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Journal of Neurotherapy
Investigations in Neuromodulation, Neurofeedback and Applied Neuroscience
Volume 15, 2011 - Issue 2
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RESEARCH ARTICLES

Placebos and Neurofeedback: A Case for Facilitating and Maximizing Placebo Response in Neurofeedback Treatments

Pages 94-114 | Received 15 Feb 2011, Accepted 01 Mar 2011, Published online: 20 May 2011

REFERENCES

  • Andrews , G. ( 2001 ). Placebo response in depression: Bane of research, boon to therapy [Editorial] . British Journal of Psychiatry , 178 , 192 – 194 .
  • Angelakis , E. , Stathopoulou , S. , Frymiare , J. L. , Green , D. L. , Lubar , J. F. , & Kounios , J. ( 2006 ). EEG neurofeedback: A brief overview and an example of peak alpha frequency training for cognitive enhancement in the elderly . The Clinical Neuropsychologist , 21 ( 1 ), 110 – 129 .
  • Antonuccio , D. O. , Danton , W. G. , DeNelsky , G. Y. , Greenberg , R. P. , & Gordon , J. S. ( 1999 ). Raising questions about antidepressants . Psychotherapy & Psychosomatics , 68 , 3 – 14 .
  • Bagby , R. M. , Ryder , A. G. , Schuller , D. R. , & Marshall , M. B. ( 2004 ). The Hamilton Depression Rating Scale: Has the gold standard become a lead weight? American Journal of Psychiatry , 161 , 2163 – 2177 .
  • Barsky , A. J. , Saintfort , R. , Rogers , M. P. , & Borus , J. F. ( 2002 ). Non-specific medication side effects and the nocebo phenomenon . Journal of the American Medical Association , 287 , 622 – 627 .
  • Benedetti , F. ( 2009 ). Placebo effects: Understanding the mechanisms in health and disease . New York , NY : Oxford University Press .
  • Benedetti , F. , Carlino , E. , & Pollo , A. ( 2011 ). How placebos change the patient's brain . Neuropsychopharmacology Reviews , 36 , 339 – 354 .
  • Benedetti , F. , Maggi , G. , Lopiano , L. , Lanotte , M. , Rainero , I. , Vighetti , S. , & Pollo , A. ( 2003 ). Open versus hidden medical treatments: The patient's knowledge about a therapy affects the therapy outcome . Prevention & Treatment , 6 ( 1 ). Available from http://content2.apa.org/journals/pre/6/1/1
  • Benedetti , F. , Mayberg , H. S. , Wager , T. D. , Stohler , C. S. , & Zubieta , J. K. ( 2005 ). Neurobiological mechanisms of the placebo effect . Journal of Neuroscience , 25 , 10390 – 10402 .
  • Benedetti , F. , Pollo , A. , Lopiano , L. , Lanotte , M. , Vighetti , S. , & Rainero , I. ( 2003 ). Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses . Journal of Neuroscience , 23 , 4315 – 4323 .
  • Benkert , O. A. , Szegedi , H. , Wetzel , H. J. , Staab , W. , Meister , W. , & Philipp , M. ( 1997 ). Continued doses of paroxetine and maprotiline: A prospective study in depressed outpatients with inadequate treatment response . Acta Psychiatrica Scandinavica , 95 , 288 – 296 .
  • Benson , H. , Klemchuyk , H. P. , & Graham , J. R. (1974). The usefulness of the relaxation response in the therapy of headache. Headache , 14(1), 49–52.
  • Benson , H. , & McCallie , D. P. ( 1979 ). Angina pectoris and the placebo effect . New England Journal of Medicine , 300 , 1424 – 1429 .
  • Bockting , C. L. H. , Schene , A. H. , Spinhoven , P. , Koeter , J. W. J. , Wouters , L. F. , Huyser , J. , & Kamphuis , J. H. ( 2005 ). Preventing relapse/recurrence in recurrent depression with cognitive therapy: A randomized controlled trial . Journal of Consulting & Clinical Psychology , 73 , 647 – 657 .
  • Blom , M. B. J. , Jonker , K. , Dusseldorp , E. , Spinhoven , P. , Hoencamp , E. , Haffmans , J. , & van Dyck , R. ( 2007 ). Combination treatment for acute depression is superior only when psychotherapy is added to medication . Psychotherapy & Psychosomatics , 76 , 289 – 297 .
  • Braithwaite , A. , & Cooper , P. ( 1981 ). Analgesic effects of branding in treatment of headaches . British Medical Journal , 282 , 1576 – 1578 .
  • Brody , A. L. , Saxena , S. , Stoessel , P. , Gillies , L. A. , Fairbanks , L. A. , & Alborzian , S. ( 2001 ). Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy . Archives of General Psychiatry , 58 , 631 – 640 .
  • Burneo , J. G. , Montori , V. M. , & Faught , E. ( 2002 ). Magnitude of the placebo effect in randomized trials of antiepileptic agents . Epilepsy & Behavior , 3 , 532 – 534 .
  • Chambless , D. L. , Baker , M. J. , Baucaom , D. H. , Beutler , L. E. , Calhoun , K. S. , Crits-Christoph , P. , … McCurry , S. ( 1998 ). Update on empirically validated therapies II . The Clinical Psychologist , 51 , 3 – 16 .
  • Cho , H. J. , Hotopf , M. , & Wessely , S. ( 2005 ). The placebo response in the treatment of chronic fatigue syndrome: A systematic review and meta-analysis . Psychosomatic Medicine , 67 , 301 – 313 .
  • Choi , S. W. , Chi , S. E. , Chung , S. Y. , Kim , J. W. , Ahn , C. Y. , & Kim , H. T. ( 2011 ). Is alpha wave neurofeedback effective with randomized clinical trials in depression? A pilot study . Neuropsychobiology , 63 , 43 – 51 .
  • Cobb , L. , Thomas , G. I. , Dillard , D. H. , Merendino , K. A. , & Bruce , R. A. ( 1959 ). An evaluation of internal-mammary artery ligation by a double blind technique . New England Journal of Medicine , 260 , 115 – 118 .
  • Colloca , L. , Lopiano , L. , Lanotte , M. & Benedetti , F. ( 2004 ). Overt versus covert treatment for pain, anxiety and Parkinson's disease . Lancet Neurology , 3 , 679 – 684 .
  • Cosgrove , L. ( 2010 ). Psychiatric taxonomy, psychopharmacology and big pharma . The Tablet: Newsletter of APA Division , 55 , 60 – 63 , 67 .
  • Daniels , A. M. , & Sallie , R. ( 1981 ). Headache, lulmbar puncture, and expectation . The Lancet , 1 , 1003 .
  • Dimond , E. G. , Kittle , C. F. , & Crockett , J. E. ( 1960 ). Comparison of internal mammary ligation and sham operation for angina pectoris . American Journal of Cardiology , 5 , 483 – 486 .
  • Drug Effectiveness Review Project ( 2005 ). Drug class review on pharmacologic treatments for ADHD . Portland : Oregon Health & Science University . Available from http://ww.ohsu.edu/drugeffectivensss/reports/documents/adhd%20Final%20Report.pdf
  • Fava , G. A. ( 1994 ). Do antidepressant and antianxiety drugs increase chronicity in affective disorders? Psychotherapy & Psychosomatics , 61 , 125 – 131 .
  • Fava , G. A. ( 2003 ). Can long-term treatment with antidepressant drugs worsen the course of depression? Journal of Clinical Psychiatry , 64 , 123 – 133 .
  • Fernandez , T. , Herrera , W. , Harmony , T. , Diaz-Comas , L. , Santiago , E. , Sanchez , L. , … Valdes , P. ( 2003 ). EEG and behavioral changes following neurofeedback treatment in learning disabled children . Clinical Electroencephalography , 34 , 145 – 150 .
  • Frankenhaeuser , M. , Jarpe , G , Svan , H. , & Wrangsjo , B. (1963). Physiological reactions to two different placebo treatments. Scandinavian Journal of Psychology , 4, 2145–2150.
  • Fratello , B. , Curcio , G. , Ferrara , M. , Marzano , C. , Couyoumdjian , A. , Petrillo , G. , … De Gennaro , L. ( 2005 ). Can an inert sleeping pill affect sleep? Effects on polysomnographic, behavioral and subjective measures . Psychopharmacology , 181 , 761 – 770 .
  • Freeman , E. W. , & Rickels , K. ( 1999 ). Characteristics of placebo responses in medical treatment of premenstrual syndrome . American Journal of Psychiatry , 159 , 1403 – 1408 .
  • Freemantle , N. , Anderson , I. M. , & Young , P. ( 2000 ). Predictive value of pharmacological activity for the relative efficacy of antidepressant drugs: Meta-regression analysis . British Journal of Psychiatry , 177 , 292 – 302 .
  • Friedman , M. A. , Detweiler-Bedell , J. B. , Leventhal , H. E. , Horne , R. , Keitner , G. I. , & Miller , I. W. ( 2004 ). Combined psychotherapy and pharmacotherapy for the treatment of major depressive disorder . Clinical Psychology: Science & Practice , 11 ( 1 ), 47 – 68 .
  • Fuchs , T. , Birbaumer , N. , Lutzenberger , W. , Gruzelier , J. H. , & Kaiser , J. ( 2003 ). Neurofeedback Treatment for attention deficit/hyperactivity disorder in children: A comparison with methylphenidate . Applied Psychophysiology & Biofeedback , 28 , 1 – 12 .
  • Gauld , A. ( 1992 ). A history of hypnotism . Cambridge , UK : Cambridge University Press .
  • Goldapple , K. , Segal , Z. , Garson , C. , Lau , M. , Bieling , P. , Kennedy , S. , & Mayberg , H. ( 2004 ). Modulation of cortical-limbic pathways in major depression: Treatment-specific effects of cognitive-behavior therapy compared to paroxetine . Archives of General Psychiatry , 61 ( 1 ), 34 – 41 .
  • Greenberg , R. P. , Bornstein , R. F. , Greenberg , M. D. , & Fisher , S. ( 1992 ). A meta-analysis of antidepressant outcome under “blinder” conditions . Journal of Consulting & Clinical Psychology , 60 , 664 – 669 .
  • Greenberg , R. P. , Bornstein , R. F. , Zborowski , M. J. , Fisher , S. , & Greenberg , M. D. ( 1994 ). A meta-analysis of Fluoxetine outcome in the treatment of depression . Journal of Nervous & Mental Disease , 182 , 547 – 551 .
  • Greenberg , R. P. , & Fisher , S. ( 1989 ). Examining antidepressant effectiveness: Findings, ambiguities, and some vexing puzzles . In S. Fisher & R. P. Greenberg (Eds.), The limits of biological treatment for psychological distress: Comparisons with psychotherapy and placebo , (pp. 1 – 37 ). Hillsdale , NJ : Erlbaum .
  • Hammond , D. C. ( 1990 ). Handbook of hypnotic suggestions & metaphors . New York , NY : Norton .
  • Hammond , D. C. ( 2003 ). QEEG-guided neurofeedback in the treatment of obsessive compulsive disorder . Journal of Neurotherapy , 7 ( 2 ), 25 – 52 .
  • Hammond , D. C. ( 2007 ). Review of the efficacy of clinical hypnosis with headaches and migraine . International Journal of Clinical & Experimental Hypnosis , 55 , 207 – 219 .
  • Hammond , D. C. ( 2010 ). Hypnosis in the treatment of anxiety and stress related disorders . Expert Reviews in Neurotherapeutics , 10 , 263 – 273 .
  • Hammond , D. C. , Bodenhamer-Davis , E. , Gluck , G. , Stokes , D. , Harper , S. H. , Trudeau , D. , … Kirk , L. ( 2011 ). Standards of practice for neurofeedback and neurotherapy: A position paper of the International Society for Neurofeedback & Research . Journal of Neurotherapy , 15 , 54 – 64 . Available from http://www.informaworld.com/smpp/651834977-68185396/content~db=all?content=10.1080/10874208.2010.545760
  • Hammond , D. C. , Hepworth , D. , & Smith , V. G. ( 1977 ). Improving therapeutic communication: A guide for developing effective techniques . San Francisco , CA : Jossey-Bass .
  • Hoedlmoser , K. , Pecherstorfer , T. , Gruber , G. , Anderer , P. , Doppelmayr , M. , Klimesch , W. , & Schabus , M. ( 2008 ). Instrumental conditioning of human sensorimotor rhythm 12–15 Hz) and its impact on sleep as well as declarative learning . Sleep , 31 , 1401 – 1408 .
  • Hollon , M. F. ( 2005 ). Direct-to-consumer advertising: A haphazard approach to health promotion . Journal of the American Medical Association , 293 , 2030 – 2033 .
  • Hollon , S. D. , DeRubeis , R. J. , Shelton , R. C. , & Weiss , B. (2002). The emperor's new drugs: effect size and moderation effects. Prevention & Treatment , 5(1). Available from http://psycnet.apa.org/journals/pre/5/1/28c/
  • Hrobjartsson , A. , & Gotzsche , P. C. ( 2001 ). Is the placebo powerless? An analysis of clinical trails comparing placebo with no treatment . New England Journal of Medicine , 344 , 1594 – 1602 .
  • Ikemi , Y. , & Nakagawa , S. ( 1962 ). A psychosomatic study of contagious dermatitis . Kyoshu Journal of Medical Science , 13 , 335 – 350 .
  • Jackson , G. E. ( 2005 ). Rethinking psychiatric drugs: A guide for informed consent . Bloomington , IN : Authorhouse .
  • Jackson , G. E. ( 2009 ). Drug-induced dementia: A perfect crime . Bloomington , IN : Authorhouse .
  • Joughin , C. , & Zwi , M. ( 1999 ). Focus on the use of stimulants in children with attention deficit hyperactivity disorder. Primary evidence-base briefing No. 1 . London , UK : Royal College of Psychiatrists Research Unit .
  • Kaptchuk , T. J. , Kelley , J. M. , Conboy , L. A. , Davis , R. G. , Kerr , C. E. , Jacobson , E. E. , … Lembo , A. J. ( 2008 ). Components of the placebo effect: A randomized controlled trial in irritable bowel syndrome . British Medical Journal , 336 , 998 – 1003 .
  • Kelley , J. M. , Lembo , A. J. , Ablon , J. S. , Villaneueva , J. J. , Conboy , L. A. , Levy , R. , … Kaptchuk , T. J. ( 2009 ). Patient and practitioner influences on the placebo effect in irritable bowel syndrome . Psychosomatic Medicine , 71 , 789 – 797 .
  • Khan , A. , Khan , S. , & Brown , W. A. ( 2002 ). Are placebo controls necessary to test new antidepressants and anxiolytics? International Journal of Neuropsychopharmacology , 5 , 193 – 197 .
  • Kirkley , A. , Birmingham , T. B. , Litchfield , R. B. , Giffin , J. R. , Willits , K. R. , Wong , C. J. , … Fowler , P. J. ( 2008 ). A randomized trial of arthroscopic surgery for osetoarthritis of the knee . New England Journal of Medicine , 359 , 1097 – 1107 .
  • Kirsch , I. ( 1990 ). Changing expectations: A key to effective psychotherapy . Belmont , CA : Brooks/Cole .
  • Kirsch , I. ( 2002 ). Yes, there is a placebo effect, but is there a powerful antidepressant drug effect? Prevention & Treatment , 5 ( 1 ). Available from http://psycnet.apa.org/journals/pre/5/1/22i/
  • Kirsch , I. ( 2005 ). Medication and suggestion in the treatment of depression . Contemporary Hypnosis , 22 ( 2 ), 59 – 66 .
  • Kirsch , I. ( 2010 ). The emperor's new drugs: Exploding the antidepressant myth . New York , NY : Basic Books .
  • Kirsch , I. , & Moncrieff , J. ( 2007 ). Clinical trials and the response rate illusion . Contemporary Clinical Trials , 28 , 348 – 351 .
  • Kirsch , I. , Moore , T. J. , Scoboria , A. , & Nicholls , S. S. ( 2002 ). The emperor's new drugs: An analysis of antidepressant medication data submitted to the U.S. Food and Drug Administration . Prevention & Treatment , 5 ( 1 ). Available from http://psycnet.apa.org/journals/pre/5/1/23a/
  • Kirsch , I. , & Sapirstein , G. ( 1998 ). Listening to Prozac but hearing placebo: A meta-analysis of antidepressant medication . Prevention & Treatment , 1 ( 2 ). Available from http://psycnet.apa.org/journals/pre/1/2/2a/
  • Kirsch , I. , & Weixel , L. J. ( 1988 ). Double-blind versus deceptive administration of a placebo . Behavioral Neuroscience , 102 , 319 – 323 .
  • Klein , D. F. ( 1998 ). Listening to meta-analysis but hearing bias . Prevention & Treatment , 1 ( 2 ). Available from http://psycnet.apa.org/journals/pre/1/2/6c/
  • Kradin , R. ( 2008 ). The placebo response and the power of unconscious healing . New York , NY : Routledge .
  • Krell , H. V. , Leuchter , A. F. , Morgan , M. , Cook , I. A. , & Abrams , M. ( 2004 ). Subject expectations of treatment effectiveness and outcome of treatment with an experimental antidepressant . Journal of Clinical Psychiatry , 65 , 1174 – 1179 .
  • Lansbergen , M. M. , van Dongen-Boomsma , M. , Buitelaar , J. K. , & Slaats-Willemse , D. ( 2010 ). ADHD and EEG-neurofeedback: A double-blind randomized placebo-controlled feasibility study . Journal of Neural Transmission , 118 , 275 – 284 .
  • Lanza , F. , Goff , J. , Scowcroft , C. , Jennings , D. , & Greski-Rose , P. (1994). Double-blind comparison of lansoprazole, ranitidine, and placebo in the treatment of acute duodenal ulcer. American Journal of Gastroenterology , 8, 1191–1200.
  • Larsen , S. , Larsen , R. , Hammond , D. C. , Sheppard , S. , Ochs , L. , Johnson , S. , … Chapman , C. ( 2006 ). The LENS neurofeedback with animals . Journal of Neurotherapy , 10 ( 2–3 ), 89 – 104 .
  • La Vaque , T. J. ( 2001 ). Pills, politics, and placebos . Journal of Neurotherapy , 5 ( 1–2 ), 73 – 86 .
  • La Vaque , T. J. , Hammond , D. C. , Trudeau , D. , Monastra , V. , Perry , L. J. , Lehrer , P. , … Sherman , R. ( 2002 ). Template for developing guidelines for the evaluation of the clinical efficacy of psycholophysiological interventions . Journal of Neurotherapy , 6 ( 4 ), 11 – 23 .
  • Leuchter , A. F. , Cook , I. A. , Witte , E. A. , Morgan , M. , & Abrams , M. ( 2002 ). Change in brain function of depressed subjects during treatment with placebo . American Journal of Psychiatry , 159 , 122 – 129 .
  • Leuchter , A. F. , Morgan , M. , Cook , I. A. , Dunkin , J. , Abrams , M. , & Witte , E. ( 2004 ). Pretreatment neurophysiological and clinical characteristics of placebo responders in treatment trials for major depression . Psychopharmacology , 177 , 15 – 22 .
  • Linde , K. , Witt , C. M. , Streng , A. , Weidenhammer , W. , Wagenpfeil , S. , Brinkhaus , B. , … Meichart , D. ( 2007 ). The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic pain . Pain , 128 , 264 – 271 .
  • Linden , M. , Habib , T. , & Radojevic , V. ( 1996 ). A controlled study of the effects of EEG biofeedback on cognition and behavior of children with attention deficit disorder and learning disabilities . Biofeedback & Self-Regulation , 21 ( 1 ), 35 – 49 .
  • Lubar , J. F. ( 1995 ). Neurofeedback for the management of attention_deficit/hyperactivity disorders . In M. S. Schwartz (Ed.), Biofeedback: A practitioner's guide (pp. 493 – 522 ). New York , NY : Guilford .
  • Lurie , P. , & Wolfe , S. ( 1997 ). Unethical trials of interventions to reduce perinatal transmission of the human immunodeficiency virus in developing countries . New England Journal of Medicine , 337 ( 15 ), 853 – 856 .
  • Martin , S. D. , Martin , E. , Rai , S. S. , Richardson , M. A. , & Royall , R. ( 2001 ). Brain blood flow changes in depressed patients treated with interpersonal psychotherapy or venlafaxine hydrochloride . Archives of General Psychiatry , 58 , 641 – 664 .
  • Mavissakalian , M. , Jones , B. , & Olson , S. ( 1990 ). Absence of placebo response in obsessive-compulsive disorder . Journal of Nervous & Mental Disease , 178 , 268 – 270 .
  • Mayberg , H. S. , Silva , J. A. , Brannan , S. K. , Teckell , J. L. , Mahurin , R. K. , & McGinnis , S. ( 2002 ). The functional neuroanatomy of the placebo effect . American Journal of Psychiatry , 159 , 728 – 737 .
  • Melander , H. , Ahlqvist-Rastad , J. , Meijer , G. , & Beermann , B. ( 2003 ). Evidence b(i)ased medicine selective reporting from studies sponsored by pharmaceutical industry: Review of studies in new drug applications . British Medical Journal , 326 , 1171 – 1173 .
  • Molina , B. S. , Hinshaw , S. P. , Swanson , J. M. , Arnold , L. E. , Vitiello , B. , Jensen , P. S. , … Houck , P. R. ( 2009 ). MTA at 8 years: Prospective follow-up of children treated for combined-type ADHD in a multisite study . Journal of the Academy of Child & Adolescent Psychiatry , 48 , 484 – 500 .
  • Monastra , V. J. , Monastra , D. M. , & George , S. ( 2002 ). The effects of stimulant therapy, EEG biofeedback, and parenting style on the primary symptoms of attention-deficit/hyperactivity disorder . Applied Psychophysiology & Biofeedback , 27 , 231 – 249 .
  • Moncreiff , J. ( 2002 ). The antidepressant debate . British Journal of Psychiatry , 180 , 193 – 194 .
  • Moncrieff , J. ( 2003 ). A comparison of antidepressant trials using active and inert placebos . International Journal of Methods in Psychiatric Research , 12 , 117 – 127 .
  • Moncrieff , J. (2009). The myth of the chemical cure: A critique of psychiatric drug treatment . New York , NY : Palgrave Macmillan.
  • Moncrieff , J. , & Cohen , D. ( 2005 ). Rethinking models of psychotropic drug action . Psychotherapy & Psychosomatics , 74 , 145 – 153 .
  • Moncrieff , J. , & Kirsch , I. ( 2005 ). Efficacy of antidepressants in adults . British Medical Journal , 331 , 155 – 157 .
  • Moncrieff , J. , Wessely , S. , & Hardy , R. ( 1998 ). Meta-analysis of trials comparing antidepressants with active placebos . British Journal of Psychiatry , 172 , 227 – 231 .
  • Montgomery , G. H. , DuHamel , K. N. , & Redd , W. H. ( 2000 ). A meta-analysis of hypnotically induced analgesia: How effective is hypnosis? International Journal of Clinical & Experimental Hypnosis , 48 , 138 – 153 .
  • Montgomery , G. H. , & Kirsch , I. ( 1997 ). Classical conditioning and the placebo effect . Pain , 72 ( 1–2 ), 107 – 113 .
  • Moseley , J. B. , O'Malley , K. , Petersen , N. J. , Menke , T. J. , Brody , B. A. , Kuykendall , D. H. , … Wray , N. P. ( 2002 ). A controlled trial of arthroscopic surgery for osteoarthritis of the knee . New England Journal of Medicine , 347 , 81 – 88 .
  • MTA Cooperative Group . ( 1999 ). A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal treatment study of children with ADHD . Archives of General Psychiatry , 56 , 1073 – 1086 .
  • Myers , M. G. , Calms , J. A. , & Singer , J. ( 1987 ). The consent form as a possible cause of side effects . Clinical Pharmacology & Therapeutics , 42 , 250 – 253 .
  • Olfson , M. , Marcus , S. C. , Druss , B. , Elinson , L. , Tanielian , T. , & Rincus , H. A. ( 2002 ). National trends in the outpatient treatment of depression . Journal of the American Medical Association , 287 , 203 – 209 .
  • Olness , K. , & Kohen , D. ( 1996 ). Hypnosis and hypnotherapy with children () , 3rd ed. . New York , NY : Guilford .
  • Pariente , J. , White , P. , Frackowiak , R. S. J. , & Lewith , G. ( 2005 ). Expectancy and belief modulate the neuronal substrates of pain treated by acupuncture . Neuroimage , 25 , 1161 – 1167 .
  • Petrovic , P. , Kalso , E. , Petersson , K. M. , & Ingvar , M. ( 2002 ). Placebo and opiod analgesia–imaging a shared neuronal network . Science , 295 , 1737 – 1740 .
  • Pigott , H. E. , Leventhal , A. M. , Alter , G. S. , & Boren , J. J. ( 2009 ). Efficacy and effectiveness of antidepressants: Current status of research . Psychotherapy & Psychosomatics , 79 , 267 – 279 .
  • Pogge , R. ( 1963 ). The toxic placebo . Medical Times , 91 , 773 – 778 .
  • Pollo , A. , Amanzio , M. , Arslanian , A. , Casadio , C. , Maggi , G. , & Benedetti , F. ( 2001 ). Response expectancies in placebo analgesia and their clinical relevance . Pain , 93 , 77 – 84 .
  • Quality Assurance Project . ( 1983 ). Treatment outline for depressive disorders . Australian & New Zealand Journal of Psychiatry , 17 , 129 – 146 .
  • Rabkin , J. G. , Markowitz , J. S. , Stewart , J. W. , McGrath , P. J. , Harrison , W. , Quitkin , F. J. , & Klein , D. F. ( 1986 ). How blind is blind? Assessment of patient and doctor medication guesses in a placebo-controlled trial of imipramine and phenelzine . Psychiatry Research , 19 , 75 – 86 .
  • Raymond , J. , Varney , C. , Parkinson , L. A. , & Gruzelier , J. H. ( 2005 ). The effects of alpha/theta neurofeedback on personality and mood . Cognitive Brain Research , 23 , 287 – 292 .
  • Reeves , R. R. , Ladner , M. E. , Hart , R. H. , & Burke , R. S. ( 2007 ). Nocebo effects with antidepressant clinical drug trial placebos . General Hospital Psychiatry , 29 , 275 – 277 .
  • Reidenberg , M. M. , & Lowenthal , D. T. ( 1968 ). Adverse nondrug reactions . New England Journal of Medicine , 279 , 678 – 679 .
  • Rothman , D. J. ( 1987 ). Ethical and social issues in the development of new drugs & vaccines . Bulletin of the New York Academy of Medicine , 63 ( 6 ), 557 – 568 .
  • Sangal , R. B. , & Sangal , J. M. ( 2003 ). What is a significant response in drug studies of attention-deficit/hyperactivity disorder: Statistical significance is necessary, but is it sufficient? Psychopharmcology Bulletin , 37 ( 2 ), 50 – 58 .
  • Schachter , H. M. , Pham , B. , King , J. , Langford , S. , & Moher , D. (2001). How efficacious and safe is short-acting methylphenidate for the treatment of attention-deficit disorder in children and adolescents? A meta-analysis. Canadian Medical Association Journal , 165, 1475–1488.
  • Schwartz , J. M. , Stoessel , P. W. , Baxter , L. R. , Martin , K. M. , & Phelps , M. E. ( 1996 ). Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder . Archives of General Psychiatry , 53 , 109 – 113 .
  • Scott , D. J. , Stohler , C. S. , Egnatuk , C. M. , Want , H. , Koeppe , R. A. , & Zubieta , J. K. ( 2008 ). Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses . Archives of General Psychiatry , 65 , 220 – 231 .
  • Sodergren , S. C. , & Hyland , M. E. ( 1999 ). Expectancy and asthma . In I. Kirsch (Ed.), How expectancies shape experience (pp. 197 – 212 ). Washington , DC : American Psychological Association .
  • Sterman , M. B. ( 1973 ). Neurophysiological and clinical studies of sensorimotor EEG biofeedback training: Some effects on epilepsy . Seminars in Psychiatry , 5 , 507 – 525 .
  • Swanson , J. M. , Elliott , G. R. , Greenhill , L. L. , Wigal , T. , Arnold , L. E. , Vitiello , B. , … Volkow , N. ( 2007 ). Effects of stimulant medication on growth rates across 3 years in the MTA follow-up . Journal of the Academy of Child & Adolescent Psychiatry , 46 , 1015 – 1027 .
  • Thomas , K. B. ( 1987 ). General practice consultations: Is there any point in being positive? British Medical Journal , 294 , 1200 – 1202 .
  • Traut , E. F. , & Passarelli , E. W. ( 1957 ). Placebos in the treatment of rheumatoid arthritis and other rheumatic conditions . Annals of Rheumatic Diseases , 16 , 18 – 22 .
  • Tricoci , P. , Allen , J. M. , Kramer , J. M. , Califf , R. M. , & Smith , S. C. ( 2009 ). Scientific evidence underlying the ACC/AHA clinical practice guidelines . Journal of the American Medical Association , 301 , 8321 – 8341 .
  • Turner , E. H. , Matthews , A. M. , Linardatos , E. , Tell , R. A. , & Rosenthal , R. ( 2008 ). Selective publication of antidepressant trials and its influence on apparent efficacy . New England Journal of Medicine , 358 , 252 – 260 .
  • Vase , L. , Riley , J. L. , & Price , D. D. ( 2002 ). A comparison of placebo effects in clinical analgesic trails versus studies in placebo analgesia . Pain , 99 , 443 – 452 .
  • Vase , L. , Robinson , M. E. , Verne , G. N. , & Price , D. D. ( 2003 ). The contributions of suggestion, expectancy, and desire to placebo effect in irritable bowel syndrome patients . Pain , 105 , 17 – 25 .
  • Verne , G. N. , Robinson , M. E. , Vase , L. , & Price , D. D. ( 2003 ). Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patients . Pain , 105 , 223 – 230 .
  • Wager , T. D. , Rilling , J. K. , Smith , E. E. , Sokolik , A. , Casey , K. L. , Davidson , R. J. , … Cohen , J. D. ( 2004 ). Placebo-induced changes in fMRI in the anticipation and experience of pain . Science , 303 , 1162 – 1166 .
  • Walsh , B. T. , Seidman , S. N. , Sysko , R. , & Gould , M. ( 2002 ). Placebo response in studies of major depression: Variable, substantial, and growing . Journal of the American Medical Association , 287 , 1840 – 1847 .
  • Watson , A. , El-Deredy , W. , Vogt , B. A. , & Jones , A. ( 2007 ). Placebo analgesia is not due to compliance or habituation: EEG and behavioural evidence . NeuroReport , 18 , 771 – 775 .
  • Whitaker , R. ( 2010 ). Anatomy of an epidemic: Magic bullets, psychiatric drugs, and the astonishing rise of mental illness in America . New York , NY : Crown .
  • Williams , J. W. , Mulrow , C. D. , Chiquette , E. , Noel , P. H. , Aguilar , C. , & Cornell , J. ( 2000 ). A systematic review of newer pharmacotherapies for depression in adults: Evidence report summary . Annals of Internal Medicine , 132 , 743 – 756 .
  • Wolfe , S. ( 1950 ). Effects of suggestion and conditioning on the action of chemical agents in human subjects–the pharmacology of placebos . Journal of Clinical Investigation , 29 , 100 – 109 .
  • World Medical Association. (2000, October). Declaration of Helsinki. Amended by the 52nd WMA General Assembly, Edinburgh, Scotland. Journal of the American Medical Association , 284, 3043–2045.
  • Wyatt , W. J. , & Midkiff , D. M. ( 2006 ). Biological psychiatry: A practice in search of a science . Behavior & Social Issues , 15 , 132 – 151 .
  • Zimmerman , M. , Mattia , J. I. , & Posternak , M. A. ( 2002 ). Are subjects in pharmacological treatment trials of depression representative of patients in routine clinical practice? American Journal of Psychiatry , 159 , 469 – 473 .

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