Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis

References

• Abdul-Hamid M, Moustafa N, Abd Alla Asran AEM, Mowafy L. 2017. Cypermethrin-induced histopathological, ultrastructural and biochemical changes in liver of albino rats: the protective role of propolis and curcumin. Beni Suef Univ J Basic Appl Sci. 6(2):160–173.
   Google Scholar
• Afrasiabi S, Pourhajibagher M, Chiniforush N, Bahador A. 2020. Propolis nanoparticle enhances the potency of antimicrobial photodynamic therapy against Streptococcus mutans in a synergistic manner. Sci Rep. 10(1):1–16.
   PubMed Web of Science ®Google Scholar
• Ahn JC, Kang J-W, Shin J-I, Chung P-S. 2012. Combination treatment with photodynamic therapy and curcumin induces mitochondria-dependent apoptosis in AMC-HN3 cells. Int J Oncol. 41(6):2184–2190.
   PubMed Web of Science ®Google Scholar
• Akomeah FK, Martin GP, Brown MB. 2007. Variability in human skin permeability in vitro: comparing penetrants with different physicochemical properties. J Pharm Sci. 96(4):824–834.
   PubMed Web of Science ®Google Scholar
• Ames FQ, Sato F, de Castro LV, de Arruda LLM, da Rocha BA, Cuman RKN, Baesso ML, Bersani-Amado CA. 2017. Evidence of anti-inflammatory effect and percutaneous penetration of a topically applied fish oil preparation: a photoacoustic spectroscopy study. J Biomed Opt. 22(5):55003.
   PubMed Web of Science ®Google Scholar
• Arab F, Alemzadeh I, Maghsoudi V. 2011. Determination of antioxidant component and activity of rice bran extract. Scientia Iranica 18(6):1402–1406.
   Web of Science ®Google Scholar
• Baesso ML, Shen J, Snook RD. 1994. Laser-induced photoacoustic signal phase study of stratum corneum and epidermis. Analyst. 119(4):561–562.
   PubMed Web of Science ®Google Scholar
• Basnet P, Hussain H, Tho I, Skalko-Basnet N. 2012. Liposomal delivery system enhances anti-inflammatory properties of curcumin. J Pharm Sci. 101(2):598–609.
   PubMed Web of Science ®Google Scholar
• Bonacucina G, Martelli S, Palmieri GF. 2004. Rheological, mucoadhesive and release properties of Carbopol gels in hydrophilic cosolvents. Int J Pharm. 282(1-2):115–130.
   PubMedGoogle Scholar
• Bonté F, Girard D, Archambault J-C, Desmoulière A. 2019. Skin changes during ageing. Subcell Biochem. 91:249–280.
   PubMedGoogle Scholar
• Boyacioglu D, editor. 2019. Bee products and their applications in the food and pharmaceutical industries. Amsterdam: Elsevier.
   Google Scholar
• Bruschi ML. 2015. Strategies to modify the drug release from pharmaceutical systems. Cambridge (UK): Woodhead Publishing.
   Google Scholar
• Bruschi ML, Cardoso MLC, Lucchesi MB, Gremião MPD. 2003. Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization. Int J Pharm. 264(1-2):45–55.
   PubMed Web of Science ®Google Scholar
• Bruschi ML, Jones DS, Panzeri H, Gremião MPD, De Freitas O, Lara EHG. 2007. Semisolid systems containing propolis for the treatment of periodontal disease: in vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties. J Pharm Sci. 96(8):2074–2089.
   PubMed Web of Science ®Google Scholar
• Bruschi ML, Klein T, Lopes RS, Franco SL, Gremião MPD. 2002. Contribution to the quality control protocol of propolis and its extracts. Revista de Ciencias Farmaceuticas. 23(2):289–306.
   Google Scholar
• Bruschi ML, Pereira RRA, de Francisco LMB. 2016. The use of propolis in micro/nanostructured pharmaceutical formulations. Recent Pat Drug Deliv Formul. 10(2):130–140.
   PubMedGoogle Scholar
• Burdock GA. 1998. Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol. 36(4):347–363.
   PubMed Web of Science ®Google Scholar
• Campanholi KdS, Silva Junior R d, Gonçalves RS, Bassi da Silva J, Pedroso de Morais FA, Said dos Santos R, Vilsinski BH, Oliveira G d, Pozza MS, dos S, et al. 2022. Design and optimization of a natural medicine from Copaifera reticulata Ducke for skin wound care. Polymers. 14(21):4483.
   PubMed Web of Science ®Google Scholar
• Can Z, Yildiz O, Sahin H, Akyuz Turumtay E, Silici S, Kolayli S. 2015. An investigation of Turkish honeys: their physico-chemical properties, antioxidant capacities and phenolic profiles. Food Chem. 180:133–141.
   PubMed Web of Science ®Google Scholar
• Carvalho FC, Calixto G, Hatakeyama IN, Luz GM, Gremião MPD, Chorilli M. 2013. Rheological, mechanical, and bioadhesive behavior of hydrogels to optimize skin delivery systems. Drug Dev Ind Pharm. 39(11):1750–1757.
   PubMed Web of Science ®Google Scholar
• Chorilli M, Brizante AC, Rodrigues CA, Salgado HRN. 2007. General aspects in transdermal systems of drugs release. Rev Bras Farm. 88(1):7–13.
   Google Scholar
• Choudhury H, Gorain B, Pandey M, Chatterjee LA, Sengupta P, Das A, Molugulu N, Kesharwani P. 2017. Recent update on nanoemulgel as topical drug delivery system. J Pharm Sci. 106(7):1736–1751.
   PubMed Web of Science ®Google Scholar
• Dias KKB, Cardoso AL, da Costa AAF, Passos MF, Costa C d, Rocha Filho G d, Andrade EH, de A, Luque R, Nascimento L d, et al. 2023. Biological activities from andiroba (Carapa guianensis Aublet.) and its biotechnological applications: a systematic review. Arabian J Chem. 16(4):104629.
   Web of Science ®Google Scholar
• Dickel H, Kuss O, Schmidt A, Kretz J, Diepgen TL. 2002. Importance of irritant contact dermatitis in occupational skin disease. Am J Clin Dermatol. 3(4):283–289.
   PubMedGoogle Scholar
• Dujic J, Kippenberger S, Hoffmann S, Ramirez-Bosca A, Miquel J, Diaz-Alperi J, Bereiter-Hahn J, Kaufmann R, Bernd A. 2007. Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light. J Invest Dermatol. 127(8):1992–2000.
   PubMed Web of Science ®Google Scholar
• Falto-Aizpurua L, Simmons B, Nouri K. 2015. The history of skin cancer. J Am Acad Dermatol. 72(5): AB27.
   Google Scholar
• Ferreira SdS, Braga G, Oliveira É d, Rosseto HC, Hioka N, Caetano W, Bruschi ML. 2020. Colloidal systems composed of poloxamer 407, different acrylic acid derivatives and curcuminoids: optimization of preparation method, type of bioadhesive polymer and storage conditions. J Drug Deliv Sci Technol [Internet]. 57:101686.
   Web of Science ®Google Scholar
• Ferreira SdS, Slowik KM, Castro Hoshino L d, Baesso ML, Murdoch C, Colley HE, Bruschi ML. 2020. Mucoadhesive emulgel systems containing curcumin for oral squamous cell carcinoma treatment: from pre-formulation to cytotoxicity in tissue-engineering oral mucosa. Eur J Pharm Sci. 151:105372.
   PubMed Web of Science ®Google Scholar
• Ferrera TS, Heldwein AB, dos Santos CO, Somavilla JC, Sautter CK. 2016. Phenolic substances, flavonoids, and antioxidant capacity in herbs under 1081 different soil covers and shadings. Rev Bras Plantas Med. 18(2 suppl 1):588–596.
   Google Scholar
• Final report on the safety assessment of carbomers-934, -910, -934P, -940, -941, and -962. 1982. J Am Coll Toxicol.
   Google Scholar
• Florence AT, Attwood D. 2011. Physicochemical Principles of Pharmacy. 5th ed. London: pharmaceutical Press.
   Google Scholar
• Folzer E, Gonzalez D, Singh R, Derendorf H. 2014. Comparison of skin permeability for three diclofenac topical formulations: an in vitro study. Pharmazie. 69:27–31.
   PubMed Web of Science ®Google Scholar
• Fonseca AdMd, Sampaio GHL, Araujo WP, Silva R d, Ribeiro FdO, Brito M dP, Sousa FdM, Torres AA, Araújo A d, Pinto ASB. 2020. Photodynamic therapy with propolis: antibacterial effects on Staphylococcus aureus, Streptococcus mutans and Escherichia coli analysed by atomic force microscopy. J Lasers Med Sci. 11(Suppl 1):S107–S112.
   PubMedGoogle Scholar
• de Francisco L, Pinto D, Rosseto H, Toledo L, Santos R, Tobaldini-Valério F, Svidzinski T, Bruschi M, Sarmento B, Oliveira MBPP, et al. 2018. Evaluation of radical scavenging activity, intestinal cell viability and antifungal activity of Brazilian propolis by-product. Food Res Int. 105:537–547.
   PubMed Web of Science ®Google Scholar
• de Francisco LMB, Pinto D, Rosseto HC, de Toledo L de AS, dos Santos RS, Costa P, Rodrigues F, Oliveira MBPP, Sarmento B, Bruschi ML. 2018. Development of a microparticulate system containing Brazilian propolis by-product and gelatine for ascorbic acid delivery: evaluation of intestinal cell viability and radical scavenging activity. Food Funct. 9(8):4194–4206.
   PubMed Web of Science ®Google Scholar
• de Francisco LMB, Rosseto HC, de Alcântara Sica de Toledo L, dos Santos RS, de Souza Ferreira SB, Bruschi ML. 2019. Organogel composed of poloxamer 188 and passion fruit oil: sol-gel transition, rheology, and mechanical properties. J Mol Liq. 289:111170.
   Web of Science ®Google Scholar
• de Funari CS, de Oliveira Ferro V, Mathor MB. 2007. Analysis of propolis from Baccharis dracunculifolia DC. (Compositae) and its effects on mouse fibroblasts. J Ethnopharmacol. 111(2):206–212.
   PubMed Web of Science ®Google Scholar
• Goebel K, Sato MEO, Souza D d, Murakami FS, Andreazza IF. 2013. In vitro release of diclofenac diethylamine from gels: evaluation of generic semisolid drug products in Brazil. Braz J Pharm Sci. 49(2):211–219.
   Web of Science ®Google Scholar
• Goel A, Aggarwal BB. 2010. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer. 62(7):919–930.
   PubMed Web of Science ®Google Scholar
• Guimarães R, Barros L, Barreira JCM, Sousa MJ, Carvalho AM, Ferreira ICFR. 2010. Targeting excessive free radicals with peels and juices of citrus fruits: grapefruit, lemon, lime and orange. Food Chem Toxicol. 48(1):99–106.
   PubMed Web of Science ®Google Scholar
• Hidayat MA, Fitri A, Kuswandi B. 2017. Scanometry as microplate reader for high throughput method based on DPPH dry reagent for antioxidant assay. Acta Pharm Sin B. 7(3):395–400.
   PubMed Web of Science ®Google Scholar
• Ivarsson D, Wahlgren M. 2012. Comparison of in vitro methods of measuring mucoadhesion: ellipsometry, tensile strength and rheological measurements. Colloids Surf B Biointerfaces. 92:353–359.
   PubMed Web of Science ®Google Scholar
• Ji H-F, Shen L. 2014. Can improving bioavailability improve the bioactivity of curcumin? Trends Pharmacol Sci. 35(6):265–266.
   PubMed Web of Science ®Google Scholar
• Jones DS, Bruschi ML, de Freitas O, Gremião MPD, Lara EHG, Andrews GP. 2009. Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamer 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity. Int J Pharm. 372(1-2):49–58.
   PubMed Web of Science ®Google Scholar
• Jug M, Hafner A, Lovrić J, Kregar ML, Pepić I, Vanić Ž, Cetina-Čižmek B, Filipović-Grčić J. 2018. An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems. J Pharm Biomed Anal. 147:350–366.
   PubMed Web of Science ®Google Scholar
• Junginger HE, Verhoef JC. 1998. Macromolecules as safe penetration enhancers for hydrophilic drugs - A fiction? Pharm Sci Technol Today. 1(9):370–376.
   Google Scholar
• Junqueira MV, Borghi-Pangoni FB, Ferreira SBS, Rabello BR, Hioka N, Bruschi ML. 2016. Functional polymeric systems as delivery vehicles for methylene blue in photodynamic therapy. Langmuir. 32(1):19–27.
   PubMed Web of Science ®Google Scholar
• Kaur G, Grewal J, Jyoti K, Jain UK, Chandra R, Madan J. 2018. Oral controlled and sustained drug delivery systems: concepts, advances, preclinical, and clinical status. In Drug Targeting and Stimuli Sensitive Drug Delivery Systems. Norwich: William Andrew.
   Google Scholar
• Kazantzis KT, Koutsonikoli K, Mavroidi B, Zachariadis M, Alexiou P, Pelecanou M, Politopoulos K, Alexandratou E, Sagnou M. 2020. Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and: in vitro studies with prostate cancer cells. Photochem Photobiol Sci. 19(2):193–206.
   PubMed Web of Science ®Google Scholar
• Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. 1983. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm. 15(1):25–35.
   Web of Science ®Google Scholar
• Korsmeyer RW, Peppas NA. 1981. Macromolecular and modeling aspects of swelling controlled systems. Controlled Release Delivery Systems. 43(1):77–90.
   Google Scholar
• Küçük M, Kolaylı S, Karaoğlu Ş, Ulusoy E, Baltacı C, Candan F. 2007. Biological activities and chemical composition of three honeys of different types from Anatolia. Food Chem. 100(2):526–534.
   Web of Science ®Google Scholar
• Lira AAM. 2003. In vitro permeation and thermal evaluation study of a lapachol-based topical emulgel. Recife : Federal University of Pernambuco.
   Google Scholar
• Lopes CM, Lobo JMS, Costa P. 2005. Modified release of drug delivery systems: hydrophilic polymers. Rev Bras Cienc Farm. 41(2):143–154.
   Google Scholar
• López-Alarcón C, Denicola A. 2013. Evaluating the antioxidant capacity of natural products: a review on chemical and cellular-based assays. Anal Chim Acta. 763:1–10.
   PubMed Web of Science ®Google Scholar
• Lubrizol 2013a. Pharmaceutical polymers typical properties and specifications: Excipients for oral solid dosage forms. Cleveland:p.1-2.
   Google Scholar
• Lubrizol 2013b. Pharmaceutical polymers typical properties and specifications. Excipients for liquid and semisolid dosage forms oral and topical applications. Cleveland:p. 1–14.
   Google Scholar
• Lubrizol 2021. Carbopol® polymers: Product reviews and recommendations [Internet]. [accessed 2021 Feb 9]. http://www.lubrizol.com/Pharmaceutical/Products/CarbopolPolymers.html.
   Google Scholar
• Lv KJ, Chen TC, Wang GH, Yao YN, Yao H. 2019. Clinical safety and efficacy of curcumin use for oral lichen planus: a systematic review. J Dermatol Treat. 30(6):605–611.
   PubMed Web of Science ®Google Scholar
• MdS Rufino RE, Alves ES, de Brito SM, de Morais CDG, Sampaio F-C. 2007. Scientific methodology: determination of total antioxidant activity in fruits by free radical capture ABTS + Title [Internet]. Fortaleza. Available from: https://www.embrapa.br/busca-de-publicacoes/-/publicacao/426954/metodologia-cientifica-determinacao-da-atividade-antioxidante-total-em-frutas-pela-captura-do-radical-livre-abts.
   Google Scholar
• Martinello M, Mutinelli F. 2021. Antioxidant activity in bee products: a review. Antioxidants [Internet]. 10(1):71.
   Web of Science ®Google Scholar
• Martins MRFM, Veiga F. 2002. Permeation enhancers in transdermal drug delivery systems: a new application of cyclodextrins. Brazilian Journal of Pharmaceutical Sciences [Internet]. 38(1):33–54.
   Google Scholar
• Mazzarino L, Silva LFC, Curta JC, Licínio MA, Costa A, Pacheco LK, Siqueira JM, Montanari J, Romero E, Assreuy J, et al. 2011. Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: an in vitro and in vivo antitumor activity on b16-f10 melanoma and macrophage uptake comparative study. J Biomed Nanotechnol. 7(3):406–414.
   PubMed Web of Science ®Google Scholar
• Missoun F, de los Ríos AP, Ortiz-Martínez V, Salar-García MJ, Hernández-Fernández J, Hernández-Fernández FJ. 2020. Discovering low toxicity ionic liquids for Saccharomyces cerevisiae by using the agar well diffusion test. Processes. 8(9):1163.
   Web of Science ®Google Scholar
• Mohamed AA, Thabet HZ, Abdel-Hafez AM. 2017. Toxicity of monosodium glutamate on male rat reproductive system and effect of curcumin and propolis co-administration. The Egyptian Journal of Forensic Sciences and Applied Toxicology. 17(1):129–146.
   Google Scholar
• de Morais FAP, Gonçalves RS, Vilsinski BH, Lazarin-Bidóia D, Balbinot RB, Tsubone TM, Brunaldi K, Nakamura CV, Hioka N, Caetano W. 2020. Hypericin photodynamic activity in DPPC liposomes – part II: stability and application in melanoma B16-F10 cancer cells. Photochem Photobiol Sci. 19(5):620–630.
   PubMed Web of Science ®Google Scholar
• de Oliveira ÉL, Ferreira SBS, de Castro-Hoshino LV, Campanholi KdS, Calori IR, de Morais FAP, Kimura E, da Silva Junior RC, Bruschi ML, Sato F, et al. 2021. Thermoresponsive hydrogel-loading aluminum chloride phthalocyanine as a drug release platform for topical administration in photodynamic therapy. Langmuir. 37(10):3202–3213.
   PubMed Web of Science ®Google Scholar
• De Oliveira LV, De Faria NS, Garcia Gonzaga Napoleone FM, Ingraci Barboza MA, Studart Leitão Filho FS, De Mattos LC, Donner CF, Barja PR. 2011. Photoacoustic technique: a new method for measuring the rheologic properties of human bronchial mucus. Multidiscip Respir Med. 6(4):238.
   PubMed Web of Science ®Google Scholar
• Oliveira MB, da Silva JB, Montanha MC, Kimura E, Diniz A, Bruschi ML. 2018. Design and characterization of mucoadhesive gelatin-ethylcellulose microparticles for the delivery of curcumin to the bladder. Curr Drug Deliv. 15(8):1112–1122.
   PubMed Web of Science ®Google Scholar
• Park K, Lee J-H. 2007. Photosensitizer effect of curcumin on UVB-irradiated HaCaT cells through activation of caspase pathways. Oncol Rep. 17(3):537–540.
   PubMed Web of Science ®Google Scholar
• Penido C, Costa KA, Costa Mf de S, Pereira J de FG, Siani AC, Henriques M, das Gm de O. 2006. Inhibition of allergen-induced eosinophil recruitment by natural tetranortriterpenoids is mediated by the suppression of IL-5, CCL11/eotaxin and NFκB activation. Int Immunopharmacol. 6(2):109–121.
   PubMed Web of Science ®Google Scholar
• Pereira RRA, Bruschi ML. 2013. Evaluation of two spectrophotometric methods for analysis of green propolis extract. Lat Am J Pharm. 32(5):719–726
   Web of Science ®Google Scholar
• Pierre MBR, Lopez RFV, Bentley MVLB. 2009. Influence of ceramide 2 on in vitro skin permeation and retention of 5-ALA and its ester derivatives, for photodynamic therapy. Braz J Pharm Sci. 45(1):109–116.
   Web of Science ®Google Scholar
• Rachmawati H, Shaal LA, Müller RH, Keck CM. 2013. Development of curcumin nanocrystal: physical aspects. J Pharm Sci. 102(1):204–214.
   PubMed Web of Science ®Google Scholar
• Raz A, Serrano A, Hernandez A, Euler CW, Fischetti VA. 2019. Isolation of phage lysins that effectively kill Pseudomonas aeruginosa in mouse models of lung and skin infection. Antimicrob Agents Chemother. 63(7):e00024–19.
   PubMed Web of Science ®Google Scholar
• Ritger PL, Peppas NA. 1987. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Rel. 5(1):37–42.
   Google Scholar
• Rocha JCB, Pedrochi F, Hernandes L, de Mello JCP, Baesso ML. 2007. Ex vivo evaluation of the percutaneous penetration of proanthocyanidin extracts from Guazuma ulmifolia using photoacoustic spectroscopy. Anal Chim Acta. 587(1):132–136.
   PubMed Web of Science ®Google Scholar
• Rodrigues F, Palmeira-de-Oliveira A, das Neves J, Sarmento B, Amaral MH, Oliveira MB. 2013. Medicago spp. extracts as promising ingredients for skin care products. Ind Crops Prod. 49:634–644.
   Web of Science ®Google Scholar
• Rufino MdS, Alves RE, de Brito ES, de Morais SM, Sampaio CdG, Pérez-Jiménez J, Saura-Calixto FD. 2006. Scientific Methodology: determination of total antioxidant activity in fruits by the iron reduction method (FRAP). Fortaleza: Embrapa.
   Google Scholar
• Rufino M do SM, Alves RE, Brito ES, Morais SM, Sampaio C de G, Pérez-Jiménez J, Saura-Calixto FD. 2007. Scientific methodology: determination of total antioxidant activity in fruits by free radical capture DPPH [Internet]. Fortaleza: Embrapa.
   Google Scholar
• Said dos Santos R, Bassi da Silva J, Rosseto HC, Vecchi CF, Campanholi KdS, Caetano W, Bruschi ML. 2021. Emulgels containing propolis and curcumin: the effect of type of vegetable oil, poly(acrylic acid) and bioactive agent on physicochemical stability, mechanical and rheological properties. Gels. 7(3):120.
   PubMed Web of Science ®Google Scholar
• Said dos Santos R, Rosseto HC, Bassi da Silva J, Vecchi CF, Caetano W, Bruschi ML. 2020. The effect of carbomer 934P and different vegetable oils on physical stability, mechanical and rheological properties of emulsion-based systems containing propolis. J Mol Liq. 307:112969.
   Web of Science ®Google Scholar
• Said dos Santos R, Vecchi CF, Rosseto HC, Bassi da Silva J, Dano MEL, de Castro-Hoshino LV, Baesso ML, Bruschi ML. 2020. Emulgels containing Carbopol 934P and different vegetable oils for topical propolis delivery: bioadhesion, drug release profile, and ex vivo skin permeation studies. AAPS PharmSciTech. 21(6):1–10.
   Web of Science ®Google Scholar
• Sasson CS, Sato ME, Beletti K da S, Mota FC, Piaceski AD. 2009. Influence of cosmetics vehicles on 4-methylbenzylidene-camphor’s skin penetration, in vitro. Braz Arch Biol Technol. 52(2):299–303.
   Web of Science ®Google Scholar
• Shahidi F, Zhong Y. 2015. Measurement of antioxidant activity. J Funct Foods. 18:757–781.
   Web of Science ®Google Scholar
• Silva-Buzanello R d, Souza M d, Oliveira D d, Bona E, Leimann FV, Cardozo Filho L, Araújo P d, Ferreira SRS, Gonçalves OH. 2016. Preparation of curcumin-loaded nanoparticles and determination of the antioxidant potential of curcumin after encapsulation. Polímeros. 26(3):207–214.
   Google Scholar
• Singla V, Saini S, Joshi B, Rana AC. 2012. Emulgel: a new platform fro topical drug delivery. Int J Pharma Biosci. 3(1):485–498.
   Google Scholar
• Siraichi JTG, Pedrochi F, Natali MRM, Ueda-Nakamura T, Filho BPD, Bento AC, Baesso ML, Nakamura CV. 2013. Ultraviolet (UVB and UVA) photoprotector activity and percutaneous penetration of extracts obtained from Arrabidaea chica. Appl Spectrosc. 67(10):1179–1184.
   PubMed Web of Science ®Google Scholar
• De Souza Ferreira SB, Moço TD, Borghi-Pangoni FB, Junqueira MV, Bruschi ML. 2015. Rheological, mucoadhesive and textural properties of thermoresponsive polymer blends for biomedical applications. J Mech Behav Biomed Mater. 55:164-178.
   PubMed Web of Science ®Google Scholar
• De Souza Ferreira SB, Da Silva JB, Borghi-Pangoni FB, Junqueira MV, Bruschi ML. 2017. Linear correlation between rheological, mechanical and mucoadhesive properties of polycarbophil polymer blends for biomedical applications. J Mech Behav Biomed Mater. 68:265–275.
   PubMed Web of Science ®Google Scholar
• Suhail M, Wu P-C, Minhas MU. 2020. Using carbomer-based hydrogels for control the release rate of diclofenac sodium: preparation and in vitro evaluation. Pharmaceuticals. 13(11):399.
   Web of Science ®Google Scholar
• Sulaiman GM, Al Sammarrae KW, Ad’hiah AH, Zucchetti M, Frapolli R, Bello E, Erba E, D'Incalci M, Bagnati R. 2011. Chemical characterization of Iraqi propolis samples and assessing their antioxidant potentials. Food Chem Toxicol. 49(9):2415–2421.
   PubMed Web of Science ®Google Scholar
• Sun Y, Du L, Liu Y, Li X, Li M, Jin Y, Qian X. 2014. Transdermal delivery of the in situ hydrogels of curcumin and its inclusion complexes of hydroxypropyl-β-cyclodextrin for melanoma treatment. Int J Pharm. 469(1):31–39.
   PubMed Web of Science ®Google Scholar
• Tahara K, Yamamoto K, Nishihata T. 1996. Application of model-independent and model analysis for the investigation of effect of drug solubility on its release rate from hydroxypropyl methylcellulose sustained release tablets. Int J Pharm. 133(1-2):17–27.
   Google Scholar
• Tamburic S, Craig DQM. 1995. An investigation into the rheological, dielectric and mucoadhesive properties of poly(acrylic acid) gel systems. J Control Rel. 37(1-2):59–68.
   Web of Science ®Google Scholar
• Torezan L, Niwa ABM, Festa Neto C. 2009. Photodynamic therapy in dermatology: basic principles and applications. An Bras Dermatol. 84(5):445–459.
   PubMed Web of Science ®Google Scholar
• Tijani A.O., Nunez, E., Singh, K., Khanna, G., Puri, A., 2021. Transdermal route: A viable option for systemic delivery of antidepressants. J. Pharm. Sci. 110, 3129–3149. https://doi.org/10.1016/j.xphs.2021.05.015
   Google Scholar
• Villa Nova M, Gonçalves MDCP, Nogueira AC, Herculano LDS, Medina AN, Bazotte RB, Bruschi ML. 2014. Formulation and characterization of ethylcellulose microparticles containing.l-alanyl- l-glutamine peptide. Drug Dev Ind Pharm. 40(10):1308–1317.
   PubMed Web of Science ®Google Scholar
• Walduck A, Sangwan P, Vo QA, Ratcliffe J, White J, Muir BW, Tran N. 2020. Treatment of Staphylococcus aureus skin infection in vivo using rifampicin loaded lipid nanoparticles. RSC Adv. 10(55):33608–33619.
   PubMed Web of Science ®Google Scholar
• Xie L, Ji X, Zhang Q, Wei Y. 2022. Curcumin combined with photodynamic therapy, promising therapies for the treatment of cancer. Biomed Pharmacother. 146:112567.
   PubMed Web of Science ®Google Scholar
• Younes M, Aquilina G, Engel K‐H, Fowler P, Frutos Fernandez MJ, Fürst P, Gürtler R, Gundert‐Remy U, Husøy T, Manco M, Mennes W, Passamonti S, Moldeus P, Shah R, Waalkens-Berendsen I, W€olfle D, Wright M, Barat Baviera JM, Degen G, Leblanc J-C, Herman L, Civitella C, Giarola A, Smeraldi C, Tard A, Vianello G and Castle L. 2021. Scientific Opinion on safety evaluation of crosslinked polyacrylic acid polymers (carbomer) as a new food additive. EFSA J. 19(8):6693, 26pp.
   Web of Science ®Google Scholar
• Zhu Z, Zhai Y, Zhang N, Leng D, Ding P. 2013. The development of polycarbophil as a bioadhesive material in pharmacy. Asian J Pharm Sci. 8(4):218–227.
   Google Scholar