71
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Cytisine eye drops for benzalkonium chloride-induced dry eye: safety and efficacy evaluation

, , , &
Pages 457-467 | Received 09 Dec 2023, Accepted 16 Apr 2024, Published online: 22 Apr 2024

References

  • Alfarisi O, Mave V, Gaikwad S, Sahasrabudhe T, Ramachandran G, Kumar H, Gupte N, Kulkarni V, Deshmukh S, Atre S, et al. 2018. Effect of diabetes mellitus on the pharmacokinetics and pharmacodynamics of tuberculosis treatment. Antimicrob Agents Chemother. 62(11):e01383–e01418. doi: 10.1128/AAC.01383-18.
  • Amanat S, Shal B, Kyoung Seo E, Ali H, Khan S. 2022. Icariin attenuates cyclophosphamide-induced cystitis via down-regulation of NF-кB and up-regulation of Nrf-2/HO-1 signaling pathways in mice model. Int Immunopharmacol. 106:108604. doi: 10.1016/j.intimp.2022.108604.
  • Barabino S, Chen Y, Chauhan S, Dana R. 2012. Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye disease. Prog Retin Eye Res. 31(3):271–285. doi: 10.1016/j.preteyeres.2012.02.003.
  • Bashrahil B, Taher N, Alzahrani Z, Alnabihi A, Aldahlawi A, Alkhathlan M, Alghamdi S. 2023. The efficacy and safety of varenicline nasal spray for the management of dry eye signs: a systematic review and meta-analysis. BMC Ophthalmol. 23(1):319. doi: 10.1186/s12886-023-03069-y.
  • Condon PI, McEwen CG, Wright M, Mackintosh G, Prescott RJ, McDonald C. 1999. Double blind, randomised, placebo controlled, crossover, multicentre study to determine the efficacy of a 0.1% (w/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndrome. Br J Ophthalmol. 83(10):1121–1124. doi: 10.1136/bjo.83.10.1121.
  • Contreras-Ruiz L, Zorzi GK, Hileeto D, López-García A, Calonge M, Seijo B, Sánchez A, Diebold Y. 2013. A nanomedicine to treat ocular surface inflammation: performance on an experimental dry eye murine model. Gene Ther. 20(5):467–477. doi: 10.1038/gt.2012.56.
  • de Oliveira FA, Albuquerque LJC, Nascimento-Sales M, Christoffolete MA, Bellettini IC, Giacomelli FC. 2023. Balancing gene transfection and cytotoxicity of nucleic acid carriers with focus on ocular and hepatic disorders: evaluation of hydrophobic and hydrophilic polyethyleneimine derivatives. J Mater Chem B. 11(20):4556–4571. doi: 10.1039/d3tb00477e.
  • Di Tommaso C, Torriglia A, Furrer P, Behar-Cohen F, Gurny R, Möller M. 2011. Ocular biocompatibility of novel Cyclosporin A formulations based on methoxy poly(ethylene glycol)-hexylsubstituted poly(lactide) micelle carriers. Int J Pharm. 416(2):515–524. doi: 10.1016/j.ijpharm.2011.01.004.
  • Dogru M, Kojima T, Simsek C, Tsubota K. 2018. Potential role of oxidative stress in ocular surface inflammation and dry eye disease. Invest Ophthalmol Vis Sci. 59(14):Des163–des168. doi: 10.1167/iovs.17-23402.
  • Elmowafy E, Gad H, Biondo F, Casettari L, Soliman ME. 2019. Exploring optimized methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) crystalline cored micelles in anti-glaucoma pharmacotherapy. Int J Pharm. 566:573–584. doi: 10.1016/j.ijpharm.2019.06.011.
  • Etter J-F, Lukas RJ, Benowitz NL, West R, Dresler CM. 2008. Cytisine for smoking cessation: a research agenda. Drug Alcohol Depend. 92(1-3):3–8. doi: 10.1016/j.drugalcdep.2007.06.017.
  • Fakih D, Zhao Z, Nicolle P, Reboussin E, Joubert F, Luzu J, Labbé A, Rostène W, Baudouin C, Mélik Parsadaniantz S, et al. 2019. Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem. J Neuroinflammation. 16(1):268. doi: 10.1186/s12974-019-1656-4.
  • Gedar Totuk OM, Yildiz E, Mollica A, Kabadayi K, Sahin A. 2021. The opioid peptide biphalin modulates human corneal epithelial wound healing in vitro. J Fr Ophtalmol. 44(9):1403–1412. doi: 10.1016/j.jfo.2020.09.007.
  • Goldstein MH, Silva FQ, Blender N, Tran T, Vantipalli S. 2022. Ocular benzalkonium chloride exposure: problems and solutions. Eye. 36(2):361–368. doi: 10.1038/s41433-021-01668-x.
  • He R, Cui M, Lin H, Zhao L, Wang J, Chen S, Shao Z. 2018. Melatonin resists oxidative stress-induced apoptosis in nucleus pulposus cells. Life Sci. 199:122–130. doi: 10.1016/j.lfs.2018.03.020.
  • Holland EJ, Luchs J, Karpecki PM, Nichols KK, Jackson MA, Sall K, Tauber J, Roy M, Raychaudhuri A, Shojaei A. 2017. Lifitegrast for the treatment of dry eye disease: results of a phase III, randomized, double-masked, placebo-controlled trial (OPUS-3). Ophthalmology. 124(1):53–60. doi: 10.1016/j.ophtha.2016.09.025.
  • Hou Y, Lan J, Zhang F, Wu X. 2021. Expression profiles and potential corneal epithelial wound healing regulation targets of high-mobility group box 1 in diabetic mice. Exp Eye Res. 202:108364. doi: 10.1016/j.exer.2020.108364.
  • Hussar DA, Finn LA. 2017. 2017 new drug update. Consult Pharm. 32(5):258–268. doi: 10.4140/TCP.n.2017.258.
  • Hynnekleiv L, Magno M, Vernhardsdottir RR, Moschowits E, Tønseth KA, Dartt DA, Vehof J, Utheim TP. 2022. Hyaluronic acid in the treatment of dry eye disease. Acta Ophthalmol. 100(8):844–860. doi: 10.1111/aos.15159.
  • Lagarto A, Vega R, Guerra I, González R. 2006. In vitro quantitative determination of ophthalmic irritancy by the chorioallantoic membrane test with trypan blue staining as alternative to eye irritation test. Toxicol in Vitro. 20(5):699–702. doi: 10.1016/j.tiv.2005.10.003.
  • Li Q, Wu X, Xin S, Wu X, Lan J. 2021. Preparation and characterization of a naringenin solubilizing glycyrrhizin nanomicelle ophthalmic solution for experimental dry eye disease. Eur J Pharm Sci. 167:106020. doi: 10.1016/j.ejps.2021.106020.
  • Li Y, Guan Q, Xu J, Zhang H, Liu S, Ding Z, Wang Q, Wang Z, Liu M, Zhao Y. 2023. Comparative study of cyclosporine A liposomes and emulsions for ophthalmic drug delivery: process optimization through response surface methodology (RSM) and biocompatibility evaluation. Colloids Surf B Biointerfaces. 225:113267. doi: 10.1016/j.colsurfb.2023.113267.
  • Liang Q, Guo R, Tsao JR, He Y, Wang C, Jiang J, Zhang D, Chen T, Yue T, Hu K. 2023. Salidroside alleviates oxidative stress in dry eye disease by activating autophagy through AMPK-Sirt1 pathway. Int Immunopharmacol. 121:110397. doi: 10.1016/j.intimp.2023.110397.
  • Messmer EM. 2015. The pathophysiology, diagnosis, and treatment of dry eye disease. Dtsch Arztebl Int. 112(5):71–81; quiz 82. doi: 10.3238/arztebl.2015.0071.
  • Mohamed HB, Abd El-Hamid BN, Fathalla D, Fouad EA. 2022. Current trends in pharmaceutical treatment of dry eye disease: a review. Eur J Pharm Sci. 175:106206. doi: 10.1016/j.ejps.2022.106206.
  • Na YJ, Choi KJ, Jung WH, Park SB, Kang S, Ahn JH, Kim KY. 2020. A Novel Selective 11β-HSD1 Inhibitor, (E)-4-(2-(6-(2,6-Dichloro-4-(Trifluoromethyl)Phenyl)-4-Methyl-1,1-Dioxido-1,2,6-Thiadiazinan-2-yl)Acetamido)Adamantan-1-Carboxamide (KR-67607), Prevents BAC-Induced Dry Eye Syndrome. Int J Mol Sci. 21(10):3729. doi: 10.3390/ijms21103729.
  • Okmanov RY, Olimova MI, Karabaeva SB, Sapaev FA, Abdireymov KB, Weil M. 2023. Syntheses, crystal structures and Hirshfeld surface analyses of N-aryl­sulfonyl derivatives of cytisine. Acta Crystallogr E Crystallogr Commun. 79(Pt 4):313–318. doi: 10.1107/S2056989023001950.
  • Padjasek M, Qasem B, Cisło-Pakuluk A, Marycz K. 2022. Cyclosporine A delivery platform for veterinary ophthalmology-A new concept for advanced ophthalmology. Biomolecules. 12(10):1525. doi: 10.3390/biom12101525.
  • Park B, Lee IS, Hyun SW, Jo K, Lee TG, Kim JS, Kim CS. 2018. The protective effect of Polygonum cuspidatum (PCE) aqueous extract in a dry eye model. Nutrients. 10(10):1550. doi: 10.3390/nu10101550.
  • Saccà SC, Cutolo CA, Ferrari D, Corazza P, Traverso CE. 2018. The eye, oxidative damage and polyunsaturated fatty acids. Nutrients. 10(6):668. doi: 10.3390/nu10060668.
  • Srinivasan S, Garofalo R, Williams R. 2023. Safe and effective management of dry eye symptoms with hydroxypropyl guar and hyaluronic acid dual-polymer lubricating eye drops: a review of preclinical and clinical studies. Clin Ophthalmol. 17:3883–3898. doi: 10.2147/OPTH.S428725.
  • Suri R, Neupane YR, Mehra N, Nematullah M, Khan F, Alam O, Iqubal A, Jain GK, Kohli K. 2021. Sirolimus loaded chitosan functionalized poly (lactic-co-glycolic acid) (PLGA) nanoparticles for potential treatment of age-related macular degeneration. Int J Biol Macromol. 191:548–559. doi: 10.1016/j.ijbiomac.2021.09.069.
  • Wang S, He X, Li Q, Zhang Y, Hu J, Zong R, Zhuang J, Quantock AJ, Gao Y, Li W, et al. 2022. Obstructive sleep apnea affects lacrimal gland function. Invest Ophthalmol Vis Sci. 63(3):3. doi: 10.1167/iovs.63.3.3.
  • Wang TZ, Guan B, Liu XX, Ke LN, Wang JJ, Nan KH. 2022. A topical fluorometholone nanoformulation fabricated under aqueous condition for the treatment of dry eye. Colloids Surf B Biointerfaces. 212:112351. doi: 10.1016/j.colsurfb.2022.112351.
  • Wu L, Ye M, Zhang J. 2018. Vincamine prevents lipopolysaccharide induced inflammation and oxidative stress via thioredoxin reductase activation in human corneal epithelial cells. Am J Transl Res. 10(7):2195–2204.
  • Zhang R, Yang J, Luo Q, Shi J, Xu H, Zhang J. 2022. Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization. Drug Deliv. 29(1):2217–2233. doi: 10.1080/10717544.2022.2096714.
  • Zhou T, Zong R, Zhang Z, Zhu C, Pan F, Xiao X, Liu Z, He H, Ma JX, Liu Z, et al. 2012. SERPINA3K protects against oxidative stress via modulating ROS generation/degradation and KEAP1-NRF2 pathway in the corneal epithelium. Invest Ophthalmol Vis Sci. 53(8):5033–5043. doi: 10.1167/iovs.12-9729.
  • Zhu Y, Li XY, Wang J, Zhu YG. 2019. Bradykinin alleviates DR retinal endothelial injury by regulating HMGB-1/NF-κB pathway. Eur Rev Med Pharmacol Sci. 23:5535–5541.
  • Zhu Y, Peng X, Zhang Y, Lin J, Zhao G. 2021. Baicalein protects against aspergillus fumigatus keratitis by reducing fungal load and inhibiting TSLP-induced inflammatory response. Invest Ophthalmol Vis Sci. 62(6):26. doi: 10.1167/iovs.62.6.26.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.