220
Views
4
CrossRef citations to date
0
Altmetric
Research Articles

Development and characterization of lyophilized cefpodoxime proxetil-Pluronic® F127/polyvinylpyrrolidone K30 solid dispersions with improved dissolution and enhanced antibacterial activity

ORCID Icon
Pages 476-489 | Received 30 Aug 2020, Accepted 09 Feb 2021, Published online: 01 Mar 2021

References

  • Abd Alaziz DM, Sammour OA, Elshamy AEAA, Neseem DI. 2014. Formulation and evaluation of binary and ternary solid dispersions of domperidone by solvent evaporation method. Afr J Pharm Pharmacol. 8(3):66–80.
  • Ali W, Williams AC, Rawlinson CF. 2010. Stochiometrically governed molecular interactions in drug: poloxamer solid dispersions. Int J Pharm. 391(1–2):162–168.
  • Alves TF, Chaud MV, Grotto D, Jozala AF, Pandit R, Rai M, Dos Santos CA. 2018. Association of silver nanoparticles and curcumin solid dispersion: antimicrobial and antioxidant properties. AAPS PharmSciTech. 19(1):225–231.
  • Arora SC, Sharma PK, Irchhaiya R, Khatkar A, Singh N, Gagoria J. 2010. Development, characterization and solubility study of solid dispersion of cefpodoxime proxetil by solvent evaporation method. Int J ChemTech Res. 2(2):1156–1162.
  • Bangun H, Arianto A, Bangun YS, Nainggolan M. 2019. Antibacterial activity of mucoadhesive gastroretentive drug delivery system of alginate beads containing turmeric Extract - PVP Solid Dispersion. Open Access Maced J Med Sci. 7(22):3868–3873.
  • Betageri GV, Makarla KR. 1995. Enhancement of dissolution of glyburide by solid dispersion and lyophilization techniques. Int J Pharm. 126(1-2):155–160.
  • Bhargava S, Agrawal GP. 2008. Preparation & characterization of solid inclusion complex of cefpodoxime proxetil with β-cyclodextrin. Curr Drug Deliv. 5(1):1–6.
  • Bikiaris DN. 2011. Solid dispersions, part I: recent evolutions and future opportunities in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs. Expert Opin Drug Deliv. 8(11):1501–1519.
  • Borin MT. 1991. A review of the pharmacokinetics of cefpodoxime proxetil. Drugs. 42:13–21.
  • Chiou WL, Riegelman S. 1971. Pharmaceutical applications of solid dispersion systems. J Pharm Sci. 60(9):1281–1302.
  • [CLSI] Clinical and Laboratory Standards Institute. 2015. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 11th ed. Wayne (PA): CLSI standard M07.
  • Craig DQ. 2002. The mechanisms of drug release from solid dispersions in water-soluble polymers. Int J Pharm. 231(2):131–144.
  • Crauste-Manciet S, Brossard D, Decroix MO, Farinotti R, Chaumeil JC. 1998. Cefpodoxime proxetil protection from intestinal lumen hydrolysis by oil-in-water submicron emulsions. Int J Pharm. 165(1):97–106.
  • Date AA, Nagarsenker MS. 2007. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int J Pharm. 329(1–2):166–172.
  • Dhoka MV, Nimbalkar UA, Pande A. 2011. Preparation of cefpodoxime proxetil-polymeric microspheres by the emulsion solvent diffusion method for taste masking. Int J PharmTech Res. 3(1):411–419.
  • Dhoka MV, Rao SH, Joshi PP, Gawande VT. 2009. Preparation and evaluation of solid dispersions of cefpodoxime proxetil. J Pharm Res. 2(9):1481–1484.
  • Diaz DA, Colgan ST, Langer CS, Bandi NT, Likar MD, Alstine LV. 2016. Dissolution similarity requirements: how similar or dissimilar are the global regulatory expectations? AAPS J. 18(1):15–22.
  • El-Badry M, Fathy M. 2006. Enhancement of the dissolution and permeation rates of meloxicam by formation of its freeze-dried solid dispersions in polyvinylpyrrolidone K-30. Drug Dev Ind Pharm. 32(2):141–150.
  • Faisal Ali S, Joshi M, Akhtar N, Sharma V, Pathak K. 2016. Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan. Pharm Biomed Res. 2(1):23–35.
  • Fathy M, Sheha M. 2000. In vitro and in vivo evaluation of an amylobarbitone/hydroxypropylbetacyclodextrin complex prepared by a freeze-drying method. Pharmazie. 55:513–517.
  • FDA. 2020. Guidance for industry dissolution testing of immediate release solid oral dosage forms. [accessed 2020 Feb 29]:[17 p.]. https://www.fda.gov/media/70936/download.
  • Fitriani L, Ismed F, Bakhtiar A. 2019. Hydrogel formulation of usnic acid and antibacterial activity test against Propionibacterium acne. Sci Pharm. 87(1):1–8.
  • Fu X, Huck D, Makein L, Armstrong B, Willen U, Freeman T. 2012. Effect of particle shape and size on flow properties of lactose powders. Particuology. 10(2):203–208.
  • Fusco S, Borzacchiello A, Netti PA. 2006. Perspectives on: PEO-PPOPEO triblock copolymers and their biomedical applications. J Bioact Compat Pol. 21(2):149–164.
  • Gao Y, Qian S, Zhang J. 2010. Physicochemical and pharmakokinetic characterization of a spray-dried cefpodoxime proxetil nanosuspension. Chem Pharm Bull. 58(7):912–917.
  • Ghaderkhani J, Yousefimashouf R, Arabestani M, Roshanaei G, Asl SS, Abbasalipourkabir R. 2019. Improved antibacterial function of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus. Artif Cell Nanomed B. 47(1):1181–1193.
  • Gundogdu E, Koksal C, Karasulu E. 2012. Comparison of cefpodoxime proxetil release and antimicrobial activity from tablet formulations: complexation with hydroxypropyl-β-cyclodextrin in the presence of water soluble polymer. Drug Dev Ind Pharm. 38(6):689–696.
  • Gupta S, Munjal T, Kaur A, Bagga KS. 2014. Fabrication and characterization of cefpodoxime proxetil solid dispersion for solubility enhancement. Int J Pharm Sci Drug Res. 6(4):271–277.
  • Gupta P, Thilagavathi R, Chakraborti AK, Bansal AK. 2005. Role of molecular interaction in stability of celecoxib-PVP amorphous systems. Mol Pharm. 2(5):384–391.
  • Gyulai G, Magyar A, Rohonczy J, Orosz J, Yamasaki M, Bosze S, Kiss E. 2016. Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles. Express Polym Lett. 10(3):216–224.
  • Iannuccelli V, Coppi G, Leo E, Fontana F, Bernabei MT. 2000. PVP solid dispersions for the controlled release of furosemide from a floating multiple-unit system. Drug Dev Ind Pharm. 26(6):595–603.
  • Ismail MY, Ghareeb MM. 2018. Enhancement of the solubility and dissolution rate of rebamipide by using solid dispersion technique (Part I). Iraqi J of Pharm Sci. 27(2):55–65.
  • Jatinder K, Aggarwal G, Singh G, Rana AC. 2012. Improvement of drug solubility using solid dispersion. Int J Pharm Pharm Sci. 4:47–53.
  • Junior SAF, Barbosa IS, Santos VLD, Silva RL, Junior EC. 2014. Test of dissolution and comparison of in vitro dissolution profiles of coated ranitidine tablets marketed in Bahia, Brazil. Braz J Pharm Sci. 50(1):83–89.
  • Kakumanu VK, Arora V, Bansal AK. 2006. Investigation of factors responsible for low oral bioavailability of cefpodoxime proxetil. Int J Pharm. 317(2):155–160.
  • Karolewicz B, Gajda M, Górniak A, Owczarek A, Mucha I. 2017. Pluronic F127 as a suitable carrier for preparing the imatinib base solid dispersions and its potential in development of a modified release dosage forms. J Therm Anal Calorim. 130(1):383–390.
  • Karolewicz B, Gajda M, Owczarek A, Pluta J, Górniak A. 2014. Physicochemical and dissolution studies of simvastatin solid dispersions with Pluronic F127. Pharmazie. 69(8):589–594.
  • Kassem AA, Zaki SA, Mursi NM, Tayel SA. 1979. Antimicrobial activity of chloramphenicol in solid dispersion systems. Pharmazie. 34(1):43–44.
  • Kawakami K. 2012. Modification of physicochemical characteristics of active pharmaceutical ingredients and application of supersaturatable dosage forms for improving bioavailability of poorly absorbed drugs. Adv Drug Deliv Rev. 64(6):480–495.
  • Khan F, Katara R, Ramteke S. 2010. Enhancement of bioavailability of cefpodoxime proxetil using different polymeric microparticles. AAPS PharmSciTech. 11(3):1368–1375.
  • Kim MJ, Lee JH, Yoon H, Kim SJ, Jeon DY, Jang JE, Lee D, Khang G. 2013. Preparation, characterization and in vitro dissolution of aceclofenac-loaded PVP solid dispersions prepared by spray drying or rotary evaporation method. J Pharm Investig. 43(2):107–113.
  • Kim NA, Oh HK, Lee JC, Choi YH, Jeong SH. 2020. Comparison of solubility enhancement by solid dispersion and micronized butein and its correlation with in vivo study. J Pharm Investig. [accessed 2020 Apr 24]:[8 p.] https://doi.org/https://doi.org/10.1007/s40005-020-00486-9.
  • Kolašinac N, Kachrimanis K, Homšek I, Grujić B, Ðurić Z, Ibrić S. 2012. Solubility enhancement of desloratadine by solid dispersion in poloxamers. Int J Pharm. 436(1–2):161–170.
  • Kukati L, Chittimalli K, Shaik NB. 2014. Formulation and evaluation of floating tablets of cefpodoxime proxetil. J Sci Res. 6(3):563–579.
  • Kumar P, Mohan C, Shankar MKSU, Gulati M. 2011. Physiochemical characterization and release rate studies of solid dispersions of ketoconazole with Pluronic F127 and PVP K-30. Iran J Pharm Res. 10(4):685–694.
  • Leuner C, Dressman J. 2000. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm. 50(1):47–60.
  • Marsac PJ, Li T, Taylor LS. 2009. Estimation of drug-polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters. Pharm Res. 26(1):139–151.
  • Medarevic DP, Kachrimanis K, Mitric M, Djuris J, Djuric Z, Ibric S. 2016. Dissolution rate enhancement and physicochemical characterization of carbamazepine-poloxamer solid dispersions. Pharm Dev Technol. 21(3):268–276.
  • Muratkar D, Untwali L, Naik J. 2012. Preparation and characterization of biodegradable cefpodoxime proxetil nanocapsules. Asian J Pharm Sci. 7(2):143–148.
  • Nepal PR, Han HK, Choi HK. 2010. Enhancement of solubility and dissolution of Coenzyme Q10 using solid dispersion formulation. Int J Pharm. 383(1–2):147–153.
  • Newa M, Bhandari KH, Li DX, Kwon TH, Kim JA, Yoo BK, Woo JS, Lyoo WS, Yong CS, Choi HG. 2007. Preparation, characterization and in vivo evaluation of ibuprofen binary solid dispersions with poloxamer 188. Int J Pharm. 343(1–2):228–237.
  • Nimbalkar UA, Dhoka MV, Sonawane PA. 2011. Solid lipid nanoparticles for enhancement of oral bioavailability of cefpodoxime proxetil. IJPRS. 2(11):2974–2982.
  • Pandit JK, Khakurel BK. 1984. In vitro and in vivo evaluation of some fast release dosage forms of hydrochlorothiazide. Drug Dev Ind Pharm. 10(10):1709–1724.
  • Papageorgiou GZ, Bikiaris D, Kanaze FI, Karavas E, Stergiou A, Georgarakis E. 2008. Tailoring the release rates of fluconazole using solid dispersions in polymer blends. Drug Dev Ind Pharm. 34(3):336–346.
  • Park J, Cho W, Cha KH, Ahn J, Han K, Hwang SJ. 2013. Solubilization of the poorly water soluble drug, telmisartan, using supercritical anti-solvent (SAS) process. Int J Pharm. 441(1–2):50–55.
  • Ramadhani N, Shabir M, McConville C. 2014. Preparation and characterisation of Kolliphor® P 188 and P 237 solid dispersion oral tablets containing the poorly water soluble drug disulfiram. Int J Pharm. 475(1–2):514–522.
  • Rodriguez-Aller M, Guillarme D, Veuthey JL, Gurny R. 2015. Strategies for formulating and delivering poorly water-soluble drugs. J Drug Deliv Sci Technol. 30:342–351.
  • Sankari T, Al-Hariri S. 2018. Preparation and characterization of cefuroxime axetil solid dispersions using poloxamer 188. Braz J Pharm Sci. 54(4):e17644.
  • Sareen S, Mathew G, Joseph L. 2012. Improvement in solubility of poor water-soluble drugs by solid dispersion. Int J Pharm Investig. 2(1):12–17.
  • Savjani KT, Gajjar AK, Savjani JK. 2012. Drug solubility: importance and enhancement techniques. ISRN Pharm. 2012:195727.
  • Shabir GA. 2003. Validation of high-performance liquid chromatography methods for pharmaceutical analysis. Understanding the differences and similarities between validation requirements of the US Food and Drug Administration, the US Pharmacopeia and the International Conference on Harmonization. J Chromatogr A. 987(1–2):57–66.
  • Sharma A, Jain CP. 2010. Preparation and characterization of solid dispersions of carvedilol with PVP K30. Res Pharm Sci. 5(1):49–56.
  • Singh A, Mooter GV. 2016. Spray drying formulation of amorphous solid dispersions . Adv Drug Deliv Rev. 100:27–50.
  • Sinha S, Ali M, Baboota S, Ahuja A, Kumar A, Ali J. 2010. Solid dispersion as an approach for bioavailability enhancement of poorly water-soluble drug ritonavir. AAPS PharmSciTech. 11(2):518–527.
  • Song CK, Yoon IS, Kim DD. 2016. Poloxamer-based solid dispersions for oral delivery of docetaxel: differential effects of F68 and P85 on oral docetaxel bioavailability. Int J Pharm. 507(1–2):102–108.
  • Thybo P, Pedersen BL, Hovgaard L, Holm R, Müllertz A. 2008. Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30. Pharm Dev Technol. 13(5):375–386.
  • Tran P, Pyo YC, Kim DH, Lee SE, Kim JK, Park JS. 2019. Overview of the manufacturing methods of solid dispersion technology for improving the solubility of poorly water-soluble drugs and application to anticancer drugs. Pharmaceutics. 11(3):132.
  • Vo CLN, Park C, Lee BJ. 2013. Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs. Eur J Pharm Biopharm. 85(3 Pt B):799–813.
  • Wiswaja M, Bhikshapathi DVRN. 2018. Improvement of solubility and dissolution of rilpivirine solid dispersions by solvent evaporation technique and novel carriers. Int J Pharm Sci Nanotech. 11(4):4177–4184.
  • Xu H, Kuo SW, Huang CF, Chang FC. 2004. Characterization of poly (vinyl pyrrolidone‐co‐isobutylstyryl polyhedral oligomeric silsesquioxane) nanocomposites. J Appl Polym Sci. 91(4):2208–2215.
  • Yurtdaş G, Demirel M, Genç L. 2011. Inclusion complexes of fluconazole with β-cyclodextrin: physicochemical characterization and in vitro evaluation of its formulation. J Incl Phenom Macrocycl Chem. 70(3–4):429–435.
  • Yurtdaş-Kırımlıoğlu G. 2019. A systematic evaluation of formulation parameters on the characteristics of biodegradable PLGA-based nanoparticles for ophthalmic application. Lat Am J Pharm. 38(11):2131–2142.
  • Yurtdaş-Kırımlıoğlu G. 2020. Host-guest inclusion complex of desloratadine with 2-(hydroxy)propyl-β-cyclodextrin (HP-β-CD): preparation, binding behaviors and dissolution properties. J Res Pharm. 24(5):693–707.
  • Yurtdaş-Kırımlıoğlu G. 2021. A promising approach to design thermosensitive in situ gel based on solid dispersions of desloratadine with Kolliphor® 188 and Pluronic® F127. J Therm Anal Calorim. [accessed 2021 Jan 5]:[21 p.]. https://doi.org/https://doi.org/10.1007/s10973-020-10460-0.
  • Yurtdaş-Kırımlıoğlu G, Görgülü Ş. 2021. Surface modification of PLGA nanoparticles with Chitosan or Eudragit® RS 100: characterization, prolonged release, cytotoxicity, and enhanced antimicrobial activity. J Drug Dev Tech. 61:102145.
  • Zhang X, Xing H, Zhao Y, Ma Z. 2018. Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs. Pharmaceutics. 10(3):74.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.