A Prospective Study of the Safety and Effectiveness of Droperidol in Children for Prehospital Acute Behavioral Disturbance

References

• Downes MA, Healy P, Page CB, Bryant JL, Isbister GK. Structured team approach to the agitated patient in the emergency department. Emerg Med Australas. 2009;21:196–202.
   PubMed Web of Science ®Google Scholar
• Queensland Ambulance Service Final Report (April 2016). Paramedic safety taskforce. https://www.ambulance.qld.gov.au/docs/QAS-Paramedic-Safety-Taskforce-Final-Report.pdf
   Google Scholar
• Pourshaikhian M, Abolghasem Gorji H, Aryankhesal A, Khorasani-Zavareh D, Barati A. A systematic literature review: workplace violence against emergency medical services personnel. Arch Trauma Res. 2016;5(1):e28734.
   PubMed Web of Science ®Google Scholar
• Spain D, Crilly J, Whyte I, Jenner L, Carr V, Baker A. Safety and effectiveness of high-dose midazolam for severe behavioural disturbance in an emergency department with suspected psychostimulant-affected patients. Emerg Med Australia. 2008;20(2):112–20.
   PubMed Web of Science ®Google Scholar
• Calver L, Page CB, Downes MA, Chan B, Kinnear F, Wheatley L, Spain D, Isbister GK. The safety and effectiveness of droperidol for sedation of acute behavioral disturbance in the emergency department. Ann Emerg Med. 2015;66(3):230–8.
   PubMed Web of Science ®Google Scholar
• Isbister GK, Calver LA, Downes MA, Page CB. Ketamine as rescue treatment for difficult-to-sedate severe acute behavioral disturbance in the emergency department. Ann Emerg Med. 2016;67(5):581–7.
   PubMed Web of Science ®Google Scholar
• Isbister GK, Calver LA, Page CB, Stokes B, Bryant JL, Downes MA. Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study. Ann Emerg Med. 2010;56(4):392–401.
   PubMed Web of Science ®Google Scholar
• Taylor DM, Yap CY, Knott JC, Taylor SE, Phillips GA, Karro J, Chan EW, Kong DCM, Castle DJ. Midazolam-droperidol, droperidol, or olanzapine for acute agitation: a randomized clinical trial. Ann Emerg Med. 2017;69(3):318–26.
   PubMed Web of Science ®Google Scholar
• Richards JR, Derlet RW, Duncan DR. Chemical restraint for the agitated patient in the emergency department: lorazepam versus droperidol. J Emerg Med. 1998;16(4):567–73.
   PubMedGoogle Scholar
• Calver LA, Downes MA, Page CB, Bryant JL, Isbister GK. The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department. BMC Emerg Med. 2010;10:14.
   Google Scholar
• Rosen CL, Ratliff AF, Wolfe RE, Branney SW, Roe EJ, Pons PT. The efficacy of intravenous droperidol in the prehospital setting. J Emerg Med. 1997;15(1):13–7.
   PubMedGoogle Scholar
• Hick JL, Mahoney BD, Lappe M. Prehospital sedation with intramuscular droperidol: a one-year pilot. Prehosp Emerg Care. 2001;5(4):391–4.
   PubMedGoogle Scholar
• Martel M, Miner J, Fringer R, Sufka K, Miamen A, Ho J, Clinton J, Biros M. Discontinuation of droperidol for the control of acutely agitated out-of-hospital patients. Prehosp Emerg Care. 2005;9(1):44–8.
   PubMedGoogle Scholar
• Page CB, Parker LE, Rashford SJ, Bosley E, Isoardi KZ, Williamson FE, Isbister GK. A prospective before and after study of droperidol for prehospital acute behavioral disturbance. Prehosp Emerg Care 2018:1–9.
   Google Scholar
• Cole JB, Moore JC, Nystrom PC, Orozco BS, Stellpflug SJ, Kornas RL, Fryza BJ, Steinberg LW, O'Brien-Lambert A, Bache-Wiig P, Engebretsen KM, Ho JD. A prospective study of ketamine versus haloperidol for severe prehospital agitation. Clin Toxicol. 2016;54(7):556–62.
   PubMed Web of Science ®Google Scholar
• Scheppke KA, Braghiroli J, Shalaby M, Chait R. Prehospital use of I.M. ketamine for sedation of violent and agitated patients. West J Emerg Med. 2014;15(7):736–4.
   PubMedGoogle Scholar
• Olives TD, Nystrom PC, Cole JB, Dodd KW, Ho JD. Intubation of profoundly agitated patients treated with prehospital ketamine. Prehosp Disaster Med. 2016;31(6):593–602.
   PubMed Web of Science ®Google Scholar
• Burnett AM, Peterson BK, Stellpflug SJ, Engebretsen KM, Glasrud KJ, Marks J, Frascone RJ. The association between ketamine given for prehospital chemical restraint with intubation and hospital admission. Am J Emerg Med. 2015;33(1):76–9.
   PubMed Web of Science ®Google Scholar
• Cole JB, Klein LR, Nystrom PC, Moore JC, Driver BE, Fryza BJ, Harrington J, Ho JD. A prospective study of ketamine as primary therapy for prehospital profound agitation. Am J Emerg Med. 2018;36(5):789–96.
   PubMed Web of Science ®Google Scholar
• Szwak K, Sacchetti A. Droperidol use in pediatric emergency department patients. Pediatr Emerg Care. 2010;26(4):248–50.
   PubMed Web of Science ®Google Scholar
• Cole JB, Klein LR, Strobel AM, Blanchard SR, Nahum R, Martel ML. The use, safety, and efficacy of olanzapine in a level I pediatric trauma center emergency department over a 10-year period. Pediatr Emerg Care. 2017.
   PubMedGoogle Scholar
• Hampton LM, Daubresse M, Chang HY, Alexander GC, Budnitz DS. Emergency department visits by children and adolescents for antipsychotic drug adverse events. JAMA Psychiatr. 2015;72(3):292–4.
   PubMed Web of Science ®Google Scholar
• Calver LA, Stokes B, Isbister GK. Sedation assessment tool to score acute behavioural disturbance in the emergency department. Emerg Med Australia. 2011;23(6):732–40.
   PubMed Web of Science ®Google Scholar
• Calver L, Isbister GK. Parenteral sedation of elderly patients with acute behavioral disturbance in the ED. Am J Emerg Med. 2013;31(6):970–3.
   PubMed Web of Science ®Google Scholar
• Sonnier L, Barzman D. Pharmacologic management of acutely agitated pediatric patients. Paediatr Drugs. 2011;13(1):1–10.
   PubMed Web of Science ®Google Scholar
• Battaglia J. Pharmacological management of acute agitation. Drugs 2005; 65 (9): 1207–22
   PubMed Web of Science ®Google Scholar
• Knott JC, Taylor DM, Castle DJ. Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department. Ann Emerg Med. 2006;47:61–7.
   PubMed Web of Science ®Google Scholar
• Keepers GA, Clappison VJ, Casey DE. Initial anticholinergic prophylaxis for acute neuroleptic induced extrapyramidal syndromes. Arch Gen Psychiatr. 1983; 40:1113–7.
   PubMed Web of Science ®Google Scholar
• Horowitz BZ, Bizovi K, Moreno R. Droperidol–behind the black box warning. Acad Emerg Med. 2002 9(6):615–8.
   PubMed Web of Science ®Google Scholar
• Kao LW, Kirk MA, Evers SJ, Rosenfeld SH. Droperidol, QT prolongation, and sudden death: what is the evidence? Ann Emerg Med. 2003;41(4):546–58.
   PubMed Web of Science ®Google Scholar
• Perkins J, Ho JD, Vilke GM, DeMers G. American academy of emergency medicine position statement: safety of droperidol use in the emergency department. J Emerg Med. 2015;49(1):91–7.
   PubMed Web of Science ®Google Scholar
• Lischke V, Behne M, Doelken P, Schledt U, Probst S, Vettermann J. Droperidol causes a dose-dependent prolongation of the QT interval. Anesth Analg. 1994;79(5):983–6.
   PubMed Web of Science ®Google Scholar
• Khokhar MA, Rathbone J. Droperidol for psychosis‐induced aggression or agitation. Cochrane Database Syst Rev. 2016, 12. Art. No.: CD002830. DOI: 10.1002/14651858.CD002830.pub3.
   PubMed Web of Science ®Google Scholar
• Kowalski JM, Kopec KT, Lavelle J, Osterhoudt K. A novel agent for management of agitated delirium: a case series of ketamine utilization in the pediatric emergency department. Pediatr Emerg Care. 2017;33(9):e58–62.
   PubMed Web of Science ®Google Scholar