Controlled release of bioactive IL-2 from visible light photocured biodegradable elastomers for cancer immunotherapy applications

References

• Achkar T, Arjunan A, Wang H, Saul M, Davar D, Appleman LJ, Friedland D, Parikh RA. 2017. High-dose interleukin 2 in patients with metastatic renal cell carcinoma with sarcomatoid features. PloS One. 12(12):e0190084.
   PubMed Web of Science ®Google Scholar
• Andrus L, Granelli-Piperno A, Reich E. 1984. Cytotoxic T cells both produce and respond to interleukin 2. J Exp Med. 159(2):647–652.
   PubMed Web of Science ®Google Scholar
• Ash C, Dubec M, Donne K, Bashford T. 2017. Effect of wavelength and beam width on penetration in light-tissue interaction using computational methods. Lasers Med Sci. 32(8):1909–1918.
   PubMed Web of Science ®Google Scholar
• Chan YP, Meyrueix R, Kravtzoff R, Nicolas F, Lundstrom K. 2007. Review on Medusa:a polymer-based sustained release technology for protein and peptide drugs. Expert Opin Drug Deliv. 4(4):441–451.
   PubMed Web of Science ®Google Scholar
• Chapanian R, Amsden BG. 2010. Combined and sequential delivery of bioactive VEGF165 and HGF from poly(trimethylene carbonate) based photo-cross-linked elastomers. J Control Release. 143(1):53–63.
   PubMed Web of Science ®Google Scholar
• Corona-Ortega MT, Valle-Mendiola A, Aguilar-Santelises L, del Valle AG, Rangel-Corona R, Weiss-Steider B. 2018. Preclinical studies for a cationic liposome formulation containing Il-2 Intended for the treatment of Human Tumors. Arch Pharm Pharma Sci. 2: 051–059.
   Google Scholar
• Den OW, Jacobs JJ, Battermann JJ, Hordijk GJ, Krastev Z, Moiseeva EV, Stewart RJ, Ziekman PG, Koten JW. 2008. Local therapy of cancer with free IL-2. Cancer Immunol Immunother. 57(7):931–950.
   PubMed Web of Science ®Google Scholar
• Egilmez NK, Jong YS, Iwanuma Y, Jacob JS, Santos CA, Chen FA, Mathiowitz E, Bankert RB. 1998. Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model. Cancer Immunol Immunother. 46(1):21–24.
   PubMed Web of Science ®Google Scholar
• El-Laboudy H, Shaker MA, Younes HM. 2011. Soft Biodegradable Elastomers Based on Poly (Octanediol-Tartarate) for Drug Delivery and Tissue Engineering: Synthesis, Characterization and Biocompatibility Studies. Soft Mater. 9(4):409–428.
   Web of Science ®Google Scholar
• Gounili P. 1999. The effect of pH and temperature on the conformational stability of recombinant human interleukin-2. University of Connecticut.
   Google Scholar
• Gu F, Younes HM, El-Kadi AO, Neufeld RJ, Amsden BG. 2005. Sustained interferon-gamma delivery from a photocrosslinked biodegradable elastomer. J Control Release. 102(3):607–617.
   PubMed Web of Science ®Google Scholar
• Hanes J, Sills A, Zhao Z, Suh KW, Tyler B, DiMeco F, Brat DJ, Choti MA, Leong KW, Pardoll DM, et al. 2001. Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors. Pharm Res. 18(7):899–906.
   PubMed Web of Science ®Google Scholar
• Hsu W, Lesniak MS, Tyler B, Brem H. 2005. Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma. J Neurooncol. 74(2):135–140.
   PubMed Web of Science ®Google Scholar
• Ismail HM, Zamani S, Elrayess MA, Kafienah W, Younes HM. 2018. New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications. Polymers. 10(4):455.
   PubMed Web of Science ®Google Scholar
• Jiang T, Zhou C, Ren S. 2016. Role of IL-2 in cancer immunotherapy. Oncoimmunology. 5(6):e1163462.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhou L, Sun B, Li X, Duan K, Wu Y, Ouyang W. 2015. Interleukin-2 administration after modified radical mastectomy in breast cancer therapy increases peripheral regulatory T cells. Int J Clin Exp Med. 8(5):7816–7822. eng.
   PubMed Web of Science ®Google Scholar
• Liang SM, Thatcher DR, Liang CM, Allet B. 1986. Studies of structure-activity relationships of human interleukin-2. J Biol Chem. 261(1):334–337.
   PubMed Web of Science ®Google Scholar
• Lipiäinen T, Peltoniemi M, Sarkhel S, Yrjönen T, Vuorela H, Urtti A, Juppo A. 2015. Formulation and stability of cytokine therapeutics. J Pharm Sci. 104(2):307–326.
   PubMed Web of Science ®Google Scholar
• Masuko T, Minami A, Iwasaki N, Majima T, Nishimura SI, Lee YC. 2005. Carbohydrate analysis by a phenolG_ôsulfuric acid method in microplate format. Anal Biochem. 339(1):69–72.
   PubMed Web of Science ®Google Scholar
• Nagy N, Kaber G, Kratochvil MJ, Kuipers HF, Ruppert SM, Yadava K, Yang J, Heilshorn SC, Long SA, Pugliese A, et al. 2021. Weekly injection of IL-2 using an injectable hydrogel reduces autoimmune diabetes incidence in NOD mice. Diabetologia. 64(1):152–158.
   PubMed Web of Science ®Google Scholar
• Qiao M, Chen D, Ma X, Liu Y. 2005. Injectable biodegradable temperature-responsive PLGA-PEG-PLGA copolymers: synthesis and effect of copolymer composition on the drug release from the copolymer-based hydrogels. Int J Pharm. 294(1-2):103–112.
   PubMed Web of Science ®Google Scholar
• Raker VK, Becker C, Landfester K, Steinbrink K. 2020. Targeted Activation of T Cells with IL-2-Coupled Nanoparticles. Cells. 9(9):2063.
   Web of Science ®Google Scholar
• Rhines LD, Sampath P, DiMeco F, Lawson HC, Tyler BM, Hanes J, Olivi A, Brem H. 2003. Local immunotherapy with interleukin-2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma. Neurosurgery. 52(4):872–879.
   PubMed Web of Science ®Google Scholar
• Robb RJ, Kutny RM, Panico M, Morris HR, Chowdhry V. 1984. Amino acid sequence and post-translational modification of human interleukin 2. Proc Natl Acad Sci U S A. 81(20):6486–6490.
   PubMed Web of Science ®Google Scholar
• Samlowski WE, McGregor JR, Jurek M, Baudys M, Zentner GM, Fowers KD. 2006. ReGel polymer-based delivery of interleukin-2 as a cancer treatment. J Immunother. 29(5):524–535.
   PubMed Web of Science ®Google Scholar
• Shaker MA, Daneshtalab N, Dore JE, Younes HM. 2012. Biocompatibility and biodegradability of implantable drug delivery matrices based on novel poly(decane-co-tricarballylate) photocured elastomers. Journal of Bioactive and Compatible Polymers. 27(1):78–94.
   Web of Science ®Google Scholar
• Shaker MA, Dore JJ, Younes HM. 2010. Synthesis, characterization and cytocompatibility of a poly(diol-tricarballylate) visible light photo-cross-linked biodegradable elastomer. J Biomater Sci Polym Ed. 21(4):507–528.
   PubMed Web of Science ®Google Scholar
• Shaker MA, Younes HM. 2010. Osmotic-driven release of papaverine hydrochloride from novel poly(decane-co-tricarballylate) elastomeric matrices. Ther Deliv. 1(1):37–50.
   PubMedGoogle Scholar
• Sharma A, Harper CM, Hammer L, Nair RE, Mathiowitz E, Egilmez NK. 2004. Characterization of cytokine-encapsulated controlled-release microsphere adjuvants. Cancer Biother Radiopharm. 19(6):764–769.
   PubMed Web of Science ®Google Scholar
• Silva D-A, Yu S, Ulge UY, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, et al. 2019. De novo design of potent and selective mimics of IL-2 and IL-15. Nature. 565(7738):186–191.
   PubMed Web of Science ®Google Scholar
• Spolski R, Li P, Leonard WJ. 2018. Biology and regulation of IL-2: from molecular mechanisms to human therapy. Nat Rev Immunol. 18(10):648–659.
   PubMed Web of Science ®Google Scholar
• Tang A, Harding F. 2019. The challenges and molecular approaches surrounding interleukin-2-based therapeutics in cancer. Cytokine: X. 1(1):100001.
   Google Scholar
• Thomas TT, Kohane DS, Wang A, Langer R. 2004. Microparticulate formulations for the controlled release of interleukin-2. J Pharm Sci. 93(5):1100–1109.
   PubMed Web of Science ®Google Scholar
• Vidovic D, Giacomantonio C. 2020. Insights into the Molecular Mechanisms Behind Intralesional Immunotherapies for Advanced Melanoma. Cancers (Basel). 12(5):1321.
   Web of Science ®Google Scholar
• Vile GF, Tyrrell RM. 1995. UVA radiation-induced oxidative damage to lipids and proteins in vitro and in human skin fibroblasts is dependent on iron and singlet oxygen. Free Radic Biol Med. 18(4):721–730.
   PubMed Web of Science ®Google Scholar
• Wang W. 2000. Lyophilization and development of solid protein pharmaceuticals. Int J Pharm. 203(1–2):1–60.
   PubMed Web of Science ®Google Scholar
• Wrangle JM, Patterson A, Johnson CB, Neitzke DJ, Mehrotra S, Denlinger CE, Paulos CM, Li Z, Cole DJ, Rubinstein MP. 2018. IL-2 and Beyond in Cancer Immunotherapy. J Interferon Cytokine Res. 38(2):45–68.
   PubMed Web of Science ®Google Scholar
• Younes HM, inventor; Qatar University, assignee. 2016. Biodegradable Elastomers Prepared by the Condensation of an Organic Di-, Tri- or Tetra-Carboxylic Acid and an Organic Diol. USA patent U.S. Patent 9,422,396.
   Google Scholar