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Research Articles

Gelatin-methacryloyl hydrogel based in vitro blood–brain barrier model for studying breast cancer-associated brain metastasis

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Pages 490-500 | Received 16 Aug 2020, Accepted 03 Jan 2021, Published online: 15 Feb 2021

References

  • Agarwal KC, Parks RE. 1983. Forskolin: a potential antimetastatic agent. Int J Cancer. 32(6):801–804.
  • Alessio E, Mestroni G, Bergamo A, Sava G. 2004. Ruthenium antimetastatic agents. Curr Top Med Chem. 4(15):1525–1535.
  • Anderson RL, Balasas T, Callaghan J, Coombes RC, Evans J, Hall JA, Kinrade S, Jones D, Jones PS, Jones R. et al. 2019. A framework for the development of effective anti-metastatic agents. Nat Rev Clin Oncol. 16(3):185–204.
  • Augustine R, Hasan A, Dalvi Y B, Rehman S R U, Varghese R, Unni R N, Yalcin H C, Alfkey R, Thomas S, Al Moustafa A-E. 2021. Growth factor loaded in situ photocrosslinkable poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/gelatin methacryloyl hybrid patch for diabetic wound healing. Materials Science and Engineering: C. 118:111519 doi:https://doi.org/10.1016/j.msec.2020.111519.
  • Augustine R, Zahid A A, Hasan A, Dalvi Y B, Jacob J. 2021. Cerium Oxide Nanoparticle-Loaded Gelatin Methacryloyl Hydrogel Wound-Healing Patch with Free Radical Scavenging Activity. ACS Biomater Sci Eng. 7(1):279–290. doi:https://doi.org/10.1021/acsbiomaterials.0c01138. 33320529
  • Augustine R, Alhussain H, Hasan A, Ahmed MB, Yalcin HC, Al Moustafa AE. 2020. A novel in ovo model to study cancer metastasis using chicken embryos and GFP expressing cancer cells. Bosn J Basic Med Sci. 20(1):140–148.
  • Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE. 2004. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol. 22(14):2865–2872.
  • Benam KH, Dauth S, Hassell B, Herland A, Jain A, Jang K-J, Karalis K, Kim HJ, MacQueen L, Mahmoodian R, et al. 2015. Engineered in vitro disease models. Annu Rev Pathol. 10:195–262.
  • Bersini S, Jeon JS, Moretti M, Kamm RD. 2014. In vitro models of the metastatic cascade: from local invasion to extravasation. Drug Discov Today. 19(6):735–742.
  • Bhowmik A, Khan R, Ghosh MK. 2015. Blood brain barrier: a challenge for effectual therapy of brain tumors. Biomed Res Int. 2015:320941–320920.
  • Brosnan EM, Anders CK. 2018. Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies. Ann Transl Med. 6(9):163–163.
  • Brown Chandler K, E. Costello C, Rahimi N. 2019. Glycosylation in the tumor microenvironment: implications for tumor angiogenesis and metastasis. Cells. 8(6):544.
  • Burns AR, Bowden RA, MacDonell SD, Walker DC, Odebunmi TO, Donnachie EM, Simon SI, Entman ML, Smith CW. 2000. Analysis of tight junctions during neutrophil transendothelial migration. J Cell Sci. 113(1):45–57.
  • Debeir OD, Decaestecker C, Debeir O, Adanja I, Kiss R. 2008. Models of cancer cell migration and cellular imaging and analysis. In: The motile actin system in health and disease. Vol. 661. Trivandrum, India: Transworld Research Network; p. 123–156.
  • Domura R, Sasaki R, Okamoto M, Hirano M, Kohda K, Napiwocki B, Turng LS. 2017. Comprehensive study on cellular morphologies, proliferation, motility, and epithelial-mesenchymal transition of breast cancer cells incubated on electrospun polymeric fiber substrates. J Mater Chem B. 5(14):2588–2600.
  • Gandalovičová A, Rosel D, Fernandes M, Veselý P, Heneberg P, Čermák V, Petruželka L, Kumar S, Sanz-Moreno V, Brábek J. 2017. Migrastatics-anti-metastatic and anti-invasion drugs: promises and challenges. Trends Cancer. 3(6):391–406.
  • Goggins E, Kakkad S, Mironchik Y, Jacob D, Wildes F, Krishnamachary B, Bhujwalla ZM. 2018. Hypoxia inducible factors modify collagen I fibers in MDA-MB-231 triple negative breast cancer xenografts. Neoplasia. 20(2):131–139.
  • Hatherell K, Couraud PO, Romero IA, Weksler B, Pilkington GJ. 2011. Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models. J Neurosci Methods. 199(2):223–229.
  • Honn KV, Cicone B, Skoff A. 1981. Prostacyclin: a potent antimetastatic agent. Science (80-). 212(4500):1270–1272.
  • Kasiotis KM, Magiatis P, Pratsinis H, Skaltsounis A-L, Abadji V, Charalambous A, Moutsatsou P, Haroutounian SA. 2001. Synthesis and biological evaluation of novel daunorubicin-estrogen conjugates. Steroids. 66(10):785–791.
  • Kessler L, Gehrke S, Winnefeld M, Huber B, Hoch E, Walter T, Wyrwa R, Schnabelrauch M, Schmidt M, Kückelhaus M, et al. 2017. Methacrylated gelatin/hyaluronan-based hydrogels for soft tissue engineering. J Tissue Eng. 8:1–14.
  • Khanna C, Hunter K. 2004. Modeling metastasis in vivo. Carcinogenesis [Internet]. 26(3):513–523.
  • Kim JI, Lakshmikanthan V, Frilot N, Daaka Y. 2010. Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome. Mol Cancer Res. 8(4):569–577.
  • Klotz BJ, Gawlitta D, Rosenberg AJWP, Malda J, Melchels FPW. 2016. Gelatin-methacryloyl hydrogels: towards biofabrication-based tissue repair. Trends Biotechnol. 34(5):394–407.
  • Langley RR, Fidler IJ. 2007. Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis. Endocr Rev. 28(3):297–321.
  • Lécuyer MA, Kebir H, Prat A. 2016. Glial influences on BBB functions and molecular players in immune cell trafficking. Biochim Biophys Acta - Mol Basis Dis. 1862(3):472–482.
  • Li J, Zhang Y, Mao F, Lin Y, Xiao S, Xiang Z, Ma H, Zhang Y, Yu Z. 2018. The first morphologic and functional characterization of hemocytes in Hong Kong oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 81:423–429.
  • Liebner S, Dijkhuizen RM, Reiss Y, Plate KH, Agalliu D, Constantin G. 2018. Functional morphology of the blood-brain barrier in health and disease. Acta Neuropathol. 135(3):311–336.
  • Liu Q, Zhang Z, Liu Y, Cui Z, Zhang T, Li Z, Ma W. 2018. Cancer cells growing on perfused 3D collagen model produced higher reactive oxygen species level and were more resistant to cisplatin compared to the 2D model. J Appl Biomater Funct Mater. 16(3):144–150.
  • Malandrino A, Kamm RD, Moeendarbary E. 2018. In vitro modeling of mechanics in cancer metastasis. ACS Biomater Sci Eng. 4(2):294–301.
  • Man S, Ubogu EE, Williams KA, Tucky B, Callahan MK, Ransohoff RM. 2008. Human brain microvascular endothelial cells and umbilical vein endothelial cells differentially facilitate leukocyte recruitment and utilize chemokines for T cell migration. Clin Dev Immunol. 2008:384982.
  • Mehlen P, Puisieux A. 2006. Metastasis: a question of life or death. Nat Rev Cancer. 6(6):449–458.
  • Modarres H P, Janmaleki M, Novin M, Saliba J, El-Hajj F, Rezayaticharan M, Seyfoori A, Sadabadi H, Vandal M, Nguyen M D, et al. 2018. In vitro models and systems for evaluating the dynamics of drug delivery to the healthy and diseased brain. J. Controlled Release. 273:108–130. doi:https://doi.org/10.1016/j.jconrel.2018.01.024.
  • Narkhede AA, Shevde LA, Rao SS. 2017. Biomimetic strategies to recapitulate organ specific microenvironments for studying breast cancer metastasis. Int J Cancer. 141(6):1091–1109.
  • Nichol JW, Koshy ST, Bae H, Hwang CM, Yamanlar S, Khademhosseini A. 2010. Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials. 31(21):5536–5544.
  • Pelham RJ, Wang Y. l. 1997. Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc Natl Acad Sci USA. 94(25):13661–13665.
  • Pestalozzi BC, Holmes E, de Azambuja E, Metzger-Filho O, Hogge L, Scullion M, Láng I, Wardley A, Lichinitser M, Sanchez RIL, et al. 2013. CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01). Lancet Oncol. 14(3):244–248.
  • Raimondi C, Gradilone A, Naso G, Vincenzi B, Petracca A, Nicolazzo C, Palazzo A, Saltarelli R, Spremberg F, Cortesi E, et al. 2011. Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients. Breast Cancer Res Treat. 130(2):449–455.
  • Ravi M, Paramesh V, Kaviya SR, Anuradha E, Paul Solomon FD. 2015. 3D cell culture systems: advantages and applications. J Cell Physiol. 230(1):16–26.
  • Rodrigues T, Kundu B, Silva-Correia J, Kundu SC, Oliveira JM, Reis RL, Correlo VM. 2018. Emerging tumor spheroids technologies for 3D in vitro cancer modeling. Pharmacol Ther. 184:201–211.
  • Singh P, Singh A. 2012. Ocular adverse effects of anti-cancer chemotherapy. J Cancer Ther Res. 1(1):5–5.
  • Sledge GW, Loehrer PJ, Roth BJ, Einhorn LH. 1988. Cisplatin as first-line therapy for metastatic breast cancer. J Clin Oncol. 6(12):1811–1814.
  • Sobierajska K, Ciszewski WM, Wawro ME, Wieczorek-Szukała K, Boncela J, Papiewska-Pajak I. 2019. TUBB4B downregulation is critical for increasing migration of metastatic colon cancer cells. Cells. 8:810.
  • Stone NL, England TJ, O’Sullivan SE. 2019. A novel transwell blood brain barrier model using primary human cells. Front Cell Neurosci. 13:230.
  • Tominaga N, Kosaka N, Ono M, Katsuda T, Yoshioka Y, Tamura K, Lötvall J, Nakagama H, Ochiya T. 2015. Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier. Nat Commun. 6:6716
  • Visakorpi T, Hyytinen E, Koivisto P, Tanner M, Keinänen R, Palmberg C, Palotie A, Tammela T, Isola J, Kallioniemi OP. 1995. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet. 9(4):401–406.
  • Wang Y, Ma M, Wang J, Zhang W, Lu W, Gao Y, Zhang B, Guo Y. 2018. Development of a photo-crosslinking, biodegradable GelMA/PEGDA hydrogel for guided bone regeneration materials. Materials (Basel). 11(8):1345.
  • Wilhelm I, Molnár J, Fazakas C, Haskó J, Krizbai IA. 2013. Role of the blood-brain barrier in the formation of brain metastases. Int J Mol Sci. 14(1):1383–1411.
  • Yue K, Trujillo-de Santiago G, Alvarez MM, Tamayol A, Annabi N, Khademhosseini A. 2015. Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels. Biomaterials. 73:254–271.