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Research Articles

Development of cyclosporine A nanosuspension: cytotoxicity and permeability on Caco-2 cell lines

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Pages 52-62 | Received 21 Jun 2021, Accepted 16 Dec 2021, Published online: 29 Dec 2021

References

  • Ağardan NBM, Değim Z, Yılmaz Ş, Altıntaş L, Topal T. 2020. Tamoxifen/raloxifene loaded liposomes for oral treatment of breast cancer. J Drug Deliv Sci Technol. 57:101612.
  • Ahire E, Thakkar S, Darshanwad M, Misra M. 2018. Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications. Acta Pharm Sin B. 8(5):733–755.
  • Al-Heibshy FNS, Başaran E, Arslan R, Öztürk N, Vural İ, Demirel M. 2019. Preparation, characterization and pharmacokinetic evaluation of rosuvastatin calcium incorporated cyclodextrin–polyanhydride nanoparticles. Drug Dev Ind Pharm. 45(10):1635–1645.
  • Artursson P, Karlsson J. 1991. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun. 175(3):880–885.
  • Attari Z, Bhandari A, Jagadish PC, Lewis S. 2016. Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: preparation by combinative technology. Saudi Pharm J. 24(1):57–63.
  • Bilgili E, Li M, Afolabi A. 2016. Is the combination of cellulosic polymers and anionic surfactants a good strategy for ensuring physical stability of BCS Class II drug nanosuspensions? Pharm Dev Technol. 21(4):499–510.
  • Budavari SM, O’Neal J, Smith A, Heckelman PE. 1996. The Merck Index: an encyclopedia of chemicals, drugs and biologicals. 12th ed. Whitehouse Station (NJ): Merck & Company, Inc.; p. 1498.
  • Çelik Tekeli M, Aktas Y, Celebi N. 2021. Oral self-nanoemulsifying formulation of GLP-1 agonist peptide exendin-4: development, characterization and permeability assesment on Caco-2 cell monolayer. Amino Acids. 53(1):73–88.
  • Föger F, Kopf A, Loretz B, Albrecht K, Bernkop Schnürch A. 2008. Correlation of in vitro and in vivo models for the oral absorption of peptide drugs. Amino Acids. 35(1):233–241.
  • Ghosh I, Schenck D, Bose S, Liu F, Motto M. 2013. Identification of critical process parameters and its interplay with nanosuspension formulation prepared by top down media milling technology—a QbD perspective. Pharm Dev Technol. 18(3):719–729.
  • Gökbulut E, Vural İ, Aşıkoğlu M, Özdemir N. 2019. Floating drug delivery system of itraconazole: formulation, in vitro and in vivo studies. J Drug Deliv Sci Technol. 49:491–501.
  • Guada M, Beloqui A, Kumar MNVR, Préat V, Dios-Viéitez MDC, Blanco-Prieto MJ. 2016. Reformulating cyclosporine A (CsA): more than just a life cycle management strategy. J Control Release. 225:269–282.
  • Gülbağ Pınar S, Çelebi N. 2019a. Cyclosporine A nanosuspension produced by wet media milling method: development and characterization. EUFEPS Annual Meeting 2019; Mar 6–8; Germany. Flash presentation-05.
  • Gülbağ Pınar S, Çelebi N. 2019b. Optimization and evaluation of cyclosporine A nanosuspension stabilized by combination stabilizers using high pressure homogenization method. J Res Pharm. 23:1009–1021.
  • Gülbağ Pınar S, Karaküçük A, Mutlu Ağardan N, Çelebi N. 2019a. The effects of process parameters of the cyclosporine A nanosuspension produced by wet milling stabilized with hydroxypropyl methylcellulose. CRS Annual Meeting 2019; Jul 21–24; Spain. Poster session II. p. 657.
  • Gülbağ Pınar S, Mutlu Ağardan B, Çelebi N. 2019b. Evaluation of dissolution properties of cyclosporine A nanosuspensions prepared with two different top down technologies. The 8th BBBB International Conference on Pharmaceutical Sciences; Oct 14–16; Turkey. Oral presentations-6.
  • Gülbağ S, Çelebi N. 2017. Cyclosporine A and new approaches to cyclosporine A formulations. FABAD J Pharm Sci. 42:39–58.
  • Gulsun T, Borna SE, Vural I, Sahin S. 2018. Preparation and characterization of furosemide nanosuspensions. J Drug Deliv Sci Technol. 45:93–100.
  • Gulsun T, Ozturk N, Kaynak MS, Vural I, Sahin S. 2017. Preparation and evaluation of furosemide containing orally disintegrating tablets by direct compression. Pharmazie. 72(7):389–394.
  • Hautz T, Brandacher G, Zelger B, Gorantla VS, Lee AW, Pratschke J, Schneeberger S. 2010. Immunologic aspects and rejection in solid organ versus reconstructive transplantation. Transplant Proc. 42(9):3347–3353.
  • He J, Han Y, Xu G, Yin L, Ngandeu NM, Zhou J, Ding Y. 2017. Preparation and evaluation of celecoxib nanosuspensions for bioavailability enhancement. RSC Adv. 7(22):13053–13064.
  • Junghanns JU, Müller RH. 2008. Nanocrystal technology, drug delivery and clinical applications. Int J Nanomedicine. 3(3):295–309.
  • Junyaprasert VB, Morakul B. 2015. Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs. Asian J Pharm Sci. 10(1):13–23.
  • Karakucuk A, Celebi N. 2020. Investigation of formulation and process parameters of wet media milling to develop etodolac nanosuspensions. Pharm Res. 37(6):111.
  • Karakucuk A, Celebi N, Teksin ZS. 2016. Preparation of ritonavir nanosuspensions by microfluidization using polymeric stabilizers: I. A design of experiment approach. Eur J Pharm Sci. 95:111–121.
  • Karakucuk A, Ozturk N, Celebi N. 2020b. Evaluation of Caco-2 cell permeability of ritonavir nanosuspensions. Istanbul J Pharm. 50(3):251–255.
  • Karakucuk A, Tashan E, Ozturk N, Celebi N. 2020a. In vitro Caco-2 cell permeability studies of ziprasidone hydrochloride monohydrate nanocrystals. Turk J Pharm Sci. 18(2):223–227.
  • Karamustafa F, Celebi N, Değim Z, Unal N. 2009. Transport evaluation of alendronate across Caco-2 cell monolayers. Pharmazie. 64(2):98–103.
  • Kocbek P, Baumgartner S, Kristl J. 2006. Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs. Int J Pharm. 312(1–2):179–186.
  • Li W, Yang Y, Tian Y, Xu X, Chen Y, Mu L, Zhang Y, Fang L. 2011. Preparation and in vitro/in vivo evaluation of revaprazan hydrochloride nanosuspension. Int J Pharm. 408(1–2):157–162.
  • Liu Y, Wang Y, Yang J, Zhang H, Gan L. 2019. Cationized hyaluronic acid coated spanlastics for cyclosporine A ocular delivery: prolonged ocular retention, enhanced corneal permeation and improved tear production. Int J Pharm. 565:133–142.
  • Ma B, Wang J, Sun J, Li M, Xu H, Sun G, Sun X. 2014. Permeability of rhynchophylline across human intestinal cell in vitro. Int J Clin Exp Pathol. 7(5):1957–1966.
  • Malaekeh-Nikouei B, Nassirli H, Davies N. 2007. Enhancement of cyclosporine aqueous solubility using α- and hydroxypropyl β-cyclodextrin mixtures. J Incl Phenom Macrocycl Chem. 59(3–4):245–250.
  • Malamatari M, Taylor KMG, Malamataris S, Douroumis D, Kachrimanis K. 2018. Pharmaceutical nanocrystals: production by wet milling and applications. Drug Discov Today. 23(3):534–547.
  • Mauludin R, Müller RH, Keck CM. 2009. Development of an oral rutin nanocrystal formulation. Int J Pharm. 370(1–2):202–209.
  • Medarevic D, Djuris J, Ibric S, Mitric M, Kachrimanis K. 2018. Optimization of formulation and process parameters for the production of carvedilol nanosuspension by wet media milling. Int J Pharm. 540(1–2):150–161.
  • Modra L, Hilton A. 2015. Ethical issues in organ transplantation. Anaesth Intens Care Med. 16(7):321–323.
  • Nakarani M, Patel P, Patel J, Patel P, Murthy RSR, Vaghani SS. 2010. Cyclosporine A-nanosuspension: formulation, characterization and in vivo comparison with a marketed formulation. Sci Pharm. 78(2):345–361.
  • Oktay AN, Ilbasmis-Tamer S, Celebi N. 2019. The effect of critical process parameters of the high pressure homogenization technique on the critical quality attributes of flurbiprofen nanosuspensions. Pharm Dev Technol. 24(10):1278–1286.
  • Oktay AN, Ilbasmis-Tamer S, Han S, Uludag O, Celebi N. 2020. Preparation and in vitro/in vivo evaluation of flurbiprofen nanosuspension-based gel for dermal application. Eur J Pharm Sci. 155:105548.
  • Patel VR, Agrawal YK. 2011. Nanosuspension: an approach to enhance solubility of drugs. J Adv Pharm Technol Res. 2(2):81–87.
  • Pawar VK, Singh Y, Meher JG, Gupta S, Chourasia MK. 2014. Engineered nanocrystal technology: in-vivo fate, targeting and applications in drug delivery. J Control Release. 183:51–66.
  • Sakai R, Ooba Y, Watanabe A, Nakamura H, Kawamata Y, Shimada T, Takumi A, van Goudoever JB, Narita T. 2020. Glutamate metabolism in a human intestinal epithelial cell layer model. Amino Acids. 52(11–12):1505–1519.
  • Shekhawat P, Pokharkar V. 2019. Risk assessment and QbD based optimization of an eprosartan mesylate nanosuspension: in-vitro characterization, PAMPA and in-vivo assessment. Int J Pharm. 567:118415.
  • Sinha B, Müller RH, Moschwitzer JP. 2013. Bottom-up approaches for preparing drug nanocrystals: formulations and factors affecting particle size. Int J Pharm. 453(1):126–141.
  • Survase SA, Kagliwal LD, Annapure US, Singhal RS. 2011. Cyclosporin A—a review on fermentative production, downstream processing and pharmacological applications. Biotechnol Adv. 29(4):418–435.
  • Taymouri S, Ahmadi Z, Mirian M, Tavakoli N. 2021. Simvastatin nanosuspensions prepared using a combination of pH-sensitive and timed-release approaches for potential treatment of colorectal cancer. Pharm Dev Technol. 26(3):335–348.
  • Toziopoulou F, Malamatari M, Nikolakakis I, Kachrimanis K. 2017. Production of aprepitant nanocrystals by wet media milling and subsequent solidification. Int J Pharm. 533(2):324–334.
  • Verma V, Jasuja S. 2008. Current immunosuppression drugs used in transplant: classification & status. Apollo Med. 5(4):373–376.
  • Wenger RM, Payne TG, Schreier MH. 1986. Cyclosporine: chemistry, structure-activity relationships and mode of action. In: Metabolic control in diabetes mellitus beta adrenoceptor blocking drugs NMR analysis of cancer cells immunoassay in the clinical laboratory cyclosporine. Progress in Clinical Biochemistry and Medicine, vol 3. Berlin, Heidelberg: Springer; p. 157–191.
  • Wu CY, Benet L. 2005. Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res. 22(1):11–23.
  • Yavuz B, Bilensoy E, Vural I, Sumnu M. 2010. Alternative oral exemestane formulation: improved dissolution and permeation. Int J Pharm. 398(1–2):137–145.
  • Yue PF, Li Y, Wan J, Yang M, Zhu WF, Wang CH. 2013. Study on formability of solid nanosuspensions during nanodispersion and solidification: I. Novel role of stabilizer/drug property. Int J Pharm. 454(1):269–277.

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