003. Detection of water–polar solvent interaction using melting of a eutectic. Thermochim Acta. 399:139–144.
  • OECD. 2004a. Test Guideline 427: Skin absorption: in vivo Method. Paris: Organisation for Economic Co-operation and Development.
  • OECD. 2004b. Test Guideline 428: Skin absorption: in vitro Method. Paris: Organisation for Economic Co-operation and Development.
  • OECD. 2004c. Guidance document for the conduct of skin absorption studies. OECD Series on Testing and Assessment Number 28. Paris: Organisation for Economic Co-operation and Development.
  • Patel P, Bhadra S. 2015. Development of topical formulation of linezolid for complicated skin infections. Pharmagene. 2.
  • Prausnitz MR, Elias PM, Franz TJ, Schmuth M, Tsai JC, Menon GK, Holleran WM, Feingold KR. 2012. Skin barrier and transdermal drug delivery. Dermatology. 3:2065–2073.
  • Rezaeifar M, Mahmoudvand H, Amiria M. 2016. Formulation and evaluation of diphenhydramine gel using different gelling agents. Der Pharma Chemica. 8:243–249.
  • Sabale V, Kunjwani H, Sabale P. 2011. Formulation and in vitro evaluation of the topical antiageing preparation of the fruit of Benincasa hispida. J Ayurveda Integr Med. 2:124.
  • Schaefer H, Stüttgen G. 1976. Absolute concentrations of an antimycotic agent, econazole, in the human skin after local application. Arzneimittel-Forschung. 26:432–435.
  • Sheikh K, Saringat B, Bukhari N. 2011. Investigation of factors affecting physicochemical properties of palm-olein creams using optimisation techique-qualiy by design. J App Pharm. 3:301–319.
  • Singh S, Parhi R, Garg A. 2011. Formulation of topical bioadhesive gel of aceclofenac using 3-level factorial design. Iran J Pharm Res. 10:435.
  • So J, Ahn J, Lee T-H, Park K-H, Paik M-K, Jeong M, Cho M-H, Jeong S-H. 2014. Comparison of international guidelines of dermal absorption tests used in pesticides exposure assessment for operators. Toxicol Res. 30:251.
  • Sunderkötter C, Riemekasten G. 2006. Pathophysiology and clinical consequences of Raynaud's phenomenon related to systemic sclerosis. Rheumatology. 45:iii33–iii35.
  • Teh L, Manning J, Moore T, Tully M, O'Reilly D, Jayson M. 1995. Sustained-release transdermal glyceryl trinitrate patches as a treatment for primary and secondary Raynaud's phenomenon. Rheumatology. 34:636–641.
  • Trimble JO, inventor; Humco Holding Group, Inc., assignee. 2017 Sep 5. Transdermal silicone gel (silogel) compositions and methods of preparation. United States patent US US9750689B2.
  • Wigley FM. 2002. Clinical practice. Raynaud's Phenomenon. N Engl J Med. 347:1001–1008.

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