Pharmacokinetics in special populations

References

• Affrime, M., Banfield, C., Gupta, S., Cohen, A., Boutros, T., Thonoor, M., et al. (2002a). Effect of race and sex on single- and multiple-dose pharmacokinetics of desloratadine. Clin Pharmacokinet 41(Suppl 1):21–28.
   PubMedGoogle Scholar
• Affrime, M., Gupta, S., Banfield, C., Cohen, A. (2002b). A pharmacokinetic profile of desloratadine in healthy adults, including elderly. Clin Pharmacokinet 41(Suppl 1):13–19.
   PubMedGoogle Scholar
• Ahmed, N., Mandel, R., Fain, M.J. (2007). Frailty: an emerging geriatric syndrome. Am J Med 120:748–753.
   PubMed Web of Science ®Google Scholar
• Akutsu, T., Kobayashi, K., Sakurada, K., Ikegaya, H., Furihata, T., Chiba, K. (2007). Identification of human cytochrome P450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos 35:72–78.
   PubMed Web of Science ®Google Scholar
• Alcorn, J., McNamara, P.J. (2008). Using ontogeny information to build predictive models for drug elimination. Drug Discov Today 13:507–512.
   PubMed Web of Science ®Google Scholar
• Anderson, B.J., Holford, NHG. (2008). Mechanism-based concepts of size and maturity in pharmacokinetics. Annu Rev Pharmacol Toxicol 48:303–332.
   PubMed Web of Science ®Google Scholar
• Anderson, B.J., Meakin, G.H. (2002). Scaling for size: some implications for paediatric anaesthesia dosing. Paediatr Anaesth 12:205–219.
   PubMed Web of Science ®Google Scholar
• Anderson, G.D. (2007). Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin Pharmacokinet 4:989–1008.
   Google Scholar
• Anger, G.J., Piquette-Miller, M. (2008). Pharmacokinetic studies in pregnant women. Clin Pharmacol Ther 83:184–187.
   PubMed Web of Science ®Google Scholar
• Anthes, J.C., Gilchrest, H., Richard, C., Eckel, S., Hesk, D., West, R.E., Jr, et al. (2002). Biochemical characterization of desloratadine, a potent antagonist of the human histamine H1 receptor. Eur J Pharmacol 449:229–237.
   PubMed Web of Science ®Google Scholar
• Awni, W.M., Yeh, J., Halstenson, C.E., Opsahl, J.A., Chung, M., Matzke, G.R. (1990). Effect of haemodialysis on the pharmacokinetics of cetirizine. Eur J Clin Pharmacol 38:67–69.
   PubMed Web of Science ®Google Scholar
• Baltes, E., Coupez, R., Giezek, H., Voss, G., Meyerhoff, C., Strolin Benedetti, M. (2001). Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers. Fundam Clin Pharmacol 15:269–277.
   PubMed Web of Science ®Google Scholar
• Bechtel, P., and Bechtel, Y. (2000). Pharmacogenetics of biotransformations. In: Sirtori, C. (Ed.), Clinical Pharmacology (pp 25–36 ). London: McGraw-Hill International Ltd.
   Google Scholar
• Bertilsson, L. (1995). Geographical/interracial differences in polymorphic drug oxidation. Clin Pharmacokinet 29:192–209.
   PubMed Web of Science ®Google Scholar
• Bjorkman, S. (2004). Prediction of drug disposition in infants and children by means of physiologically based PK modeling: theophylline and midazolam as model drugs. Br J Clin Pharmacol 59:691–704.
   Web of Science ®Google Scholar
• Bjorkman, S. (2006). Prediction of cytochrome p450-mediated hepatic drug clearance in neonates, infants, and children: how accurate are available scaling methods? Clin Pharmacokinet 45:1–11.
   PubMed Web of Science ®Google Scholar
• Blouin, R.A., Warren, G.W. (1999). Pharmacokinetic considerations in obesity. J Pharmaceut Sci 88:1–7.
   PubMed Web of Science ®Google Scholar
• Blyden, G.T., Greenblatt, D.J., Scavone, J.M., Shader, R.I. (1986). Pharmacokinetics of diphenhydramine and a demethylated metabolite following intravenous and oral administration. J Clin Pharmacol 26:529–533.
   PubMed Web of Science ®Google Scholar
• Bousquet, J., Bousquet, J., Khaltaev, N., Cruz, A.A., Denburg, J., Fokkens, W.J., et al. World Health Organization; GA(2)LEN; AllerGen. (2008). Allergic rhinitis and its impact on asthma 2008 update (in collaboration with World Health Organization, GA(2)LEN, and AllerGen). Allergy 63(Suppl 86):8–160.
   PubMed Web of Science ®Google Scholar
• Bouzom, F., Walther, B. (2008). Pharmacokinetic predictions in children by using the physiologically based pharmacokinetic modeling. Fundam Clin Pharmacol 22:579–587.
   PubMed Web of Science ®Google Scholar
• Boyle, J., Ridout, F., Meadows, R., Johnsen, S., Hindmarch, I. (2005). Suppression of the histamine-induced wheal and flare response by fexofenadine HCL 60 mg twice-daily, loratadine 10 mg once-daily, and placebo in healthy Japanese volunteers. Curr Med Res Opin 21:1495–1503.
   PubMed Web of Science ®Google Scholar
• Briggs, G.G., Freeman, R.K., Yaffe, S.J. (2008). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins, Baltimore.
   Google Scholar
• Brockmöller, J., Roots, I. (1994). Assessment of liver metabolic function. Clinical implications. Clin Pharmacokinet 27:216–248.
   PubMed Web of Science ®Google Scholar
• Brockmöller, J., Thomsen, T., Wittstock, M., Coupez, R., Lochs, H., Roots, I. (2005). Pharmacokinetics of levetiracetam in patients with moderate to severe liver cirrhosis (Child-Pugh classes A, B, and C): characterization by dynamic liver function tests. Clin Pharmacol Ther 77:529–541.
   PubMed Web of Science ®Google Scholar
• Brocks, D.R., Upward, J., Hust, R., Köester, F.E., Collie, H., Qian, Y., et al. (1996). The pharmacokinetics of pranlukast in healthy young and elderly subjects. Int J Clin Pharmacol Ther 34: 375–379.
   PubMed Web of Science ®Google Scholar
• Brutsche, M.H., Brutsche, I.C., Munawar, M., Langley, S.J., Masterson, C.M., Daley-Yates, P.T., et al. (2000). Comparison of pharmacokinetics and systemic effects of inhaled fluticasone propionate in patients with asthma and healthy volunteers: a randomised crossover study. Lancet 356:556–561.
   PubMed Web of Science ®Google Scholar
• Caregaro, L., Menon, F., Angeli, P., Amodio, P., Merkel, C., Bortoluzzi, A., et al. (1994). Limitations of serum creatinine level and creatinine clearance as filtration markers in cirrhosis. Arch Intern Med 154:201–205.
   PubMed Web of Science ®Google Scholar
• Chang, T., Okerholm, R.A., Glazko, A.J. (1974). Identification of diphenhydramine metabolites in human subjects. Res Commun Chem Pathol Pharmacol 9:391–404.
   PubMedGoogle Scholar
• Cheng, W.S.C., Murphy, T.L., Smith, M.T., Cooksley, W.G.E., Halliday, J.W., Powell, L.W. (1990). Dose-dependent pharmacokinetics of caffeine in humans: relevance as a test of quantitative liver function. Clin Pharmacol Ther 47:516–524.
   PubMed Web of Science ®Google Scholar
• Cheymol, G. (2000). Effects of obesity on pharmacokinetics. implications for drug therapy. Clin Pharmacokinet 39:215–231.
   PubMed Web of Science ®Google Scholar
• Cheymol, G., Jaillon, P. (1989). The effect of cardiac insufficiency on pharmacokinetics. Arch Mal Coeur Vaiss 82:391–397.
   PubMedGoogle Scholar
• Ciprandi, G., Pistorio, A., Tosca, M., Ferraro, M.R., Cirillo, I. (2009). Body mass index, respiratory function, and bronchial hyperreactivity in allergic rynithis and asthma. Respiratory Medicine 103:289–295.
   PubMed Web of Science ®Google Scholar
• Cockcroft, D.W., Gault, M.H. (1976). Prediction of creatinine clearance from serum creatinine. Nephron 16:31–41.
   PubMed Web of Science ®Google Scholar
• Cohn, J.N., Levine, T.B., Francis, G.S., Goldsmith, S. (1981). Neurohumoral control mechanisms in congestive heart failure. Am Heart J 102:509–514.
   PubMed Web of Science ®Google Scholar
• Collier, A.C., Ganley, N.A., Tingle, M.D., Blumenstein, M., Marvin, K.W., Paxton, J.W., et al. (2002). UDP-glucuronosyltransferase activity, expression, and cellular localization in human placenta at term. Biochem Pharmacol 63:409–419.
   PubMed Web of Science ®Google Scholar
• Collier, A.C., Tingle, M.D., Keelan, J.A., Paxton, J.W., Mitchell, M.D. (2000). A highly sensitive fluorescent microplate method for the determination of UDP-glucuronosyl transferase activity in tissues and placental cell lines. Drug Metab Dispos 28:1184–1186.
   PubMed Web of Science ®Google Scholar
• Cranswick, N., Turziková, J., Fuchs, M., Hulhoven, R. (2005). Levocetirizine in 1–2-year-old children: pharmacokinetic and pharmacodynamic profile. Int J Clin Pharmacol Ther 43:172–177.
   PubMed Web of Science ®Google Scholar
• Creasy, R., Resnick, R. (1999). Maternal-Fetal Medicine. W.B. Saunders, Philadelphia.
   Google Scholar
• Cristescu, C., Voicu, M., Bunu, C. (2004). Particularities of pharmacotherapy during pregnancy. Timisoara Med J. 52:201–206.
   Google Scholar
• Croner, S. (1992). Prediction and detection of allergy development: influence of genetic and environmental factors. J Pediatr 121:S58–S63.
   PubMed Web of Science ®Google Scholar
• Cutler, D.L., Banfield, C., Affrime, M.B. (2006). Safety of mometasone furoate nasal spray in children with allergic rhinitis as young as 2 years of age: a randomized, controlled trial. Pediatr Asthma Allerg Immunol 19:146–153.
   Google Scholar
• Daley-Yates, P.T., Price, A.C., Sisson, J.R., Pereira, A., Dallow, N. (2001). Beclomethasone dipropionate: absolute bioavailability, pharmacokinetics, and metabolism following intravenous, oral, intranasal, and inhaled administration in man. Br J Clin Pharmacol 51:400–409.
   PubMed Web of Science ®Google Scholar
• Daly, A.K. (2003). Pharmacogenetics of the major polymorphic metabolizing enzymes. Fundam Clin Pharmacol 17:27–41.
   PubMed Web of Science ®Google Scholar
• Davison, J.M. (1987). Kidney function in pregnant women. Am J Kidney Dis 9:248–252.
   PubMed Web of Science ®Google Scholar
• Dawes, M., Chowienczyk, P.J. (2001). Drugs in pregnancy. Pharmacokinetics in pregnancy. Best Pract Res Clin Obstet Gynaecol 15:819–826.
   PubMed Web of Science ®Google Scholar
• de Benedictis, F.M., de Benedictis, D., Canonica, G.W. (2008). New oral H1 antihistamines in children: facts and unmeet needs. Allergy 63:1395–1404.
   PubMed Web of Science ®Google Scholar
• De Swert, L.F. (1999). Risk factors for allergy. Eur J Pediatr 158:89–94.
   PubMed Web of Science ®Google Scholar
• Dekhuijzen, R., Koopmans, P.P. (2002). Pharmacokinetic profile of zafirlukast. Clin Pharmacokinet 41:105–114.
   PubMed Web of Science ®Google Scholar
• Desager, J.P., Dab, I., Horsmans, Y., Harvengt, C. (1993). A pharmacokinetic evaluation of the second-generation H1-receptor antagonist cetirizine in very young children. Clin Pharmacol Ther 53:431–435.
   PubMed Web of Science ®Google Scholar
• Devine, B.J. (1974). Gentamycine therapy. Drug Intel Clin Pharm 8:650–655.
   Google Scholar
• Dreisbach, A.W., Lertora, J.J. (2003). The effect of chronic renal failure on hepatic drug metabolism and drug disposition. Sem Dial 16:45–50.
   PubMed Web of Science ®Google Scholar
• Drescher, S., Schaeffeler, E., Hitzl, M., Hofmann, U., Schwab, M., Brinkmann, U., et al. (2002). MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine. Br J Clin Pharmacol 53:526–534.
   PubMed Web of Science ®Google Scholar
• Drug Monographs. McGraw-Hill Available at: www.accessmedicine.com.
   Google Scholar
• Dubois, D., Dubois, E.F. (1916). A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 17:863–870.
   Google Scholar
• Dwyer, J.H., Allayee, H., Dwyer, K., Fan, J., Wu, H., Mar, R., et al. (2004). Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonoc acid, and atherosclerosis. New Engl J Med 350:29–37 2004
   PubMed Web of Science ®Google Scholar
• Edginton, A.N., Schmitt, W., Willmann, S. (2006). Development and evaluation of a generic physiologically based pharmacokinetic model for children. Clin Pharmacokinet 45:1013–1034.
   PubMed Web of Science ®Google Scholar
• Edsbacker, S., Andersson, T. (2004). Pharmacokinetics of budesonide (Entocort™ EC) capsules for Crohn’s disease. Clin Pharmacokinet 43:803–821.
   PubMed Web of Science ®Google Scholar
• Edwards, J.A., Price Evans, DA. (1967). Ethanol metabolism in subjects possessing typical and atypical liver alcohol dehydrogenase. Clin Pharmacol Ther 8:824–829.
   PubMed Web of Science ®Google Scholar
• El Desoky, E. (2007). Pharmacokinetic-pharmacodynamic crisis in the elderly. Am J Ther 14:488–498.
   PubMedGoogle Scholar
• Fält, A., Bengtsson, T., Kennedy, B., Gyllenberg, A., Lindberg, B., Thorsson, L., et al. (2007). Exposure of infants to budesonide through breast milk of asthmatic mothers. J Allergy Clin Immunol 120:798–802.
   PubMed Web of Science ®Google Scholar
• Flegal, K.M., Carroll, M.D., Ogden, C.L., Johnson, C.L. (2002). Prevalence and trends in obesity among U.S. adults, 1999–2000. J Am Med Assoc 288:1723–1727.
   PubMed Web of Science ®Google Scholar
• Frederiksen, M.C. (2001). Physiologic changes in pregnancy and their effect on drug disposition. Sem Perinatol 25:120–123.
   PubMed Web of Science ®Google Scholar
• Ghosal, A., Yuan, Y., Hapangama, N., Achanfuo-Yeboah, J., Iannucci, R., Chowdhury, S., et al. (2004). Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine. Biopharm Drug Dispos 25:243–252.
   PubMed Web of Science ®Google Scholar
• Gillard, M., Christophe, B., Wels, B., Peck, M., Massingham, R., Chatelain, P. (2003). H1 antagonists: receptor affinity versus selectivity. Inflamm Res 52:S49–S50.
   PubMed Web of Science ®Google Scholar
• Gillard, M., Strolin Benedetti, M., Chatelain, P., Baltes, E. (2005). Histamine H1 receptor occupancy and pharmacodynamics of second-generation H1-antihistamines. Inflamm Res 54:367–369.
   PubMed Web of Science ®Google Scholar
• Gillard, M., Vanderperren, C., Moguilevsky, N., Massingham, R., Chatelain, P. (2002). Binding characteristics of cetirizine and levocetirizine to human H1 histamine receptors: contribution of Lys(191) and Thr(194). Mol Pharmacol 61:391–399.
   PubMed Web of Science ®Google Scholar
• Ginsberg, G., Hattis, D., Russ, A., Sonawane, B. (2004). Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children’s risks from environmental agents. J Toxicol Health A 67:297–329.
   PubMed Web of Science ®Google Scholar
• Goedde, H.W., Harada, S., Agarwal, D.P. (1979). Racial differences in alcohol sensitivity: a new hypothesis. Hum Genet 51:331–334.
   PubMed Web of Science ®Google Scholar
• Guengerich, F.P. (2001). Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem Res Toxicol 14:611–650.
   PubMed Web of Science ®Google Scholar
• Gupta, S., Kantesaria, B., Wang, Z., Khalilieh, S. (2004). Pharmacokinetics of desloratadine in poor metabolizers. Presented at the Annual Meeting of the American College of Allergy in Boston, Massachusetts, USA (Abstract, p 249). November 12–17, 2004
   Google Scholar
• Gupta, S., Khalilieh, S., Kantesaria, B., Banfield, C. (2006). Pharmacokinetics of desloratadine in children between 2 and 11 years of age. Br J Clin Pharmacol 63:534–540.
   Web of Science ®Google Scholar
• Gupta, S.K., Kantesaria, B., Banfield, C, Wang Z. (2007). Desloratadine dose selection in children aged 6 months to 2 years: comparison of population pharmacokinetics between children and adults. Br J Clin Pharmacol. 64:174–184.
   PubMed Web of Science ®Google Scholar
• Hakkola, J., Pasanen, M., Hukkanen, J., Pelkonen, O., Mäenpää, J., Edwards, R.J., et al. (1996a). Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. Biochem Pharmacol 51:403–411.
   PubMed Web of Science ®Google Scholar
• Hakkola, J., Raunio, H., Purkunen, R., Pelkonen, O., Saarikoski, S., Cresteil, T., et al. (1996b). Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. Biochem Pharmacol 52:379–383.
   PubMed Web of Science ®Google Scholar
• Halpern, S.A. (1998). American Pediatrics: the Social Dynamic of Professionalism, 1880–1980 (p 52 ). Berkeley, California, USA: University of California Press.
   Google Scholar
• Hammerlein, A., Derendorf, H., Lowenthal, D.T. (1998). Pharmacokinetic and pharmacodynamic changes in the elderly. Clinical Implications. Clin Pharmacokinet 35:49–64.
   PubMed Web of Science ®Google Scholar
• Han, P.Y., Duffull, S.B., Kirkpatrick, C.M.J., Green, B. (2008). Dosing in obesity: a simple solution to a big problem. Clin Pharmacol Ther 82:505–508.
   Web of Science ®Google Scholar
• Harada, S., Misawa, S., Agarwal, D.P., Goedde, H.W. (1980). Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication. Am J Hum Genet 32:8–15.
   PubMed Web of Science ®Google Scholar
• Hashizume, T., Mise, M., Terauchi, Y., O, L., Fujii, T., Miyazaki, H., et al. (1998). N-dealkylation and hydroxylation of ebastine by human liver cytochrome P450. Drug Metab Dispos 26:566–571.
   PubMed Web of Science ®Google Scholar
• Herman, H. (2007). Once-daily administration of intranasal corticosteroids for allergic rhinitis: a comparative review of efficacy, safety, patient preference, and cost. Am J Rhinol 21:70–79.
   PubMedGoogle Scholar
• Hilbert, J.M., Radwanski, E., Weglein, R., Luc, V., Perentesis, G., Symchowicz, S., et al. (1987). Pharmacokinetics and dose proportionality of loratadine. J Clin Pharmacol 27:694–698.
   PubMed Web of Science ®Google Scholar
• Hilli, J., Rane, A., Lundgren, S., Bertilsson, L. (2007). Genetic polymorphism of cytochrome P450s and P-glycoprotein in the Finnish population. Fundam Clin Pharmacol 21:379–386.
   PubMed Web of Science ®Google Scholar
• Hilmer, S.A., McLachlan, A.J., Le Couteur, DG. (2007). Clinical pharmacology in the geriatric patient. Fundament Clin Pharmacol 21:217–230.
   PubMed Web of Science ®Google Scholar
• Hodge, L.S., Tracy, T.S. (2007). Alterations in drug disposition during pregnancy. Expert Opin Drug Metab Toxicol 3:557–571.
   PubMed Web of Science ®Google Scholar
• Hoffmeyer, S., Burk, O., von Richter, O., Arnold, H.P., Brockmöller, J., Johne, A., et al. (2000). Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A 97: 3473–3478.
   PubMed Web of Science ®Google Scholar
• Holford, N.H. (1996). A size standard for pharmacokinetics. Clin Pharmacokinet 30:329–332.
   PubMed Web of Science ®Google Scholar
• Horsmans, Y., Desager, J.P., Hulhoven, R., Harvengt, C. (1993). Single-dose pharmacokinetics of cetirizine in patients with chronic liver disease. J Clin Pharmacol 33:929–932.
   PubMed Web of Science ®Google Scholar
• Hughes, S.C., Shardlow, P.C., Hollis, F.J., Scott, R.J., Motivaras, D.S., Allen, A., et al. (2008). Metabolism and disposition of fluticasone furoate, an enhanced-affinity glucocorticoid, in humans. Drug Metab Dispos 36:2337–2344.
   PubMed Web of Science ®Google Scholar
• ICH, harmonized tripartite guideline. (July 20, 2000). Clinical Investigation of Medicinal Products in the Pediatric Population. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. FDA site, accessed May 13, 2009 http://www.fda.gov/cder/guidance/4099 FNL.PDF
   Google Scholar
• Janeway, C., Travers, P., Walport, M., Shlomchik, M. (2001). Immunobiology. New York/London: Garland Science, e-book. ISBN: 0-8153-4101-6.
   Google Scholar
• Janmahasatian, S., Duffull, S.B., Ash, S., Ward, L.C., Byrne, N.M., Green, B. (2005). Quantification of lean bodyweight. Clin Pharmacokinet 44:1061–1065.
   Google Scholar
• Jarvis, D., Burney, P. (1997). Epidemiology of atopy and atopic disease. In: Kay, A.B. (Ed.), Allergy and Allergic Diseases (pp. 1208–1224 ). London: Blackwell Science.
   Google Scholar
• Jeannesson, E., Albertini, L., Siest, G., Gomes, A-M., Ribeiro, V., Aslanidis, C., et al. (2007). Determination of ABCB1 polymorphisms and haplotypes frequencies in a French population. Fundam Clin Pharmacol 21:411–418.
   PubMed Web of Science ®Google Scholar
• Johnson, T.N. (2004). A comparison of methods to predict drug clearance in neonates, infants and children. Br J Clin Pharmacol 57:677–678.
   Web of Science ®Google Scholar
• Johnson, T.N. (2008). The problems in scaling adult drug doses to children. Arch Dis Child 93:207–211.
   Web of Science ®Google Scholar
• Juniper, E.F., Ståhl, E., Doty, R.L., Simons, F.E.R., Allen, D.B., Howarth, P.H. (2005). Clinical outcomes and adverse effect monitoring in allergic rhinitis. J Allergy Clin Immunol 115: S390–S413.
   PubMedGoogle Scholar
• Juurlink, D.N., Mamdani, M., Kopp, A., Laupacis, A., Redelmeier, D.A. (2003). Drug-drug interactions among elderly patients hospitalized for drug toxicity. J Am Med Assoc 289:1652–1658.
   PubMed Web of Science ®Google Scholar
• Kasper, D.L., Braunwald, E., Fauci, A.S., Hauser, S.L., Longo, D.L., Jameson, JL. (Eds.) (2005). Chronic kidney disease (CKD) and uremia. In Harrison’s Manual of Medicine,16th ed. (p 707 ). McGraw-Hill.
   Google Scholar
• Katoh, M., Matsui, T., Yokoi, T. (2007). Glucuronidation of antiallergic drug, Tranilast: identification of human UDP-glucuronosyltransferase isoforms and effect of its phase I metabolite. Drug Metab Dispos 35:583–589.
   PubMed Web of Science ®Google Scholar
• Kearns, G.L., Abdel-Rahman, S.M., Alander, S.W., Blowey, D.L., Leeder, J.S., Kauffman, R.E. (2003). Developmental pharmacology—drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157–1167.
   PubMed Web of Science ®Google Scholar
• Khalilieh, S., Lutsky, B., Lorber, R. (2004). Safety of desloratadine in poor metabolizers. Presented at the Annual Meeting of the American College of Allergy in Boston, Massachusetts, USA, Abstract (p 248). November 12–17, 2004.
   Google Scholar
• Kim, R.B., Leake, B.F., Choo, E.F., Dresser, G.K., Kubba, S.V., Schwarz, U.I., et al. (2001). Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther 70:189–199.
   PubMed Web of Science ®Google Scholar
• Knorr, B., Holland, S., Schwartz, J., Douglas Rogers, J., Reiss, T.F. (2001). Clinical pharmacology of montelukast. Clin Exp Allergy Rev 1:254–260.
   Google Scholar
• Koren, G., Cairns, J., Chitayat, D., Gaedigk, A., Leeder, S.J. (2006). Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet 368:704.
   PubMed Web of Science ®Google Scholar
• Kovacs, S.J., Tenero, D.M., Martin, D.E., Ilson, B.E., Jorkasky, D.K. (1999). Pharmacokinetics and protein binding of eprosartan in hemodialysis-dependent patients with end-stage renal disease. Pharmacotherapy 19:612–619.
   PubMed Web of Science ®Google Scholar
• Kuntz, H.D., Straub, H., May, B. (1983). Theophylline elimination in congestive heart failure. Klin Wochenschr 61:1105–1106.
   PubMedGoogle Scholar
• Kusunoki, T., Morimoto, T., Nishikomori, R., Heike, T., Ito, M., Hosoi, S., et al. (2008). Obesity and the prevalence of allergic diseases in schoolchildren. Pediatr Allergy Immunol 19:527–534.
   PubMedGoogle Scholar
• Lafite, P., Andre, F., Dijols, S., Dansette, P.M., Zeldin, D.C., Mansuy, D. (2006). Fingerprints of human cytochrome P450 2J2 active site: substrates hydroxylation regioselectivity and molecular modeling. 16th International Symposium on Microsomes and Drug Oxidations, Abstract book: 85 (PS-YIW-1). 3–7 September 2006, Budapest, Hungary.
   Google Scholar
• Lasseter, K.C., Dilzer, S.C., Vargas, R., Waldman, S., Noveck, R.J. (2004). Pharmacokinetics and safety of ebastine in patients with impaired hepatic function compared with healthy volunteers. Clin Pharmacokinet 43:121–129.
   PubMed Web of Science ®Google Scholar
• Lebrun-Vignes, B., Diquet, B., Chosidow, O. (2001). Clinical pharmacokinetics of mizolastine. Clin Pharmacokinet 40:501–507.
   PubMed Web of Science ®Google Scholar
• Lee, D.K., Gardiner, M., Haggart, K., Fujihara, S., Lipworth, B.J. (2004). Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis. Clin Exp Allergy 34:650–653.
   PubMed Web of Science ®Google Scholar
• Lee, J.B., Winstead, P.S., Cook, A.M. (2006). Pharmacokinetic alterations in obesity. Orthopedics 29:984–988.
   PubMed Web of Science ®Google Scholar
• Lin, C.C., Radwanski, E., Affrime, M., Cayen, M. (1995). Pharmacokinetics of loratadine in pediatric subjects. Am J Ther 2:504–508.
   PubMedGoogle Scholar
• Loebstein, R., Koren, G. (2002). Clinical relevance of therapeutic drug monitoring during pregnancy.Ther Drug Monit 24:15–22.
   PubMed Web of Science ®Google Scholar
• Loebstein, R., Lalkin, A., Koren, G. (1997). Pharmacokinetic changes during pregnancy and their clinical relevance. Clin Pharmacokinet 33:328–343.
   PubMed Web of Science ®Google Scholar
• Loebstein, R., Lalkin, A., Koren, G. (2001). Pharmacokinetic changes during pregnancy and their clinical relevance. In: Maternal-Fetal Toxicology: A Clinician’s Guide. New York: Informa Health Care.
   Google Scholar
• Mahmood, I. (2006). Prediction of drug clearance in children from adults; a comparison of several allometric methods. Br J Clin Pharmacol 61:545–557.
   PubMed Web of Science ®Google Scholar
• Makino, Y., Osada, K., Sone, H., Sugiyama, K., Komai, M., Ito, M., et al. (1999). Percutaneous absorption of biotin in healthy subjects and in atopic dermatitis patients. J Nutr Sci Vitaminol (Tokyo) 45:347–352.
   PubMed Web of Science ®Google Scholar
• Mallet, L., Spinewhine, A., Huang, A. (2007). The challenge of managing drug interactions in elderly people. Lancet 370:185–191.
   PubMed Web of Science ®Google Scholar
• Martin, D.E., Chapelsky, M.C., Ilson, B., Tenero, D., Boike, S.C., Zariffa, N., et al. (1998). Pharmacokinetics and protein binding of eprosartan in healthy volunteers and in patients with varying degrees of renal impairment. J Clin Pharmacol 38: 129–137.
   PubMed Web of Science ®Google Scholar
• Matzke, G.R., Yeh, J., Awni, W.M., Halstenson, C.E., Chung, M. (1987). Pharmacokinetics of cetirizine in the elderly and patients with renal insufficiency. Ann Allergy 59:25–30.
   PubMedGoogle Scholar
• McCormack, P.L., Scott, L.J. (2007). Fluticasone furoate. Intranasal use in allergic rhinitis. Drugs 67:1905–1915.
   PubMed Web of Science ®Google Scholar
• McNamara, P., Alcorn, J. (2002). Protein binding predictions in infants. AAPS PharmSci 4:1–8. Available at: http:/www.aapspharmsci.org. Accessed May 13, 2009.
   Google Scholar
• Meyer, U.A. (2000). Pharmacogenetics and adverse drug reactions. The Lancet 356:1667–1671.
   PubMed Web of Science ®Google Scholar
• Meltzer, E.O., Gillman, S.A. (2007). Efficacy of fexofenadine vs. desloratadine in suppressing histamine-induced wheal and flare. Allergy Asthma Proc 28:67–73.
   PubMed Web of Science ®Google Scholar
• Molimard, M., Diquet, B., Strolin Benedetti, M. (2004). Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine, and mizolastine in humans. Fundam Clin Pharmacol 18:399–411.
   PubMed Web of Science ®Google Scholar
• Molino, G., Cavanna, A., Avagnina, P., Ballaré, M., Torchio, M. (1987). Hepatic clearance of D-sorbitol. Noninvasive test for evaluating functional liver plasma flow. Digest Dis Sci 32:753–758.
   PubMed Web of Science ®Google Scholar
• Mosteller, R.D. (1987). Simplified calculation of body-surface area. N Engl J Med 317:1098.
   PubMed Web of Science ®Google Scholar
• Motika, M.S., Zhang, J., Cashman, J.R. (2007). Flavin-containing monooxygenase 3 and human disease. Expert Opin Drug Metab Toxicol 3:831–845.
   PubMed Web of Science ®Google Scholar
• Ng, T.M., Munger, M.A., Lombardi, W.L., Doing, T.H., Ryujin, D.T., Young, D.C., et al. (2002). Chronically inhaled salmeterol improves pulmonary function in heart failure. J Cardiovasc Pharmacol 40:140–145.
   PubMed Web of Science ®Google Scholar
• NIH. (1998). Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults—the evidence report. National Institutes of Health. Obes Res 6 (Suppl 2):51S–209S. Erratum in: Obes Res 1998;6:464. Available at: http://www.nhlbi.nih.gov/guidelines/obesity/ob_gdlns.htm. Accessed December 9, 2008.
   PubMedGoogle Scholar
• Noiri, E., Ozawa, H., Fujita, T., Nakao, A. (2001). Pharmacokinetics of cetirizine in chronic hemodialysis patients: multiple-dose study. Nephron 89:101–104.
   PubMedGoogle Scholar
• Noveck, R.J., Preston, R.A., Swan, S.K. (2007). Pharmacokinetics and safety of ebastine in healthy subjects and patients with renal impairment. Clin Pharmacokinet 46:525–534.
   PubMed Web of Science ®Google Scholar
• Ogden, C.L., Carroll, M.D., Curtin, L.R., McDowell, M.A., Tabak, C.J., Flegal, K.M. (2006). Prevalence of overweight and obesity in the United States, 1999–2004. J Am Med Assoc 295:1549–1555.
   PubMed Web of Science ®Google Scholar
• Ogden, C.L., Carroll, M.D., McDowell, M.A., Flegal, K.M. (2007). Obesity among adults in the United States—no change since 2003–2004. NCHS data brief no 1. Hyattsville, Maryland, USA: National Center for Health Statistics. Available at: http://www.cdc.gov/nchs/data/databriefs/db01.pdf. Accessed December 2, 2008.
   Google Scholar
• Onrust, S.V., Lamb, H.M. (1998). Mometasone furoate. A review of its intranasal use in allergic rhinitis. Drugs 56:725–745.
   PubMed Web of Science ®Google Scholar
• Pacheco, L.D., Ghulmiyyah, L.M., Snodgrass, W.R., Hankins, GDV. (2007). Pharmacokinetics of corticosteroids during pregnancy. Am J Perinatol 24:79–82.
   PubMed Web of Science ®Google Scholar
• Papadakis, M.A., Arieff, A.I. (1987). Unpredictability of clinical evaluation of renal function in cirrhosis. Prospective study. Am J Med 82:945–952.
   PubMed Web of Science ®Google Scholar
• Parant, F., Moulsma, M., Gagnieu, M.C., Lardet, G. (2005). Hydroxyzine and metabolites as a source of interference in carbamazepine particle-enhanced turbidimetric inhibition immunoassay (Petinia). Ther Drug Monit 27:457–462.
   PubMed Web of Science ®Google Scholar
• Pariente-Khayat, A., Rey, E., Dubois, M.C., Vauzelle-Kervroedan, F., Pons, G., D’Athis, P., et al. (1995). Pharmacokinetics of cetirizine in 2- to 6-year-old children. Int J Clin Pharmacol Ther 33:340–344.
   PubMed Web of Science ®Google Scholar
• Park, B.K. (1982). Assessment of the drug metabolism capacity of the liver. Br J Clin Pharmac 14:631–651.
   PubMed Web of Science ®Google Scholar
• Passalacqua, G., Altrinetti, V., Mariani, G., Falagiani, P., Mistrello, G., Brizzolara, R., et al. (2005). Pharmacokinetics of radiolabelled Par j 1 administered intranasally to allergic and healthy subjects. Clin Exp Allergy 35:880–883.
   PubMed Web of Science ®Google Scholar
• Patterson, S.E., Cohn, V.H. (1984). Hepatic drug metabolism in rats with experimental chronic renal failure. Biochem Pharmacol. 33:711–716.
   PubMed Web of Science ®Google Scholar
• Pearce, R.E., Leeder, J.S., Kearns, G.L. (2006). Biotransformation of fluticasone: in vitro characterization. Drug Metab.Dispos 34:1035–1040.
   PubMed Web of Science ®Google Scholar
• Pentel, P., Benowitz, N. (1984). Pharmacokinetic and pharmacodynamic considerations in drug therapy of cardiac emergencies. Clin Pharmacokinet 9:273–308.
   PubMed Web of Science ®Google Scholar
• Piafsky, K.M., Sitar, D.S., Rangno, R.E., Ogilvie, R.I. (1977). Theophylline kinetics in acute pulmonary edema. Clin Pharmacol Ther 21:310–316.
   PubMed Web of Science ®Google Scholar
• Pichette, V., Leblond, F.A. (2003). Drug metabolism in chronic renal failure. Curr Drug Metab 4:91–103.
   PubMed Web of Science ®Google Scholar
• Pritchard-Davies, R., Gross, A.S., Shenfield, G.M. (1994). The effect of liver disease and food on plasma MEGX concentrations. Br J Clin Pharmac 37:298–301.
   PubMed Web of Science ®Google Scholar
• Ricketti, A.J. (2002). Allergic rhinitis. In: Grammer, L.C., Greenberger, P.A. (Eds.), Patterson’s Allergic Diseases, 6th ed. (pp 159–178 ). Lippincott Williams & Wilkins, Philadelphia.
   Google Scholar
• Ridout, F., Hindmarch, I. (2003). The effects of acute doses of fexofenadine, promethazine, and placebo on cognitive and psychomotor function in healthy Japanese volunteers. Ann Allergy Asthma Immunol 90:404–410.
   PubMed Web of Science ®Google Scholar
• Rosenblut, A., Bardin, P.G., Muller, B., Faris, M.A., Wu, W.W., Caldwell, M.F., et al. (2007). Long-term safety of fluticasone furoate nasal spray in adults and adolescents with perennial allergic rhinitis. Allergy 62:1071–1077.
   PubMed Web of Science ®Google Scholar
• Salazar, D.E., Corcoran, G.B. (1988). Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass. Am J Med 84:1053–1060.
   PubMed Web of Science ®Google Scholar
• Schenker, S., Yang, Y., Mattiuz, E., Tatum, D., Lee, M. (1999). Olanzapine transfer by human placenta. Clin Exp Pharmacol Physiol 26:691–697.
   PubMed Web of Science ®Google Scholar
• Schwartz, J.B. (2007). The current state of knowledge on age, sex, and their interactions on clinical pharmacology. Clin Pharmacol Ther 82:87–96
   PubMed Web of Science ®Google Scholar
• Shammas, F.V., Dickstein, K. (1988). Clinical pharmacokinetics in heart failure. An updated review. Clin Pharmacokinet 15:94–113.
   PubMed Web of Science ®Google Scholar
• Simons, F.E.R., Bergman, J.N., Watson, W.T.A., Simons, K.J. (1996). The clinical pharmacology of fexofenadine in children. J Allergy Clin Immunol 98:1062–1064.
   PubMed Web of Science ®Google Scholar
• Simons, F.E.R., Johnston, L., Simons, K.J. (2000). Clinical pharmacology of the H1-receptor antagonists, cetirizine and loratadine, in children. Pediatr Allergy Immunol 11:116–119.
   PubMed Web of Science ®Google Scholar
• Simons, F.E.R., Murray, H.E., Simons, K.J. (1995). Quantitation of H1-receptor antagonists in skin and serum. J Allergy Clin Immunol 95:759–764.
   PubMed Web of Science ®Google Scholar
• Simons, F.E.R., Semus, M.J., Goritz, S.S., Simons, K.J. (2003). H1 antihistaminic activity of cetirizine and fexofenadine in allergic children. Pediatr Allergy Immunol 14:207–211.
   PubMed Web of Science ®Google Scholar
• Simons, F.E.R., Simons, K.J. (2005). Levocetirizine: pharmacokinetics and pharmacodynamics in children age 6 to 11 years. J Allergy Clin Immunol 116:355–361.
   PubMed Web of Science ®Google Scholar
• Simons, K.J., Strolin Benedetti, M., Simons, F.E.R., Gillard, M., Baltes, E. (2007). Relevance of H1-receptor occupancy to H1-antihistamine dosing in children. Letters to the Editor. J Allergy Clin Immunol 1551–1554.
   PubMed Web of Science ®Google Scholar
• Simons, K.J., Watson, W.T.A., Martin, T.J., Chen, X.Y., Simons, FER. (1990). Diphenhydramine: pharmacokinetics and pharmacodynamics in elderly adults, young adults, and children. J Clin Pharmacol 30:665–671.
   PubMed Web of Science ®Google Scholar
• Simons, F.E.R., Watson, W.T.A., Minuk, G.Y., Simons, K.J. (1993). Cetirizine pharmacokinetics and pharmacodynamics in primary biliary cirrhosis. J Clin Pharmacol 33:949–954.
   PubMed Web of Science ®Google Scholar
• Simpson, K.H., Stakes, F., Miller, M. (1988). Pregnancy delays paracetamol absorption and gastric emptying in patients undergoing surgery. Br J Anaesth 60:24–27.
   PubMed Web of Science ®Google Scholar
• Smelt, V.A., Upton, A., Adjaye, J., Payton, M.A., Boukouvala, S., Johnson, N., et al. (2000). Expression of arylamine N-acetyltransferases in preterm placentas and in human preimplantation embryos. Hum Mol Genet 9:1101–1107.
   PubMed Web of Science ®Google Scholar
• Sotaniemi, E.A., Rautio, A., Bäckstrom, M., Arvela, P., Pelkonen, O. (1995). CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients. Br J Clin Pharmac 39:71–76.
   PubMed Web of Science ®Google Scholar
• Spector, R., Choudhury, A.K., Chiang, C-K., Goldberg, M.J., Ghoneim, M.M. (1980). Diphenhydramine in orientals and caucasians. Clin Pharmacol Ther 28:229–234.
   PubMed Web of Science ®Google Scholar
• Špičák, V., Dab, I., Hulhoven, R., Desager, J.P., Klánová, M., de Longueville, M., et al. (1997). Pharmacokinetics and pharmacodynamics of cetirizine in infants and toddlers. Clin Pharmacol Ther 61:325–330.
   PubMed Web of Science ®Google Scholar
• Spinewhine, A., Schmader, K.E., Barber, N., Hughes, C., Lapane, K.L., Swine, C., et al. (2007). Appropriate prescribing in elderly people: how well can it be measured and optimized? Lancet 370:173–184.
   PubMed Web of Science ®Google Scholar
• Stamatoyannopoulos, G., Chen, S-H., Fukui, M. (1975). Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity. Am J Hum Genet 27:789–796.
   PubMed Web of Science ®Google Scholar
• Stanaland, B.E. (2004). Once-daily budesonide aqueous nasal spray for allergic rhinitis: a review. Clin Ther 26:473–492.
   PubMed Web of Science ®Google Scholar
• Stange, J., Mitzner, S.R., Klammt, S., Freytag, J., Peszynski, P., Loock, J., et al. (2000). Liver support by extracorporeal blood purification: a clinical observation. Liver Transpl 6:603–613.
   PubMed Web of Science ®Google Scholar
• Stanley, E.L., Hume, R., Visser, T.J., Coughtrie, M.W. (2001). Differential expression of sulfotransferase enzymes involved in thyroid hormone metabolism during human placental development. J Clin Endocrinol Metab 86:5944–5955.
   PubMed Web of Science ®Google Scholar
• Strolin Benedetti, M., Baltes, E. (2003). Drug metaboilsm and disposition in children. Fundam Clin Pharmacol 17:281–299.
   PubMed Web of Science ®Google Scholar
• Strolin Benedetti, M., Otoul, C., Whomsley, R., Watelet, J-B. (2008). Pharmacokinetics of levocetirizine in subjects with varying degrees of renal function. Abstracts from the 10th European Regional ISSX Meeting. Drug Metab Rev 40:147–148, 1–172.
   Web of Science ®Google Scholar
• Strolin Benedetti, M., Plisnier, M., Kaise, J., Maier, L., Baltes, E., Arendt, C., et al. (2001). Absorption, distribution, metabolism, and excretion of [14C] levocetirizine, the R enantiomer of cetirizine, in healthy volunteers. Eur J Clin Pharmacol 57:571–582.
   PubMed Web of Science ®Google Scholar
• Strolin Benedetti, M., Tipton, K.F., Whomsley, R. (2007a). Amine oxidases and mono-oxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected? Fundam Clin Pharmacol 21:467–479.
   PubMed Web of Science ®Google Scholar
• Strolin Benedetti, M., Whomsley, R., Baltes, E. (2005). Differences in absorption, distribution, metabolism, and excretion of xenobiotics between the paediatric and adult populations. Expert Opin Drug Metab Toxicol 1:447–471.
   PubMed Web of Science ®Google Scholar
• Strolin Benedetti, M., Whomsley, R., Baltes, E. (2006). Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opin Drug Metab Toxicol 2:895–921.
   PubMed Web of Science ®Google Scholar
• Strolin Benedetti, M., Whomsley, R., Canning, M. (2007b). Drug metabolism in the paediatric population and in the elderly. Drug Discov Today 12:599–610.
   PubMed Web of Science ®Google Scholar
• Strolin Benedetti, M., Whomsley, R., Nicolas, J-M., Young, C., Baltes, E. (2003). Pharmacokinetics and metabolism of 14C-levetiracetam, a new antiepileptic agent, in healthy volunteers. Eur J Clin Pharmacol 59:621–630.
   PubMed Web of Science ®Google Scholar
• Sun, H., Frassetto, L., Benet, L.Z. (2006). Effects of renal failure on drug transport and metabolism. Pharmacol Ther 109:1–11.
   PubMed Web of Science ®Google Scholar
• Swartjes, J.M., van Geijn, H.P. (1998). Pregnancy and epilepsy. Eur J Obstet Gynecol Reprod Biol 79:3–11.
   PubMed Web of Science ®Google Scholar
• Syme, M.R., Paxton, J.W., Keelan, J.A. (2004). Drug transfer and metabolism by the human placenta. Clin Pharmacokinet 43:487–514.
   PubMed Web of Science ®Google Scholar
• Taburet, A.M., Singlas, E. (1996). Drug interactions with antiviral drugs. Clin Pharmacokinet 30:385–401.
   PubMed Web of Science ®Google Scholar
• Takabatake, T., Ohta, H., Ishida, Y., Hara, H., Ushiogi, Y., Hattori, N. (1988). Low serum creatinine levels in severe hepatic disease. Arch Intern Med 148:1313–1315.
   PubMed Web of Science ®Google Scholar
• Tomson, T., Palm, R., Källén, K., Ben-Menachem, E., Söderfeldt, B., Danielsson, B., et al. (2007). Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period, and lactation. Epilepsia 48:1111–1116.
   PubMed Web of Science ®Google Scholar
• Touchette, M.A., Slaughter, R.L. (1991). The effect of renal failure on hepatic drug clearance. DICP, The Annals of Pharmacotherapy 25:1214–1224.
   PubMedGoogle Scholar
• Tsutsumi, K., Kotegawa, T., Matsuki, S., Tanaka, Y., Ishii, Y., Kodama, Y., et al. (2001). The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans. Clin Pharmacol Ther 70:121–125.
   PubMed Web of Science ®Google Scholar
• Ueda, C.T., Dzindzio, B.S. (1981). Bioavailability of quinidine in congestive heart failure. Br J Clin Pharmacol 11:571–577.
   PubMed Web of Science ®Google Scholar
• Vanholder, R., De Smet, R., Glorieux, G., Argilés, A., Baurmeister, U., Brunet, P., et al. (2003). Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 63:1934–1943.
   PubMed Web of Science ®Google Scholar
• Varon, J., Marik, P. (2001). Management of the obese critically ill patient. Endocr Metabol Dysfunct Syndr Crit Ill 17:187–200.
   Google Scholar
• Verstuyft, C., Schwab, M., Schaeffeler, E., Kerb, R., Brinkmann, U., Jaillon, P., Funk-brentano, C., Becquemont L.(2003). Digoxin pharmacokinetics and MDR1 genetic polymorphisms. Euro J Clin Pharmacol 58:809–812.
   PubMed Web of Science ®Google Scholar
• Vidal, F., Perez, J., Panisello, J., Toda, R., Gutierrez, C., Richart, C. (1993). Atypical liver alcohol dehydrogenase in the Spanish population: its relation with the development of alcoholic liver disease. Alcohol Clin Exp Res 17:782–785.
   PubMed Web of Science ®Google Scholar
• von Wartburg, J.P., Schurch, P.M. (1968). Atypical human liver alcohol dehydrogenase. Ann N Y Acad Sci 151:936–946.
   PubMed Web of Science ®Google Scholar
• Watson, W.T.A., Simons, K.J., Chen, X.Y., Simons, FER. (1989). Cetirizine: a pharmacokinetic and pharmacodynamic evaluation in children with seasonal allergic rhinitis. J Allergy Clin Immunol 84:457–464.
   PubMed Web of Science ®Google Scholar
• White, R., Manitpisitkul, P. (2001). Pharmacokinetic theory of cassette dosing in drug discovery. Drug Metab Dispos 29: 957–966.
   PubMed Web of Science ®Google Scholar
• Whomsley, R., Collart, P., Strolin Benedetti, M., Baltes, E., Nicolas, J-M. (2003). Stereoselectivity of cetirizine metabolism. Drug Metab Rev 35(Suppl 1):30.
   Google Scholar
• Whomsley, R., Strolin Benedetti, M. (2005). Development of new H1 antihistamines: the importance of pharmacokinetics in the evaluation of safe and therapeutically effective agents. Curr Med Chem Anti-Inflam Anti-Allergy Agents 4:451–464.
   Google Scholar
• Whomsley, R., Strolin Benedetti, M., Espie, P., Usuki, E., Wolff, A., Baltes, E. (2005). The conversion of hydroxyzine to cetirizine is mediated by alcohol dehydrogenase. Drug Metab Rev 37 (Suppl 2):390–391.
   Google Scholar
• Wolff, P.H. (1972). Ethnic differences in alcohol sensitivity. Science (Washington, DC) 175:449–450.
   PubMed Web of Science ®Google Scholar
• Wu, S., Moomaw, C.R., Tomer, K.B., Falck, J.R., Zeldin, D.C. (1996). Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J Biol Chem 271:3460–3468.
   PubMed Web of Science ®Google Scholar
• Yaffe, S.J., and Aranda, J.V. (1992). Introduction and historical perspectives. In: Yaffe SJ, Aranda JV (eds). Pediatric Pharmacology: Therapeutic principles in practice 2nd ed. WB Saunders, Philadelphia, pp. 3–9.
   Google Scholar
• Zhao, J.J., Rogers, J.D., Holland, S.D., Larson, P., Amin, R.D., Haesen, R., et al. (1997). Pharmacokinetics and bioavailability of montelukast sodium (MK-0476) in healthy young and elderly volunteers. Biopharm Drug Dispos 18:769–777.
   PubMed Web of Science ®Google Scholar
• Zitt, M., Kosoglou, T., Hubbell, J. (2007). Mometasone furoate nasal spray. Drug Saf 30:317–326.
   PubMed Web of Science ®Google Scholar