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Research Article

Mechanoradical-Induced Degradation in a Pharmaceutical Blend during High-Shear Processing

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Pages 457-462 | Received 07 Apr 2008, Accepted 26 Jun 2008, Published online: 20 Oct 2008

REFERENCES

  • HG Brittain. (2002). Effects of mechanical processing on phase composition. J Pharm Sci. 91 (7):1573–1580.
  • PLD Wildfong, KR Morris, CA Anderson, and SM Short. (2007). Demonstration of shear-based solid-state phase transformation in a small molecular organic system: Chlorpropamide. J Pharm Sci. 96 (5):1100–1113.
  • BC Hancock, and G Zografi. (1997). Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci. 86 (1):1–12.
  • BC Hancock, SL Shamblin, and G Zografi. (1995). Molecular mobility of amorphous pharmaceuticals below their glass transition temperatures. Pharm Res. 12 (6):799–806.
  • MK Beyer, and H Clausen-Scaumann. (2005). Mechanochemistry: The mechanical activation of covalent bonds. Chem Rev. 105 (8):2921–2948.
  • DS Hon. (1987). Mechanochemistry of lignocellulosic materials. Devel Polym Degrad. 7:165–191.
  • J Sohma, and M Sakaguchi. (1975). ESR Studies on mechanical degradation of polymers and their reactivity. Adv Poly Sci. 20:109–158.
  • D Campbell. (1970). Electron spin resonance of polymers. J Polym Sci. 4:97–181.
  • JJ Gilman. (1996). Mechanochemistry. Science. 274:65.
  • N Furgiuele, AH Lebovitz, K Khait, and JM Torkelson. (2000). Novel strategy for polymer blend compatibilization: Solid-state shear pulverization. Macromolecules. 33 (2):225–228.
  • AH Lebovitz, K Khait, and JM Torkelson. (2002). In situ block copolymer formation during solid-state shear pulverization: An explanation for blend compartibilization via interpolymer radical reactions. Macromolecules. 35:9716–9722.
  • . Reactive oxygen species in chemistry, biology, and medicineA Quintanilha. Plenum Press, New York and London, (1988) .
  • . Oxygen radicals in biology and medicineMG Simic, KA Taylor, JF Ward, and C Von Sonntag. Plenum Press, New York and London, (1988) .
  • KC Waterman, RC Adami, KM Alsante, and et al (2002). Stabilization of pharmaceuticals to oxidative degradation. Pharmaceut Dev Tech. 7 (1):1–32.
  • M Kuzuya, Y Yamauchi, and S-i Kondo. (1999). Mechanolysis of glucose-based polysaccharides as studied by electron spin resonance. J Phys Chem B. 103:8051–8059.
  • MA Gibbs, HR Howard, JS Sprouse, JB Schachter, PB Chappell. Aralkyl and aralkylidene heterocyclic lactams and imidesUS patent 6 423 708December 8, 2000.
  • JT Carstensen, and CT Rhodeseditors. Drug stability: Principles and practices3rd ed. Marcel Dekker, New York, (2000) .
  • . Pharmaceutical preformulation and formulationM Gibson. Interpharm/CRC, Boca RatonFL, (2001) .
  • WPL Carter, KR Darnall, RA Graham, AM WIner, and JN Pitts. (1979). Reactions of C2 and C4 alpha-hydroxy radicals with oxygen. J Phys Chem B. 83:2305.
  • A Miyoshi, and H Matsui. (1990). Rates of reaction of hyrdoxyalkyl radicals with molecular oxygen. J Phys Chem B. 94:3016–3019.

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