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Pharmaceutical Development and Technology Volume 25, 2020 - Issue 6
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Research Articles

Empirical prediction model based process optimization for droplet size and spraying angle during pharmaceutical fluidized bed granulation

Jia ZengInnovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China; ;Shanghai Institute of Planned Parenthood Research, NHC Key Laboratory of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, PR China; ORCID Iconhttp://orcid.org/0000-0002-4009-2179
ORCID Icon,
Liangshan MingCollege of Pharmacy, Gannan Medical University, Ganzhou, PR China
,
Jiamiao WangInnovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China;
,
Ting HuangShanghai Institute of Planned Parenthood Research, NHC Key Laboratory of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, PR China; ORCID Iconhttp://orcid.org/0000-0001-8560-5532
ORCID Icon,
Binbin LiuInnovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China;
,
Linglin FengShanghai Institute of Planned Parenthood Research, NHC Key Laboratory of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, PR China;
,
Man XueShanghai Institute of Planned Parenthood Research, NHC Key Laboratory of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, PR China;
,
Jianxing ChenShanghai Institute of Planned Parenthood Research, NHC Key Laboratory of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai, PR China;
,
Ruo-fei DuInnovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China; Correspondence[email protected]
&
Yi FengInnovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China; Correspondence[email protected]
 show all
Pages 720-728 | Received 11 Jul 2019, Accepted 02 Mar 2020, Published online: 15 Mar 2020

References

  • Börner M, Bück A, Tsotsas E. 2017. DEM-CFD investigation of particle residence time distribution in top-spray fluidised bed granulation. Chem Eng Sci. 161:187–197.
  • Bouffard J, Kaster M, Dumont H. 2005. Influence of process variable and physicochemical properties on the granulation mechanism of mannitol in a fluid bed top spray granulator. Drug Dev Ind Pharm. 31:923–933.
  • Bruhns S, Werther J. 2005. An investigation of the mechanism of liquid injection into fluidized beds. Aiche J. 51:766–775.
  • Chen XY, Zhou W, Cai XS, Huang Y, Yuan Y. 2014. Particle size distribution measurement of large spray by imaging. CIESC J. 65:480–487.
  • Ehlers H, Larjo J, Antikainen O, Raikkonen H, Heinamaki J, Yliruusi J. 2010. In situ droplet size and speed determination in a fluid-bed granulator. Int J Pharm. 391:148–154.
  • Hede PD, Bach P, Jensen AD. 2008. Two-fluid spray atomisation and pneumatic nozzles for fluid bed coating/agglomeration purposes: a review. Chem Eng Sci. 63:3821–3842.
  • Juslin L. 1995. Droplet size measurement: I. Effect of three independent variables on droplet size distribution and spray angle from a pneumatic nozzle. Int J Pharm. 123:247–256.
  • Kafui DK, Thornton C. 2008. Fully-3D DEM simulation of fluidised bed spray granulation using an exploratory surface energy-based spray zone concept. Powder Technol. 184:177–188.
  • Kong K, ZhiQiang HU, Yao WQ, Huang SQ, XueFeng XV. 2013. Sizes distribution characteristics of cutting fluid droplets for electrostatic atomization minimum quantity lubrication. J Mech Electr Eng. 30:1472–1476.
  • Liu R, Li L, Yin W, Xu D, Zang H. 2017. Near-infrared spectroscopy monitoring and control of the fluidized bed granulation and coating processes—A review. Int J Pharm. 530:308–315.
  • Liu H, Thomas OC, Lee S, Yoon SK. 2018. A process optimization strategy of a pulsed-spray fluidized bed granulation process based on predictive three-stage population balance model. Powder Technol. 327:188–200.
  • Ming L, Li Z, Wu F, Du R, Feng Y. 2017. A two-step approach for fluidized bed granulation in pharmaceutical processing: assessing different models for design and control. Plos One. 12:e0180209.
  • Nicholas P, Cedric B, Franco B, Jennifer MM. 2018. Effect of spray nozzle attachment geometry on rate of liquid released from agglomerates produced by gas-atomized liquid injection into a fluidized bed. Powder Technol. 325:280–288.
  • Qiu K, Dong Y. 1994. The uniform-size droplets of three-fluid atomizer and characteristics of spray angle. Chem Eng (China). 1994:59–62.
  • Rajniak P, Mancinelli C, Chern RT, Stepanek F, Farber L, Hill BT. 2007. Experimental study of wet granulation in fluidized bed: impact of the binder properties on the granule morphology. Int J Pharm. 334:92–102.
  • Sanaei-Moghadam M, Jahangiri M, Hormozi F. 2019. An experimental study on the spray characteristics of pressure nozzle in a fluid bed granulation. Particul Sci Technol. 37 :39–50.
  • Schaafsma SH, Vonk P, Kossen N. 2000. Fluid bed agglomeration with a narrow droplet size distribution. Int J Pharm. 193:175–187.
  • Schafer W, Rosenkranz S, Brinckmann F, Tropea C. 2016. Analysis of pneumatic atomizer spray profiles. Particuology. 29:80–85.
  • Shirazian S, Kuhs M, Darwish S, Croker D, Walker GM. 2017. Artificial neural network modelling of continuous wet granulation using a twin-screw extruder. Int J Pharm. 521:102–109.
  • Thybo P, Hovgaard L, Andersen SK, Lindelov J. 2008. Droplet size measurements for spray dryer scale-up. Pharm Dev Technol. 13:93–104.
  • Vemavarapu C, Surapaneni M, Hussain M, Badawy S. 2009. Role of drug substance material properties in the processibility and performance of a wet granulated product. Int J Pharm. 374:96–105.
  • Wang XZ, Yu CY, Zhou CJ. 2003. Spray drying. 2nd ed. Beijing (China): Chemical Industry Press.

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