Preparation and functional evaluation of electrospun polymeric nanofibers as a new system for sustained topical ocular delivery of itraconazole

References

• Abelson MB, Udell IJ, Weston JH. 1981. Normal human tear pH by direct measurement. Arch Ophthalmol. 99(2):301–301.
   PubMedGoogle Scholar
• Aksungur P, Demirbilek M, Denkbaş EB, Ünlü N. 2012. Comparative evaluation of cyclosporine A/HPβCD-incorporated PLGA nanoparticles for development of effective ocular preparations. J Microencapsul. 29(6):605–613.
   PubMed Web of Science ®Google Scholar
• Alhowyan AA, Altamimi MA, Kalam MA, Khan AA, Badran M, Binkhathlan Z, Alkholief M, Alshamsan A. 2019. Antifungal efficacy of Itraconazole loaded PLGA-nanoparticles stabilized by vitamin-E TPGS: in vitro and ex vivo studies. J Microbiol Methods. 161:87–95.
   PubMed Web of Science ®Google Scholar
• Ameeduzzafar AJ, Fazil M, Qumbar M, Khan N, Ali A. 2016. Colloidal drug delivery system: amplify the ocular delivery. Drug Deliv. 23(3):700–716.
   Web of Science ®Google Scholar
• AnjiReddy K, Karpagam S. 2019. Hyperbranched cellulose polyester of oral thin film and nanofiber for rapid release of donepezil; preparation and in vivo evaluation. Int J Biol Macromol. 124:871–887.
   PubMed Web of Science ®Google Scholar
• Bagherian Far M, Ziyadi H. 2016. Fabrication of polyvinyl alcohol/kefiran nanofibers membrane using electrospinning. JPHS. 4(3):211–2018.
   Google Scholar
• Bahrami S, Nouri M. 2009. Chitosan-poly (vinyl alcohol) blend nanofibers: morphology, biological and antimicrobial properties. E-Polymers. 9(1):133.
   Google Scholar
• Ball M, Rebhun W, Trepanier L, Gaarder J, Schwark W. 1997. Corneal concentrations and preliminary toxicological evaluation of an itraconazole/dimethyl sulphoxide ophthalmic ointment. J Vet Pharmacol Ther. 20(2):100–104.
   PubMed Web of Science ®Google Scholar
• Bognitzki M, Czado W, Frese T, Schaper A, Hellwig M, Steinhart M, Greiner A, Wendorff JH. 2001. Nanostructured fibers via electrospinning. Adv Mater. 13(1):70–72.
   Web of Science ®Google Scholar
• Bolourchian N, Mahboobian MM, Dadashzadeh S. 2013. The effect of PEG molecular weights on dissolution behavior of Simvastatin in solid dispersions. Iran J Pharm Res. 12(Suppl):11–20.
   PubMed Web of Science ®Google Scholar
• Bui HT, Chung OH, Cruz JD, Park JS. 2014. Fabrication and characterization of electrospun curcumin-loaded polycaprolactone-polyethylene glycol nanofibers for enhanced wound healing. Macromol Res. 22(12):1288–1296.
   Web of Science ®Google Scholar
• Çay A, Miraftab M, Kumbasar EPA. 2014. Characterization and swelling performance of physically stabilized electrospun poly (vinyl alcohol)/chitosan nanofibres. Eur Polym J. 61:253–262.
   Web of Science ®Google Scholar
• Chidambaram P, Bowen C, Chakravarthi S, Machala C, Wise R. 2006. Fundamentals of silicon material properties for successful exploitation of strain engineering in modern CMOS manufacturing. IEEE Trans Electron Dev. 53(5):944–964.
   Web of Science ®Google Scholar
• Cholkar K, Patel SP, Vadlapudi AD, Mitra AK. 2013. Novel strategies for anterior segment ocular drug delivery. J Ocul Pharmacol Ther. 29(2):106–123.
   PubMed Web of Science ®Google Scholar
• Chou S-F, Carson D, Woodrow KA. 2015. Current strategies for sustaining drug release from electrospun nanofibers. J Control Release. 220:584–591.
   PubMed Web of Science ®Google Scholar
• Christoforou T, Doumanidis C. 2010. Biodegradable cellulose acetate nanofiber fabrication via electrospinning. J Nanosci Nanotechnol. 10(9):6226–6233.
   PubMed Web of Science ®Google Scholar
• Cohan BE, Leenslag JW, Miles J, Pennings AJ. 1985. An evaluation of ultrastrong polyethylene fiber as an ophthalmic suture. Arch Ophthalmol. 103(12):1816–1821.
   PubMedGoogle Scholar
• De Beule K, Van Gestel J. 2001. Pharmacology of itraconazole. Drugs. 61(1):27–37.
   PubMedGoogle Scholar
• Deepak A, Goyal AK, Rath G. 2018. Nanofiber in transmucosal drug delivery. J Drug Deliv Sci Technol. 43:379–387.
   Web of Science ®Google Scholar
• Duxfield L, Sultana R, Wang R, Englebretsen V, Deo S, Rupenthal ID, Al-Kassas R. 2016. Ocular delivery systems for topical application of anti-infective agents. Drug Dev Ind Pharm. 42(1):1–11.
   PubMed Web of Science ®Google Scholar
• Gan L, Wang J, Jiang M, Bartlett H, Ouyang D, Eperjesi F, Liu J, Gan Y. 2013. Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers. Drug Discov Today. 18(5–6):290–297.
   PubMed Web of Science ®Google Scholar
• Garg T, Malik B, Rath G, Goyal AK. 2014. Development and characterization of nano-fiber patch for the treatment of glaucoma. Eur J Pharm Sci. 53:10–16.
   PubMed Web of Science ®Google Scholar
• Gaudana R, Ananthula HK, Parenky A, Mitra AK. 2010. Ocular drug delivery. AAPS J. 12(3):348–360.
   PubMed Web of Science ®Google Scholar
• Ghate D, Edelhauser HF. 2006. Ocular drug delivery. Expert Opin Drug Deliv. 3(2):275–287.
   PubMedGoogle Scholar
• Gupta H, Aqil M, Khar R, Ali A, Bhatnagar A, Mittal G. 2011. Biodegradable levofloxacin nanoparticles for sustained ocular drug delivery. J Drug Target. 19(6):409–417.
   PubMed Web of Science ®Google Scholar
• Han SO, Youk JH, Min KD, Kang YO, Park WH. 2008. Electrospinning of cellulose acetate nanofibers using a mixed solvent of acetic acid/water: effects of solvent composition on the fiber diameter. Mater Lett. 62(4–5):759–762.
   Web of Science ®Google Scholar
• Karataş A, Algan AH, Pekel-Bayramgil N, Turhan F, Altanlar N. 2016. Ofloxacin loaded electrospun fibers for ocular drug delivery: effect of formulation variables on fiber morphology and drug release. Curr Drug Deliv. 13(3):433–443.
   PubMed Web of Science ®Google Scholar
• Jung JH, Chiang B, Grossniklaus HE, Prausnitz MR. 2018. Ocular drug delivery targeted by iontophoresis in the suprachoroidal space using a microneedle. J Control Release. 277:14–22.
   PubMed Web of Science ®Google Scholar
• Kalam MA, Humayun M, Parvez N, Yadav S, Garg A, Amin S, Sultana Y, Ali A. 2007. Release kinetics of modified pharmaceutical dosage forms: a review. Cont J Pharm Sci. 1(1):30–35.
   Google Scholar
• Kamble R, Mehtre R, Mehta P, Nangare P, Patil S. 2019. Albendazole electrospun nanofiber films: in-vitro and ex-vivo assessment. BioNanoSci. 9(3):625–636.
   Web of Science ®Google Scholar
• Karuppuswamy P, Venugopal JR, Navaneethan B, Laiva AL, Ramakrishna S. 2015. Polycaprolactone nanofibers for the controlled release of tetracycline hydrochloride. Mater Lett. 141:180–186.
   Web of Science ®Google Scholar
• Kaur IP, Garg A, Singla AK, Aggarwal D. 2004. Vesicular systems in ocular drug delivery: an overview. Int J Pharm. 269(1):1–14.
   PubMed Web of Science ®Google Scholar
• Kaur IP, Rana C, Singh H. 2008. Development of effective ocular preparations of antifungal agents. J Ocul Pharmacol Ther. 24(5):481–494.
   PubMed Web of Science ®Google Scholar
• Kumar N. 2015. D-optimal experimental approach for designing topical microemulsion of itraconazole: characterization and evaluation of antifungal efficacy against a standardized Tinea pedis infection model in Wistar rats. Eur J Pharm Sci. 67:97–112.
   PubMed Web of Science ®Google Scholar
• Lim S, Jane J. 1994. Storage stability of injection-molded starch-zein plastics under dry and humid conditions. J Environ Polym Degr. 2(2):111–120.
   Google Scholar
• Liu H, Tang C. 2007. Electrospinning of cellulose acetate in solvent mixture N,N-dimethylacetamide (DMAc)/acetone. Polym J. 39(1):65–72.
   Web of Science ®Google Scholar
• Martins AF, Facchi SP, da Câmara PC, Camargo SE, Camargo CH, Popat KC, Kipper MJ. 2018. Novel poly(ε-caprolactone)/amino-functionalized tannin electrospun membranes as scaffolds for tissue engineering. J Colloid Interface Sci. 525:21–30.
   PubMed Web of Science ®Google Scholar
• Mehrandish S, Mirzaeei S. 2021. A review on ocular novel drug delivery systems of antifungal drugs: functional evaluation and comparison of conventional and novel dosage forms. Adv Pharm Bull. 11(1):28–38.
   PubMed Web of Science ®Google Scholar
• Mehrandish S, Mirzaeei S. 2022. Design of novel nanoemulsion formulations for topical ocular delivery of itraconazole: development, characterization and in vitro bioassay. Adv Pharm Bull. forthcoming.
   Web of Science ®Google Scholar
• Mirzaeei S, Barfar D. 2022. Design and development of antibacterial/anti-inflammatory dual drug-loaded nanofibrous inserts for ophthalmic sustained delivery of gentamicin and methylprednisolone: in vitro bioassay, solvent, and method effects’ evaluation. Adv Pharm Bull. forthcoming.
   Google Scholar
• Mirzaeei S, Berenjian K, Khazaei R. 2018. Preparation of the potential ocular inserts by electrospinning method to achieve the prolong release profile of triamcinolone acetonide. Adv Pharm Bull. 8(1):21–27.
   PubMed Web of Science ®Google Scholar
• Mirzaeei S, Taghe S, Asare-Addo K, Nokhodchi A. 2021. Polyvinyl alcohol/chitosan single-layered and polyvinyl alcohol/chitosan/Eudragit RL100 multi-layered electrospun nanofibers as an ocular matrix for the controlled release of ofloxacin: an in vitro and in vivo evaluation. AAPS PharmSciTech. 22(5):1–13.
   Web of Science ®Google Scholar
• Mishra D, Gilhotra R. 2008. Design and characterization of bioadhesive in-situ gelling ocular inserts of gatifloxacin sesquihydrate. DARU J Pharm Sci. 16(1):1–8.
   Web of Science ®Google Scholar
• Mohammadi G, Mirzaeei S, Taghe S, Mohammadi P. 2019. Preparation and evaluation of Eudragit® L100 nanoparticles loaded impregnated with KT tromethamine loaded PVA-HEC insertions for ophthalmic drug delivery. Adv Pharm Bull. 9(4):593–600.
   PubMed Web of Science ®Google Scholar
• Murphy S, Leeke G, Jenkins M. 2012. A Comparison of the use of FTIR spectroscopy with DSC in the characterisation of melting and crystallisation in polycaprolactone. J Therm Anal Calorim. 107(2):669–674.
   Web of Science ®Google Scholar
• Pandey P, Panwar AS, Dwivedi P, Jain P, Agrawal A, Jain D. 2011. Design and evaluation of ocular inserts for controlled drug delivery of Acyclovir. Int J Pharm Biol Arch. 2(4):1106–1110.
   Google Scholar
• Park J-C, Ito T, Kim K-O, Kim K-W, Kim B-S, Khil M-S, Kim H-Y, Kim I-S. 2010. Electrospun poly (vinyl alcohol) nanofibers: effects of degree of hydrolysis and enhanced water stability. Polym J. 42(3):273–276.
   Web of Science ®Google Scholar
• Patane MA, Cohen A, Sheppard JD, Nguyen QD. 2011. Ocular iontophoresis for drug delivery. Retin Today. 6:64–66.
   Google Scholar
• Patel A, Cholkar K, Agrahari V, Mitra AK. 2013. Ocular drug delivery systems: an overview. World J Pharmacol. 2(2):47–64.
   PubMedGoogle Scholar
• Pérez-González GL, Villarreal-Gómez LJ, Serrano-Medina A, Torres-Martínez EJ, Cornejo-Bravo JM. 2019. Mucoadhesive electrospun nanofibers for drug delivery systems: applications of polymers and the parameters' roles. Int J Nanomedicine. 14:5271–5285.
   PubMed Web of Science ®Google Scholar
• Pham Le Q, Uspenskaya MV, Olekhnovich RO, Baranov MA. 2021. The mechanical properties of PVC nanofiber mats obtained by electrospinning. Fibers. 9(1):2.
   Web of Science ®Google Scholar
• Phiriyawirut M, Phaechamud T. 2012. Gallic acid-loaded cellulose acetate electrospun nanofibers: thermal properties, mechanical properties, and drug release behavior. OJPChem. 02 (01):21–29.
   Google Scholar
• Queiroz KM, Silva M-LM, Prado ND, Lima PMA, Diniz RDL, César IC, Pianetti GA, Santos DA. 2009. Comparison of microbiological assay and HPLC-UV for determination of fluconazole in capsules. Braz J Pharm Sci. 45(4):693–700.
   Web of Science ®Google Scholar
• Ravikumar R, Ganesh M, Senthil V, Ramesh YV, Jakki SL, Choi EY. 2018. Tetrahydro curcumin loaded PCL-PEG electrospun transdermal nanofiber patch: preparation, characterization, and in vitro diffusion evaluations. J Drug Deliv Sci Technol. 44:342–348.
   Web of Science ®Google Scholar
• Rieger KA, Birch NP, Schiffman JD. 2013. Designing electrospun nanofiber mats to promote wound healing – a review. J Mater Chem B. 1(36):4531–4541.
   PubMed Web of Science ®Google Scholar
• Sarkar S, Bhattacharya TK, Roy A, Ghosh K. 2016. A review of ocular fungal infections other than keratomycosis: the global and Indian scenario. J Evol Med Dent Sci. 5(49):3268–3272.
   Web of Science ®Google Scholar
• Scaffaro R, Lopresti F, Maio A, Botta L, Rigogliuso S, Ghersi G. 2017. Electrospun PCL/GO-g-PEG structures: processing-morphology-properties relationships. Compos Part A Appl Sci Manuf. 92:97–107.
   Web of Science ®Google Scholar
• Schiffman JD, Schauer CL. 2008. A review: electrospinning of biopolymer nanofibers and their applications. Polym Rev. 48(2):317–352.
   Web of Science ®Google Scholar
• Sebe I, Szabó P, Kállai-Szabó B, Zelkó R. 2015. Incorporating small molecules or biologics into nanofibers for optimized drug release: a review. Int J Pharm. 494(1):516–530.
   PubMed Web of Science ®Google Scholar
• Singla J, Bajaj T, Goyal AK, Rath G. 2019. Development of nanofibrous ocular insert for retinal delivery of fluocinolone acetonide. Curr Eye Res. 44(5):541–550.
   PubMed Web of Science ®Google Scholar
• Son WK, Youk JH, Park WH. 2006. Antimicrobial cellulose acetate nanofibers containing silver nanoparticles. Carbohydr Polym. 65(4):430–434.
   Web of Science ®Google Scholar
• Sun X, Yu Z, Cai Z, Yu L, Lv Y. 2016. Voriconazole composited polyvinyl alcohol/hydroxypropyl-β-cyclodextrin nanofibers for ophthalmic delivery. PLoS One. 11(12):e0167961.
   PubMed Web of Science ®Google Scholar
• Taepaiboon P, Rungsardthong U, Supaphol P. 2007. Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E. Eur J Pharm Biopharm. 67(2):387–397.
   PubMed Web of Science ®Google Scholar
• Taghe S, Mehrandish S, Mirzaeei S. 2022. Preparation of azithromycin nanofibers as controlled release ophthalmic drug carriers using electrospinning technique: in-vitro and in-vivo characterization. Adv Pharm Bull. forthcoming.
   Google Scholar
• Taghe S, Mirzaeei S. 2019. Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery. Braz J Pharm Sci. 55:e17105.
   Web of Science ®Google Scholar
• Taghe S, Mirzaeei S, Alany RG, Nokhodchi A. 2020. Polymeric inserts containing Eudragit® L100 nanoparticle for improved ocular delivery of azithromycin. Biomedicines. 8(11):466.
   Web of Science ®Google Scholar
• Tan H-L, Kai D, Pasbakhsh P, Teow S-Y, Lim Y-Y, Pushpamalar J. 2020. Electrospun cellulose acetate butyrate/polyethylene glycol (CAB/PEG) composite nanofibers: a potential scaffold for tissue engineering. Colloids Surf B Biointerfaces. 188:110713.
   PubMed Web of Science ®Google Scholar
• Tang C, Chen P, Liu H. 2008. Cocontinuous cellulose acetate/polyurethane composite nanofiber fabricated through electrospinning. Polym Eng Sci. 48(7):1296–1303.
   Web of Science ®Google Scholar
• Tawfik EA, Alshamsan A, Kalam MA, Raish M, Alkholief M, Stapleton P, Harvey K, Craig DQ, Barker SA. 2021. In vitro and in vivo biological assessment of dual drug-loaded coaxial nanofibers for the treatment of corneal abrasion. Int J Pharm. 604:120732.
   PubMedGoogle Scholar
• Teixeira MA, Paiva MC, Amorim MTP, Felgueiras HP. 2020. Electrospun nanocomposites containing cellulose and its derivatives modified with specialized biomolecules for an enhanced wound healing. Nanomaterials. 10(3):557.
   Web of Science ®Google Scholar
• Troke P, Andrews R, Pye G, Richardson K. 1990. Fluconazole and other azoles: translation of in vitro activity to in vivo and clinical efficacy. Rev Infect Dis. 12(Supplement_3):S276–S280.
   PubMedGoogle Scholar
• Van Do C, Nguyen TTT, Park JS. 2012. Fabrication of polyethylene glycol/polyvinylidene fluoride core/shell nanofibers via melt electrospinning and their characteristics. Sol Energy Mater Sol Cells. 104:131–139.
   Web of Science ®Google Scholar
• Vuddanda PR, Mathew AP, Velaga S. 2016. Electrospun nanofiber mats for ultrafast release of ondansetron. React Funct Polym. 99:65–72.
   Web of Science ®Google Scholar
• Wroblewska K, Kucinska M, Murias M, Lulek J. 2015. Characterization of new eye drops with choline salicylate and assessment of their irritancy by in vitro short time exposure tests. Saudi Pharm J. 23(4):407–412.
   PubMed Web of Science ®Google Scholar
• Xue R, Qian Y, Li L, Yao G, Yang L, Sun Y. 2017. Polycaprolactone nanofiber scaffold enhances the osteogenic differentiation potency of various human tissue-derived mesenchymal stem cells. Stem Cell Res Ther. 8(1):1–9.
   PubMedGoogle Scholar
• Yellepeddi VK, Palakurthi S. 2016. Recent advances in topical ocular drug delivery. J Ocul Pharmacol Ther. 32(2):67–82.
   PubMed Web of Science ®Google Scholar